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Erschienen in: Critical Care 4/2013

01.08.2013 | Review

Clinical review: Glucose control in severely burned patients - current best practice

verfasst von: Marc G Jeschke

Erschienen in: Critical Care | Ausgabe 4/2013

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Abstract

Tight glucose control changed the way many burn centers practice burn ICU care. However, after the initial impressive data, various clinical trials followed that showed mixed results. The objective of the present review is to discuss recent studies in the area of burn and critical care, and to identify the current best practice for current burn care providers. We reviewed relevant publications from PubMed and selected high-impact publications on tight glycemic control in various patient populations with a focus on burn patients. We conclude that in burns there seems to be a signal that insulin administration to a target range of 130 to 150 mg/dl is beneficial in terms of morbidity and mortality without the risk of hypoglycemia.
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Literatur
1.
Zurück zum Zitat Bringham PA, McLoughlin E: Burn incidence and medical care use in the United States: estimates, trends and data sources. J Burn Care Rehabil. 1996, 17: 95-107. 10.1097/00004630-199603000-00003.CrossRef Bringham PA, McLoughlin E: Burn incidence and medical care use in the United States: estimates, trends and data sources. J Burn Care Rehabil. 1996, 17: 95-107. 10.1097/00004630-199603000-00003.CrossRef
2.
Zurück zum Zitat World Health Organization: A Graphical Overview of the Global Burden of Injuries. The Injury Chart Book. 2002, Geneva: WHO, 29: World Health Organization: A Graphical Overview of the Global Burden of Injuries. The Injury Chart Book. 2002, Geneva: WHO, 29:
3.
Zurück zum Zitat Herndon DN, Tompkins RG: Support of the metabolic response to burn injury. Lancet. 2004, 363: 1895-1902. 10.1016/S0140-6736(04)16360-5.PubMedCrossRef Herndon DN, Tompkins RG: Support of the metabolic response to burn injury. Lancet. 2004, 363: 1895-1902. 10.1016/S0140-6736(04)16360-5.PubMedCrossRef
4.
Zurück zum Zitat Jeschke MG, Chinkes DL, Finnerty CC, Kulp G, Suman OE, Norbury WB, Branski LK, Gauglitz GG, Mlcak RP, Herndon DN: Pathophysiologic response to severe burn injury. Ann Surg. 2008, 248: 387-401.PubMedPubMedCentralCrossRef Jeschke MG, Chinkes DL, Finnerty CC, Kulp G, Suman OE, Norbury WB, Branski LK, Gauglitz GG, Mlcak RP, Herndon DN: Pathophysiologic response to severe burn injury. Ann Surg. 2008, 248: 387-401.PubMedPubMedCentralCrossRef
5.
Zurück zum Zitat Wolfe RR, Durkot MJ, Allsop JR, Burke JF: Glucose metabolism in severely burned patients. Metabolism. 1979, 28: 1031-1039. 10.1016/0026-0495(79)90007-6.PubMedCrossRef Wolfe RR, Durkot MJ, Allsop JR, Burke JF: Glucose metabolism in severely burned patients. Metabolism. 1979, 28: 1031-1039. 10.1016/0026-0495(79)90007-6.PubMedCrossRef
6.
Zurück zum Zitat Wolfe RR, Herndon DN, Peters EJ, Jahoor F, Desai MH, Holland OB: Regulation of lipolysis in severely burned children. Ann Surg. 1987, 206: 214-221. 10.1097/00000658-198708000-00016.PubMedPubMedCentralCrossRef Wolfe RR, Herndon DN, Peters EJ, Jahoor F, Desai MH, Holland OB: Regulation of lipolysis in severely burned children. Ann Surg. 1987, 206: 214-221. 10.1097/00000658-198708000-00016.PubMedPubMedCentralCrossRef
7.
Zurück zum Zitat Wolfe RR, Jahoor F, Hartl WH: Protein and amino acid metabolism after injury. Diabetes Metab Rev. 1989, 5: 149-164. 10.1002/dmr.5610050205.PubMedCrossRef Wolfe RR, Jahoor F, Hartl WH: Protein and amino acid metabolism after injury. Diabetes Metab Rev. 1989, 5: 149-164. 10.1002/dmr.5610050205.PubMedCrossRef
8.
Zurück zum Zitat Wolfe RR, Miller HI, Spitzer JJ: Glucose and lactate kinetics in burn shock. Am J Physiol. 1977, 232: E415-E418.PubMed Wolfe RR, Miller HI, Spitzer JJ: Glucose and lactate kinetics in burn shock. Am J Physiol. 1977, 232: E415-E418.PubMed
9.
Zurück zum Zitat Wilmore DW: Hormonal responses and their effect on metabolism. Surg Clin North Am. 1976, 56: 999-1018.PubMed Wilmore DW: Hormonal responses and their effect on metabolism. Surg Clin North Am. 1976, 56: 999-1018.PubMed
10.
Zurück zum Zitat Wilmore DW, Aulick LH: Metabolic changes in burned patients. Surg Clin North Am. 1978, 58: 1173-1187.PubMed Wilmore DW, Aulick LH: Metabolic changes in burned patients. Surg Clin North Am. 1978, 58: 1173-1187.PubMed
11.
Zurück zum Zitat Gore DC, Chinkes D, Heggers J, Herndon DN, Wolf SE, Desai M: Association of hyperglycemia with increased mortality after severe burn injury. J Trauma. 2001, 51: 540-544. 10.1097/00005373-200109000-00021.PubMedCrossRef Gore DC, Chinkes D, Heggers J, Herndon DN, Wolf SE, Desai M: Association of hyperglycemia with increased mortality after severe burn injury. J Trauma. 2001, 51: 540-544. 10.1097/00005373-200109000-00021.PubMedCrossRef
12.
