Introduction
Materials and methods
Search strategy
Selection criteria
Data extraction
Statistical analysis
Results
Study characteristics
Study, year | Country | Ethnicity | No. of cases/controls | BC diagnosis | Matching criteria | Genotyping method | Menopausal status | Control sources | Quality control | HWE6(p value) |
---|---|---|---|---|---|---|---|---|---|---|
Lavigne 1997 | America | Caucasian | 113/114 | NR | Age, race | PCR-RFLP | Pre-, Post- | HB | NR | 0.862 |
Thompson 1998 | America | Caucasian | 281/289 | Histologically confirmed | Age, region | PCR-RFLP | Pre-, Post- | PB | NR | 0.522 |
Millikana 1998 | America | Caucasian | 389/379 | Histologically confirmed | Age, race | PCR-RFLP | Pre-, Post- | PB | Yes | 0.916 |
Millikanb 1998 | America | Mixed/other | 265/263 | Histologically confirmed | Age, race | PCR-RFLP | Pre-, Post- | PB | Yes | 0.838 |
Huang 1999 | China | Asian | 118/125 | Pathologically conformed | NR | PCR-RFLP | Pre-, Post- | HB | NR | 0.612 |
Goodman 2001 | America | Caucasian | 112/113 | Histologically confirmed | Age, race | PCR-RFLP | Mixed | PB | Yes | 0.788 |
Mitrunen 2001 | Finland | Caucasian | 481/480 | Histologically confirmed | NR | PCR-RFLP | Pre-, Post- | PB | NR | 0.921 |
Yim 2001 | Korea | Asian | 163/163 | Histopathologically confirmed | Age | PCR-RFLP | Pre-, Post- | HB | Yes |
0.004
|
Jungestrom 2001 | Sweden | Caucasian | 126/117 | NR | Age | PCR-RFLP | Pre- | HB | NR | 0.209 |
Hamajima 2001 | Japan | Asian | 150/165 | Histologically confirmed | NR | PCR-RFLP | Pre-, Post- | HB | NR | 0.079 |
Kocabas 2002 | Turkey | Caucasian | 84/103 | Histologically confirmed | Age | PCR-RFLP | Pre-, Post- | HB | NR | 0.227 |
Comings 2003 | America | Caucasian | 67/145 | NR | Region | PCR-RFLP | Post- | PB | NR | 0.335 |
Wedren 2003 | Sweden | Caucasian | 1490/1340 | NR | Age | DASH | Post- | PB | Yes | 0.772 |
Wu 2003 | America | Asian | 589/562 | NR | Age, race | TaqMan | Mixed | PB | NR | 0.646 |
Tan 2003 | China | Asian | 250/250 | Histopathologically confirmed | Age | PCR-RFLP | Pre-, Post- | HB | NR | 0.174 |
Sazci 2004 | Turkey | Caucasian | 130/224 | Histopathologically confirmed | Age | PCR-RFLP | Pre- | PB | NR |
0.000
|
Dunning 2004 | UK | Caucasian | 2850/1908 | NR | Age, region | TaqMan | Post- | PB | Yes | 0.232 |
Hefler 2004 | Austria | Caucasian | 391/1698 | Histologically confirmed | Age, region | Sequencing | Mixed | HB | Yes | 0.577 |
Ahsan 2004 | America | Caucasian | 313/262 | Histopathologically confirmed | Age | LP | Mixed | FB | Yes | 0.108 |
Modugno 2005 | America | Caucasian | 250/3950 | Histopathologically confirmed | NR | TaqMan | Post- | PB | NR | 0.391 |
