Background
Methods
BRC patient samples
Human Cancer cell Xenograft model
Cell culture
Establishment of transfected cell lines
Western blot analysis
Quantitative PCR analysis
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GAPDH-F: GAACGGGAAGCTCACTGG;
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GAPDH-R: GCCTGCTTCACCACCTTCT;
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GOLPH3L-F: GTAAATGACCCTCAGCGTATGG;
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GOLPH3L-R: GTTCTACTAAGTCCTTGGCTCGAT;
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miRNA-1185-2-3p: AUAUACAGGGGGAGACUCUCAU;
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miRNA-1185-2-3p-F: ACACTCCAGCTGGGATATACAGGGGGAGAC;
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miRNA-1185-2-3p-R: CTCAACTGGTGTCGTGGA;
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U6-F: GCTTCGGCAGCACATATACTAAAAT;
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U6-R: CGCTTCATGAATTTGCGTGTCAT;
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miRNA-1185-2-3p mimic-F: AUAUACAGGGGGAGACUCUCAU;
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miRNA-1185-2-3p mimic-R: GAGAGUCUCCCCCUGUAUAUUU;
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miRNA-1185-2-3p inhibitor: AUGAGAGUCUCCCCCUGUAUAU.
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SERPINE1-F: ACCGCAACGTGGTTTTCTCA;
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SERPINE1-R: TTGAATCCCATAGCTGCTTGAAT.
Cell proliferation, apoptosis, migration assay and cell cycle assay
Dual-luciferase reporter assay
Metabolomic analysis
Transcriptome sequencing
Seahorse assay
Protein stability analysis
Coimmunoprecipitation assay
Statistical analysis
Results
GOLPH3L is highly expressed in breast Cancer and promotes the tumorigenesis of breast Cancer cells
miRNA-1185-2-3p negatively regulates GOLPH3L and positively correlates with the prognosis of human breast Cancer patients
GOLPH3L affects glucose metabolism in breast Cancer cells
Name | ID | VIP | Fold change | p-value |
---|---|---|---|---|
M348T450 | Adenosine monophosphate (AMP) | 5.35017309 | 0.343953619 | 1.85022E-09 |
M489T438 | Cytidine 5′-diphosphocholine (CDP-choline) | 3.769023161 | 0.294683065 | 2.09147E-09 |
M325T436 | Uridine 5′-monophosphate (UMP) | 2.859910755 | 0.36416908 | 1.85344E-08 |
M136T425 | Adenine | 3.624555449 | 0.541578913 | 3.52988E-08 |
M216T387 | sn-Glycerol 3-phosphoethanolamine | 3.817810077 | 0.662660731 | 1.64313E-07 |
M113T160 | Uracil | 2.339930939 | 0.254999039 | 2.66289E-07 |
M162T355_2 | L-carnitine | 2.259917766 | 0.687860774 | 5.55508E-07 |
M244T235 | Cytidine | 1.320380286 | 0.343617832 | 6.16343E-07 |
M664T430 | Nicotinamide adenine dinucleotide (NAD) | 5.426903613 | 0.531267518 | 6.8003E-07 |
M204T426 | N-acetyl-D-glucosamine | 2.162566187 | 0.585855735 | 6.80877E-07 |
M268T167 | Adenosine | 2.080090077 | 0.506337679 | 8.19558E-07 |
M152T457 | 2-Hydroxyadenine | 1.192073219 | 0.418366736 | 1.00101E-06 |
M364T457 | Guanosine 5′-monophosphate (GMP) | 2.20531908 | 0.381298814 | 1.34425E-06 |
M598T474 | Uridine 5′-diphosphoglucuronic acid (UDP-D-glucuronate) | 1.241389474 | 0.627904863 | 2.896E-06 |
