Introduction
Biogenesis and characteristics of exosome
Noncoding RNAs in exosome
MicroRNA
Long-noncoding RNA
Circular RNA
The functional roles of exosomal ncRNAs in glioma
NcRNAs | Parent cell | Target cell | Biological function | Reference |
---|---|---|---|---|
miR-221 | U87MG | SHG-44 | Promote proliferation, migration and TMZ resistance | [62] |
lncRNA-ATB | Glioma cells | Normal human astrocytes | Promote invasion | [6] |
miR-148a | Glioma cells | Glioma cells | Promote proliferation and metastasis | [63] |
miR-451/miR-21 | Glioma cells | Microglia/macrophages | Promote proliferation and immune suppression | [24] |
miR-1587 | Mesenchymal Stem Cells | Glioma Stem-like Cells | Increase tumorigenicity | [64] |
miR-1 | Glioblastoma cells | Endothelial cells and glioblastoma cells | Inhibit angiogenesis, invasion, and neurosphere formation | [65] |
miR-124 | Mesenchymal stem cells | glioblastoma cells | Inhibit proliferation, migration and confer chemosensitivity | [28] |
miR-302-367 | Glioma stem-like cells | Glioblastoma cells | Inhibit growth | [66] |
miR-7 | Mesenchymal stem cells | Glioblastoma cells | Increase apoptosis and suppress growth | [30] |
miR-584 | Mesenchymal stem cells | Glioma cells | Suppress tumor progress | [29] |
miR-146b | Marrow stromal cells | Gliosarcoma cells | Reduce glioma growth in vivo | [25] |
miR-124a | Mesenchymal stem cells | Glioma stem cell | Antiglioma agent | [31] |
miRNA-199a | Mesenchymal stem cells | Glioma cells | Inhibit proliferation, invasion and enhance chemosensitivity | [27] |
miR-375 | Marrow stromal cells | Glioma cells | Inhibit glioma progression | [26] |
lncRNA-HOTAIR | Glioblastoma cells | Endothelial cells | Promote angiogenesis | [49] |
lincRNA-CCAT2 | Glioma cells | Endothelial cells | Promote angiogenesis | [67] |
lincRNA-POU3F3 | Glioma cells | Endothelial cells | Promote angiogenesis | [68] |
miR- 26a | Glioma stem cells | Endothelial cells | Promote angiogenesis | [69] |
miR-21 | Glioma stem cells | Endothelial cells | Promotes angiogenesis | [70] |
miR-9 | Glioma cells | Endothelial cells | Promote tumorigenesis and angiogenesis | [71] |
miR-10a, miR-21 | Hypoxic glioma cells | Myeloid-derived suppressor cells | Mediate immunosuppressive microenvironments | [72] |
miR-29a, miR-92a | Hypoxic glioma cells | Myeloid-derived suppressor cells | Mediate immunosuppressive microenvironments | [73] |
miR-1246 | Hypoxic glioma cells | Macrophages | Mediate immunosuppressive microenvironment | [74] |
miR-21 | Glioma cells | Microglia | Mediate immunosuppressive microenvironment | [75] |
miR-151a | TMZ-resistant glioblastoma cells | TMZ-sensitive glioblastoma cells | Enhances chemosensitivity to TMZ | [76] |
lncRNA-SBF2-AS1 | TMZ-resistant glioblastoma cells | Chemoresponsive glioblastoma cells | Enhances chemoresistance to TMZ | [77] |
circATP8B4 | Radioresistant glioma cells | Normal glioma cells | Promote cell radioresistance | [78] |
miR-301a | Hypoxic glioma cells | Normoxia-cultured glioma cells | Promote radiation resistance | [79] |
lncRNA-AHIF | Radioresistant glioblastoma cells | Glioblastoma cells | Promote invasion and radioresistance | [48] |
Exosomal ncRNAs and cell proliferation/invasion in glioma
Exosomal ncRNAs and glioma angiogenesis
Exosomal ncRNAs and immunosuppressive microenvironment
Exosomal ncRNAs and treatment resistance
Potential clinical applications of exosomal ncRNAs in glioma
Exosomal ncRNAs serve as promising biomarkers
NcRNA Canditates | Source of exosome | Exosome isolation techniques | System | Biomarker potential | Reference |
---|---|---|---|---|---|
miR-21 | CSF | Ultracentrifugation | GBM | A biomarker for GBM diagnosis | [109] |
miR-21 | CSF & serum | Ultracentrifugation | Glioma | A biomarker for glioma diagnosis and prognosis | [110] |
miR-151a | CSF & serum | Ultracentrifugation | GBM | Predict prognosis of GBM patients | [76] |
miR-320 & miR-574-3p | Serum | Precipitation method | GBM | A biomarker for GBM diagnosis | [108] |
miR-221 | Serum | Precipitation method | Glioma | A biomarker for glioma diagnosis and grade prediction | [62] |
miR-21, miR-222 & miR-124-3p | Serum | PEG-based method | Glioma | A biomarker for glioma diagnosis and grade prediction | [104] |
miR-301a | Serum | Precipitation method | Glioma | Serve as diagnostic and prognostic biomarker | [105] |
miR-148a | Serum | Precipitation method | GBM | A biomarker for GBM diagnosis | [63] |
miR-454-3p | Serum | Immunoaffinity capture | Glioma | A biomarker for glioma diagnosis | [106] |
lncRNA-HOTAIR | Serum | Precipitation method | GBM | A biomarker for GBM diagnosis | [107] |
lncRNA-SBF2-AS1 | Serum | Ultracentrifugation | GBM | Serve as diagnostic biomarker for therapy-refractory GBM | [77] |