Lin 2005 | China | Asian | 99/366 | Pathologically conformed | Age, region | PCR-RFLP | Mixed | PB | Yes | 0.972 |
Lin 2005 | China | Asian | 87/341 | Pathologically conformed | Age, region | PCR-RFLP | Mixed | PB | Yes | 0.393 |
Marchand 2005 | America | Mixed/other | 1339/1370 | NR | Age | PCR-RFLP | Post- | PB | NR | 0.109 |
Wen 2005 | China | Asian | 1120/1191 | Pathologically conformed | Age | PCR-RFLP | Pre-, post- | PB | Yes | 0.698 |
Cheng 2005 | China | Asian | 496/740 | Pathologically conformed | Age | NR | Mixed | HB | Yes | 0.006 |
Gaudeta 2006 | America | Caucasian | 1048/1092 | Pathologically conformed | Age | MALDI-TOF | Pre-, post- | PB | Yes | 0.853 |
Gaudetb 2006 | Poland | Caucasian | 1983/2279 | Histopathologically confirmed | Age | TaqMan | Mixed | PB | Yes | 0.525 |
Gallicchio 2006 | America | Caucasian | 81/1251 | Pathologically conformed | NR | TaqMan | Mixed | PB | NR | 0.440 |
Chang 2006 | China | Asian | 189/321 | Histologically confirmed | Age | PCR-RFLP | Mixed | HB | NR | 0.068 |
Onay 2006 | Canada | Caucasian | 398/372 | Pathologically conformed | Age | TaqMan | Pre- | FB | Yes | 0.283 |
Pharoah 2007 | UK | Caucasian | 2176/2012 | NR | NR | TaqMan | Mixed | PB | NR | 0.287 |
Ralpha 2007 | America | Caucasian | 1626/3286 | NR | Age | TaqMan | Pre-, post- | HB | Yes | 0.758 |
Ralphb 2007 | America | Caucasian | 500/1005 | NR | Age | TaqMan | Pre-, post- | HB | Yes | 0.549 |
Akisik 2007 | Turkey | Caucasian | 114/108 | NR | Age | PCR-RFLP | Mixed | NR | NR | 0.966 |
Hu 2007 | China | Asian | 112/110 | Pathologically conformed | Age | Sequencing | Pre-, post- | HB | NR | 0.252 |
Takata 2007 | America | Mixed/other | 325/250 | Mammographically examed | Age | PCR-RFLP | Pre-, post- | PB | NR | 0.104 |
Onaya 2008 | Canada | Caucasian | 1217/714 | Pathologically conformed | Age | TaqMan | Mixed | FB | Yes | 0.832 |
Onayb 2008 | Finland | Caucasian | 708/549 | Pathologically conformed | Age | TaqMan | Mixed | FB | Yes | 0.676 |
Justenhoven 2008 | Germany | Caucasian | 606/622 | NR | Age | MALDI-TOF MS | Mixed | PB | Yes | 0.654 |
He 2009 | America | Caucasian | 1212/1683 | Pathologically conformed | Age | TaqMan | Mixed | HB | Yes | 0.850 |
Reding 2009 | America | Caucasian | 891/878 | NR | Age | TaqMan | post- | PB | Yes | 0.606 |
GENICA 2009 | Germany | Caucasian | 3144/5481 | Histologically conformed | Age, region | MALDI-TOF MS | post- | PB | Yes | 0.094 |
Yadav 2009 | India | Asian | 154/166 | NR | Region | PCR-RFLP | Pre-, post- | HB | NR | 0.570 |
Shrubsole 2009 | China | Asian | 1093/1169 | Pathologically conformed | Age | PCR-RFLP | Pre-, post- | PB | Yes | — |
