Ausgabe 1/2021
Inhalt (404 Artikel)
Hepatitis B virus P protein initiates glycolytic bypass in HBV-related hepatocellular carcinoma via a FOXO3/miRNA-30b-5p/MINPP1 axis
Wenbiao Chen, Jingjing Jiang, Lan Gong, Zheyue Shu, Dairong Xiang, Xujun Zhang, Kefan Bi, Hongyan Diao
CDK13 upregulation-induced formation of the positive feedback loop among circCDK13, miR-212-5p/miR-449a and E2F5 contributes to prostate carcinogenesis
Jin-Chun Qi, Zhan Yang, Tao Lin, Long Ma, Ya-Xuan Wang, Yong Zhang, Chun-Cheng Gao, Kai-Long Liu, Wei Li, An-Ning Zhao, Bei Shi, Hong Zhang, Dan-Dan Wang, Xiao-Lu Wang, Jin-Kun Wen, Chang-Bao Qu
ASC-J9® suppresses prostate cancer cell proliferation and invasion via altering the ATF3-PTK2 signaling
Hao Tian, Fu-ju Chou, Jing Tian, Yong Zhang, Bosen You, Chi-Ping Huang, Shuyuan Yeh, Yuanjie Niu, Chawnshang Chang
Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T cell exclusion
Wenli Fang, Ting Zhou, He Shi, Mengli Yao, Dian Zhang, Husun Qian, Qian Zeng, Yange Wang, Fangfang Jin, Chengsen Chai, Tingmei Chen
Choline kinase alpha impairment overcomes TRAIL resistance in ovarian cancer cells
Andrea Rizzo, Alessandro Satta, Giulia Garrone, Adalberto Cavalleri, Alessandra Napoli, Francesco Raspagliesi, Mariangela Figini, Loris De Cecco, Egidio Iorio, Antonella Tomassetti, Delia Mezzanzanica, Marina Bagnoli
Circular RNA circLMO7 acts as a microRNA-30a-3p sponge to promote gastric cancer progression via the WNT2/β-catenin pathway
Jiacheng Cao, Xing Zhang, Penghui Xu, Haixiao Wang, Sen Wang, Lu Zhang, Zheng Li, Li Xie, Guangli Sun, Yiwen Xia, Jialun Lv, Jing Yang, Zekuan Xu
Correction to: The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer
Liying Ma, Xing Bian, Wenchu Lin
Preclinical models of pancreatic ductal adenocarcinoma: challenges and opportunities in the era of precision medicine
Yiqi Yu, Gang Yang, Hua Huang, Ziyao Fu, Zhe Cao, Lianfang Zheng, Lei You, Taiping Zhang
Lnc-GAN1 expression is associated with good survival and suppresses tumor progression by sponging mir-26a-5p to activate PTEN signaling in non-small cell lung cancer
Rui-Qi Wang, Xiao-Ran Long, Ning-Ning Zhou, Dong-Ni Chen, Mei-Yin Zhang, Zhe-Sheng Wen, Lan-Jun Zhang, Fa-Zhong He, Zhi-Lin Zhou, Shi-Juan Mai, Hui-Yun Wang
Impact of the acidic environment on gene expression and functional parameters of tumors in vitro and in vivo
Mandy Rauschner, Luisa Lange, Thea Hüsing, Sarah Reime, Alexander Nolze, Marcel Maschek, Oliver Thews, Anne Riemann
Noncoding RNAs regulate alternative splicing in Cancer
Yunze Liu, Xin Liu, Changwei Lin, Xianhong Jia, Hongmei Zhu, Jun Song, Yi Zhang
Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b/β-catenin/c-Myc signaling and reprogramming glycolysis
Yu Jiang, Qiuju Han, Huajun Zhao, Jian Zhang
Hypoxia-sensitive long noncoding RNA CASC15 promotes lung tumorigenesis by regulating the SOX4/β-catenin axis
Jianyong Sun, Yanlu Xiong, Kuo Jiang, Bo Xin, Tongtong Jiang, Renji Wei, Yuankang Zou, Hong Tan, Tao Jiang, Angang Yang, Lintao Jia, Lei Wang
Thrombospondin 4/integrin α2/HSF1 axis promotes proliferation and cancer stem-like traits of gallbladder cancer by enhancing reciprocal crosstalk between cancer-associated fibroblasts and tumor cells
Yu Shi, Liankang Sun, Rui Zhang, Yuan Hu, Yinying Wu, Xuyuan Dong, Danfeng Dong, Chen Chen, Zhimin Geng, Enxiao Li, Yangwei Fan
Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer
Pietro Paolo Vitiello, Giulia Martini, Luigi Mele, Emilio Francesco Giunta, Vincenzo De Falco, Davide Ciardiello, Valentina Belli, Claudia Cardone, Nunzia Matrone, Luca Poliero, Virginia Tirino, Stefania Napolitano, Carminia Della Corte, Francesco Selvaggi, Gianpaolo Papaccio, Teresa Troiani, Floriana Morgillo, Vincenzo Desiderio, Fortunato Ciardiello, Erika Martinelli