M810T418 | Acetyl coenzyme A (Acetyl-CoA) | 1.148074386 | 0.537400888 | 7.08625E-06 |
M148T391 | L-glutamate | 3.853584751 | 0.737242788 | 8.94063E-06 |
M584T438 | UDP-D-galactose | 1.033843982 | 0.641425356 | 9.98778E-06 |
M137T166 | Hypoxanthine | 6.446185931 | 0.11746834 | 1.93784E-05 |
M428T452_2 | Adenosine 5′-diphosphate (ADP) | 7.163025043 | 0.57751916 | 2.09404E-05 |
M447T442 | CDP-ethanolamine | 1.026217107 | 0.611693587 | 2.16949E-05 |
M291T464 | Argininosuccinic acid | 1.026399168 | 1.525518377 | 2.31077E-05 |
M188T257 | DL-indole-3-lactic acid | 1.240956561 | 0.489217809 | 2.34219E-05 |
M102T391 | 1-Aminocyclopropanecarboxylic acid | 1.410081315 | 0.756256635 | 2.38876E-05 |
M246T242 | 2-Methylbutyroylcarnitine | 7.369334193 | 0.509326233 | 3.52739E-05 |
M106T299 | Diethanolamine | 1.53304285 | 14.44114449 | 3.92078E-05 |
M245T409 | Pro-Glu | 1.083816026 | 0.642279716 | 4.4156E-05 |
M316T193 | Decanoyl-L-carnitine | 1.705457563 | 0.620089802 | 8.50963E-05 |
M204T303 | Acetylcarnitine | 10.77036712 | 0.725339373 | 0.000102368 |
M422T466 | Uridine 5′-diphosphate (UDP) | 1.109528766 | 0.668781099 | 0.000142935 |
M400T159_2 | L-palmitoylcarnitine | 8.34588634 | 0.644174553 | 0.000177908 |
M147T369 | L-pyroglutamic acid | 1.765274591 | 1.542951135 | 0.000179981 |
M233T395 | Gamma-glutamylcysteine | 1.388401872 | 0.540837694 | 0.000320962 |
M112T236 | Cytosine | 1.593691839 | 0.555964705 | 0.000415561 |
M542T430 | ADP-ribose | 1.028412857 | 0.622601002 | 0.00064559 |
M308T428 | Glutathione | 4.266509616 | 0.504989177 | 0.000716522 |
M123T61 | Nicotinamide | 1.851347574 | 0.566997397 | 0.000943254 |
M156T441 | L-histidine | 1.2602915 | 1.504208252 | 0.00100569 |
M170T397 | 3-Methyl-L-histidine | 2.097791259 | 7.382253419 | 0.001046756 |
M120T256 | Tyramine | 1.693843786 | 0.657319643 | 0.001442055 |
M166T256 | L-phenylalanine | 1.120111864 | 0.675428936 | 0.002216965 |
M146T374_2 | (3-Carboxypropyl) trimethylammonium cation | 3.995126207 | 0.750604189 | 0.002386475 |
M132T263 | L-leucine | 1.432367955 | 0.424002729 | 0.002807843 |
M179T427 | Cys-Gly | 1.127437605 | 0.643923687 | 0.006537627 |
M258T457 | Glycerophosphocholine | 1.162325024 | 0.70923693 | 0.018142168 |
M508T581 | Adenosine 5′-triphosphate (ATP) | 1.252149198 | 0.44136226 | 0.018216171 |
M391T33 | Dioctyl phthalate | 5.057833924 | 0.806525311 | 0.019249997 |
M613T491 | Glutathione disulfide | 2.467281297 | 0.722876989 | 0.059115948 |
M468T200 | 1-Myristoyl-sn-glycero-3-phosphocholine | 1.668722344 | 2.054758707 | 0.059687763 |
M118T462 | Betaine | 2.078707794 | 1.308639016 | 0.05975974 |
M184T566 | Phosphorylcholine | 1.969089209 | 0.217723196 | 0.060512883 |
M496T166 | 1-Palmitoyl-sn-glycero-3-phosphocholine | 3.467532932 | 1.405433036 | 0.060816012 |
M203T505 | NG,NG-dimethyl-L-arginine (ADMA) | 1.02231111 | 0.612169445 | 0.079805836 |
M130T542 | D-pipecolinic acid | 1.22345702 | 0.462637578 | 0.081203784 |
M279T33 | Phthalic acid mono-2-ethylhexyl ester | 2.038184914 | 0.869293803 | 0.088733314 |
M341T395 | maltose | 2.111953392 | 0.028561128 | 3.10543E-17 |
M347T439 | Inosine 5′-monophosphate (IMP) | 3.625592991 | 0.301881382 | 6.71817E-16 |