Zurück zum Zitat Gore DC, Chinkes DL, Hart DW, Wolf SE, Herndon DN, Sanford AP: Hyperglycemia exacerbates muscle protein catabolism in burn-injured patients. Crit Care Med. 2002, 30: 2438-2442. 10.1097/00003246-200211000-00006.PubMedCrossRef Gore DC, Chinkes DL, Hart DW, Wolf SE, Herndon DN, Sanford AP: Hyperglycemia exacerbates muscle protein catabolism in burn-injured patients. Crit Care Med. 2002, 30: 2438-2442. 10.1097/00003246-200211000-00006.PubMedCrossRef
13.
Zurück zum Zitat Hemmila MR, Taddonio MA, Arbabi S, Maggio PM, Wahl WL: Intensive insulin therapy is associated with reduced infectious complications in burn patients. Surgery. 2008, 144: 629-635. 10.1016/j.surg.2008.07.001.PubMedPubMedCentralCrossRef Hemmila MR, Taddonio MA, Arbabi S, Maggio PM, Wahl WL: Intensive insulin therapy is associated with reduced infectious complications in burn patients. Surgery. 2008, 144: 629-635. 10.1016/j.surg.2008.07.001.PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Jeschke MG, Kulp GA, Kraft R, Finnerty CC, Mlcak R, Lee JO, Herndon DN: Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial. Am J Respir Crit Care Med. 2010, 182: 351-359. 10.1164/rccm.201002-0190OC.PubMedPubMedCentralCrossRef Jeschke MG, Kulp GA, Kraft R, Finnerty CC, Mlcak R, Lee JO, Herndon DN: Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial. Am J Respir Crit Care Med. 2010, 182: 351-359. 10.1164/rccm.201002-0190OC.PubMedPubMedCentralCrossRef
15.
Zurück zum Zitat Gore DC, Ferrando A, Barnett J, Wolf SE, Desai M, Herndon DN, Goodwin C, Wolfe RR: Influence of glucose kinetics on plasma lactate concentration and energy expenditure in severely burned patients. J Trauma. 2000, 49: 673-678. 10.1097/00005373-200010000-00015.PubMedCrossRef Gore DC, Ferrando A, Barnett J, Wolf SE, Desai M, Herndon DN, Goodwin C, Wolfe RR: Influence of glucose kinetics on plasma lactate concentration and energy expenditure in severely burned patients. J Trauma. 2000, 49: 673-678. 10.1097/00005373-200010000-00015.PubMedCrossRef
16.
Zurück zum Zitat Van den Berghe G: Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med. 2000, 342: 135-author reply 135-136PubMed Van den Berghe G: Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med. 2000, 342: 135-author reply 135-136PubMed
17.
Zurück zum Zitat Van den Berghe G: Insulin therapy for the critically ill patient. Clin Cornerstone. 2003, 5: 56-63. 10.1016/S1098-3597(03)90018-4.PubMedCrossRef Van den Berghe G: Insulin therapy for the critically ill patient. Clin Cornerstone. 2003, 5: 56-63. 10.1016/S1098-3597(03)90018-4.PubMedCrossRef
18.
Zurück zum Zitat Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R: Intensive insulin therapy in the medical ICU. N Engl J Med. 2006, 354: 449-461. 10.1056/NEJMoa052521.PubMedCrossRef Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R: Intensive insulin therapy in the medical ICU. N Engl J Med. 2006, 354: 449-461. 10.1056/NEJMoa052521.PubMedCrossRef
19.
Zurück zum Zitat van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001, 345: 1359-1367. 10.1056/NEJMoa011300.PubMedCrossRef van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001, 345: 1359-1367. 10.1056/NEJMoa011300.PubMedCrossRef
20.
Zurück zum Zitat Van den Berghe GH: Role of intravenous insulin therapy in critically ill patients. Endocr Pract. 2004, 10 (Suppl 2): 17-20.PubMedCrossRef Van den Berghe GH: Role of intravenous insulin therapy in critically ill patients. Endocr Pract. 2004, 10 (Suppl 2): 17-20.PubMedCrossRef
21.
Zurück zum Zitat Ellger B, Debaveye Y, Vanhorebeek I, Langouche L, Giulietti A, Van Etten E, Herijgers P, Mathieu C, Van den Berghe G: Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin. Diabetes. 2006, 55: 1096-1105. 10.2337/diabetes.55.04.06.db05-1434.PubMedCrossRef Ellger B, Debaveye Y, Vanhorebeek I, Langouche L, Giulietti A, Van Etten E, Herijgers P, Mathieu C, Van den Berghe G: Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin. Diabetes. 2006, 55: 1096-1105. 10.2337/diabetes.55.04.06.db05-1434.PubMedCrossRef
22.
Zurück zum Zitat Ingels C, Debaveye Y, Milants I, Buelens E, Peeraer A, Devriendt Y, Vanhoutte T, Van Damme A, Schetz M, Wouters PJ, Van den Berghe G: Strict blood glucose control with insulin during intensive care after cardiac surgery: impact on 4-years survival, dependency on medical care, and quality-of-life. Eur Heart J. 2006, 27: 2716-2724. 10.1093/eurheartj/ehi855.PubMedCrossRef Ingels C, Debaveye Y, Milants I, Buelens E, Peeraer A, Devriendt Y, Vanhoutte T, Van Damme A, Schetz M, Wouters PJ, Van den Berghe G: Strict blood glucose control with insulin during intensive care after cardiac surgery: impact on 4-years survival, dependency on medical care, and quality-of-life. Eur Heart J. 2006, 27: 2716-2724. 10.1093/eurheartj/ehi855.PubMedCrossRef
23.