Selective exosome exclusion of miR-375 by glioma cells promotes glioma progression by activating the CTGF-EGFR pathway
Xiangdong Xu, Yang Liu, Yan Li, Huajian Chen, Yuxuan Zhang, Jie Liu, Shaokang Deng, Yaofeng Zheng, Xinlin Sun, Jihui Wang, Taoliang Chen, Min Huang, Yiquan Ke
Correction to: microRNA-216b enhances cisplatin-induced apoptosis in osteosarcoma MG63 and SaOS-2 cells by binding to JMJD2C and regulating the HIF1α/HES1 signaling axis
Dong Yang, Tianyang Xu, Lin Fan, Kaiyuan Liu, Guodong Li
Alcoholic fatty liver disease inhibited the co-expression of Fmo5 and PPARα to activate the NF-κB signaling pathway, thereby reducing liver injury via inducing gut microbiota disturbance
Lingjian Kong, Jing Chen, Xiaoli Ji, Qian Qin, Huiyu Yang, Dan Liu, Deliang Li, Meiling Sun
The immunomodulatory effects of endocrine therapy in breast cancer
Huanhuan Huang, Jun Zhou, Hailong Chen, Jiaxin Li, Chao Zhang, Xia Jiang, Chao Ni
Cell surface GRP78 regulates BACE2 via lysosome-dependent manner to maintain mesenchymal phenotype of glioma stem cells
Zihang Chen, Huizhi Wang, Zongpu Zhang, Jianye Xu, Yanhua Qi, Hao Xue, Zijie Gao, Rongrong Zhao, Shaobo Wang, Shouji Zhang, Wei Qiu, Xing Guo, Gang Li
Exosomal ANGPTL1 attenuates colorectal cancer liver metastasis by regulating Kupffer cell secretion pattern and impeding MMP9 induced vascular leakiness
Kai Jiang, Haiyan Chen, Yimin Fang, Liubo Chen, Chenhan Zhong, Tongtong Bu, Siqi Dai, Xiang Pan, Dongliang Fu, Yucheng Qian, Jingsun Wei, Kefeng Ding
PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells
Federica Liotti, Narender Kumar, Nella Prevete, Maria Marotta, Daniela Sorriento, Caterina Ieranò, Andrea Ronchi, Federica Zito Marino, Sonia Moretti, Renato Colella, Efiso Puxeddu, Simona Paladino, Yoshihito Kano, Michael Ohh, Stefania Scala, Rosa Marina Melillo
ACTN1 supports tumor growth by inhibiting Hippo signaling in hepatocellular carcinoma
Qian Chen, Xiao-Wei Zhou, Ai-Jun Zhang, Kang He
Targeting hypoxia in the tumor microenvironment: a potential strategy to improve cancer immunotherapy
Bin Wang, Qin Zhao, Yuyu Zhang, Zijing Liu, Zhuangzhuang Zheng, Shiyu Liu, Lingbin Meng, Ying Xin, Xin Jiang
The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer
Weikun Qian, Ke Chen, Tao Qin, Ying Xiao, Jie Li, Yangyang Yue, Cancan Zhou, Jiguang Ma, Wanxing Duan, Jianjun Lei, Liang Han, Li Li, Xin Shen, Zheng Wu, Qingyong Ma, Zheng Wang
Linc-SCRG1 accelerates progression of hepatocellular carcinoma as a ceRNA of miR26a to derepress SKP2
Jun-Jie Hu, Cui Zhou, Xin Luo, Sheng-Zheng Luo, Zheng-Hong Li, Zi-Xin Xu, Ming-Yi Xu
YAP and endothelin-1 signaling: an emerging alliance in cancer
Piera Tocci, Giovanni Blandino, Anna Bagnato
Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons
Muhlis Akman, Dimas Carolina Belisario, Iris Chiara Salaroglio, Joanna Kopecka, Massimo Donadelli, Enrico De Smaele, Chiara Riganti
Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway
Xuehui Wang, Changle Ji, Jiashu Hu, Xiaochong Deng, Wenfang Zheng, Yunhe Yu, Kaiyao Hua, Xiqian Zhou, Lin Fang
A novel humanized Frizzled-7-targeting antibody enhances antitumor effects of Bevacizumab against triple-negative breast cancer via blocking Wnt/β-catenin signaling pathway
Wei Xie, Huijie Zhao, Fengxian Wang, Yiyun Wang, Yuan He, Tong Wang, Kunchi Zhang, Hao Yang, Zhaoli Zhou, Haibin Shi, Jin Wang, Gang Huang
Let-7a regulates EV secretion and mitochondrial oxidative phosphorylation by targeting SNAP23 in colorectal cancer
You Dong Liu, Xiao Peng Zhuang, Dong Lan Cai, Can Cao, Qi Sheng Gu, Xue Ni Liu, Bin Bin Zheng, Bing Jie Guan, Liang Yu, Ji Kun Li, Hui Bin Ding, Dong Wang Yan
A receptor-antibody hybrid hampering MET-driven metastatic spread
Chiara Modica, Cristina Basilico, Cristina Chiriaco, Nicla Borrelli, Paolo M. Comoglio, Elisa Vigna
Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma
Aurore Dumond, Etienne Brachet, Jérôme Durivault, Valérie Vial, Anna K. Puszko, Yves Lepelletier, Christopher Montemagno, Marina Pagnuzzi-Boncompagni, Olivier Hermine, Christiane Garbay, Nathalie Lagarde, Matthieu Montes, Luc Demange, Renaud Grépin, Gilles Pagès
Vitamin C sensitizes BRAFV600E thyroid cancer to PLX4032 via inhibiting the feedback activation of MAPK/ERK signal by PLX4032
Xi Su, Peng Li, Bin Han, Hao Jia, Qingzhuang Liang, Haichao Wang, Mengwei Gu, Jiaxuan Cai, Shaolei Li, Yaqi Zhou, Xin Yi, Wei Wei
The roles of extracellular vesicles in the development, microenvironment, anticancer drug resistance, and therapy of head and neck squamous cell carcinoma
Xueying Wang, Junnan Guo, Pingyang Yu, Lunhua Guo, Xionghui Mao, Junrong Wang, Susheng Miao, Ji Sun
Long noncoding RNA SNHG14 promotes hepatocellular carcinoma progression by regulating miR-876-5p/SSR2 axis
Zhibin Liao, Hongwei Zhang, Chen Su, Furong Liu, Yachong Liu, Jia Song, He Zhu, Yawei Fan, Xuewu Zhang, Wei Dong, Xiaoping Chen, Huifang Liang, Bixiang Zhang
Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors
Francesca Paolini, Carla Amici, Mariantonia Carosi, Claudia Bonomo, Paola Di Bonito, Aldo Venuti, Luisa Accardi
Hypoxic tumour cell-derived exosomal miR-340-5p promotes radioresistance of oesophageal squamous cell carcinoma via KLF10
Fangyu Chen, Bing Xu, Jie Li, Xi Yang, Junjie Gu, Xijuan Yao, Xinchen Sun
Cytosolic sensor STING in mucosal immunity: a master regulator of gut inflammation and carcinogenesis
Qiongyuan Hu, Quan Zhou, Xuefeng Xia, Lihua Shao, Meng Wang, Xiaofeng Lu, Song Liu, Wenxian Guan
NOX1 inhibition attenuates the development of a pro‐tumorigenic environment in experimental hepatocellular carcinoma
Astrid Vandierendonck, Helena Degroote, Bart Vanderborght, Xavier Verhelst, Anja Geerts, Lindsey Devisscher, Hans Van Vlierberghe
LncRNA CBR3-AS1 regulates of breast cancer drug sensitivity as a competing endogenous RNA through the JNK1/MEK4-mediated MAPK signal pathway
Ming Zhang, Yan Wang, Longyang Jiang, Xinyue Song, Ang Zheng, Hua Gao, Minjie Wei, Lin Zhao
Gut microbiota influence tumor development and Alter interactions with the human immune system
Yanshan Ge, Xinhui Wang, Yali Guo, Junting Yan, Aliya Abuduwaili, Kasimujiang Aximujiang, Jie Yan, Minghua Wu
Targeted eicosanoids profiling reveals a prostaglandin reprogramming in breast Cancer by microRNA-155
Sinae Kim, Eun Sung Lee, Eun ji Lee, Jae Yun Jung, Sae Byul Lee, Hee Jin Lee, Jisun Kim, Hee Jeong Kim, Jong Won Lee, Byung Ho Son, Gyungyub Gong, Sei-Hyun Ahn, Suhwan Chang
A positive feedback loop between TAZ and miR-942-3p modulates proliferation, angiogenesis, epithelial-mesenchymal transition process, glycometabolism and ROS homeostasis in human bladder cancer
Feifan Wang, Mengjing Fan, Xuejian Zhou, Yanlan Yu, Yueshu Cai, Hongshen Wu, Yan Zhang, Jiaxin Liu, Shihan Huang, Ning He, Zhenghui Hu, Guoqing Ding, Xiaodong Jin
LINC00680 enhances hepatocellular carcinoma stemness behavior and chemoresistance by sponging miR-568 to upregulate AKT3
Gege Shu, Huizhao Su, Zhiqian Wang, Shihui Lai, Yan Wang, Xiaomeng Liu, Luo Dai, Yin Bi, Wei Chen, Weiyu Huang, Ziyan Zhou, Songqing He, Hongliang Dai, Bo Tang
Correction to: Mir-20a-5p induced WTX deficiency promotes gastric cancer progressions through regulating PI3K/AKT signaling pathway
Jian Li, Danli Ye, Peng Shen, Xiaorong Liu, Peirong Zhou, Guifang Zhu, Yangwei Xu, Yun Fu, Xuanqi Li, Jingbo Sun, Jia Xu, Qingling Zhang
The miR-1185-2-3p—GOLPH3L pathway promotes glucose metabolism in breast cancer by stabilizing p53-induced SERPINE1
Youqin Xu, Wancheng Chen, Jing Liang, Xiaoqi Zeng, Kaiyuan Ji, Jianlong Zhou, Shijun Liao, Jiexian Wu, Kongyang Xing, Zilong He, Yang Yang, Qianzhen Liu, Pingyi Zhu, Yuchang Liu, Li Li, Minfeng Liu, Wenxiao Chen, Wenhua Huang