M322T450 | Cytidine 5′-monophosphate (CMP) | 1.192275542 | 0.62674391 | 2.23826E-14 |
M662T429 | Nicotinamide adenine dinucleotide (NAD) | 5.135975169 | 0.567384075 | 4.63725E-13 |
M547T437 | Cytidine 5′-diphosphocholine (CDP-choline) | 1.791062321 | 0.406528182 | 1.40724E-12 |
M362T455 | Guanosine 5′-monophosphate (GMP) | 3.653583959 | 0.407242856 | 4.41861E-12 |
M540T428 | Cyclic adenosine diphosphate ribose | 4.068411598 | 0.566724985 | 6.8843E-12 |
M606T424 | UDP-N-acetylglucosamine | 18.47592875 | 0.611830043 | 7.85683E-12 |
M323T434 | Uridine 5′-monophosphate (UMP) | 7.171175055 | 0.404982084 | 1.33639E-11 |
M346T422 | Adenosine monophosphate (AMP) | 14.34548448 | 0.318588959 | 2.04199E-11 |
M203T254 | L-tryptophan | 2.120508327 | 0.500782842 | 3.29102E-11 |
M214T388 | sn-Glycerol 3-phosphoethanolamine | 9.759185833 | 0.725105379 | 3.90018E-11 |
M242T234 | Cytidine | 1.768227149 | 0.351697024 | 1.48152E-10 |
M445T440 | CDP-ethanolamine | 2.832548838 | 0.60943293 | 2.32647E-10 |
M808T416 | Acetyl coenzyme A (acetyl-CoA) | 1.321582442 | 0.559526257 | 3.85093E-10 |
M742T485 | Nicotinamide adenine dinucleotide phosphate (NADP) | 1.711544078 | 0.624512533 | 8.56497E-10 |
M130T260 | L-Isoleucine | 3.729655739 | 0.588743745 | 1.07604E-09 |
M613T434 | Cytidine monophosphate N-acetylneuraminic acid | 3.365736279 | 0.515824367 | 1.14679E-09 |
M171T383 | Glycerol 3-phosphate | 3.123463887 | 0.690487464 | 1.17292E-09 |
M147T385 | (S)-2-Hydroxyglutarate | 2.209506147 | 0.672217978 | 1.29056E-09 |
M167T451 | Phosphoenolpyruvate | 3.418641375 | 1.879691109 | 1.38673E-09 |
M174T387_2 | N-Acetyl-L-aspartic acid | 5.248401418 | 0.659295634 | 2.85219E-09 |
M258T410 | D-Glucosamine 1-phosphate (glucosamine-1P) | 1.215448728 | 0.595730278 | 2.98007E-09 |
M135T165 | Hypoxanthine | 2.83515564 | 0.155797031 | 3.3521E-09 |
M565T436 | Uridine diphosphate glucose (UDP-D-glucose) | 4.94082239 | 0.593931258 | 5.65669E-09 |
M239T387 | D-Mannose | 1.267493145 | 0.837341404 | 1.65544E-08 |
M131T253 | Ethylmalonic acid | 1.942789906 | 0.670553701 | 2.25702E-08 |
M182T474 | Phosphorylcholine | 1.592146407 | 0.776441511 | 5.19225E-08 |
M426T481 | Adenosine 5′-diphosphate (ADP) | 2.142482016 | 0.786728943 | 6.27755E-08 |
M403T463 | Uridine 5′-diphosphate (UDP) | 6.023335277 | 0.590303313 | 6.92096E-08 |
M164T253 | L-phenylalanine | 2.745272587 | 0.649759377 | 1.09694E-07 |
M128T370_1 | L-pyroglutamic acid | 1.084478181 | 1.326574096 | 1.35422E-07 |
M259T448 | Alpha-D-glucose 1-phosphate | 1.955748269 | 1.727049692 | 6.43531E-07 |
M303T435 | N-acetylaspartylglutamate (NAAG) | 1.092531363 | 0.622574707 | 1.04037E-06 |
M145T372 | L-glutamine | 4.84006701 | 1.691397723 | 1.33369E-06 |
M117T380_2 | Succinate | 3.22018177 | 0.745112292 | 1.33821E-06 |
M146T390_2 | L-glutamate | 6.383368133 | 0.805813766 | 1.34212E-06 |
M111T83 | Uracil | 4.093084571 | 0.338717051 | 1.98724E-06 |
M255T38 | Palmitic acid | 15.91857778 | 1.482478443 | 2.63587E-06 |
M462T486 | Adenylsuccinic acid | 1.400896234 | 0.601445092 | 3.04252E-06 |
M179T387_2 | Myo-Inositol | 1.869509045 | 0.876085103 | 3.53295E-06 |
