Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Die Highlights vom Kongress des American College of Cardiology 2024

Im April diskutierten die Herz-Kreislauf-Spezialisten aus der ganzen Welt auf dem  Kongress des American College of Cardiology (ACC) u.a. neue Therapieansätze bei akutem Myokardinfarkt, koronarer Herzerkrankung, kardiogenem Schock oder Aortenklappenstenose. In unserem Kongress-Dossier haben wir für Sie Berichte über die „Late-Breaking Trials“ und andere wichtige Studien zusammengestellt. 
Erweiterte Suche
Anmelden
nach oben
Head and Neck Pathology
Erschienen in: Head and Neck Pathology 1/2022

21.03.2022 | Proceeding of the North American Society of Head and Neck Pathology Companion Meeting, March 20, 2022, Los Angeles, CA

Proceedings of the North American Society of Head and Neck Pathology, Los Angeles, CA, March 20, 2022: Emerging Entities in Salivary Gland Tumor Pathology

verfasst von: Justin A. Bishop

Erschienen in: Head and Neck Pathology | Ausgabe 1/2022

Einloggen, um Zugang zu erhalten

Abstract

Salivary gland tumor pathology is one of the most challenging areas in all head and neck surgical pathology. Compounding its inherent difficulty are numerous novel entities, variants and concepts, most of which have been based on recent molecular discoveries. This review will serve to update the practicing pathologist on a selected group of emerging entities in salivary gland tumor pathology.
Literatur
1.
Weinreb I, Seethala RR, Perez-Ordonez B, Chetty R, Hoschar AP, Hunt JL. Oncocytic mucoepidermoid carcinoma: clinicopathologic description in a series of 12 cases. Am J Surg Pathol. 2009;33(3):409–16.CrossRefPubMed
2.
Garcia JJ, Hunt JL, Weinreb I, McHugh JB, Barnes EL, Cieply K, et al. Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic test. Hum Pathol. 2011;42(12):2001–9.CrossRefPubMed
3.
Bishop JA, Cowan ML, Shum CH, Westra WH. MAML2 rearrangements in variant forms of mucoepidermoid carcinoma: ancillary diagnostic testing for the ciliated and Warthin-like variants. Am J Surg Pathol. 2018;42(1):130–6.CrossRefPubMedPubMedCentral
4.
Ishibashi K, Ito Y, Masaki A, Fujii K, Beppu S, Sakakibara T, et al. Warthin-like mucoepidermoid carcinoma: a combined study of fluorescence in situ hybridization and whole-slide imaging. Am J Surg Pathol. 2015;39(11):1479–87.CrossRefPubMed
5.
Mathew EP, Todorovic E, Truong T, Dickson BC, Enepekides D, Poon I, et al. Metatypical adenoid cystic carcinoma: a variant showing prominent squamous differentiation with a predilection for the sinonasal tract and skull base. Am J Surg Pathol. 2022; In press.
6.
Bishop JA. IDK what’s next for IDC: The unfolding saga of intraductal carcinoma of salivary glands. Cancer Cytopathol. 2021;129(12):926–7.CrossRefPubMed
7.
Skalova A, Ptakova N, Santana T, Agaimy A, Ihrler S, Uro-Coste E, et al. NCOA4-RET and TRIM27-RET are characteristic gene fusions in salivary intraductal carcinoma, including invasive and metastatic tumors: is “intraductal” correct? Am J Surg Pathol. 2019;43(10):1303–13.CrossRefPubMed
8.
Weinreb I, Bishop JA, Chiosea SI, Seethala RR, Perez-Ordonez B, Zhang L, et al. Recurrent RET gene rearrangements in intraductal carcinomas of salivary gland. Am J Surg Pathol. 2018;42(4):442–52.CrossRefPubMedPubMedCentral
9.
Skalova A, Vanecek T, Uro-Coste E, Bishop JA, Weinreb I, Thompson LDR, et al. Molecular profiling of salivary gland intraductal carcinoma revealed a subset of tumors harboring NCOA4-RET and novel TRIM27-RET fusions: a report of 17 cases. Am J Surg Pathol. 2018;42(11):1445–55.CrossRefPubMed
10.
Bishop JA, Gagan J, Krane JF, Jo VY. Low-grade apocrine intraductal carcinoma: expanding the morphologic and molecular spectrum of an enigmatic salivary gland tumor. Head Neck Pathol. 2020;14:869–75.CrossRefPubMedPubMedCentral
11.
Hsieh MS, Lee YH, Jin YT, Kuo YJ. Clinicopathological study of intraductal carcinoma of the salivary gland, with emphasis on the apocrine type. Virchows Arch. 2020;477:581–92.CrossRefPubMed
12.
Bishop JA, Nakaguro M, Whaley RD, Ogura K, Imai H, Laklouk I, et al. Oncocytic intraductal carcinoma of salivary glands: a distinct variant with TRIM33-RET fusions and BRAF V600E mutations. Histopathology. 2020;79:338–46.CrossRef
13.
Lu H, Graham RP, Seethala R, Chute D. Intraductal carcinoma of salivary glands harboring TRIM27-RET fusion with mixed low grade and apocrine types. Head Neck Pathol. 2020;14(1):239–45.CrossRefPubMed
14.
Todorovic E, Weinreb I. Intraductal carcinoma. Surgical pathology clinics. 2020; In press.
15.
Rooper LM, Thompson LDR, Gagan J, Oliai BR, Weinreb I, Bishop JA. Salivary intraductal carcinoma arising within intraparotid lymph node: a report of 4 cases with identification of a novel STRN-ALK fusion. Head Neck Pathol. 2020;15:179–85.CrossRefPubMedPubMedCentral
