Background
Methods
DNA samples
Illumina array
Clustering
Clone sequencing
IDH1 and IDH2mutation status
TCGA samples
Results
CIMP is an early event in secondary gliomagenesis that can be retained throughout progression
Identification of hypermethylated loci dependent upon glioma grade
Identification of the hypermethylated loci conserved during tumor grade progression
Identification of sGBM preferentially methylated targets
sGBM Ingenuity analysis(w)
| Category(x)
| No. of Genes(y)
| p-value range(z)
|
---|---|---|---|
Diseases and disorder | Cancer | 36/180 (20.0%) | 2.52E-04 – 1.05E-02 |
Molecular and cellular functions | Cellular compromise | 12/180 (6.7%) | 3.53E-06 – 8.01E-03 |
Molecular and cellular functions | Cellular assembly and organization | 44/180 (24.4%) | 1.56E-05 – 7.76E-03 |
Molecular and cellular functions | Cell morphology | 45/180 (25.0%) | 1.29E-04 – 1.29E-04 |
Molecular and cellular functions | cell death and survival | 47/180 (26.1%) | 2.52E-04 – 1.02E-02 |
Molecular and cellular functions | Cellular function and maintenance | 38/180 (21.1%) | 2.52E-04 – 1.05E-02 |
pGBM Ingenuity analysis
(w)
|
Category
(x)
|
No. of Genes
(y)
|
p-value range
(z)
|
Diseases and disorder | Cancer | 183/338 (54.1%) | 7.67E-09 – 2.68E-04 |
Molecular and cellular functions | Gene expression | 104/338 (30.8%) | 7.23E-23 – 1.28E-04 |
Molecular and cellular functions | Cellular development | 124/338 (36.7%) | 4.44E-20 – 7.94E-04 |
Molecular and cellular functions | Cell morphology | 73/338 (21.6%) | 1.16E-09 – 8.32E-04 |
Molecular and cellular functions | Cellular movement | 90/338 (26.6%) | 4.41E-09 – 6.52E-04 |
Molecular and cellular functions | Cellular growth and proliferation | 116/338 (34.3%) | 2.45E-08 – 7.69E-04 |