Zurück zum Zitat Mesotten D, Gielen M, Sterken C, Claessens K, Hermans G, Vlasselaers D, Lemiere J, Lagae L, Gewillig M, Eyskens B, Vanhorebeek I, Wouters PJ, Van den Berghe G: Neurocognitive development of children 4 years after critical illness and treatment with tight glucose control: a randomized controlled trial. JAMA. 2012, 308: 1641-1650. 10.1001/jama.2012.12424.PubMedCrossRef Mesotten D, Gielen M, Sterken C, Claessens K, Hermans G, Vlasselaers D, Lemiere J, Lagae L, Gewillig M, Eyskens B, Vanhorebeek I, Wouters PJ, Van den Berghe G: Neurocognitive development of children 4 years after critical illness and treatment with tight glucose control: a randomized controlled trial. JAMA. 2012, 308: 1641-1650. 10.1001/jama.2012.12424.PubMedCrossRef
24.
Zurück zum Zitat Finney SJ, Zekveld C, Elia A, Evans TW: Glucose control and mortality in critically ill patients. JAMA. 2003, 290: 2041-2047. 10.1001/jama.290.15.2041.PubMedCrossRef Finney SJ, Zekveld C, Elia A, Evans TW: Glucose control and mortality in critically ill patients. JAMA. 2003, 290: 2041-2047. 10.1001/jama.290.15.2041.PubMedCrossRef
25.
Zurück zum Zitat Preiser JC, Devos P: Clinical experience with tight glucose control by intensive insulin therapy. Crit Care Med. 2007, 35: S503-S507. 10.1097/01.CCM.0000278046.24345.C7.PubMedCrossRef Preiser JC, Devos P: Clinical experience with tight glucose control by intensive insulin therapy. Crit Care Med. 2007, 35: S503-S507. 10.1097/01.CCM.0000278046.24345.C7.PubMedCrossRef
26.
Zurück zum Zitat Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K: Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008, 358: 125-139. 10.1056/NEJMoa070716.PubMedCrossRef Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K: Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008, 358: 125-139. 10.1056/NEJMoa070716.PubMedCrossRef
27.
Zurück zum Zitat Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Henderson WR, Hebert PC, Heritier S, Heyland DK, McArthur C, McDonald E, Mitchell I, Myburgh JA, Norton R, Potter J, Robinson BG, Ronco JJ: Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009, 360: 1283-1297.PubMedCrossRef Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Henderson WR, Hebert PC, Heritier S, Heyland DK, McArthur C, McDonald E, Mitchell I, Myburgh JA, Norton R, Potter J, Robinson BG, Ronco JJ: Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009, 360: 1283-1297.PubMedCrossRef
28.
Zurück zum Zitat Preiser JC, Devos P, Ruiz-Santana S, Melot C, Annane D, Groeneveld J, Iapichino G, Leverve X, Nitenberg G, Singer P, Wernerman J, Joannidis M, Stecher A, Chiolero R: A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study. Intensive Care Med. 2009, 35: 1738-1748. 10.1007/s00134-009-1585-2.PubMedCrossRef Preiser JC, Devos P, Ruiz-Santana S, Melot C, Annane D, Groeneveld J, Iapichino G, Leverve X, Nitenberg G, Singer P, Wernerman J, Joannidis M, Stecher A, Chiolero R: A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study. Intensive Care Med. 2009, 35: 1738-1748. 10.1007/s00134-009-1585-2.PubMedCrossRef
29.
Zurück zum Zitat Agus MS, Steil GM, Wypij D, Costello JM, Laussen PC, Langer M, Alexander JL, Scoppettuolo LA, Pigula FA, Charpie JR, Ohye RG, Gaies MG: Tight glycemic control versus standard care after pediatric cardiac surgery. N Engl J Med. 2012, 367: 1208-1219. 10.1056/NEJMoa1206044.PubMedPubMedCentralCrossRef Agus MS, Steil GM, Wypij D, Costello JM, Laussen PC, Langer M, Alexander JL, Scoppettuolo LA, Pigula FA, Charpie JR, Ohye RG, Gaies MG: Tight glycemic control versus standard care after pediatric cardiac surgery. N Engl J Med. 2012, 367: 1208-1219. 10.1056/NEJMoa1206044.PubMedPubMedCentralCrossRef
30.
Zurück zum Zitat Hermayer KL, Egidi MF, Finch NJ, Baliga P, Lin A, Kettinger L, Biggins S, Carter RE: A randomized controlled trial to evaluate the effect of glycemic control on renal transplantation outcomes. J Clin Endocrinol Metab. 2012, 97: 4399-4406. 10.1210/jc.2012-1979.PubMedCrossRef Hermayer KL, Egidi MF, Finch NJ, Baliga P, Lin A, Kettinger L, Biggins S, Carter RE: A randomized controlled trial to evaluate the effect of glycemic control on renal transplantation outcomes. J Clin Endocrinol Metab. 2012, 97: 4399-4406. 10.1210/jc.2012-1979.PubMedCrossRef
31.
Zurück zum Zitat Egi M, Bellomo R, Stachowski E, French CJ, Hart GK, Taori G, Hegarty C, Bailey M: Hypoglycemia and outcome in critically ill patients. Mayo Clin Proc. 2010, 85: 217-224. 10.4065/mcp.2009.0394.PubMedPubMedCentralCrossRef Egi M, Bellomo R, Stachowski E, French CJ, Hart GK, Taori G, Hegarty C, Bailey M: Hypoglycemia and outcome in critically ill patients. Mayo Clin Proc. 2010, 85: 217-224. 10.4065/mcp.2009.0394.PubMedPubMedCentralCrossRef
32.
Zurück zum Zitat Finfer S, Liu B, Chittock DR, Norton R, Myburgh JA, McArthur C, Mitchell I, Foster D, Dhingra V, Henderson WR, Ronco JJ, Bellomo R, Cook D, McDonald E, Dodek P, Hebert PC, Heyland DK, Robinson BG: Hypoglycemia and risk of death in critically ill patients. N Engl J Med. 2012, 367: 1108-1118.PubMedCrossRef Finfer S, Liu B, Chittock DR, Norton R, Myburgh JA, McArthur C, Mitchell I, Foster D, Dhingra V, Henderson WR, Ronco JJ, Bellomo R, Cook D, McDonald E, Dodek P, Hebert PC, Heyland DK, Robinson BG: Hypoglycemia and risk of death in critically ill patients. N Engl J Med. 2012, 367: 1108-1118.PubMedCrossRef
33.
