nach oben

Erschienen in:

01.01.2013 | Original article

Diffusional kurtosis imaging of normal-appearing white matter in multiple sclerosis: preliminary clinical experience

verfasst von: Mariko Yoshida, Masaaki Hori, Kazumasa Yokoyama, Issa Fukunaga, Michimasa Suzuki, Koji Kamagata, Keigo Shimoji, Atsushi Nakanishi, Nobutaka Hattori, Yoshitaka Masutani, Shigeki Aoki

Erschienen in: Japanese Journal of Radiology | Ausgabe 1/2013

Einloggen, um Zugang zu erhalten

Abstract

Purpose

We evaluated diffusional changes in normal-appearing white matter (NAWM) regions remote from multiple sclerosis (MS) plaques by using diffusional kurtosis imaging (DKI) to investigate the non-Gaussian behavior of water diffusion.

Materials and methods

Participants were 11 MS patients and 6 age-matched healthy volunteers. DKI was performed on a 3-T MR imager. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), and diffusional kurtosis (DK) maps were computed. Regions of interest (ROIs) were compared in 24 cerebral regions, including the frontal, parietal, and temporal lobe white matter (WM) in controls and NAWM in MS patients.

Results

The mean FA of all ROIs was 0.468 ± 0.014 (SD) (controls) or 0.431 ± 0.029 (MS group) (P = 0.016). Mean ADC was 0.785 ± 0.034 × 10⁻³ mm²/s (controls) or 0.805 ± 0.041 × 10⁻³ mm²/s (MS group). The mean DK of all ROIs was 0.878 ± 0.020 (controls) or 0.823 ± 0.032 (MS group) (P = 0.002). Analysis of individual ROIs revealed significant differences in DK in 3 ROIs between normal WM and NAWM, but significant differences in ADC and FA in only one ROI each.

Conclusion

DKI may be a new sensitive indicator for detecting tissue damage in MS patients in addition to conventional diffusional evaluations, for example diffusion tensor imaging.

Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, et al. Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging. 2001;13:534–46.PubMedCrossRef

Rocca MA, Cercignani M, Iannucci G, Comi G, Filippi M. Weekly diffusion-weighted imaging of normal-appearing white matter in MS. Neurology. 2000;55:882–4.PubMedCrossRef

Cercignani M, Iannucci G, Filippi M. Diffusion-weighted imaging in multiple sclerosis. Ital J Neurol Sci. 1999;20:S246–9.PubMedCrossRef

Horsfield MA, Lai M, Webb SL, Barker GJ, Tofts PS, Turner R, et al. Apparent diffusion coefficients in benign and secondary progressive multiple sclerosis by nuclear magnetic resonance. Magn Reson Med. 1996;36:393–400.PubMedCrossRef

Basser PJ. Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR Biomed. 1995;8:333–44.PubMedCrossRef

Guo AC, MacFall JR, Provenzale JM. Multiple sclerosis: diffusion tensor MR imaging for evaluation of normal-appearing white matter. Radiology. 2002;222:729–36.PubMedCrossRef

Filippi M, Agosta F. Imaging biomarkers in multiple sclerosis. J Magn Reson Imaging. 2010;31:770–88.PubMedCrossRef

Rovaris M, Agosta F, Pagani E, Filippi M. Diffusion tensor MR imaging. Neuroimaging Clin N Am. 2009;19:37–43.PubMedCrossRef

Werring DJ, Brassat D, Droogan AG, Clark CA, Symms MR, Barker GJ, et al. The pathogenesis of lesions and normal-appearing white matter changes in multiple sclerosis: a serial diffusion MRI study. Brain. 2000;123(Pt 8):1667–76.PubMedCrossRef

10.

Castriota Scanderbeg A, Tomaiuolo F, Sabatini U, Nocentini U, Grasso MG, Caltagirone C. Demyelinating plaques in relapsing-remitting and secondary-progressive multiple sclerosis: assessment with diffusion MR imaging. AJNR Am J Neuroradiol. 2000;21:862–8.PubMed

11.

Tsuchiya K, Hachiya J, Maehara T. Diffusion-weighted MR imaging in multiple sclerosis: comparison with contrast-enhanced study. Eur J Radiol. 1999;31:165–9.PubMedCrossRef

12.

