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Head and Neck Pathology

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21.03.2022 | Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands

verfasst von: Alena Skálová, Martin D. Hyrcza, Ilmo Leivo

Erschienen in: Head and Neck Pathology | Ausgabe 1/2022

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Abstract

The salivary gland section in the 5th edition of the World Health Organization Classification of Head and Neck Tumours features a description and inclusion of several new entities, including sclerosing polycystic adenoma, keratocystoma, intercalated duct adenoma, and striated duct adenoma among the benign neoplasms; and microsecretory adenocarcinoma and sclerosing microcystic adenocarcinoma as the new malignant entities. The new entry also includes mucinous adenocarcinoma subdivided into papillary, colloid, signet ring, and mixed subtypes with recurrent AKT1 E17K mutations across patterns suggesting that mucin-producing salivary adenocarcinomas represent a histologically diverse single entity that may be related to salivary intraductal papillary mucinous neoplasm (IPMN). Importantly, the number of entities in the salivary chapter has been reduced by omitting tumors or lesions if they do not occur exclusively or predominantly in salivary glands, including hemangioma, lipoma, nodular fasciitis and hematolymphoid tumors. They are now discussed in detail elsewhere in the book. Cribriform adenocarcinoma of salivary gland origin (CASG) now represents a distinctive subtype of polymorphous adenocarcinoma (PAC). PAC is defined as a clinically, histologically and molecularly heterogeneous disease group. Whether CASG is a different diagnostic category or a variant of PAC is still controversial. Poorly differentiated carcinomas and oncocytic carcinomas are discussed in the category “Salivary carcinoma not otherwise specified (NOS) and emerging entities”. New defining genomic alterations have been characterized in many salivary gland tumors. In particular, they include gene fusions, which have shown to be tightly tumor-type specific, and thus valuable for use in diagnostically challenging cases. The recurrent molecular alterations were included in the definition of mucoepidermoid carcinoma, adenoid cystic carcinoma, secretory carcinoma, polymorphous adenocarcinoma, hyalinizing clear cell carcinoma, mucinous adenocarcinoma, and microsecretory adenocarcinoma.

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Titel: Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands
verfasst von: Alena Skálová
Martin D. Hyrcza
Ilmo Leivo
Publikationsdatum: 21.03.2022
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 1/2022
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-022-01420-1

Springer Medizin

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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