Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Die Highlights vom Kongress des American College of Cardiology 2024

Im April diskutierten die Herz-Kreislauf-Spezialisten aus der ganzen Welt auf dem  Kongress des American College of Cardiology (ACC) u.a. neue Therapieansätze bei akutem Myokardinfarkt, koronarer Herzerkrankung, kardiogenem Schock oder Aortenklappenstenose. In unserem Kongress-Dossier haben wir für Sie Berichte über die „Late-Breaking Trials“ und andere wichtige Studien zusammengestellt. 
Erweiterte Suche
Anmelden
nach oben
Critical Care
Erschienen in: Critical Care 5/2004

01.10.2004 | Review

Science review: Extracellular acidosis and the immune response: clinical and physiologic implications

verfasst von: John A Kellum, Mingchen Song, Jinyou Li

Erschienen in: Critical Care | Ausgabe 5/2004

Einloggen, um Zugang zu erhalten

Abstract

Metabolic acidosis is among the most common abnormalities seen in patients suffering from critical illness. Its etiologies are multiple and treatment of the underlying condition is the mainstay of therapy. However, growing evidence suggests that acidosis itself has profound effects on the host, particularly in the area of immune function. Given the central importance of immune function to the outcome of critical illness, there is renewed interest in elucidating the effects of this all too common condition on the immune response. In this review we concentrate on the effects of extracellular acids on production and release of inflammatory mediators, and we demonstrate that different acids produce different effects despite similar extracellular pH. Finally, we discuss potential clinical implications.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Chu EK, Whitehead T, Slutsky AS: Effects of cyclic opening and closing at low- and high-volume ventilation on bronchoalveolar lavage cytokines. Crit Care Med 2004, 32: 168-174. 10.1097/01.CCM.0000104203.20830.AECrossRefPubMed
2.
Burne-Taney MJ, Kofler J, Yokota N, Weisfeldt M, Traystman RJ, Rabb H: Acute renal failure after whole body ischemia is characterized by inflammation and T cell-mediated injury. Am J Physiol Renal Physiol 2003, 285: F87-F94.CrossRefPubMed
3.
Joyce DE, Grinnell BW: Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-kappaB. Crit Care Med 2002, Suppl: S288-S293. 10.1097/00003246-200205001-00019CrossRef
4.
Annane D, Cavaillon JM: Corticosteroids in sepsis: from bench to bedside? Shock 2003, 20: 197-207. 10.1097/01.shk.0000079423.72656.2fCrossRefPubMed
5.
Heming TA, Dave SK, Tuazon DM, Chopra AK, Peterson JW, Bidani A: Effects of extracellular pH on tumour necrosis factor-alpha production by resident alveolar macrophages. Clin Sci 2001, 101: 267-274. 10.1042/CS20010139CrossRefPubMed
6.
Bellocq A, Suberville S, Philippe C, Bertrand F, Perez J, Fouqueray B, Cherqui G, Baud L: Low environmental pH is responsible for the induction of nitric-oxide synthase in macrophages. Evidence for involvement of nuclear factor-kappaB activation. J Biol Chem 1998, 273: 5086-5092. 10.1074/jbc.273.9.5086CrossRefPubMed
7.
Heming TA, Tuazon DM, Dave SK, Chopra AK, Peterson JW, Bidani A: Post-transcriptional effects of extracellular pH on tumour necrosis factor-alpha production in RAW 246.7 and J774 A.1 cells. Clin Sci 2001, 100: 259-266. 10.1042/CS20000192CrossRefPubMed
8.
Bidani A, Wang CZ, Saggi SJ, Heming TA: Evidence for pH sensitivity of tumor necrosis factor-alpha release by alveolar macrophages. Lung 1998, 176: 111-121.CrossRefPubMed
9.
Huang CJ, Haque IC, Slovin PN, Nielsen RB, Fang X, Skimming JW: Environmental pH regulates LPS-induced nitric oxide formation in murine macrophages. Nitric Oxide 2002, 6: 73-78. 10.1006/niox.2001.0391CrossRefPubMed
10.
Jensen JC, Buresh C, Norton JA: Lactic acidosis increases tumor necrosis factor secretion and transcription in vitro. J Surg Res 1990, 49: 350-353. 10.1016/0022-4804(90)90036-2CrossRefPubMed
