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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 5/2015

01.10.2015 | Bone and Joint Pain (PW Mantyh and TJ Schnitzer, Section Editors)

The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain

verfasst von: Rachel E. Miller, Phuong B. Tran, Alia M Obeidat, Padmanabhan Raghu, Shingo Ishihara, Richard J. Miller, Anne-Marie Malfait

Erschienen in: Current Osteoporosis Reports | Ausgabe 5/2015

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Abstract

Knee osteoarthritis is characterized by progressive damage and remodeling of all tissues in the knee joint. Pain is the main symptom associated with knee osteoarthritis. Recent clinical and pre-clinical studies have provided novel insights into the mechanisms that drive the pain associated with joint destruction. In this narrative review, we describe current knowledge regarding the changes in the peripheral and central nervous systems that occur during the progression of osteoarthritis and discuss how therapeutic interventions may provide pain relief.
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Metadaten
Titel
The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain
verfasst von
Rachel E. Miller
Phuong B. Tran
Alia M Obeidat
Padmanabhan Raghu
Shingo Ishihara
Richard J. Miller
Anne-Marie Malfait
Publikationsdatum
01.10.2015
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 5/2015
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-015-0280-1

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