16.
Bishop JA, Rooper LM, Sangoi AR, Gagan J, Thompson LDR, Inagaki H. The myoepithelial cells of salivary intercalated duct-type intraductal carcinoma are neoplastic: a study using combined whole-slide imaging, immunofluorescence, and RET fluorescence in situ hybridization. Am J Surg Pathol. 2020;45:507–15.CrossRef
17.
18.
Rooper LM, Argyris PP, Thompson LDR, Gagan J, Westra WH, Jordan RC, et al. Salivary mucinous adenocarcinoma is a histologically diverse single entity with recurrent AKT1 E17K mutations: clinicopathologic and molecular characterization with proposal for a Unified Classification. Am J Surg Pathol. 2021;45:1337–47.CrossRefPubMed
19.
Rooper LM, Agaimy A, Bishop JA, Gnepp DR, Leivo I. Mucinous adenocarcinoma. In: Board WCTE, editor. Head and neck tumours. 5th ed. Lyon: International Agency for Research on Cancer; 2022.
20.
Agaimy A, Mueller SK, Bumm K, Iro H, Moskalev EA, Hartmann A, et al. Intraductal papillary mucinous neoplasms of minor salivary glands with AKT1 p.Glu17Lys mutation. Am J Surg Pathol. 2018;42(8):1076–82.CrossRefPubMed
21.
Skalova A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B, et al. Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 2010;34(5):599–608.CrossRefPubMed
22.
Bishop JA, Weinreb I, Swanson D, Westra WH, Qureshi HS, Sciubba J, et al. Microsecretory adenocarcinoma: a novel salivary gland tumor characterized by a recurrent MEF2C-SS18 fusion. Am J Surg Pathol. 2019;43(8):1023–32.CrossRefPubMed
23.
24.
Kawakami F, Nagao T, Honda Y, Sakata J, Yoshida R, Nakayama H, et al. Microsecretory adenocarcinoma of the hard palate: a case report of a recently described entity. Pathol Int. 2020;70(10):781–5.CrossRefPubMed
25.
Bishop JA, Mikami Y, Weinreb I. Microsecretory adenocarcinoma. In: Board WCTE, editor. Head and neck tumours. 5th ed. Lyon: International Agency for Research on Cancer; 2022.
26.
Bishop JA, Koduru P, Veremis BM, Oliai BR, Weinreb I, Rooper LM, et al. SS18 break-apart fluorescence in situ hybridization is a practical and effective method for diagnosing microsecretory adenocarcinoma of salivary glands. Head Neck Pathol. 2021;15:723–6.CrossRefPubMedPubMedCentral
27.
Mills AM, Policarpio-Nicholas ML, Agaimy A, Wick MR, Mills SE. Sclerosing microcystic adenocarcinoma of the head and neck mucosa: a neoplasm closely resembling microcystic adnexal carcinoma. Head Neck Pathol. 2016;10(4):501–8.CrossRefPubMedPubMedCentral
28.
Wood A, Conn BI. Sclerosing microcystic adenocarcinoma of the tongue: a report of 2 further cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125(4):e94-102.CrossRefPubMed
29.
Zhang R, Cagaanan A, Hafez GR, Hu R. Sclerosing microcystic adenocarcinoma: report of a rare case and review of literature. Head Neck Pathol. 2019;13(2):215–9.CrossRefPubMed
30.
Basile JR, Lin YL. A salivary gland adenocarcinoma mimicking a microcystic adnexal carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(4):e28–33.CrossRefPubMed
31.
Bondi R, Urso C. Syringomatous adenocarcinoma of minor salivary glands. Tumori. 1990;76(3):286–9.CrossRefPubMed
32.
Ide F, Kikuchi K, Kusama K. Microcystic adnexal (sclerosing sweat duct) carcinoma of intraoral minor salivary gland origin: an extracutaneous adnexal neoplasm? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(3):284–6.CrossRefPubMed
33.
Ide F, Matsumoto N, Kikuchi K, Kusama K. Microcystic adenocarcinoma: an initially overlooked first proposal of the term. Head Neck Pathol. 2019;13(3):487–8.CrossRefPubMed
34.
Johnston CA, Toker C. Syringomatous tumors of minor salivary gland origin. Hum Pathol. 1982;13(2):182–4.CrossRefPubMed
35.
Petersson F, Skogvall I, Elmberger G. Sclerosing sweat duct-like carcinoma of the tongue-a case report and a review of the literature. Am J Dermatopathol. 2009;31(7):691–4.CrossRefPubMed
36.
Schipper JH, Holecek BU, Sievers KW. A tumour derived from Ebner’s glands: microcystic adnexal carcinoma of the tongue. J Laryngol Otol. 1995;109(12):1211–4.CrossRefPubMed
37.
Wenig BM. Sclerosing microcystic adenocarcinoma. In: Board WCTE, editor. Head and neck tumours. 5th ed. Lyon: International Agency for Research on Cancer; 2022.
38.
Rooper LM, Mansour M, Yonescu R, Oliai BR, Bishop JA, Westra WH. The decline of salivary adenocarcinoma not otherwise specified as a tumor entity: reclassification using contemporary immunohistochemical profiling and diagnostic criteria. Am J Surg Pathol. 2021;45(6):753–64.CrossRefPubMed
Metadaten
Titel
Proceedings of the North American Society of Head and Neck Pathology, Los Angeles, CA, March 20, 2022: Emerging Entities in Salivary Gland Tumor Pathology
verfasst von
Justin A. Bishop
Publikationsdatum
21.03.2022
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 1/2022
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-022-01422-z