The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex
Mingyi Zhou, Zhuo Yang, Danbo Wang, Peng Chen, Yong Zhang
Distinct profile of CD34+ cells and plasma-derived extracellular vesicles from triple-negative patients with Myelofibrosis reveals potential markers of aggressive disease
Dorian Forte, Martina Barone, Cristina Morsiani, Giorgia Simonetti, Francesco Fabbri, Samantha Bruno, Erika Bandini, Daria Sollazzo, Salvatore Collura, Maria Chiara Deregibus, Giuseppe Auteri, Emanuela Ottaviani, Nicola Vianelli, Giovanni Camussi, Claudio Franceschi, Miriam Capri, Francesca Palandri, Michele Cavo, Lucia Catani
FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter
Zhuoying Lin, Wenjie Huang, Qin He, Dongxiao Li, Zhihui Wang, Yangyang Feng, Danfei Liu, Tongyue Zhang, Yijun Wang, Meng Xie, Xiaoyu Ji, Mengyu Sun, Dean Tian, Limin Xia
Alternative polyadenylation: methods, mechanism, function, and role in cancer
Yi Zhang, Lian Liu, Qiongzi Qiu, Qing Zhou, Jinwang Ding, Yan Lu, Pengyuan Liu
LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification
Pingfu Hou, Sen Meng, Minle Li, Tian Lin, Sufang Chu, Zhongwei Li, Junnian Zheng, Yuming Gu, Jin Bai
MiR-144-3p-mediated dysregulation of EIF4G2 contributes to the development of hepatocellular carcinoma through the ERK pathway
Shuangshuang Li, Jiajia Shao, Guohua Lou, Chao Wu, Yanning Liu, Min Zheng
Overexpression of NELFE contributes to gastric cancer progression via Wnt/β-catenin signaling-mediated activation of CSNK2B expression
Shijun Yu, Li Li, Hui Cai, Bin He, Yong Gao, Yandong Li
Retraction Note: LncRNA TUG1 promoted KIAA1199 expression via miR-600 to accelerate cell metastasis and epithelial-mesenchymal transition in colorectal cancer
Junfeng Sun, Jiyi Hu, Guojun Wang, Zhen Yang, Chunlin Zhao, Xiefu Zhang, Jiaxiang Wang
Actin-like protein 6A/MYC/CDK2 axis confers high proliferative activity in triple-negative breast cancer
Yunting Jian, Xinjian Huang, Lishan Fang, Meng Wang, Qinghua Liu, Hongyi Xu, Lingzhi Kong, Xiangfu Chen, Ying Ouyang, Xi Wang, Weidong Wei, Libing Song
Long non-coding RNA CCDC183-AS1 acts AS a miR-589-5p sponge to promote the progression of hepatocellular carcinoma through regulating SKP1 expression
He Zhu, Hongwei Zhang, Youliang Pei, Zhibin Liao, Furong Liu, Chen Su, Yachong Liu, Renshun Dong, Jia Song, Xuewu Zhang, Yawei Fan, Huifang Liang, Bixiang Zhang, Xiaoping Chen
TMEM52B suppression promotes cancer cell survival and invasion through modulating E-cadherin stability and EGFR activity
Yunhee Lee, Dongjoon Ko, Junghwa Yoon, Younghoon Lee, Semi Kim
USP16 regulates castration-resistant prostate cancer cell proliferation by deubiquitinating and stablizing c-Myc
Jianchao Ge, Wandong Yu, Junhong Li, Hangbin Ma, Pengyu Wang, Yinghao Zhou, Yang Wang, Jun Zhang, Guowei Shi
What is the prospect of indoleamine 2,3-dioxygenase 1 inhibition in cancer? Extrapolation from the past
Yu Yao, Heng Liang, Xin Fang, Shengnan Zhang, Zikang Xing, Lei Shi, Chunxiang Kuang, Barbara Seliger, Qing Yang
Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer
Stuart R. Pierce, Ziwei Fang, Yajie Yin, Lindsay West, Majdouline Asher, Tianran Hao, Xin Zhang, Katherine Tucker, Allison Staley, Yali Fan, Wenchuan Sun, Dominic T. Moore, Chang Xu, Yi-Hsuan Tsai, Joel Parker, Varun Vijay Prabhu, Joshua E. Allen, Douglas Lee, Chunxiao Zhou, Victoria Bae-Jump
HOXA10 mediates epithelial-mesenchymal transition to promote gastric cancer metastasis partly via modulation of TGFB2/Smad/METTL3 signaling axis
Chenlong Song, Chongzhi Zhou
High activity and low toxicity of a novel CD71-targeting nanotherapeutic named The-0504 on preclinical models of several human aggressive tumors
Elisabetta Falvo, Verena Damiani, Giamaica Conti, Federico Boschi, Katia Messana, Patrizio Giacomini, Michele Milella, Vincenzo De Laurenzi, Veronica Morea, Gianluca Sala, Giulio Fracasso, Pierpaolo Ceci