Jensen JH, Helpern JA, Ramani A, Lu H, Kaczynski K. Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med. 2005;53:1432–40.PubMedCrossRef

13.

Lu H, Jensen JH, Ramani A, Helpern JA. Three-dimensional characterization of non-gaussian water diffusion in humans using diffusion kurtosis imaging. NMR Biomed. 2006;19:236–47.PubMedCrossRef

14.

Hori M, Fukunaga I, Masutani Y, Taoka T, Kamagata K, Suzuki Y, et al. Visualizing non-Gaussian diffusion: clinical application of q-space imaging and diffusional kurtosis imaging of the brain and spine. Magn Reson Med Sci. 2012;11(4):221–8.

15.

McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001;50:121–7.PubMedCrossRef

16.

Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69:292–302.PubMedCrossRef

17.

Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”. Ann Neurol. 2005;58:840–6.PubMedCrossRef

18.

Kurtzke JF. A new scale for evaluating disability in multiple sclerosis. Neurology. 1955;5:580–3.PubMedCrossRef

19.

Jensen JH, Helpern JA. MRI quantification of non-Gaussian water diffusion by kurtosis analysis. NMR Biomed. 2010;23:698–710.PubMedCrossRef

20.

Stejeskal EO, Tanner JE. Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J Chem Phys. 1965;42:288–92.CrossRef

21.

McFarlin DE, McFarland HF. Multiple sclerosis (first of two parts). N Engl J Med. 1982;307:1183–8.PubMedCrossRef

22.

McFarlin DE, McFarland HF. Multiple sclerosis (second of two parts). N Engl J Med. 1982;307:1246–51.PubMedCrossRef

23.

Rodriguez M, Siva A, Ward J, Stolp-Smith K, O’Brien P, Kurland L. Impairment, disability, and handicap in multiple sclerosis: a population-based study in Olmsted County Minnesota. Neurology. 1994;44:28–33.PubMedCrossRef

24.

Vigeveno RM, Wiebenga OT, Wattjes MP, Geurts JJ, Barkhof F. Shifting imaging targets in multiple sclerosis: from inflammation to neurodegeneration. J Magn Reson Imaging. 2012;36:1–19.PubMedCrossRef

25.

Geurts JJ, Stys PK, Minagar A, Amor S, Zivadinov R. Gray matter pathology in (chronic) MS: modern views on an early observation. J Neurol Sci. 2009;282:12–20.PubMedCrossRef

26.

Fazekas F, Barkhof F, Filippi M, Grossman RI, Li DK, McDonald WI, et al. The contribution of magnetic resonance imaging to the diagnosis of multiple sclerosis. Neurology. 1999;53:448–56.PubMedCrossRef

27.

Barkhof F, van Walderveen M. Characterization of tissue damage in multiple sclerosis by nuclear magnetic resonance. Philos Trans R Soc Lond B Biol Sci. 1999;354:1675–86.PubMedCrossRef

28.

Miki Y, Grossman RI, Udupa JK, van Buchem MA, Wei L, Phillips MD, et al. Differences between relapsing-remitting and chronic progressive multiple sclerosis as determined with quantitative MR imaging. Radiology. 1999;210:769–74.PubMed

29.

Miki Y, Grossman RI, Udupa JK, Wei L, Polansky M, Mannon LJ, et al. Relapsing-remitting multiple sclerosis: longitudinal analysis of MR images—lack of correlation between changes in T2 lesion volume and clinical findings. Radiology. 1999;213:395–9.PubMed

30.

Phillips MD, Grossman RI, Miki Y, Wei L, Kolson DL, van Buchem MA, et al. Comparison of T2 lesion volume and magnetization transfer ratio histogram analysis and of atrophy and measures of lesion burden in patients with multiple sclerosis. AJNR Am J Neuroradiol. 1998;19:1055–60.PubMed

31.

Werring DJ, Clark CA, Barker GJ, Thompson AJ, Miller DH. Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis. Neurology. 1999;52:1626–32.PubMedCrossRef

32.