Sangrajrang 2009 | Thailand | Asian | 565/486 | Histologically conformed | NR | TaqMan | Mixed | HB | Yes | 0.610 |
Mónica 2010 | Mexico | Caucasian | 91/94 | Pathologically conformed | Age, education | PCR-RFLP | Pre-, post- | HB | NR | 0.669 |
Syamalaa 2010 | India | Asian | 219/367 | Histologically conformed | Age | PCR-RFLP | Mixed | PB | NR | 0.183 |
Syamalab 2010 | India | Asian | 140/367 | Histologically conformed | Age | PCR-RFLP | Mixed | FB | NR | 0.183 |
Peterson 2010 | America | Caucasian | 1584/1416 | Pathologically conformed | Age | TaqMan | Mixed | PB | Yes |
0.026
|
Delort 2010 | France | Caucasian | 910/1000 | Pathologically conformed | Age | TaqMan | Mixed | PB | Yes | 0.230 |
Wang 2011 | China | Asian | 400/400 | Histopathologically conformed | Age | Sequencing | Pre-, post- | PB | Yes | 0.389 |
Naushad 2011 | India | Asian | 212/233 | Histopathologically conformed | NR | PCR-RFLP | Mixed | HB | NR | 0.201 |
Cribb 2011 | Canada | Caucasian | 207/621 | Histopathologically conformed | Age | PCR-RFLP | Mixed | HB | NR | 0.208 |
Cerne 2011 | Slovenia | Caucasian | 530/270 | NR | Age | TaqMan | post- | HB | Yes | 0.903 |
Lajin 2011 | Syria | Mixed/other | 135/107 | Pathologically conformed | Age | PCR-RFLP | Pre-, post- | PB | NR | 0.887 |
Santos 2011 | Brazil | Mixed/other | 62/62 | Pathologically conformed | Age | PCR-RFLP | Pre-, post- | PB | NR | — |
Quantitative synthesis of data
Comparison | Population | Sample size | No. of studies | Test of association | Mode | Test of heterogeneity | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
Case | Control | OR | 95% CI | P value |
χ
2
| P value |
I
2
| ||||
LL vs. HH | Overall | 17,223 | 23,069 | 54 | 0.999 | 0.925-1.078 | 0.976 | R | 117.76 | 0.000 | 55.0 |
Caucasian | 12,942 | 18,066 | 32 | 0.960 | 0.897-1.028 | 0.240 | R | 49.28 | 0.020 | 37.1 | |
Asian | 3,009 | 3,790 | 17 | 1.243 | 0.942-1.641 | 0.125 | R | 54.34 | 0.000 | 70.6 | |
Pre- | 2,095 | 2,523 | 21 | 1.049 | 0.825-1.334 | 0.697 | R | 48.22 | 0.000 | 58.5 | |
Post- | 7,215 | 10,138 | 26 | 0.982 | 0.875-1.102 | 0.757 | R | 45.40 | 0.008 | 44.9 | |
PB | 17,223 | 23,069 | 28 | 0.999 | 0.925-1.078 | 0.381 | R | 48.00 | 0.008 | 43.7 | |
HB | 3,800 | 6,169 | 20 | 1.151 | 0.946-1.402 | 0.160 | R | 58.86 | 0.000 | 67.7 | |
FB | 1,351 | 1,140 | 5 | 0.848 | 0.712-1.010 | 0.064 | F | 4.43 | 0.351 | 9.7 | |
HL vs. HH | Overall | 22,589 | 33,568 | 54 | 1.005 | 0.959-1.052 | 0.845 | R | 72.70 | 0.038 | 27.1 |
Caucasian | 19,059 | 25,912 | 32 | 0.999 | 0.958-1.042 | 0.968 | F | 30.14 | 0.510 | 0.0 | |