M588T446 | GDP-L-fucose | 1.036473053 | 0.727980689 | 3.8859E-06 |
M458T140 | L-palmitoylcarnitine | 1.71058671 | 0.69922387 | 3.95794E-06 |
M296T70 | S-methyl-5′-thioadenosine | 2.695515248 | 0.562035793 | 5.0904E-06 |
M114T308 | L-Proline | 1.492638552 | 0.844853133 | 6.29786E-06 |
M130T386 | N-acetyl-L-alanine | 1.284618775 | 0.714233544 | 7.07193E-06 |
M611T488 | Glutathione disulfide | 6.326051929 | 0.673543892 | 2.60415E-05 |
M89T221_2 | DL-lactate | 6.180555782 | 0.771109869 | 3.15076E-05 |
M506T481 | Adenosine 5′-triphosphate (ATP) | 6.265508138 | 0.776594367 | 7.93354E-05 |
M133T396 | L-malic acid | 3.710482706 | 0.870781902 | 0.00015885 |
M306T394 | Glutathione | 6.846802373 | 0.645572726 | 0.000202429 |
M452T199 | 1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine | 2.364541907 | 1.17565739 | 0.000288876 |
M281T38 | Oleic acid | 10.56865128 | 1.261282292 | 0.000386302 |
M337T38 | Erucic acid | 1.462001645 | 0.804834608 | 0.000563427 |
M483T490 | Uridine 5′-triphosphate (UTP) | 2.985361942 | 0.791767071 | 0.000765923 |
M673T189 | 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate | 1.958401653 | 1.956770427 | 0.001001254 |
M253T38 | Cis-9-palmitoleic acid | 3.035713741 | 1.176091575 | 0.004203955 |
M227T150 | Myristic acid | 1.009572648 | 1.48607569 | 0.004811555 |
M197T38 | 3-Hydroxydodecanoic acid | 2.666768268 | 0.71831232 | 0.006944812 |
M333T125 | Penicillin G | 1.82556849 | 0.584544716 | 0.009905013 |
M273T34 | Salicylamide | 1.383050648 | 0.362734521 | 0.009978679 |
M579T469 | Uridine 5′-diphosphoglucuronic acid (UDP-D-glucuronate) | 3.315658544 | 0.86375998 | 0.010231094 |
M141T353 | 2-Oxoadipic acid | 11.40052894 | 0.912787301 | 0.015048419 |
M130T344 | Creatine | 1.009533641 | 0.795141329 | 0.017407461 |
M154T411 | Urocanic acid | 1.176119208 | 1.475399848 | 0.020677476 |
M173T432 | Cis-Aconitate | 1.169850112 | 0.768659387 | 0.021442597 |
M219T2 | 4-Nonylphenol | 2.042585348 | 1.263228143 | 0.043438355 |
M134T153 | Adenine | 1.249418803 | 0.62240901 | 0.043527968 |
M269T136 | Heptadecanoic acid | 1.030910387 | 0.689149164 | 0.05747134 |
M131T375 | L-asparagine | 1.700684605 | 1.62285133 | 0.061339629 |
M191T497 | Citrate | 2.212863083 | 0.850809508 | 0.067218448 |
M181T296 | D-threitol | 1.061736173 | 0.563835355 | 0.079699611 |
Map-ID | Map name | Ref_ per | P-value | FDR | Rich factor |
---|---|---|---|---|---|
map 05230 | Central carbon metabolism in cancer | 0.902218971 | 1.52023E-15 | 1.9611E-13 | 0.378378378 |
map 00250 | Alanine, aspartate and glutamate metabolism | 0.682760302 | 1.32499E-09 | 8.54619E-08 | 0.321428571 |
map 02010 | ABC transporters | 3.340648622 | 4.36608E-09 | 1.6293E-07 | 0.116788321 |
map 00010 | Glycolysis/Gluconeogenesis | 0.780297488 | 5.05208E-09 | 1.6293E-07 | 0.28125 |
map 04974 | Protein digestion and absorption | 1.146061936 | 1.30029E-08 | 3.35475E-07 | 0.212765957 |
map 00970 | Aminoacyl-tRNA biosynthesis | 1.267983419 | 4.83446E-07 | 1.03941E-05 | 0.173076923 |
map 01230 | Biosynthesis of amino acids | 3.121189954 | 7.70926E-07 | 1.42071E-05 | 0.1015625 |
map 04978 | Mineral absorption | 0.707144599 | 9.11103E-07 | 1.46915E-05 | 0.24137931 |
