Background
Methods
Study design and participants
Measurement of clinical, lifestyle, and biochemical markers
Statistical analysis
Results
Quintile of baseline WBC count | ||||||
---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | p | |
participants, n | 715 | 715 | 672 | 673 | 641 | |
Gender | <.0001 | |||||
men, % | 36.8 | 43.9 | 49.3 | 49.5 | 56.9 | |
women, % | 63.2 | 56.2 | 50.6 | 50.7 | 43.5 | <.0001 |
Current smoker (yes), % | 26.6 | 30.8 | 39.3 | 38.2 | 48.0 | <.0001 |
Alcohol drinking (yes), % | 25.2 | 27 | 32.7 | 30.6 | 33.2 | 0.002 |
Marital status | 0.3 | |||||
single, % | 2.2 | 2.7 | 3.1 | 3.9 | 2.3 | |
Live with spouse, % | 86.2 | 85.6 | 85.9 | 87.7 | 85.5 | |
Divorced or separated, % | 11.6 | 11.6 | 11.1 | 8.5 | 12.0 | |
Education level | 0.004 | |||||
<9 years, % | 96.6 | 95 | 93.8 | 92.1 | 93.1 | |
≧9 years, % | 3.4 | 5.5 | 6.3 | 7.9 | 6.9 | |
Job status | 0.04 | |||||
No job, % | 53.6 | 50.6 | 48.8 | 47 | 44.8 | |
Farmer, laborer, % | 32.0 | 35.7 | 34.1 | 35.1 | 37.4 | |
Professional, business, % | 14.4 | 13.7 | 17.1 | 18 | 17.8 | |
Regular exercise (yes), % | 17.2 | 14.5 | 16.1 | 13.7 | 12.8 | 0.14 |
History of hypertension, % | 25.3 | 23.9 | 29.5 | 31.8 | 30.4 | 0.005 |
History of diabetic mellitus, % | 8.7 | 10.5 | 11.8 | 15.9 | 17.9 | <.0001 |
Age, years* | 55.3 | 54.8 | 54.4 | 53.6 | 54.6 | 0.1647 |
BMI, kg/m2* | 22.6 | 23.2 | 23.5 | 24.1 | 24.0 | <.0001 |
Systolic blood pressure, mmHg* | 123 | 122 | 126 | 126 | 127 | <.0001 |
Diastolic blood pressure, mmHg* | 76 | 76 | 77 | 78 | 78 | <.0001 |
Total cholesterol, mg/dL* | 190.3 | 193.4 | 200.8 | 199.6 | 205.3 | <.0001 |
Triglycerides, mg/dL* | 99.7 | 110.8 | 131.5 | 133.9 | 155.0 | <.0001 |
HDL cholesterol, mg/dL* | 50.1 | 48.9 | 46.7 | 46.2 | 45.7 | <.0001 |
LDL cholesterol, mg/dL* | 128.8 | 132.8 | 140.7 | 140.4 | 145.9 | <.0001 |
Coronary heart disease, % | 4.6 | 4.8 | 4.8 | 5.1 | 4.8 | 1 |
Atrial fibrillation, % | 1 | 1.1 | 1.3 | 0.7 | 0.9 | 0.86 |
Left ventricular hypertrophy, % | 6.4 | 7.1 | 7.7 | 7.9 | 9.4 | 0.34 |
Quintile of baseline white blood cell count | |||||||
---|---|---|---|---|---|---|---|
Q1 | Q2 | Q3 | Q4 | Q5 | P for trend | P for Hosmer and Lemeshow test | |
Median WBC count, per μl | 4400 | 5400 | 6100 | 7000 | 8500 | ||
Individuals, n | 715 | 715 | 672 | 673 | 641 | ||
Incident cases, n | 31 | 35 | 32 | 42 | 47 | ||
person-years | 10232 | 10094 | 9548 | 9568 | 8731 | ||
Rate(/1000 person-year) | 3 | 3.5 | 3.4 | 4.4 | 5.4 | ||
HR, model 1*,†
| 1 | 1.21 (0.74-1.96) | 1.17 (0.71-1.91) | 1.62 (1.02-2.58) | 2.00 (1.27-3.15) | 0.0008 | 0.72 |
HR, model 2*,‡
| 1 | 1.25 (0.76-2.03) | 1.19 (0.72-1.97) | 1.65 (1.03-2.64) | 2.06 (1.30-3.27) | 0.0006 | 0.33 |
HR, model 3*,§
| 1 | 1.18 (0.72-1.95) | 1.00 (0.59-1.67) | 1.34 (0.82-2.19) | 1.67 (1.02-2.73) | 0.03 | 0.23 |
Quintile of baseline neutrophil count | |||||||
---|---|---|---|---|---|---|---|
Q1 | Q2 | Q3 | Q4 | Q5 | P for trend | P for Hosmer and Lemeshow test | |
Median neutrophil count, per μl | 2500 | 3300 | 3800 | 4500 | 5900 | ||
Individuals, n | 694 | 615 | 603 | 631 | 610 | ||
Incident cases, n | 24 | 35 | 28 | 37 | 44 | ||
person-years | 10113 | 8756 | 8476 | 8939 | 8238 | ||
Rate(/1000 person-year) | 2.4 | 4 | 3.3 | 4.1 | 5.3 | ||
HR, model 1*,†
| 1 | 1.59 (0.95-2.68) | 1.41 (0.82-2.43) | 1.66 (0.99-2.79) | 2.27 (1.38-3.76) | 0.002 | 0.79 |
HR, model 2*,‡
| 1 | 1.63 (0.96-2.77) | 1.47 (0.85-2.56) | 1.72 (1.02-2.91) | 2.32 (1.39-3.87) | 0.002 | 0.25 |
HR, model 3*,§
| 1 | 1.52 (0.88-2.61) | 1.22 (0.69-2.17) | 1.52 (0.89-2.62) | 1.93 (1.13-3.29) | 0.02 | 0.45 |
C-statistic | Integrated discrimination improvement (IDI) | |||||
---|---|---|---|---|---|---|
95% CI | p | IDI | 95% CI | p-value | ||
Traditional model | 0.59 | 0.55 to 0.64 | reference | |||
vs | ||||||
WBC-included model | 0.60 | 0.55 to 0.65 | 0.18 | 0.003 | 0.0004 to 0.006 | 0.01 |
Traditional model | 0.59 | 0.55 to 0.64 | reference | |||
vs | ||||||
Neutrophil-included model | 0.61 | 0.56 to 0.66 | 0.002 | 0.007 | 0.004 to 0.01 | <0.01 |