Asian | 4,525 | 5,781 | 17 | 1.052 | 0.923-1.200 | 0.448 | R | 36.85 | 0.002 | 56.6 | |
Pre- | 3,204 | 3,877 | 21 | 0.962 | 0.871-1.062 | 0.440 | F | 27.59 | 0.119 | 27.5 | |
Post- | 10,480 | 14,476 | 26 | 1.009 | 0.954-1.067 | 0.762 | F | 33.83 | 0.112 | 26.1 | |
PB | 17,648 | 22,679 | 28 | 0.987 | 0.945-1.030 | 0.547 | F | 3.60 | 0.463 | 0.0 | |
HB | 5,751 | 9,128 | 20 | 1.075 | 0.966-1.195 | 0.187 | R | 33.89 | 0.019 | 43.9 | |
FB | 2,102 | 1,674 | 5 | 0.950 | 0.824-1.094 | 0.476 | F | 30.98 | 0.272 | 12.9 | |
LL vs. HL | Overall | 23,594 | 31,759 | 54 | 0.983 | 0.926-1.045 | 0.586 | R | 95.26 | 0.000 | 44.4 |
Caucasian | 19,579 | 27,208 | 32 | 0.954 | 0.911-1.001 | 0.055 | F | 36.02 | 0.245 | 13.9 | |
Asian | 2,538 | 3,135 | 17 | 1.170 | 0.895-1.528 | 0.251 | R | 49.83 | 0.000 | 67.9 | |
Pre- | 2,507 | 3,200 | 21 | 1.060 | 0.851-1.320 | 0.606 | R | 49.32 | 0.000 | 59.4 | |
Post- | 10,243 | 14,548 | 26 | 0.969 | 0.915-1.025 | 0.271 | F | 32.47 | 0.271 | 23.0 | |
PB | 16,437 | 21,768 | 28 | 0.969 | 0.909-1.032 | 0.324 | R | 39.76 | 0.054 | 32.1 | |
HB | 4,973 | 8,203 | 20 | 1.060 | 0.902-1.245 | 0.478 | R | 48.71 | 0.000 | 61.0 | |
FB | 2,099 | 1,714 | 5 | 0.882 | 0.769-1.012 | 0.073 | F | 4.37 | 0.358 | 8.6 | |
LL vs. HL+HH | Overall | 34,358 | 45,429 | 56 | 0.988 | 0.929-1.050 | 0.702 | R | 108.88 | 0.000 | 51.3 |
Caucasian | 25,790 | 35,593 | 32 | 0.956 | 0.909-1.006 | 0.081 | R | 43.54 | 0.067 | 28.8 | |
Asian | 5,770 | 7,552 | 17 | 1.204 | 0.927-1.564 | 0.164 | R | 52.91 | 0.000 | 69.8 | |
Pre- | 3,903 | 4.800 | 21 | 1.053 | 0.855-1.297 | 0.627 | R | 49.44 | 0.000 | 59.5 | |
Post- | 13,969 | 19,581 | 26 | 0.980 | 0.901-1.065 | 0.629 | R | 37.85 | 0.048 | 33.9 | |
PB | 24,205 | 31,307 | 30 | 0.966 | 0.906-1.030 | 0.290 | R | 45.36 | 0.015 | 40.5 | |
HB | 7,262 | 11,750 | 20 | 1.098 | 0.934-1.289 | 0.257 | R | 54.38 | 0.000 | 65.1 | |
FB | 2,776 | 2,264 | 5 | 0.877 | 0.760-1.013 | 0.074 | F | 4.62 | 0.328 | 13.5 | |
LL+HL vs. HH | Overall | 34,358 | 45,429 | 56 | 1.001 | 0.954-1.051 | 0.953 | R | 93.20 | 0.001 | 41.0 |
Caucasian | 25,790 | 35,593 | 32 | 0.982 | 0.944-1.022 | 0.369 | F | 37.71 | 0.189 | 17.8 | |
Asian | 5,770 | 7,552 | 17 | 1.072 | 0.952-1.208 | 0.253 | R | 42.65 | 0.001 | 60.1 | |
Pre- | 3,933 | 4.839 | 22 | 1.016 | 0.890-1.160 | 0.815 | R | 33.81 | 0.038 | 37.9 | |
Post- | 14,001 | 19,604 | 27 | 1.001 | 0.924-1.084 | 0.987 | R | 40.17 | 0.038 | 35.3 | |
PB | 24,205 | 31,307 | 30 | 0.975 | 0.924-1.028 | 0.343 | R | 42.89 | 0.047 | 32.4 | |
HB | 7,262 | 11,750 | 20 | 1.091 | 0.978-1.216 | 0.118 | R | 39.26 | 0.004 | 51.6 | |
FB | 2,776 | 2,264 | 5 | 0.914 | 0.799-1.044 | 0.186 | F | 3.81 | 0.432 | 0.0 |