map 00020 | Citrate cycle (TCA cycle) | 0.48768593 | 1.42224E-06 | 2.03854E-05 | 0.3 |
map 00230 | Purine metabolism | 2.316508169 | 1.61025E-06 | 2.07723E-05 | 0.115789474 |
map 00240 | Pyrimidine metabolism | 1.584979273 | 3.42162E-06 | 4.01262E-05 | 0.138461538 |
map 04080 | Neuroactive ligand-receptor interaction | 1.267983419 | 5.53193E-06 | 5.94683E-05 | 0.153846154 |
map 00480 | Glutathione metabolism | 0.926603267 | 6.39595E-06 | 6.34675E-05 | 0.184210526 |
map 04922 | Glucagon signaling pathway | 0.633991709 | 7.69409E-06 | 7.08956E-05 | 0.230769231 |
map 04142 | Lysosome | 0.097537186 | 2.8207E-05 | 0.00024258 | 0.75 |
map 00520 | Amino sugar and nucleotide sugar metabolism | 2.633504023 | 3.71809E-05 | 0.000299771 | 0.092592593 |
map 05231 | Choline metabolism in cancer | 0.268227262 | 3.99483E-05 | 0.000303137 | 0.363636364 |
map 00564 | Glycerophospholipid metabolism | 1.267983419 | 5.44277E-05 | 0.000390065 | 0.134615385 |
map 04068 | FoxO signaling pathway | 0.121921483 | 6.95244E-05 | 0.000472034 | 0.6 |
map 01100 | Metabolic pathways | 65.88636918 | 9.23119E-05 | 0.000595411 | 0.025166543 |
map 00630 | Glyoxylate and dicarboxylate metabolism | 1.511826384 | 0.000171042 | 0.001050688 | 0.112903226 |
map 00190 | Oxidative phosphorylation | 0.390148744 | 0.000204512 | 0.001149292 | 0.25 |
map 04216 | Ferroptosis | 0.707144599 | 0.000204912 | 0.001149292 | 0.172413793 |
map 04924 | Renin secretion | 0.414533041 | 0.00026349 | 0.001359611 | 0.235294118 |
map 04964 | Proximal tubule bicarbonate reclamation | 0.414533041 | 0.00026349 | 0.001359611 | 0.235294118 |
map 04931 | Insulin resistance | 0.463301634 | 0.000416546 | 0.00206671 | 0.210526316 |
map 05012 | Parkinson disease | 0.48768593 | 0.000513007 | 0.002451034 | 0.2 |
map 04727 | GABAergic synapse | 0.219458669 | 0.000551859 | 0.002542494 | 0.333333333 |
map 04152 | AMPK signaling pathway | 0.536454523 | 0.000751888 | 0.00334244 | 0.181818182 |
map 04022 | cGMP-PKG signaling pathway | 0.243842965 | 0.000777312 | 0.00334244 | 0.3 |
map 04714 | Thermogenesis | 0.56083882 | 0.000896782 | 0.003731772 | 0.173913043 |
map 00052 | Galactose metabolism | 1.12167764 | 0.001825222 | 0.007357924 | 0.108695652 |
map 04150 | mTOR signaling pathway | 0.097537186 | 0.002198433 | 0.008593874 | 0.5 |
map 00620 | Pyruvate metabolism | 0.755913192 | 0.002830833 | 0.010740513 | 0.129032258 |
map 05131 | Shigellosis | 0.390148744 | 0.003333451 | 0.012286147 | 0.1875 |
map 01523 | Antifolate resistance | 0.414533041 | 0.003991299 | 0.014302156 | 0.176470588 |
map 01210 | 2-Oxocarboxylic acid metabolism | 3.267495733 | 0.004212296 | 0.014686113 | 0.059701493 |
map 00061 | Fatty acid biosynthesis | 1.414289198 | 0.00508542 | 0.017263662 | 0.086206897 |
map 04918 | Thyroid hormone synthesis | 0.512070227 | 0.007380826 | 0.024413503 | 0.142857143 |
map 04925 | Aldosterone synthesis and secretion | 0.536454523 | 0.008427501 | 0.02717869 | 0.136363636 |
map 00290 | Valine, leucine and isoleucine biosynthesis | 0.56083882 | 0.009557109 | 0.027345439 | 0.130434783 |
map 00220 | Arginine biosynthesis | 0.56083882 | 0.009557109 | 0.027345439 | 0.130434783 |
