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ADHD Attention Deficit and Hyperactivity Disorders

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01.03.2015 | Original Article

Does adult ADHD interact with COMT val ¹⁵⁸ met genotype to influence working memory performance?

verfasst von: Stefanie C. Biehl, Kathrin M. Gschwendtner, Anne Guhn, Laura D. Müller, Susanne Reichert, Julia Heupel, Andreas Reif, Jürgen Deckert, Martin J. Herrmann, Christian P. Jacob

Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders | Ausgabe 1/2015

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Abstract

Both attention-deficit/hyperactivity disorder (ADHD) and catechol-O-methyltransferase (COMT) genotype have been linked to altered dopaminergic transmission and possible impairment in frontal lobe functioning. This study offers an investigation of a possible interaction between ADHD diagnosis and COMT genotype on measures of working memory and executive function. Thirty-five adults with ADHD, who were recruited from the ADHD outpatient clinic at the Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, and thirty-five matched healthy controls completed the Digit Span test and the Stroop Color Word Test. While there were no main effects of ADHD or COMT, the two factors interacted on both Digit Span subtests with the two groups’ met/met carriers showing significantly different performance on the Digit Span Forward subtest and the val/val carriers showing significantly different performance on the Digit Span Backward subtest. Findings provide preliminary support for a differential impact of COMT genotype on working memory measures in adult patients with ADHD compared to healthy controls.

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Titel: Does adult ADHD interact with COMT val 158 met genotype to influence working memory performance?
verfasst von: Stefanie C. Biehl
Kathrin M. Gschwendtner
Anne Guhn
Laura D. Müller
Susanne Reichert
Julia Heupel
Andreas Reif
Jürgen Deckert
Martin J. Herrmann
Christian P. Jacob
Publikationsdatum: 01.03.2015
Verlag: Springer Vienna
Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders / Ausgabe 1/2015
Print ISSN: 1866-6116
Elektronische ISSN: 1866-6647
DOI: https://doi.org/10.1007/s12402-014-0148-8

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