11.
Himmelseher S, Pfenninger E, Georgieff M: Basic fibroblast growth factor reduces lactic acid–induced neuronal injury in rat hippocampal neurons. Crit Care Med 1998, 26: 2029-2036. 10.1097/00003246-199812000-00035CrossRefPubMed
12.
Schurr A, Payne RS, Miller JJ, Rigor BM: Brain lactate is an obligatory aerobic energy substrate for functional recovery after hypoxia: further in vitro validation. J Neurochem 1997, 69: 423-426.CrossRefPubMed
13.
Schurr A, Payne RS, Miller JJ, Rigor BM: Brain lactate, not glucose, fuels the recovery of synaptic function from hypoxia upon reoxygenation: an in vitro study. Brain Res 1997, 744: 105-111. 10.1016/S0006-8993(96)01106-7CrossRefPubMed
14.
Jorres A, Gahl GM, Frei U: In vitro studies on the effect of dialysis solutions on peritoneal leukocytes. Perit Dial Int 1995, 15: S41-S45.PubMed
15.
Douvdevani A, Abramson O, Tamir A, Konforty A, Isakov N, Chaimovitz C: Commercial dialysate inhibits TNF alpha mRNA expression and NF-kappa B DNA-binding activity in LPS-stimulated macrophages. Kidney Int 1995, 47: 1537-1545.CrossRefPubMed
16.
AlKharfy KM, Kellum JA, Matzke G: Unintended immunomodulation: part I. Effect of common clinical conditions on cytokine biosynthesis. Shock 2000, 13: 333-345.CrossRefPubMed
17.
Kellum JA, Song M, Li J: Lactic, and hydrochloric acids induce different patterns of inflammatory response in LPS-stimulated RAW 264.7 cells. Am J Physiol Regul Integr Comp Physiol 2004, 286: R686-R692. 10.1152/ajpregu.00564.2003CrossRefPubMed
18.
Pedoto A, Caruso JE, Nandi J: Acidosis stimulates nitric oxide production and lung damage in rats. Am J Respir Crit Care Med 1999, 159: 397-402.CrossRefPubMed
19.
Lu Y, Song M, Zuo Y, Kellum JA: The inhibitory effect of lactic acid on NO release by stimulated RAW cells is not specific to LPS [abstract]. Crit Care Med 2003, Suppl: A45.
20.
Lardner A: The effects of extracellular pH on immune function. J Leukoc Biol 2001, 69: 522-530.PubMed
21.
Nahas GG, Tannieres ML, Lennon JF: Direct measurement of leukocyte motility: effects of pH and temperature. Proc Soc Exp Biol Med 1971, 138: 350-352.CrossRefPubMed
22.
Rotstein OD, Fiegel VD, Simmons RL, Knighton DR: The deleterious effect of reduced pH and hypoxia on neutrophil migration in vitro. J Surg Res 1988, 45: 298-303. 10.1016/0022-4804(88)90079-0CrossRefPubMed
23.
Rabinovich M, DeStefano MJ, Dziezanowski MA: Neutrophil migration under agarose: stimulation by lowered medium pH and osmolality. J Reticuloendothel Society 1980, 27: 189-200.
24.
Simchowitz L, Cragoe EJ Jr: Regulation of human neutrophil chemotaxis by intracellular pH. J Biol Chem 1986, 261: 6492-6500.PubMed
25.
Leblebicioglu B, Lim JS, Cario AC, Beck FM, Walters JD: pH changes observed in the inflamed gingival crevice modulate human polymorphonuclear leukocyte activation in vitro. J Periodontol 1996, 67: 472-477.CrossRefPubMed
26.
Araki A, Inoue T, Cragoe EJ Jr, Sendo F: Na+/H+ exchange modulates rat neutrophil mediated tumor cytotoxicity. Cancer Res 1991, 51: 3212-3216.PubMed
27.
28.
Gabig TG, Bearman SI, Babior BM: Effects of oxygen tension and pH on the respiratory burst of human neutrophils. Blood 1979, 53: 1133-1139.PubMed
29.
Beachy JC, Weisman LE: Acute asphyxia affects neutrophil number and function in the rat. Crit Care Med 1993, 21: 1929-1934.CrossRefPubMed
30.
Craven N, Williams MR, Field TR, Bunch KJ, Mayer SJ, Bourne FJ: The influence of extracellular and phagolysosomal pH changes on the bactericidal activity of bovine neutrophils against Staphylococcus aureus . Vet Immunol Immunopathol 1986, 13: 97-110. 10.1016/0165-2427(86)90052-8CrossRefPubMed
31.
Nakagawara A, Nathan CF, Cohn ZA: Hydrogen peroxide metabolism in human monocytes during differentiation in vitro. J Clin Invest 1981, 68: 1243-1252.PubMedCentralCrossRefPubMed
32.