ESCO2 promotes lung adenocarcinoma progression by regulating hnRNPA1 acetylation
Hui-er Zhu, Tao Li, Shengnan Shi, De-xiong Chen, Weiping Chen, Hui Chen
ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-ĸB/CD44 pathway in urinary bladder carcinoma
Mengzhao Zhang, Lu Wang, Yangyang Yue, Lu Zhang, Tianjie Liu, Minxuan Jing, Xiao Liang, Minghai Ma, Shan Xu, Ke Wang, Xinyang Wang, Jinhai Fan
Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways
Shuting Liu, Liang Chen, Hua Chen, Kangkang Xu, Xi Peng, Mingchang Zhang
A specific tRNA half, 5’tiRNA-His-GTG, responds to hypoxia via the HIF1α/ANG axis and promotes colorectal cancer progression by regulating LATS2
En-Wei Tao, Hao-Lian Wang, Wing Yin Cheng, Qian-Qian Liu, Ying-Xuan Chen, Qin-Yan Gao
Correction to: A novel ETV6-miR-429-CRKL regulatory circuitry contributes to aggressiveness of hepatocellular carcinoma
Chunmei Guo, Chao Gao, Dongting Zhao, Jiahui Li, Jinxia Wang, Xujuan Sun, Qinlong Liu, Lihong Hao, Frederick T. Greenaway, Yuxiang Tian, Shuqing Liu, Ming-Zhong Sun
The FAM3C locus that encodes interleukin-like EMT inducer (ILEI) is frequently co-amplified in MET-amplified cancers and contributes to invasiveness
Ulrike Schmidt, Gerwin Heller, Gerald Timelthaler, Petra Heffeter, Zsolt Somodi, Norbert Schweifer, Maria Sibilia, Walter Berger, Agnes Csiszar
Down-regulation of the tumor suppressor miR-34a contributes to head and neck cancer by up-regulating the MET oncogene and modulating tumor immune evasion
Xun Wu, Yi-Shing Lisa Cheng, Mathew Matthen, Angela Yoon, Gary K. Schwartz, Shashi Bala, Alison M. Taylor, Fatemeh Momen-Heravi
HOXA10 promotion of HDAC1 underpins the development of lung adenocarcinoma through the DNMT1-KLF4 axis
Tiangang Ma, Bingdi Yan, Yanbing Hu, Qinghua Zhang
Long non-coding RNA MAPKAPK5-AS1/PLAGL2/HIF-1α signaling loop promotes hepatocellular carcinoma progression
Liang Wang, Liankang Sun, Runkun Liu, Huanye Mo, Yongshen Niu, Tianxiang Chen, Yufeng Wang, Shaoshan Han, Kangsheng Tu, Qingguang Liu
Potential therapeutic targets in the tumor microenvironment of hepatocellular carcinoma: reversing the protumor effect of tumor-associated macrophages
Jingyi Zhou, Weiyu Wang, Qi Li
Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity
Allan Relecom, Maysaloun Merhi, Varghese Inchakalody, Shahab Uddin, Darawan Rinchai, Davide Bedognetti, Said Dermime
SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma
Hongda Liu, Zheng Gong, Kangshuai Li, Qun Zhang, Zekuan Xu, Yunfei Xu
CircAGAP1 promotes tumor progression by sponging miR-15-5p in clear cell renal cell carcinoma
Qi Lv, Gangmin Wang, Yinan Zhang, Aijun Shen, Junjun Tang, Yi Sun, Chunhui Ma, Peijun Wang
Claudin-2 inhibits renal clear cell carcinoma progression by inhibiting YAP-activation
Balawant Kumar, Rizwan Ahmad, Giovanna A. Giannico, Roy Zent, Geoffrey A. Talmon, Raymond C. Harris, Peter E. Clark, Vinata Lokeshwar, Punita Dhawan, Amar B. Singh
Oncogenic lncRNA ZNF561-AS1 is essential for colorectal cancer proliferation and survival through regulation of miR-26a-3p/miR-128-5p-SRSF6 axis
Zizhen Si, Lei Yu, Haoyu Jing, Lun Wu, Xidi Wang
A preliminary study of micro-RNAs as minimally invasive biomarkers for the diagnosis of prostate cancer patients
Simona Giglio, Cosimo De Nunzio, Roberto Cirombella, Antonella Stoppacciaro, Omar Faruq, Stefano Volinia, Gustavo Baldassarre, Andrea Tubaro, Hideshi Ishii, Carlo M. Croce, Andrea Vecchione
RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent
Xin Wang, Linli Tian, Yushan Li, Jingting Wang, Bingrui Yan, Like Yang, Qiuying Li, Rui Zhao, Ming Liu, Peng Wang, Yanan Sun
Single‐cell RNA sequencing in cancer research