Bammer R, Augustin M, Strasser-Fuchs S, Seifert T, Kapeller P, Stollberger R, et al. Magnetic resonance diffusion tensor imaging for characterizing diffuse and focal white matter abnormalities in multiple sclerosis. Magn Reson Med. 2000;44:583–91.PubMedCrossRef

33.

Abdallah CG, Tang CY, Mathew SJ, Martinez J, Hof PR, Perera TD, et al. Diffusion tensor imaging in studying white matter complexity: a gap junction hypothesis. Neurosci Lett. 2010;475:161–4.PubMedCrossRef

34.

Lazar M, Jensen JH, Xuan L, Helpern JA. Estimation of the orientation distribution function from diffusional kurtosis imaging. Magn Reson Med. 2008;60:774–81.PubMedCrossRef

35.

Iraji A, Davoodi-Bojd E, Soltanian-Zadeh H, Hossein-Zadeh GA, Jiang Q. Diffusion kurtosis imaging discriminates patients with white matter lesions from healthy subjects. In: Proceedings of the 33rd international conference of the IEEE engineering in medicine and biology society. 2011. p. 2796–9.

36.

Falangola MF, Jensen JH, Babb JS, Hu C, Castellanos FX, Di Martino A, et al. Age-related non-Gaussian diffusion patterns in the prefrontal brain. J Magn Reson Imaging. 2008;28:1345–50.PubMedCrossRef

37.

Cheung MM, Hui ES, Chan KC, Helpern JA, Qi L, Wu EX. Does diffusion kurtosis imaging lead to better neural tissue characterization? A rodent brain maturation study. Neuroimage. 2009;45:386–92.PubMedCrossRef

38.

Raab P, Hattingen E, Franz K, Zanella FE, Lanfermann H. Cerebral gliomas: diffusional kurtosis imaging analysis of microstructural differences. Radiology. 2010;254:876–81.PubMedCrossRef

39.

Grossman EJ, Ge Y, Jensen JH, Babb JS, Miles L, Reaume J, et al. Thalamus and cognitive impairment in mild traumatic brain injury: a diffusional kurtosis imaging study. J Neurotrauma. 2012;29:2318–27.

40.

Zhuo J, Xu S, Proctor JL, Mullins RJ, Simon JZ, Fiskum G, et al. Diffusion kurtosis as an in vivo imaging marker for reactive astrogliosis in traumatic brain injury. Neuroimage. 2012;59:467–77.PubMedCrossRef

41.

Helpern JA, Adisetiyo V, Falangola MF, Hu C, Di Martino A, Williams K, et al. Preliminary evidence of altered gray and white matter microstructural development in the frontal lobe of adolescents with attention-deficit hyperactivity disorder: a diffusional kurtosis imaging study. J Magn Reson Imaging. 2011;33:17–23.PubMedCrossRef

42.

Hori M, Aoki S, Fukunaga I, Suzuki Y, Masutani Y. A new diffusion metric, diffusion kurtosis imaging, used in the serial examination of a patient with stroke. Acta Radiol Sh Rep. 2012;1:2.

43.

Trampel R, Jensen JH, Lee RF, Kamenetskiy I, McGuinness G, Johnson G. Diffusional kurtosis imaging in the lung using hyperpolarized 3He. Magn Reson Med. 2006;56:733–7.PubMedCrossRef

44.

Allen IV, McQuaid S, Mirakhur M, Nevin G. Pathological abnormalities in the normal-appearing white matter in multiple sclerosis. Neurol Sci. 2001;22:141–4.PubMedCrossRef

Titel: Diffusional kurtosis imaging of normal-appearing white matter in multiple sclerosis: preliminary clinical experience
verfasst von: Mariko Yoshida
Masaaki Hori
Kazumasa Yokoyama
Issa Fukunaga
Michimasa Suzuki
Koji Kamagata
Keigo Shimoji
Atsushi Nakanishi
Nobutaka Hattori
Yoshitaka Masutani
Shigeki Aoki
Publikationsdatum: 01.01.2013
Verlag: Springer Japan
Erschienen in: Japanese Journal of Radiology / Ausgabe 1/2013
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-012-0147-7

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Diffusional kurtosis imaging of normal-appearing white matter in multiple sclerosis: preliminary clinical experience