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Head and Neck Pathology
Erschienen in: Head and Neck Pathology 1/2022

11.06.2021 | Case Reports

Mammary Lobular Carcinoma-Like Salivary Gland Carcinoma: Report of a Rare Case

verfasst von: Li Lei, Eric Van Staalduinen, Megan Troxell, Michael G. Ozawa, Michael Zeineh, Gerald Berry

Erschienen in: Head and Neck Pathology | Ausgabe 1/2022

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Abstract

Salivary and mammary glands are both exocrine organs sharing multiple tumorigenic processes. To the best of our knowledge, salivary gland tumors mimicking invasive lobular carcinoma of the breast have not yet been described. Herein, we report a case of a 62-year-old male who presented with progressive facial paralysis. Pathologic examination revealed an ill-defined epithelial neoplasm exhibiting discohesive growth set within an extensively fibrotic stroma. Both perineural and intraneural invasion were present. E-cadherin and p120 immunostaining showed aberrant cytoplasmic expression. Targeted next-generation sequencing detected a frameshift mutation of the CTNNA1 gene as the only known pathogenic variant. The patient was treated with surgical resection, immunotherapy, and chemotherapy. Currently, he is alive with disease twenty months after disease onset.
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Metadaten
Titel
Mammary Lobular Carcinoma-Like Salivary Gland Carcinoma: Report of a Rare Case
verfasst von
Li Lei
Eric Van Staalduinen
Megan Troxell
Michael G. Ozawa
Michael Zeineh
Gerald Berry
Publikationsdatum
11.06.2021
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 1/2022
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-021-01344-2

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