Yijie Zhang, Dan Wang, Miao Peng, Le Tang, Jiawei Ouyang, Fang Xiong, Can Guo, Yanyan Tang, Yujuan Zhou, Qianjin Liao, Xu Wu, Hui Wang, Jianjun Yu, Yong Li, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Yixin Tan, Wei Xiong
Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention
Esmee Koedoot, Eline van Steijn, Marjolein Vermeer, Román González-Prieto, Alfred C. O. Vertegaal, John W. M. Martens, Sylvia E. Le Dévédec, Bob van de Water
Selinexor versus doxorubicin in dedifferentiated liposarcoma PDXs: evidence of greater activity and apoptotic response dependent on p53 nuclear accumulation and survivin down‐regulation
Valentina Zuco, Sandro Pasquali, Monica Tortoreto, Silvia Brich, Stefano Percio, Gian Paolo Dagrada, Chiara Colombo, Roberta Sanfilippo, Calogero Lauricella, Mrinal Gounder, Rihan El Bezawy, Marta Barisella, Angelo Paolo Dei Tos, Paolo Giovanni Casali, Alessandro Gronchi, Silvia Stacchiotti, Nadia Zaffaroni
Correction to: Combination therapy of PKCζ and COX-2 inhibitors synergistically suppress melanoma metastasis
Ping Zhou, Jiaqi Qin, Yuan Li, Guoxia Li, Yinsong Wang, Ning Zhang, Peng Chen, Chunyu Li
CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression
Sheng Tan, Ming Zhang, Xinglong Shi, Keshuo Ding, Qiang Zhao, Qianying Guo, Hao Wang, Zhengsheng Wu, Yani Kang, Tao Zhu, Jielin Sun, Xiaodong Zhao
HMGA1-TRIP13 axis promotes stemness and epithelial mesenchymal transition of perihilar cholangiocarcinoma in a positive feedback loop dependent on c-Myc
Zhipeng Li, Jialiang Liu, Tianli Chen, Rongqi Sun, Zengli Liu, Bo Qiu, Yunfei Xu, Zongli Zhang
Cancer-associated fibroblasts promote the survival of irradiated nasopharyngeal carcinoma cells via the NF-κB pathway
Weiqiang Huang, Longshan Zhang, Mi Yang, Xixi Wu, Xiaoqing Wang, Wenqi Huang, Lu Yuan, Hua Pan, Yin Wang, Zici Wang, Yuting Wu, Jihong Huang, Huazhen Liang, Shaoqun Li, Liwei Liao, Laiyu Liu, Jian Guan
Overexpressed WDR3 induces the activation of Hippo pathway by interacting with GATA4 in pancreatic cancer
Wenjie Su, Shikai Zhu, Kai Chen, Hongji Yang, Mingwu Tian, Qiang Fu, Ganggang Shi, Shijian Feng, Dianyun Ren, Xin Jin, Chong Yang
TP53 drives abscopal effect by secretion of senescence-associated molecular signals in non-small cell lung cancer
Anna Tesei, Chiara Arienti, Gianluca Bossi, Spartaco Santi, Ilaria De Santis, Alessandro Bevilacqua, Michele Zanoni, Sara Pignatta, Michela Cortesi, Alice Zamagni, Gianluca Storci, Massimiliano Bonafè, Anna Sarnelli, Antonino Romeo, Carola Cavallo, Armando Bartolazzi, Stefania Rossi, Antonella Soriani, Lidia Strigari
METTL3-mediated m6A mRNA modification of FBXW7 suppresses lung adenocarcinoma
Yingtong Wu, Ning Chang, Yong Zhang, Xinxin Zhang, Leidi Xu, Yinggang Che, Tianyun Qiao, Bin Wu, Ying Zhou, Jun Jiang, Jie Xiong, Jian Zhang, Jian Zhang
Focal adhesion kinase inhibition synergizes with nab-paclitaxel to target pancreatic ductal adenocarcinoma
T. Y. S. Le Large, M. F. Bijlsma, B. El Hassouni, G. Mantini, T. Lagerweij, A. A. Henneman, N. Funel, B. Kok, T. V. Pham, R. de Haas, L. Morelli, J. C. Knol, S. R. Piersma, G. Kazemier, H. W. M. van Laarhoven, E. Giovannetti, C. R. Jimenez
RETRACTED ARTICLE: Downregulation of lncRNA ZNF582-AS1 due to DNA hypermethylation promotes clear cell renal cell carcinoma growth and metastasis by regulating the N(6)-methyladenosine modification of MT-RNR1
Wuping Yang, Kenan Zhang, Lei Li, Yawei Xu, Kaifang Ma, Haibiao Xie, Jingcheng Zhou, Lin Cai, Yanqing Gong, Kan Gong
FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis
Liwei Lang, Yuanping Xiong, Nestor Prieto-Dominguez, Reid Loveless, Caleb Jensen, Chloe Shay, Yong Teng
ROS-dependent HIF1α activation under forced lipid catabolism entails glycolysis and mitophagy as mediators of higher proliferation rate in cervical cancer cells
Serena Castelli, Fabio Ciccarone, Daniela Tavian, Maria Rosa Ciriolo