map 04724 | Glutamatergic synapse | 0.195074372 | 0.009751087 | 0.027345439 | 0.25 |
map 04211 | Longevity regulating pathway | 0.195074372 | 0.009751087 | 0.027345439 | 0.25 |
map 04740 | Olfactory transduction | 0.195074372 | 0.009751087 | 0.027345439 | 0.25 |
map 05032 | Morphine addiction | 0.195074372 | 0.009751087 | 0.027345439 | 0.25 |
map 04024 | cAMP signaling pathway | 0.609607413 | 0.012070106 | 0.033128589 | 0.12 |
map 05034 | Alcoholism | 0.243842965 | 0.015279969 | 0.041064916 | 0.2 |
map 00310 | Lysine degradation | 1.316752012 | 0.020299998 | 0.053442852 | 0.074074074 |
map 00760 | Nicotinate and nicotinamide metabolism | 1.341136308 | 0.021575257 | 0.054211054 | 0.072727273 |
map 04742 | Taste transduction | 0.755913192 | 0.021700254 | 0.054211054 | 0.096774194 |
map 04721 | Synaptic vesicle cycle | 0.292611558 | 0.021852518 | 0.054211054 | 0.166666667 |
map 01200 | Carbon metabolism | 2.779809802 | 0.022892225 | 0.055718812 | 0.052631579 |
map 00410 | Beta-alanine metabolism | 0.780297488 | 0.023615333 | 0.056414406 | 0.09375 |
map 00471 | D-Glutamine and D-glutamate metabolism | 0.316995855 | 0.025502823 | 0.059815712 | 0.153846154 |
map 00400 | Phenylalanine, tyrosine and tryptophan biosynthesis | 0.829066081 | 0.027712438 | 0.06383758 | 0.088235294 |
map 04611 | Platelet activation | 0.341380151 | 0.029381868 | 0.065349326 | 0.142857143 |
map 04923 | Regulation of lipolysis in adipocytes | 0.341380151 | 0.029381868 | 0.065349326 | 0.142857143 |
map 04066 | HIF-1 signaling pathway | 0.365764448 | 0.033479574 | 0.073201103 | 0.133333333 |
map 00500 | Starch and sucrose metabolism | 0.902218971 | 0.034522413 | 0.074223189 | 0.081081081 |
map 00561 | Glycerolipid metabolism | 0.926603267 | 0.036968063 | 0.078178362 | 0.078947368 |
map 00280 | Valine, leucine and isoleucine degradation | 1.024140454 | 0.047613224 | 0.097493744 | 0.071428571 |
map 00650 | Butanoate metabolism | 1.024140454 | 0.047613224 | 0.097493744 | 0.071428571 |
Compared group | Upregulated genes | Downregulated genes |
---|---|---|
NC--si | 133 | 72 |
CP, KRT10, PAPSS2, CASP7, UNC5B, AKR1C2, SPRY4, CHST14, FGFR3, SLC6A14, LRRC55, ILF3-AS1, EXOC3-AS1, APLNR, CDK14, AKR1C1, IFI6, OAS2, AXIN2, ZNF702P, MAN1B1-AS1, IFIT1, C2CD4A, AKR1C3, MPV17 L, HABP4, ZCCHC24, PCP4 L1, RASD2, TUB, CRH, STMN3, PALMD, GRIK4, CHD5, FLJ37453, HOXB7, SLC16A10, STEAP4, ARAP3, LOC100132249, SSTR2, SLC5A1, EGR3, ENSG00000261040.2, OASL, ADAM19, TDO2, GAREM2, ENSG00000261071.1, CEACAM1, THEM5, WFDC21P, ADGRA2, ZNF98, PPP1R1B, CDSN, IFI44, SMCO4, SLC22A31, PCDH20, GDF1, COLCA1, C1orf220, B3GNT3, ORM1, ENSG00000254024.1, ADORA1, IFI27, CMPK2, GLTPD2, CCDC177, MYEOV, ENSG00000269962.1, PTCHD1, ENSG00000266795.2, STRA6, RHBDL3, FLJ36000, ANG, RAMP2-AS1, PYDC1, TBXA2R, NELL2, LOC100996419, DLG5-AS1, SLC2A4, GAPDHP43, MYLK-AS1, VGF, EDN2, AMPD3, CNTFR, LOXL4, INSM1, ENSG00000251417.1, KCNB1, ST7-AS1, HMGB1P1, EIF4HP1, GPRC5B, ETV1, ENSG00000233029.3, SNX25P1, ENSG00000273284.1, LINC01023,4-Sep, OGFRP1, TUBB2B, C1S, ENSG00000270964.1, F11-AS1, ENSG00000256982.1, C11orf45, ENSG00000261693.1, F10, ENSG00000236514.1, ZNF663P, TOLLIP-AS1, ALOX12B, TNFAIP8 