Zurück zum Zitat Andel D, Kamolz LP: Blood glucose control in critically ill patients. Minerva Anestesiol. 2012, 78: 975-976.PubMed Andel D, Kamolz LP: Blood glucose control in critically ill patients. Minerva Anestesiol. 2012, 78: 975-976.PubMed
34.
Zurück zum Zitat Schultz MJ, Harmsen RE, Korevaar JC, Abu-Hanna A, Van Braam Houckgeest F, Van Der Sluijs JP, Spronk PE: Adoption and implementation of the original strict glycemic control guideline is feasible and safe in adult critically ill patients. Minerva Anestesiol. 2012, 78: 982-995.PubMed Schultz MJ, Harmsen RE, Korevaar JC, Abu-Hanna A, Van Braam Houckgeest F, Van Der Sluijs JP, Spronk PE: Adoption and implementation of the original strict glycemic control guideline is feasible and safe in adult critically ill patients. Minerva Anestesiol. 2012, 78: 982-995.PubMed
35.
Zurück zum Zitat Jeschke MG, Klein D, Thasler WE, Bolder U, Schlitt HJ, Jauch KW, Weiss TS: Insulin decreases inflammatory signal transcription factor expression in primary human liver cells after LPS challenge. Mol Med. 2008, 14: 11-19. 10.1007/s00894-007-0240-5.PubMedPubMedCentralCrossRef Jeschke MG, Klein D, Thasler WE, Bolder U, Schlitt HJ, Jauch KW, Weiss TS: Insulin decreases inflammatory signal transcription factor expression in primary human liver cells after LPS challenge. Mol Med. 2008, 14: 11-19. 10.1007/s00894-007-0240-5.PubMedPubMedCentralCrossRef
36.
Zurück zum Zitat Pham TN, Warren AJ, Phan HH, Molitor F, Greenhalgh DG, Palmieri TL: Impact of tight glycemic control in severely burned children. J Trauma. 2005, 59: 1148-1154.PubMedCrossRef Pham TN, Warren AJ, Phan HH, Molitor F, Greenhalgh DG, Palmieri TL: Impact of tight glycemic control in severely burned children. J Trauma. 2005, 59: 1148-1154.PubMedCrossRef
37.
38.
Zurück zum Zitat Jeschke MG, Finnerty CC, Herndon DN, Song J, Boehning D, Tompkins RG, Baker HV, Gauglitz GG: Severe injury is associated with insulin resistance, endoplasmic reticulum stress response, and unfolded protein response. Ann Surg. 2012, 255: 370-378. 10.1097/SLA.0b013e31823e76e7.PubMedPubMedCentralCrossRef Jeschke MG, Finnerty CC, Herndon DN, Song J, Boehning D, Tompkins RG, Baker HV, Gauglitz GG: Severe injury is associated with insulin resistance, endoplasmic reticulum stress response, and unfolded protein response. Ann Surg. 2012, 255: 370-378. 10.1097/SLA.0b013e31823e76e7.PubMedPubMedCentralCrossRef
39.
Zurück zum Zitat Allison SP, Hinton P, Chamberlain MJ: Intravenous glucose-tolerance, insulin, and free-fatty-acid levels in burned patients. Lancet. 1968, 2: 1113-1116.PubMedCrossRef Allison SP, Hinton P, Chamberlain MJ: Intravenous glucose-tolerance, insulin, and free-fatty-acid levels in burned patients. Lancet. 1968, 2: 1113-1116.PubMedCrossRef
40.
Zurück zum Zitat Hinton P, Allison SP: Insulin and glucose to reduce catabolic response to burns. Lancet. 1971, 1: 1247-PubMedCrossRef Hinton P, Allison SP: Insulin and glucose to reduce catabolic response to burns. Lancet. 1971, 1: 1247-PubMedCrossRef
41.
Zurück zum Zitat Wilmore DW, Long JM, Mason AD, Skreen RW, Pruitt BA: Catecholamines: mediator of the hypermetabolic response to thermal injury. Ann Surg. 1974, 180: 653-669. 10.1097/00000658-197410000-00031.PubMedPubMedCentralCrossRef Wilmore DW, Long JM, Mason AD, Skreen RW, Pruitt BA: Catecholamines: mediator of the hypermetabolic response to thermal injury. Ann Surg. 1974, 180: 653-669. 10.1097/00000658-197410000-00031.PubMedPubMedCentralCrossRef
42.
Zurück zum Zitat Ferrando AA, Chinkes DL, Wolf SE, Matin S, Herndon DN, Wolfe RR: A submaximal dose of insulin promotes net skeletal muscle protein synthesis in patients with severe burns. Ann Surg. 1999, 229: 11-18. 10.1097/00000658-199901000-00002.PubMedPubMedCentralCrossRef Ferrando AA, Chinkes DL, Wolf SE, Matin S, Herndon DN, Wolfe RR: A submaximal dose of insulin promotes net skeletal muscle protein synthesis in patients with severe burns. Ann Surg. 1999, 229: 11-18. 10.1097/00000658-199901000-00002.PubMedPubMedCentralCrossRef
43.
Zurück zum Zitat Pierre EJ, Barrow RE, Hawkins HK, Nguyen TT, Sakurai Y, Desai M, Wolfe RR, Herndon DN: Effects of insulin on wound healing. J Trauma. 1998, 44: 342-345. 10.1097/00005373-199802000-00019.PubMedCrossRef Pierre EJ, Barrow RE, Hawkins HK, Nguyen TT, Sakurai Y, Desai M, Wolfe RR, Herndon DN: Effects of insulin on wound healing. J Trauma. 1998, 44: 342-345. 10.1097/00005373-199802000-00019.PubMedCrossRef
44.
