Background
Methods
Patients and Tissue Specimens
Immunohistochemistry
SDS-Polyacrylamide Gel Electrophoresis (PAGE) and Immunoblotting
Statistical Analysis
Results
Clinical and pathological characterization of IBC versus non-IBC patients
Clinical characteristic | IBC n= 23 (%) | Non-IBC n= 27 (%) | p-value |
---|---|---|---|
Age
| |||
Range | 29-60 | 33-67 | 0.001a* |
Mean ± SD | 40.9 ± 7.5 | 49.9 ± 9.1 | t- test |
Tumor size‡
| |||
Mean ± SD | 6.5 ± 3.3 | 4.31 ± 2.30 | 1.000b |
< 2 | 1 (5.6%) | 1 (3.7%) | |
≥ 2 | 17 (94.4%) | 26 (96.3%) | |
Tumor grade
| |||
I- II | 15 (65%) | 21 (77.8%) | 0.511b |
III | 8(35%) | 6 (22.2%) | |
Axillary Lymph Node Status†
| |||
Negative | 0(0%) | 7 (25.9%) | 0.037b* |
< 4 | 3 (15%) | 9 (33.4%) | |
4-7 | 6 (30%) | 6 (22.2%) | |
≥ 8 | 11(55%) | 5 (18.5%) | |
ER
| |||
Positive | 6 (27.3%) | 6 (22.2%) | |
Negative | 17 (72.7%) | 21 (77.8%) | 0.747b |
PR
| |||
Positive | 7 (31.8%) | 8 (29.6%) | 1.000b |
Negative | 16 (68.2%) | 19 (70.4%) | |
HER-2
| |||
Positive | 4 (18.2%) | 4 (14.8%) | 1.000b |
Negative | 19 (81.8%) | 23 (85.2%) | |
Lymphovascular invasion
| |||
Positive | 17 (73.9%) | 3 (11.1%) | 0.000b* |
Negative | 6 (26.1%) | 24 (88.9%) | |
Tumor emboli
| |||
Positive | 23 (100%) | 3 (11.1%) | 0.000b* |
Negative | 0 | 24 (88.9%) |
Overexpression of CTSB in IBC versus non-IBC tissues
CTSB | Cav-1 | |||
---|---|---|---|---|
IBC | Non-IBC | IBC | Non-IBC | |
n(%) | n(%)> | n(%) | n(%) | |
negative | 0 (0%) | 1 (3.7%) | 0 (0%) | 13 (48.2%) |
+
| 0(0%) | 5 (18.5%) | 7 (30.4%) | 8 (29.6%) |
++
| 8 (34.8%) | 7 (25.9%) | 9 (39.2%) | 2 (7.4%) |
+++
| 15 (65.2%) | 14 (51.9%) | 7 (30.4%) | 4 (14.8%) |
Fisher's exact test | P = 0.025* | P = 0.001* |
Overexpression of cav-1 in IBC versus non-IBC tissues
Expression of CTSB correlates with positive metastatic lymph nodes in IBC
Variable | CTSB Expression | Cav-1 Expression | ||
---|---|---|---|---|
IBC (%) | Non-IBC (%) | IBC (%) | Non-IBC (%) | |
Lymph node metastasis | ||||
Negative | 0 (0%) | 5 (23.8%) | 0 (0%) | 3 (27.2%) |
Positive | 20 (100%) | 16 (76.25) | 14 (100%) | 8 (72.7%) |
Fisher's exact test | P = 0.0478* | P = 0.0717 |