L3, UNC5CL, VANGL2, ENSG00000269289.1, FRMPD3, PPP1R14BP3, LINC00865, USH1G, ACOT11, HEPHL1, ATP13A4, MUC4, NKX1–2 | CLDN1, STC2, FAM65C, CRIM1, PIK3CB, CNOT6, VAPA, REEP3, PON2, AVL9, TMEM45B, VAMP3, KRAS, GOLPH3L, TAF9B, ATP13A2, OLR1, EFNB2, LMBRD1, MAP 6D1, TGFB2, ANXA3, PHACTR1, SHISA2, SH3RF1, USP2, POLR3G, ANKFN1, FSIP2, SAP30 L-AS1, TGFB2-OT1, GRIK1, ACPP, SYNPO, BCHE, ABCC13, PDZK1, DNAH5, SCART1, CCL2, SYBU, ECHDC1, ENSG00000260037.1, LOC100288911, ENSG00000265242.1, SERPINE1, ADIPOQ, ENSG00000254343.2, NWD2, CCR2, KIF5C, OTOR, TCF4, GPR183, SNORD12B, LINC00312, MUM1 L1, TAB3-AS1, CYP1A1, ENSG00000267896.1, PSG9, SPOCK2, ENSG00000269680.1, SLCO2A1, ADM, ENSG00000255142.1, PLAC4, ENSG00000257193.1, ENSG00000231868.1, CRYGS, IL16, ENSG00000236933.1 |
Database | ID | P-Value | Corrected P-Value | Genes |
---|---|---|---|---|
KEGG PATHWAY | hsa04933 | 5.42713E-07 | 7.32662E-05 | CCL2;PIK3CB;SERPINE1;KRAS;TGFB2 |
KEGG PATHWAY | hsa05142 | 2.07617E-05 | 0.001401414 | CCL2;PIK3CB;TGFB2;SERPINE1 |
KEGG PATHWAY | hsa05210 | 0.000126423 | 0.003878901 | PIK3CB;TGFB2;KRAS |
KEGG PATHWAY | hsa05212 | 0.000151007 | 0.003878901 | PIK3CB;TGFB2;KRAS |
KEGG PATHWAY | hsa05211 | 0.000157602 | 0.003878901 | PIK3CB;TGFB2;KRAS |
KEGG PATHWAY | hsa04062 | 0.00018996 | 0.003878901 | CCL2;PIK3CB;KRAS;CCR2 |
KEGG PATHWAY | hsa05220 | 0.000201128 | 0.003878901 | PIK3CB;TGFB2;KRAS |
KEGG PATHWAY | hsa04211 | 0.000412618 | 0.006962933 | PIK3CB;KRAS;ADIPOQ |
KEGG PATHWAY | hsa05160 | 0.001101508 | 0.01518735 | PIK3CB;KRAS;CLDN1 |
KEGG PATHWAY | hsa04068 | 0.001124989 | 0.01518735 | PIK3CB;TGFB2;KRAS |
KEGG PATHWAY | hsa04530 | 0.001247139 | 0.015305797 | VAPA;KRAS;CLDN1 |
KEGG PATHWAY | hsa05161 | 0.001431726 | 0.016106915 | PIK3CB;TGFB2;KRAS |
KEGG PATHWAY | hsa04960 | 0.001705229 | 0.017708152 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04360 | 0.002413822 | 0.022159731 | EFNB2;PIK3CB;KRAS |
KEGG PATHWAY | hsa04930 | 0.002525744 | 0.022159731 | PIK3CB;ADIPOQ |
KEGG PATHWAY | hsa05144 | 0.002626339 | 0.022159731 | CCL2;TGFB2 |
KEGG PATHWAY | hsa05213 | 0.00293929 | 0.023341421 | PIK3CB;KRAS |
KEGG PATHWAY | hsa05223 | 0.003382408 | 0.024852551 | PIK3CB;KRAS |
KEGG PATHWAY | hsa05221 | 0.003497766 | 0.024852551 | PIK3CB;KRAS |
KEGG PATHWAY | hsa05205 | 0.003682986 | 0.024860155 | PIK3CB;TGFB2;KRAS |
KEGG PATHWAY | hsa04370 | 0.003977354 | 0.025568702 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04213 | 0.004355952 | 0.026010475 | PIK3CB;KRAS |
KEGG PATHWAY | hsa05214 | 0.004485724 | 0.026010475 | PIK3CB;KRAS |
KEGG PATHWAY | hsa05230 | 0.004750595 | 0.026010475 | PIK3CB;SERPINE1 |
KEGG PATHWAY | hsa04664 | 0.004885683 | 0.026010475 | PIK3CB;KRAS |
KEGG PATHWAY | hsa05218 | 0.005301493 | 0.026010475 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04917 | 0.005443594 | 0.026010475 | PIK3CB;KRAS |
KEGG PATHWAY | hsa03320 | 0.005443594 | 0.026010475 | OLR1;ADIPOQ |
KEGG PATHWAY | hsa04662 | 0.005587435 | 0.026010475 | PIK3CB;KRAS |
KEGG PATHWAY | hsa01521 | 0.006800173 | 0.030390563 | PIK3CB;KRAS |
KEGG PATHWAY | hsa05166 | 0.006978574 | 0.030390563 | PIK3CB;TGFB2;KRAS |