Insulin-like growth factor binding protein 3 promotes radiosensitivity of oral squamous cell carcinoma cells via positive feedback on NF-κB/IL-6/ROS signaling
Ssu-Han Wang, Yu-Lin Chen, Jenn-Ren Hsiao, Fang-Yu Tsai, Shih Sheng Jiang, Alan Yueh-Luen Lee, Hui-Jen Tsai, Ya-Wen Chen
PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways
Anuli C. Uzozie, Enes K. Ergin, Nina Rolf, Janice Tsui, Amanda Lorentzian, Samuel S. H. Weng, Lorenz Nierves, Theodore G. Smith, C. James Lim, Christopher A. Maxwell, Gregor S. D. Reid, Philipp F. Lange
Underlying mechanisms and drug intervention strategies for the tumour microenvironment
Haoze Li, Lihong Zhou, Jing Zhou, Qi Li, Qing Ji
Long non‐coding RNA NORAD promotes the prostate cancer cell extracellular vesicle release via microRNA-541-3p-regulated PKM2 to induce bone metastasis of prostate cancer
Chuan-yi Hu, Juan Chen, Xin-hua Qin, Pan You, Jie Ma, Jing Zhang, He Zhang, Ji-dong Xu
YAP promotes autophagy and progression of gliomas via upregulating HMGB1
Min Zhao, Yu Zhang, Yang Jiang, Kai Wang, Xiang Wang, Ding Zhou, Yan Wang, Rutong Yu, Xiuping Zhou
O-GlcNAcylation homeostasis controlled by calcium influx channels regulates multiple myeloma dissemination
Parinya Samart, Sudjit Luanpitpong, Yon Rojanasakul, Surapol Issaragrisil
LncRNA SPOCD1-AS from ovarian cancer extracellular vesicles remodels mesothelial cells to promote peritoneal metastasis via interacting with G3BP1
Conghui Wang, Jiaying Wang, Xiameng Shen, Mingyue Li, Yongfang Yue, Xiaodong Cheng, Weiguo Lu, Xinyu Wang, Xing Xie
Fibronectin as a multiregulatory molecule crucial in tumor matrisome: from structural and functional features to clinical practice in oncology
Sheila Spada, Annalisa Tocci, Francesca Di Modugno, Paola Nisticò
CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated β-catenin stabilization
Yiwen Xia, Jialun Lv, Tianlu Jiang, Bowen Li, Ying Li, Zhongyuan He, Zhe Xuan, Guangli Sun, Sen Wang, Zheng Li, Weizhi Wang, Linjun Wang, Zekuan Xu
Correction to: Forkhead box (FOX) G1 promotes hepatocellular carcinoma epithelial-Mesenchymal transition by activating Wnt signal through forming T-cell factor-4/Betacatenin/FOXG1 complex
Xingrong Zheng, Jiaxin Lin, Hewei Wu, Zhishuo Mo, Yunwen Lian, Peipei Wang, Zhaoxia Hu, Zhiliang Gao, Liang Peng, Chan Xie
Cirsiliol targets tyrosine kinase 2 to inhibit esophageal squamous cell carcinoma growth in vitro and in vivo
Xuechao Jia, Chuntian Huang, Yamei Hu, Qiong Wu, Fangfang Liu, Wenna Nie, Hanyong Chen, Xiang Li, Zigang Dong, Kangdong Liu
MZ1 co-operates with trastuzumab in HER2 positive breast cancer
María del Mar Noblejas-López, Cristina Nieto-Jiménez, Eva M. Galán-Moya, David Tebar-García, Juan Carlos Montero, Atanasio Pandiella, Miguel Burgos, Alberto Ocaña
Exosomal miR-106b-5p derived from melanoma cell promotes primary melanocytes epithelial-mesenchymal transition through targeting EphA4
Wenkang Luan, Yuting Ding, Haolan Xi, Hongru Ruan, Feng Lu, Shaojun Ma, Jinlong Wang
Correction to: Cancer-associated fibroblasts promote the survival of irradiated nasopharyngeal carcinoma cells via the NF-κB pathway
Weiqiang Huang, Longshan Zhang, Mi Yang, Xixi Wu, Xiaoqing Wang, Wenqi Huang, Lu Yuan, Hua Pan, Yin Wang, Zici Wang, Yuting Wu, Jihong Huang, Huazhen Liang, Shaoqun Li, Liwei Liao, Laiyu Liu, Jian Guan
ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling
Lian-Jing Cao, Yi-Jun Zhang, Si-Qi Dong, Xi-Zhao Li, Xia-Ting Tong, Dong Chen, Zi-Yi Wu, Xiao-Hui Zheng, Wen-Qiong Xue, Wei-Hua Jia, Jiang-Bo Zhang
Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma
Mitsuhito Hirano, Yoichi Imai, Yuta Kaito, Takahiko Murayama, Kota Sato, Tadao Ishida, Junichi Yamamoto, Takumi Ito, Muneyoshi Futami, Masaki Ri, Hiroshi Yasui, Tamami Denda, Yukihisa Tanaka, Yasunori Ota, Masanori Nojima, Yasuhiko Kamikubo, Noriko Gotoh, Shinsuke Iida, Hiroshi Handa, Arinobu Tojo
