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26.08.2019 | Original Article

Quantification of myocardial blood flow by CZT-SPECT with motion correction and comparison with ¹⁵O-water PET

verfasst von: Yuka Otaki, MD, PhD, Osamu Manabe, MD, PhD, Robert J. H. Miller, MD, Alain Manrique, MD, PhD, Catherine Nganoa, MD, Nathaniel Roth, MSc, Daniel S. Berman, MD, Guido Germano, PhD, Piotr J. Slomka, PhD, Denis Agostini, MD, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 4/2021

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Abstract

Background

We compared quantification of MBF and myocardial flow reserve (MFR) with a 99mTc-sestamibi CZT-SPECT to ¹⁵O-water PET.

Methods

SPECT MBF for thirty patients in the WATERDAY study was re-analyzed by QPET software with motion correction and optimal placement of the arterial input function. ¹⁵O-water PET MBF was re-quantified using dedicated software. Inter-operator variability was assessed using repeatability coefficients (RPC).

Results

Significant correlations were observed between global (r = 0.91, P < 0.001) and regional MBF (r = 0.86, P < 0.001) with SPECT compared to PET. Global MBF (rest 0.95 vs 1.05 ml/min/g, P = 0.07; stress 2.62 vs 2.68 mL/min/g, P = 0.17) and MFR (2.65 vs 2.75, P = 0.86) were similar between SPECT and PET. Rest (0.81 vs 0.98 mL/min/g, P = 0.03) and stress MBF (1.98 vs 2.61 mL/min/g, P = 0.01) in right coronary artery (RCA) were lower with SPECT compared to PET. However, MFR in the RCA territory was similar (2.54 vs 2.77, P = 0.21). The SPECT-PET RPC for global MBFs and MFR were 0.95 mL/min/g and 0.94, with inter-observer RPC of 0.59 mL/min/g and 0.74, respectively.

Conclusions

MBF and MFR derived from CZT-SPECT with motion correction and optimal placement of the arterial input function showed good agreement with ¹⁵O-water PET, as well as low inter-operator variability.

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Titel: Quantification of myocardial blood flow by CZT-SPECT with motion correction and comparison with 15O-water PET
verfasst von: Yuka Otaki, MD, PhD
Osamu Manabe, MD, PhD
Robert J. H. Miller, MD
Alain Manrique, MD, PhD
Catherine Nganoa, MD
Nathaniel Roth, MSc
Daniel S. Berman, MD
Guido Germano, PhD
Piotr J. Slomka, PhD
Denis Agostini, MD, PhD
Publikationsdatum: 26.08.2019
Verlag: Springer International Publishing
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 4/2021
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-019-01854-1

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Quantification of myocardial blood flow by CZT-SPECT with motion correction and comparison with ¹⁵O-water PET