Trevani AS, Andonegui G, Giordano M, Lopez DH, Gamberale R, Minucci F, Geffner JR: Extracellular acidification induces human neutrophil activation. J Immunol 1999, 162: 4849-4857.PubMed
33.
Miyazawa K, Inoue K: Complement activation induced by human C-reactive protein in mildly acidic conditions. J Immunol 1990, 145: 650-654.PubMed
34.
Osaki M, Sumimoto H, Takeshige K, Cragoe EJ Jr, Hori Y, Minakami S: Na+/H+ exchange modulates the production of leukotriene B4 by human neutrophils. Biochem J 1989, 257: 751-758.PubMedCentralCrossRefPubMed
35.
Grinstein S, Furuya W: Cytoplasmic pH regulation in phorbol ester-activated human neutrophils. Am J Physiol 1986, 251: C55-C65.PubMed
36.
Kellum JA, Bellomo R, Kramer DJ, Pinsky MR: Etiology of metabolic acidosis during saline resuscitation in endotoxemia. Shock 1998, 9: 364-368.CrossRefPubMed
37.
Kellum JA: Fluid resuscitation and hyperchloremic acidosis in experimental sepsis: improved survival and acid–base balance with a synthetic colloid in a balanced electrolyte solution compared to saline. Crit Care Med 2002, 30: 300-305. 10.1097/00003246-200202000-00006CrossRefPubMed
38.
Opie L: Effect of extracellular pH on function and metabolism of isolated perfused rat heart. J Appl Physiol 1965, 209: 1975-1980.
39.
Cooper D, Herbertson M, Werner H, Walley K: Bicarbonate does not increase left ventricular contractility during L-lactic acidemia in pigs. Am Rev Resp Dis 1993, 148: 317-322.CrossRefPubMed
40.
Salzman AL, Wang H, Wollert PS, Vandermeer TJ, Compton CC, Denenberg AG, Fink MP: Endotoxin-induced ileal mucosal hyperpermeability in pigs: role of tissue acidosis. Am J Physiol 1994, 266: G633-G646.PubMed
41.
Menconi MJ, Salzman AL, Unno N, Ezzell RM, Casey DM, Brown DA, Tsuji Y, Fink MP: Acidosis induces hyperpermeability in Caco-2BBe cultured intestinal epithelial monolayers. Am J Physiol 1997, 272: G1007-G1021.PubMed
42.
Gonzalez PK, Doctrow SR, Malfroy B, Fink MP: Role of oxidant stress and iron delocalization in acidosis-induced intestinal epithelial hyperpermeability. Shock 1997, 8: 108-114.CrossRefPubMed
43.
Unno N, Menconi MJ, Smith M, Aguirre DE, Fink MP: Hyperpermeability of intestinal epithelial monolayers is induced by NO: effect of low extracellular pH. Am J Physiol 1997, 272: G923-G934.PubMed
44.
Unno N, Hodin RA, Fink MP: Acidic conditions exacerbate interferon-gamma-induced intestinal epithelial hyperpermeability: role of peroxynitrous acid. Crit Care Med 1999, 27: 1429-1436. 10.1097/00003246-199908000-00003CrossRefPubMed
45.
Pedoto A, Nandi J, Oler A, Camporesi EM, Hakim TS, Levine RA: Role of nitric oxide in acidosis-induced intestinal injury in anesthetized rats. J Lab Clin Med 2001, 138: 270-276. 10.1067/mlc.2001.118176CrossRefPubMed
46.
Kellum JA, Song M, Venkataraman R: Effects of hyperchloremic acidosis on arterial pressure and circulating inflammatory molecules in experimental sepsis. Chest 2004, 125: 243-248. 10.1378/chest.125.1.243CrossRefPubMed
47.
Gunnerson KJ, Saul M, Kellum JA: Lactic versus nonlactic metabolic acidosis: outcomes in critically ill patients [abstract]. Crit Care 2003, Suppl 2: 17. 10.1186/cc1906CrossRef
48.
Severin T, Muller B, Giese G, Uhl B, Wolf B, Hauschildt S, Kreutz W: pH-dependent LAK cell cytotoxicity. Tumour Biol 1994, 15: 304-310.CrossRefPubMed
49.
Loeffler DA, Juneau PL, Masserant S: Influence of tumour physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation. Br J Cancer 1992, 66: 619-622.PubMedCentralCrossRefPubMed
50.
Loeffler DA, Juneau PL, Heppner GH: Natural killer-cell activity under conditions reflective of tumor micro-environment. Int J Cancer 1991, 48: 895-899.CrossRefPubMed
Metadaten
Titel
Science review: Extracellular acidosis and the immune response: clinical and physiologic implications
verfasst von
John A Kellum
Mingchen Song
Jinyou Li
Publikationsdatum
01.10.2004
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 5/2004
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc2900