KEGG PATHWAY | hsa04060 | 0.007424504 | 0.031322125 | CCL2;TGFB2;CCR2 |
KEGG PATHWAY | hsa04012 | 0.007950284 | 0.032246156 | PIK3CB;KRAS |
KEGG PATHWAY | hsa05215 | 0.008121254 | 0.032246156 | PIK3CB;KRAS |
KEGG PATHWAY | hsa05323 | 0.008468143 | 0.032662838 | CCL2;TGFB2 |
KEGG PATHWAY | hsa01522 | 0.009548044 | 0.034763406 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04914 | 0.009733696 | 0.034763406 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04915 | 0.009920954 | 0.034763406 | PIK3CB;KRAS |
KEGG PATHWAY | hsa05146 | 0.010109813 | 0.034763406 | PIK3CB;TGFB2 |
KEGG PATHWAY | hsa05231 | 0.010300268 | 0.034763406 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04066 | 0.010685948 | 0.035185438 | PIK3CB;SERPINE1 |
KEGG PATHWAY | hsa04660 | 0.011077952 | 0.035607703 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04668 | 0.012085376 | 0.037712623 | CCL2;PIK3CB |
KEGG PATHWAY | hsa04725 | 0.012291521 | 0.037712623 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04919 | 0.013777442 | 0.039775364 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04670 | 0.013777442 | 0.039775364 | PIK3CB;CLDN1 |
KEGG PATHWAY | hsa05145 | 0.013995787 | 0.039775364 | PIK3CB;TGFB2 |
KEGG PATHWAY | hsa04722 | 0.014215636 | 0.039775364 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04071 | 0.014436984 | 0.039775364 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04152 | 0.015337266 | 0.041410618 | PIK3CB;ADIPOQ |
KEGG PATHWAY | hsa04380 | 0.016969364 | 0.044918905 | PIK3CB;TGFB2 |
KEGG PATHWAY | hsa04650 | 0.01769056 | 0.045927416 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04910 | 0.018672129 | 0.047302645 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04210 | 0.018921058 | 0.047302645 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04550 | 0.019423126 | 0.047674946 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04072 | 0.019930779 | 0.048047414 | PIK3CB;KRAS |
KEGG PATHWAY | hsa05200 | 0.021609077 | 0.05050568 | PIK3CB;TGFB2;KRAS |
KEGG PATHWAY | hsa04932 | 0.021751022 | 0.05050568 | PIK3CB;ADIPOQ |
KEGG PATHWAY | hsa04390 | 0.022551551 | 0.05050568 | TGFB2;SERPINE1 |
KEGG PATHWAY | hsa04150 | 0.022551551 | 0.05050568 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04145 | 0.022821085 | 0.05050568 | VAMP3;OLR1 |
KEGG PATHWAY | hsa04921 | 0.023637696 | 0.051469176 | PIK3CB;KRAS |
KEGG PATHWAY | hsa05164 | 0.028783631 | 0.06167921 | CCL2;PIK3CB |
KEGG PATHWAY | hsa05168 | 0.031818708 | 0.067117587 | CCL2;TAF9B |
KEGG PATHWAY | hsa04977 | 0.036402182 | 0.075604532 | LMBRD1 |
KEGG PATHWAY | hsa05169 | 0.037582935 | 0.076394178 | POLR3G;PIK3CB |
KEGG PATHWAY | hsa05203 | 0.037914147 | 0.076394178 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04015 | 0.039924992 | 0.079262851 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04810 | 0.041287714 | 0.08078031 | PIK3CB;KRAS |
KEGG PATHWAY | hsa04320 | 0.042104357 | 0.081201261 | KRAS |
KEGG PATHWAY | hsa05216 | 0.04352471 | 0.082758252 | KRAS |
KEGG PATHWAY | hsa04014 | 0.045835719 | 0.085941973 | PIK3CB;KRAS |
KEGG PATHWAY | hsa00640 | 0.047773358 | 0.0871541 | ECHDC1 |
KEGG PATHWAY | hsa03020 | 0.047773358 | 0.0871541 | POLR3G |