Zurück zum Zitat Thomas SJ, Morimoto K, Herndon DN, Ferrando AA, Wolfe RR, Klein D, Wolf SE: The effect of prolonged euglycemic hyperinsulinemia on lean body mass after severe burn. Surgery. 2002, 132: 341-347. 10.1067/msy.2002.126871.PubMedCrossRef Thomas SJ, Morimoto K, Herndon DN, Ferrando AA, Wolfe RR, Klein D, Wolf SE: The effect of prolonged euglycemic hyperinsulinemia on lean body mass after severe burn. Surgery. 2002, 132: 341-347. 10.1067/msy.2002.126871.PubMedCrossRef
45.
Zurück zum Zitat Zhang XJ, Chinkes DL, Wolf SE, Wolfe RR: Insulin but not growth hormone stimulates protein anabolism in skin would and muscle. Am J Physiol. 1999, 276: E712-E720.PubMed Zhang XJ, Chinkes DL, Wolf SE, Wolfe RR: Insulin but not growth hormone stimulates protein anabolism in skin would and muscle. Am J Physiol. 1999, 276: E712-E720.PubMed
46.
Zurück zum Zitat Gauglitz GG, Toliver-Kinsky TE, Williams FN, Song J, Cui W, Herndon DN, Jeschke MG: Insulin increases resistance to burn wound infection-associated sepsis. Crit Care Med. 2010, 38: 202-208. 10.1097/CCM.0b013e3181b43236.PubMedCrossRef Gauglitz GG, Toliver-Kinsky TE, Williams FN, Song J, Cui W, Herndon DN, Jeschke MG: Insulin increases resistance to burn wound infection-associated sepsis. Crit Care Med. 2010, 38: 202-208. 10.1097/CCM.0b013e3181b43236.PubMedCrossRef
47.
Zurück zum Zitat Cochran A, Davis L, Morris SE, Saffle JR: Safety and efficacy of an intensive insulin protocol in a burn-trauma intensive care unit. J Burn Care Res. 2008, 29: 187-191.PubMed Cochran A, Davis L, Morris SE, Saffle JR: Safety and efficacy of an intensive insulin protocol in a burn-trauma intensive care unit. J Burn Care Res. 2008, 29: 187-191.PubMed
48.
Zurück zum Zitat Mann EA, Pidcoke HF, Salinas J, Holcomb JB, Wolf SE, Wade CE: The impact of intensive insulin protocols and restrictive blood transfusion strategies on glucose measurement in American Burn Association (ABA) verified burn centers. J Burn Care Res. 2008, 29: 718-723. 10.1097/BCR.0b013e3181848c74.PubMedCrossRef Mann EA, Pidcoke HF, Salinas J, Holcomb JB, Wolf SE, Wade CE: The impact of intensive insulin protocols and restrictive blood transfusion strategies on glucose measurement in American Burn Association (ABA) verified burn centers. J Burn Care Res. 2008, 29: 718-723. 10.1097/BCR.0b013e3181848c74.PubMedCrossRef
49.
Zurück zum Zitat Gibson BR, Galiatsatos P, Rabiee A, Eaton L, Abu-Hamdah R, Christmas C, Milner SM, Andersen DK, Elahi D: Intensive insulin therapy confers a similar survival benefit in the burn intensive care unit to the surgical intensive care unit. Surgery. 2009, 146: 922-930. 10.1016/j.surg.2009.04.035.PubMedCrossRef Gibson BR, Galiatsatos P, Rabiee A, Eaton L, Abu-Hamdah R, Christmas C, Milner SM, Andersen DK, Elahi D: Intensive insulin therapy confers a similar survival benefit in the burn intensive care unit to the surgical intensive care unit. Surgery. 2009, 146: 922-930. 10.1016/j.surg.2009.04.035.PubMedCrossRef
50.
Zurück zum Zitat Gauglitz GG, Herndon DN, Kulp GA, Meyer WJ, Jeschke MG: Abnormal insulin sensitivity persists up to three years in pediatric patients postburn. J Clin Endocrinol Metab. 2009, 94: 1656-1664. 10.1210/jc.2008-1947.PubMedPubMedCentralCrossRef Gauglitz GG, Herndon DN, Kulp GA, Meyer WJ, Jeschke MG: Abnormal insulin sensitivity persists up to three years in pediatric patients postburn. J Clin Endocrinol Metab. 2009, 94: 1656-1664. 10.1210/jc.2008-1947.PubMedPubMedCentralCrossRef
51.
Zurück zum Zitat Pierre E, Barrow RE, Sakurai Y, Wolfe RR, Herndon DN: Structural effects of insulin on wound healing. Plastic Surg. 1996, 36: 743-745. Pierre E, Barrow RE, Sakurai Y, Wolfe RR, Herndon DN: Structural effects of insulin on wound healing. Plastic Surg. 1996, 36: 743-745.
52.
Zurück zum Zitat Tuvdendorj D, Zhang XJ, Chinkes DL, Aarsland A, Kulp GA, Jeschke MG, Herndon DN: Intensive insulin treatment increases donor site wound protein synthesis in burn patients. Surgery. 2011, 149: 512-518. 10.1016/j.surg.2010.10.021.PubMedPubMedCentralCrossRef Tuvdendorj D, Zhang XJ, Chinkes DL, Aarsland A, Kulp GA, Jeschke MG, Herndon DN: Intensive insulin treatment increases donor site wound protein synthesis in burn patients. Surgery. 2011, 149: 512-518. 10.1016/j.surg.2010.10.021.PubMedPubMedCentralCrossRef
53.
Zurück zum Zitat Zhang XJ, Chinkes DL, Irtun O, Wolfe RR: Anabolic action of insulin on skin wound protein is augmented by exogenous amino acids. Am J Physiol Endocrinol Metab. 2002, 282: E1308-E1315.PubMedCrossRef Zhang XJ, Chinkes DL, Irtun O, Wolfe RR: Anabolic action of insulin on skin wound protein is augmented by exogenous amino acids. Am J Physiol Endocrinol Metab. 2002, 282: E1308-E1315.PubMedCrossRef
54.