Weitere Artikel der Ausgabe 5/2004

Critical Care 5/2004 Zur Ausgabe

Commentary

Role of iron in anaemic critically ill patients: it's time to investigate!

Research

Mild hypothermia after near drowning in twin toddlers

Research

Comparison of two percutaneous tracheostomy techniques, guide wire dilating forceps and Ciaglia Blue Rhino: a sequential cohort study

Commentary

Tracheostomy must be individualized!

Research

Effects of positive end-expiratory pressure on gastric mucosal perfusion in acute respiratory distress syndrome

Commentary

Positive end-expiratory pressure in acute respiratory distress syndrome – an old yet mysterious tool

Neu im Fachgebiet AINS

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Delir bei kritisch Kranken – Antipsychotika versus Placebo

16.05.2024 Delir Nachrichten

Um die Langzeitfolgen eines Delirs bei kritisch Kranken zu mildern, wird vielerorts auf eine Akuttherapie mit Antipsychotika gesetzt. Eine US-amerikanische Forschungsgruppe äußert jetzt erhebliche Vorbehalte gegen dieses Vorgehen. Denn es gibt neue Daten zum Langzeiteffekt von Haloperidol bzw. Ziprasidon versus Placebo.

Klinikreform soll zehntausende Menschenleben retten

15.05.2024 Klinik aktuell Nachrichten

Gesundheitsminister Lauterbach hat die vom Bundeskabinett beschlossene Klinikreform verteidigt. Kritik an den Plänen kommt vom Marburger Bund. Und in den Ländern wird über den Gang zum Vermittlungsausschuss spekuliert.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

hier abonnieren
Bildnachweise