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Translational Stroke Research

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23.08.2017 | Original Article

Protective Effects of Autologous Bone Marrow Mononuclear Cells After Administering t-PA in an Embolic Stroke Model

verfasst von: Bing Yang, Weilang Li, Nikunj Satani, Duyen M. Nghiem, XiaoPei Xi, Jaroslaw Aronowski, Sean I. Savitz

Erschienen in: Translational Stroke Research | Ausgabe 2/2018

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Abstract

Tissue plasminogen activator (t-PA) is the only FDA-approved drug for acute ischemic stroke but poses risk for hemorrhagic transformation (HT). Cell therapy has been investigated as a potential therapy to improve recovery after stroke by the modulation of inflammatory responses and the improvement of blood-brain barrier (BBB) integrity, both of which are associated with HT after t-PA. In our present study, we studied the effect of autologous bone marrow mononuclear cells (MNCs) in an embolic stroke model. We administered MNCs in a rat embolic stroke 2 h after administering t-PA. We observed that even though autologous MNCs did not alter the incidence of HT, they decreased the severity of HT and reduced BBB permeability. One possible mechanism could be through the inhibition of MMP3 released by astrocytes via JAK/STAT pathway as shown by our in vitro cell interaction studies.

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Titel: Protective Effects of Autologous Bone Marrow Mononuclear Cells After Administering t-PA in an Embolic Stroke Model
verfasst von: Bing Yang
Weilang Li
Nikunj Satani
Duyen M. Nghiem
XiaoPei Xi
Jaroslaw Aronowski
Sean I. Savitz
Publikationsdatum: 23.08.2017
Verlag: Springer US
Erschienen in: Translational Stroke Research / Ausgabe 2/2018
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-017-0563-1

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