Zurück zum Zitat Zhang XJ, Chinkes DL, Wu Z, Martini WZ, Wolfe RR: Fractional synthesis rates of DNA and protein in rabbit skin are not correlated. J Nutr. 2004, 134: 2401-2406.PubMed Zhang XJ, Chinkes DL, Wu Z, Martini WZ, Wolfe RR: Fractional synthesis rates of DNA and protein in rabbit skin are not correlated. J Nutr. 2004, 134: 2401-2406.PubMed
55.
Zurück zum Zitat Jeschke MG, Klein D, Bolder U, Einspanier R: Insulin attenuates the systemic inflammatory response in endotoxemic rats. Endocrinology. 2004, 145: 4084-4093. 10.1210/en.2004-0592.PubMedCrossRef Jeschke MG, Klein D, Bolder U, Einspanier R: Insulin attenuates the systemic inflammatory response in endotoxemic rats. Endocrinology. 2004, 145: 4084-4093. 10.1210/en.2004-0592.PubMedCrossRef
56.
Zurück zum Zitat Jeschke MG, Klein D, Herndon DN: Insulin treatment improves the systemic inflammatory reaction to severe trauma. Ann Surg. 2004, 239: 553-560. 10.1097/01.sla.0000118569.10289.ad.PubMedPubMedCentralCrossRef Jeschke MG, Klein D, Herndon DN: Insulin treatment improves the systemic inflammatory reaction to severe trauma. Ann Surg. 2004, 239: 553-560. 10.1097/01.sla.0000118569.10289.ad.PubMedPubMedCentralCrossRef
57.
Zurück zum Zitat Jeschke MG, Rensing H, Klein D, Schubert T, Mautes AE, Bolder U, Croner RS: Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats. J Hepatol. 2005, 42: 870-879. 10.1016/j.jhep.2004.12.036.PubMedCrossRef Jeschke MG, Rensing H, Klein D, Schubert T, Mautes AE, Bolder U, Croner RS: Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats. J Hepatol. 2005, 42: 870-879. 10.1016/j.jhep.2004.12.036.PubMedCrossRef
58.
Zurück zum Zitat Klein D, Schubert T, Horch RE, Jauch KW, Jeschke MG: Insulin treatment improves hepatic morphology and function through modulation of hepatic signals after severe trauma. Ann Surg. 2004, 240: 340-349. 10.1097/01.sla.0000133353.57674.cd.PubMedPubMedCentralCrossRef Klein D, Schubert T, Horch RE, Jauch KW, Jeschke MG: Insulin treatment improves hepatic morphology and function through modulation of hepatic signals after severe trauma. Ann Surg. 2004, 240: 340-349. 10.1097/01.sla.0000133353.57674.cd.PubMedPubMedCentralCrossRef
59.
Zurück zum Zitat Aarsland A, Chinkes D, Wolfe RR: Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. J Clin Invest. 1996, 98: 2008-2017. 10.1172/JCI119005.PubMedPubMedCentralCrossRef Aarsland A, Chinkes D, Wolfe RR: Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. J Clin Invest. 1996, 98: 2008-2017. 10.1172/JCI119005.PubMedPubMedCentralCrossRef
60.
Zurück zum Zitat Jeschke MG, Kraft R, Song J, Gauglitz GG, Cox RA, Brooks NC, Finnerty CC, Kulp GA, Herndon DN, Boehning D: Insulin protects against hepatic damage postburn. Mol Med. 2011, 17: 516-522.PubMedPubMedCentralCrossRef Jeschke MG, Kraft R, Song J, Gauglitz GG, Cox RA, Brooks NC, Finnerty CC, Kulp GA, Herndon DN, Boehning D: Insulin protects against hepatic damage postburn. Mol Med. 2011, 17: 516-522.PubMedPubMedCentralCrossRef
61.
Zurück zum Zitat Gauglitz GG, Halder S, Boehning DF, Kulp GA, Herndon DN, Barral JM, Jeschke MG: Post-burn hepatic insulin resistance is associated with endoplasmic reticulum (ER) stress. Shock. 2010, 33: 299-305. 10.1097/SHK.0b013e3181b2f439.PubMedCrossRef Gauglitz GG, Halder S, Boehning DF, Kulp GA, Herndon DN, Barral JM, Jeschke MG: Post-burn hepatic insulin resistance is associated with endoplasmic reticulum (ER) stress. Shock. 2010, 33: 299-305. 10.1097/SHK.0b013e3181b2f439.PubMedCrossRef
62.
Zurück zum Zitat Cree MG, Aarsland A, Herndon DN, Wolfe RR: Role of fat metabolism in burn trauma-induced skeletal muscle insulin resistance. Crit Care Med. 2007, 35: S476-S483. 10.1097/01.CCM.0000278066.05354.53.PubMedCrossRef Cree MG, Aarsland A, Herndon DN, Wolfe RR: Role of fat metabolism in burn trauma-induced skeletal muscle insulin resistance. Crit Care Med. 2007, 35: S476-S483. 10.1097/01.CCM.0000278066.05354.53.PubMedCrossRef
63.
Zurück zum Zitat Cree MG, Fram RY, Herndon DN, Qian T, Angel C, Green JM, Mlcak R, Aarsland A, Wolfe RR: Human mitochondrial oxidative capacity is acutely impaired after burn trauma. Am J Surg. 2008, 196: 234-239. 10.1016/j.amjsurg.2007.09.048.PubMedPubMedCentralCrossRef Cree MG, Fram RY, Herndon DN, Qian T, Angel C, Green JM, Mlcak R, Aarsland A, Wolfe RR: Human mitochondrial oxidative capacity is acutely impaired after burn trauma. Am J Surg. 2008, 196: 234-239. 10.1016/j.amjsurg.2007.09.048.PubMedPubMedCentralCrossRef
64.
