Erschienen in:
01.06.2012
Occult Primary Medullary Thyroid Carcinoma Presenting with Pituitary and Parotid Metastases: Case Report and Review of the Literature
verfasst von:
Andrea Conway, Andres Wiernik, Ajay Rawal, Cornelius Lam, Hector Mesa
Erschienen in:
Endocrine Pathology
|
Ausgabe 2/2012
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Excerpt
Medullary thyroid carcinoma (MTC) accounts for <10% of all thyroid malignancies and is derived from the calcitonin-producing C cell [
1,
2]. It is of particular interest because of its association with hereditary syndromes, aggressiveness, and refractoriness to adjuvant therapies, and its association with mutations in the
RET (rearranged during transfection) proto-oncogene, which encodes a receptor tyrosine kinase that may be amenable to therapy with the recently available tyrosine kinase inhibitors (TKI) [
3,
4]. Thyroid tumors metastasizing to the pituitary and parotid gland are rare, and medullary thyroid carcinoma metastatic to either site has only been reported in a handful of instances. Here, we report a rare case of an occult MTC, which presented with clinical symptoms associated with synchronous metastases to the pituitary and parotid gland, and discuss its differential diagnosis. …