Weitere Artikel der Ausgabe 1/2022

Head and Neck Pathology 1/2022 Zur Ausgabe

Author Correction

Correction to: Mutually Exclusive Expression of COL11A1 by CAFs and Tumour Cells in a Large panCancer and a Salivary Gland Carcinoma Cohort

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Nasal Cavity, Paranasal Sinuses and Skull Base

Original Paper

Ossifying Fibromas of the Head and Neck Region: A Clinicopathological Study of 45 Cases

UPDATE FROM THE 5TH EDITION OF THE WORLD HEALTH ORGANIZATION CLASSIFICATION OF HEAD AND NECK TUMORS

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Familial Tumor Syndromes

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Soft Tissue Tumors

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Open Access Biomarker Leitthema

Um auch an kleinen Gewebeproben zuverlässige und reproduzierbare Ergebnisse zu gewährleisten ist eine strenge Qualitätskontrolle in jedem Schritt des Arbeitsablaufs erforderlich. Eine nicht ordnungsgemäße Prüfung oder Behandlung des …

Vergleichende Pathologie in der onkologischen Forschung

Pathologie Leitthema

Die vergleichende experimentelle Pathologie („comparative experimental pathology“) ist ein Fachbereich an der Schnittstelle von Human- und Veterinärmedizin. Sie widmet sich der vergleichenden Erforschung von Gemeinsamkeiten und Unterschieden von …

Gastrointestinale Stromatumoren

Open Access GIST CME-Artikel

Gastrointestinale Stromatumoren (GIST) stellen seit über 20 Jahren ein Paradigma für die zielgerichtete Therapie mit Tyrosinkinaseinhibitoren dar. Eine elementare Voraussetzung für eine mögliche neoadjuvante oder adjuvante Behandlung bei …

Personalisierte Medizin in der Onkologie

Zielgerichtete Therapie Leitthema

Aufgrund des erheblichen technologischen Fortschritts in der molekularen und genetischen Diagnostik sowie zunehmender Erkenntnisse über die molekulare Pathogenese von Krankheiten hat in den letzten zwei Jahrzehnten ein grundlegender …