Zurück zum Zitat Cree MG, Zwetsloot JJ, Herndon DN, Newcomer BR, Fram RY, Angel C, Green JM, Dohm GL, Sun D, Aarsland A, Wolfe RR: Insulin sensitivity is related to fat oxidation and protein kinase C activity in children with acute burn injury. J Burn Care Res. 2008, 29: 585-594. 10.1097/BCR.0b013e31817db88f.PubMedPubMedCentralCrossRef Cree MG, Zwetsloot JJ, Herndon DN, Newcomer BR, Fram RY, Angel C, Green JM, Dohm GL, Sun D, Aarsland A, Wolfe RR: Insulin sensitivity is related to fat oxidation and protein kinase C activity in children with acute burn injury. J Burn Care Res. 2008, 29: 585-594. 10.1097/BCR.0b013e31817db88f.PubMedPubMedCentralCrossRef
65.
Zurück zum Zitat Jeschke MG, Boehning D: Endoplasmic reticulum stress and insulin resistance post-trauma: similarities to type 2 diabetes. J Cell Mol Med. 2012, 16: 437-444. 10.1111/j.1582-4934.2011.01405.x.PubMedPubMedCentralCrossRef Jeschke MG, Boehning D: Endoplasmic reticulum stress and insulin resistance post-trauma: similarities to type 2 diabetes. J Cell Mol Med. 2012, 16: 437-444. 10.1111/j.1582-4934.2011.01405.x.PubMedPubMedCentralCrossRef
66.
Zurück zum Zitat Jeschke MG, Kraft R, Emdad F, Kulp GA, Williams FN, Herndon DN: Glucose control in severely thermally injured pediatric patients: what glucose range should be the target?. Ann Surg. 2010, 252: 521-528.PubMed Jeschke MG, Kraft R, Emdad F, Kulp GA, Williams FN, Herndon DN: Glucose control in severely thermally injured pediatric patients: what glucose range should be the target?. Ann Surg. 2010, 252: 521-528.PubMed
67.
Zurück zum Zitat Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL: Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008, 36: 296-327. 10.1097/01.CCM.0000298158.12101.41.PubMedCrossRef Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL: Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008, 36: 296-327. 10.1097/01.CCM.0000298158.12101.41.PubMedCrossRef
68.
Zurück zum Zitat Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R: Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013, 41: 580-637. 10.1097/CCM.0b013e31827e83af.PubMedCrossRef Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R: Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013, 41: 580-637. 10.1097/CCM.0b013e31827e83af.PubMedCrossRef
69.
Zurück zum Zitat Langouche L, Vanhorebeek I, Van den Berghe G: Therapy insight: the effect of tight glycemic control in acute illness. Nat Clin Pract Endocrinol Metab. 2007, 3: 270-278. 10.1038/ncpendmet0426.PubMedCrossRef Langouche L, Vanhorebeek I, Van den Berghe G: Therapy insight: the effect of tight glycemic control in acute illness. Nat Clin Pract Endocrinol Metab. 2007, 3: 270-278. 10.1038/ncpendmet0426.PubMedCrossRef
70.
Zurück zum Zitat Van den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P: Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit Care Med. 2003, 31: 359-366. 10.1097/01.CCM.0000045568.12881.10.PubMedCrossRef Van den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P: Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit Care Med. 2003, 31: 359-366. 10.1097/01.CCM.0000045568.12881.10.PubMedCrossRef
71.
Zurück zum Zitat Vlasselaers D, Milants I, Desmet L, Wouters PJ, Vanhorebeek I, van den Heuvel I, Mesotten D, Casaer MP, Meyfroidt G, Ingels C, Muller J, Van Cromphaut S, Schetz M, Van den Berghe G: Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study. Lancet. 2009, 373: 547-556. 10.1016/S0140-6736(09)60044-1.PubMedCrossRef Vlasselaers D, Milants I, Desmet L, Wouters PJ, Vanhorebeek I, van den Heuvel I, Mesotten D, Casaer MP, Meyfroidt G, Ingels C, Muller J, Van Cromphaut S, Schetz M, Van den Berghe G: Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study. Lancet. 2009, 373: 547-556. 10.1016/S0140-6736(09)60044-1.PubMedCrossRef
72.
Zurück zum Zitat Pidcoke HF, Wanek SM, Rohleder LS, Holcomb JB, Wolf SE, Wade CE: Glucose variability is associated with high mortality after severe burn. J Trauma. 2009, 67: 990-995. 10.1097/TA.0b013e3181baef4b.PubMedCrossRef Pidcoke HF, Wanek SM, Rohleder LS, Holcomb JB, Wolf SE, Wade CE: Glucose variability is associated with high mortality after severe burn. J Trauma. 2009, 67: 990-995. 10.1097/TA.0b013e3181baef4b.PubMedCrossRef
73.
Zurück zum Zitat Pisarchik AN, Pochepen ON, Pisarchyk LA: Increasing blood glucose variability is a precursor of sepsis and mortality in burned patients. PLoS One. 2012, 7: e46582-10.1371/journal.pone.0046582.PubMedPubMedCentralCrossRef Pisarchik AN, Pochepen ON, Pisarchyk LA: Increasing blood glucose variability is a precursor of sepsis and mortality in burned patients. PLoS One. 2012, 7: e46582-10.1371/journal.pone.0046582.PubMedPubMedCentralCrossRef
74.
Zurück zum Zitat Mann EA, Salinas J, Pidcoke HF, Wolf SE, Holcomb JB, Wade CE: Error rates resulting from anemia can be corrected in multiple commonly used point-of-care glucometers. J Trauma. 2008, 64: 15-21. 10.1097/TA.0b013e318160b9e4.PubMedCrossRef Mann EA, Salinas J, Pidcoke HF, Wolf SE, Holcomb JB, Wade CE: Error rates resulting from anemia can be corrected in multiple commonly used point-of-care glucometers. J Trauma. 2008, 64: 15-21. 10.1097/TA.0b013e318160b9e4.PubMedCrossRef
75.
