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Neurotoxicity Research

Erschienen in:

01.01.2012 | Review

Neurotoxicity of Human Immunodeficiency Virus-1: Viral Proteins and Axonal Transport

verfasst von: Italo Mocchetti, Alessia Bachis, Valeriya Avdoshina

Erschienen in: Neurotoxicity Research | Ausgabe 1/2012

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Abstract

Human immunodeficiency virus-1 (HIV) infection of the central nervous system may cause a neurological syndrome termed HIV-associated neurocognitive disorder (HAND) which includes minor neurocognitive disorders or a more severe form of motor and cognitive impairments. Although treatment with highly active antiretroviral agents decreases the load of HIV in the brain, the prevalence of mild forms of HAND is actually increased due to longer life. Therefore, adjunctive and combined therapies must be developed to prevent and perhaps reverse the neurologic deficits observed in individuals with HAND. Key to developing effective therapies is a better understanding of the molecular and cellular mechanisms by which the virus causes this disorder. A number of HIV proteins has been shown to be released from HIV-infected cells. Moreover, these proteins have been shown to possess neurotoxic properties. This review describes new evidence of a direct interaction of the HIV protein gp120 with neurons, which might play a role in the etiopathology of HAND.

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Titel: Neurotoxicity of Human Immunodeficiency Virus-1: Viral Proteins and Axonal Transport
verfasst von: Italo Mocchetti
Alessia Bachis
Valeriya Avdoshina
Publikationsdatum: 01.01.2012
Verlag: Springer-Verlag
Erschienen in: Neurotoxicity Research / Ausgabe 1/2012
Print ISSN: 1029-8428
Elektronische ISSN: 1476-3524
DOI: https://doi.org/10.1007/s12640-011-9279-2

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