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Japanese Journal of Radiology
Erschienen in: Japanese Journal of Radiology 4/2016

01.03.2016 | Review

Contribution of metals to brain MR signal intensity: review articles

verfasst von: Tomonori Kanda, Yudai Nakai, Shuri Aoki, Hiroshi Oba, Keiko Toyoda, Kazuhiro Kitajima, Shigeru Furui

Erschienen in: Japanese Journal of Radiology | Ausgabe 4/2016

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Abstract

Various metals are essential nutrients in humans, and metal shortages lead to a variety of deficiency diseases. Metal concentration abnormalities may cause metal deposition in the brain, and magnetic resonance imaging (MRI) is the most potent and sensitive technique now available for detecting metal deposition given the difficulties associated with performing brain tissue biopsy. However, the brain contains many kinds of metals that affect the signal intensity of MRI, which has led to numerous misunderstandings in the history of metal analysis. We reviewed the history of brain metal analysis with histologic findings. Typically, manganese overload causes high signal intensity on T1-weighted images (T1WI) in the globus pallidus, iron overload causes low signal intensity in the globus pallidus on T2-weighted images, and gadolinium deposition causes high signal intensity in the dentate nucleus, globus pallidus, and pulvinar of thalamus on T1WI. However, because nonparamagnetic materials and other coexisting metals also affect the signal intensity of brain MRI, the quantitative analysis of metal concentrations is difficult. Thus, when analyzing metal deposition using MRI, caution should be exercised when interpreting the validity and reliability of the obtained data.
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Metadaten
Titel
Contribution of metals to brain MR signal intensity: review articles
verfasst von
Tomonori Kanda
Yudai Nakai
Shuri Aoki
Hiroshi Oba
Keiko Toyoda
Kazuhiro Kitajima
Shigeru Furui
Publikationsdatum
01.03.2016
Verlag
Springer Japan
Erschienen in
Japanese Journal of Radiology / Ausgabe 4/2016
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-016-0532-8

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