Zurück zum Zitat Pidcoke HF, Wade CE, Mann EA, Salinas J, Cohee BM, Holcomb JB, Wolf SE: Anemia causes hypoglycemia in intensive care unit patients due to error in single-channel glucometers: methods of reducing patient risk. Crit Care Med. 2010, 38: 471-476. 10.1097/CCM.0b013e3181bc826f.PubMedPubMedCentralCrossRef Pidcoke HF, Wade CE, Mann EA, Salinas J, Cohee BM, Holcomb JB, Wolf SE: Anemia causes hypoglycemia in intensive care unit patients due to error in single-channel glucometers: methods of reducing patient risk. Crit Care Med. 2010, 38: 471-476. 10.1097/CCM.0b013e3181bc826f.PubMedPubMedCentralCrossRef
76.
Zurück zum Zitat Damiano ER, El-Khatib FH, Zheng H, Nathan DM, Russell SJ: A comparative effectiveness analysis of three continuous glucose monitors. Diabetes Care. 2013, 36: 251-259. 10.2337/dc12-0070.PubMedPubMedCentralCrossRef Damiano ER, El-Khatib FH, Zheng H, Nathan DM, Russell SJ: A comparative effectiveness analysis of three continuous glucose monitors. Diabetes Care. 2013, 36: 251-259. 10.2337/dc12-0070.PubMedPubMedCentralCrossRef
77.
Zurück zum Zitat Mecott GA, Herndon DN, Kulp GA, Brooks NC, Al-Mousawi AM, Kraft R, Rivero HG, Williams FN, Branski LK, Jeschke MG: The use of exenatide in severely burned pediatric patients. Crit Care. 2010, 14: R153-10.1186/cc9222.PubMedPubMedCentralCrossRef Mecott GA, Herndon DN, Kulp GA, Brooks NC, Al-Mousawi AM, Kraft R, Rivero HG, Williams FN, Branski LK, Jeschke MG: The use of exenatide in severely burned pediatric patients. Crit Care. 2010, 14: R153-10.1186/cc9222.PubMedPubMedCentralCrossRef
78.
Zurück zum Zitat Gore DC, Herndon DN, Wolfe RR: Comparison of peripheral metabolic effects of insulin and metformin following severe burn injury. J Trauma. 2005, 59: 316-323. 10.1097/01.ta.0000180387.34057.5a.PubMedCrossRef Gore DC, Herndon DN, Wolfe RR: Comparison of peripheral metabolic effects of insulin and metformin following severe burn injury. J Trauma. 2005, 59: 316-323. 10.1097/01.ta.0000180387.34057.5a.PubMedCrossRef
79.
Zurück zum Zitat Gore DC, Wolf SE, Herndon DN, Wolfe RR: Metformin blunts stress-induced hyperglycemia after thermal injury. J Trauma. 2003, 54: 555-561. 10.1097/01.TA.0000026990.32856.58.PubMedCrossRef Gore DC, Wolf SE, Herndon DN, Wolfe RR: Metformin blunts stress-induced hyperglycemia after thermal injury. J Trauma. 2003, 54: 555-561. 10.1097/01.TA.0000026990.32856.58.PubMedCrossRef
80.
Zurück zum Zitat Gore DC, Wolf SE, Sanford A, Herndon DN, Wolfe RR: Influence of metformin on glucose intolerance and muscle catabolism following severe burn injury. Ann Surg. 2005, 241: 334-342. 10.1097/01.sla.0000152013.23032.d1.PubMedPubMedCentralCrossRef Gore DC, Wolf SE, Sanford A, Herndon DN, Wolfe RR: Influence of metformin on glucose intolerance and muscle catabolism following severe burn injury. Ann Surg. 2005, 241: 334-342. 10.1097/01.sla.0000152013.23032.d1.PubMedPubMedCentralCrossRef
81.
Zurück zum Zitat Cree MG, Newcomer BR, Herndon DN, Qian T, Sun D, Morio B, Zwetsloot JJ, Dohm GL, Fram RY, Mlcak RP, Aarsland A, Wolfe RR: PPAR-alpha agonism improves whole body and muscle mitochondrial fat oxidation, but does not alter intracellular fat concentrations in burn trauma children in a randomized controlled trial. Nutr Metab (Lond). 2007, 4: 9-10.1186/1743-7075-4-9.CrossRef Cree MG, Newcomer BR, Herndon DN, Qian T, Sun D, Morio B, Zwetsloot JJ, Dohm GL, Fram RY, Mlcak RP, Aarsland A, Wolfe RR: PPAR-alpha agonism improves whole body and muscle mitochondrial fat oxidation, but does not alter intracellular fat concentrations in burn trauma children in a randomized controlled trial. Nutr Metab (Lond). 2007, 4: 9-10.1186/1743-7075-4-9.CrossRef
82.
Zurück zum Zitat Elijah IE, Borsheim E, Maybauer DM, Finnerty CC, Herndon DN, Maybauer MO: Role of the PPAR-alpha agonist fenofibrate in severe pediatric burn. Burns. 2012, 38: 481-486. 10.1016/j.burns.2011.12.004.PubMedPubMedCentralCrossRef Elijah IE, Borsheim E, Maybauer DM, Finnerty CC, Herndon DN, Maybauer MO: Role of the PPAR-alpha agonist fenofibrate in severe pediatric burn. Burns. 2012, 38: 481-486. 10.1016/j.burns.2011.12.004.PubMedPubMedCentralCrossRef
Metadaten
Titel
Clinical review: Glucose control in severely burned patients - current best practice
verfasst von
Marc G Jeschke
Publikationsdatum
01.08.2013
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 4/2013
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc12678

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