Correction to: Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1
Yuhui Zhang, Weibin Huang, Yujie Yuan, Jin Li, Jing Wu, Jie Yu, Yulong He, Zhewei Wei, Changhua Zhang
ChrXq27.3 miRNA cluster functions in cancer development
Kosuke Yoshida, Akira Yokoi, Yusuke Yamamoto, Hiroaki Kajiyama
Elafin promotes tumour metastasis and attenuates the anti-metastatic effects of erlotinib via binding to EGFR in hepatocellular carcinoma
Chenwei Wang, Yadi Liao, Wei He, Hong Zhang, Dinglan Zuo, Wenwu Liu, Zhiwen Yang, Jiliang Qiu, Yichuan Yuan, Kai Li, Yuanping Zhang, Yongjin Wang, Yunxing Shi, Yuxiong Qiu, Song Gao, Yunfei Yuan, Binkui Li
Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo
Hai Huang, Song Park, Haibo Zhang, Sijun Park, Wookbong Kwon, Enugyung Kim, Xiujuan Zhang, Soyoung Jang, Duhak Yoon, Seong-Kyoon Choi, Jun-koo Yi, Sung-hyun Kim, Zigang Dong, Mee-hyun Lee, Zaeyoung Ryoo, Myoung Ok Kim
Correction to: Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway
Gangjun Yuan, Xin Chen, Zhuowei Liu, Wensu Wei, Qinghai Shu, Hussein Abou-Hamdan, Lijuan Jiang, Xiangdong Li, Rixin Chen, Laurent Désaubry, Fangjian Zhou, Dan Xie
Patient-derived organoids and high grade serous ovarian cancer: from disease modeling to personalized medicine
Camilla Nero, Giuseppe Vizzielli, Domenica Lorusso, Eleonora Cesari, Gennaro Daniele, Matteo Loverro, Giovanni Scambia, Claudio Sette
MITF induces escape from innate immunity in melanoma
Luis Sánchez-del-Campo, Román Martí-Díaz, María F. Montenegro, Rebeca González-Guerrero, Trinidad Hernández-Caselles, Enrique Martínez-Barba, Antonio Piñero-Madrona, Juan Cabezas-Herrera, Colin R. Goding, José Neptuno Rodríguez-López
HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression
Zhengyi Cao, Yuning Cheng, Jiyin Wang, Yujuan Liu, Ruixiang Yang, Wei Jiang, Hui Li, Xiaowei Zhang
The role of the circadian clock in cancer hallmark acquisition and immune-based cancer therapeutics
Elizabeth Cash, Sandra Sephton, Cassandra Woolley, Attia M. Elbehi, Anu R. I., Bene Ekine-Afolabi, Victor C. Kok
Chemotherapy-elicited exosomal miR-378a-3p and miR-378d promote breast cancer stemness and chemoresistance via the activation of EZH2/STAT3 signaling
Qianxi Yang, Shaorong Zhao, Zhendong Shi, Lixia Cao, Jingjing Liu, Teng Pan, Dongdong Zhou, Jin Zhang
Hypoxia-dependent expression of MAP17 coordinates the Warburg effect to tumor growth in hepatocellular carcinoma
Fangyuan Dong, Rongkun Li, Jiaofeng Wang, Yan Zhang, Jianfeng Yao, Shu-Heng Jiang, Xiaona Hu, Mingxuan Feng, Zhijun Bao
Efficacy and mechanism of the combination of PARP and CDK4/6 inhibitors in the treatment of triple-negative breast cancer
Xiuzhi Zhu, Li Chen, Binhao Huang, Xiaoguang Li, Liu Yang, Xin Hu, Yizhou Jiang, Zhimin Shao, Zhonghua Wang
Novel LncRNA OXCT1-AS1 indicates poor prognosis and contributes to tumorigenesis by regulating miR-195/CDC25A axis in glioblastoma
Chen Zhong, Qian Yu, Yucong Peng, Shengjun Zhou, Zhendong Liu, Yong Deng, Leiguang Guo, Shiguang Zhao, Gao Chen
Circ-MBOAT2 knockdown represses tumor progression and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer
Xiaoxiao Zhou, Kun Liu, Jing Cui, Jiongxin Xiong, Heshui Wu, Tao Peng, Yao Guo
Dehydrodiisoeugenol inhibits colorectal cancer growth by endoplasmic reticulum stress-induced autophagic pathways
Changhong Li, Kui Zhang, Guangzhao Pan, Haoyan Ji, Chongyang Li, Xiaowen Wang, Xin Hu, Ruochen Liu, Longfei Deng, Yi Wang, Liqun Yang, Hongjuan Cui
NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer
Bing Li, Zhi-Peng Qi, Dong-Li He, Zhang-Han Chen, Jing-Yi Liu, Meng-Wai Wong, Jia-Wei Zhang, En-Pan Xu, Qiang Shi, Shi-Lun Cai, Di Sun, Li-Qing Yao, Ping-Hong Zhou, Yun-Shi Zhong
Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma
Sanghwa Kim, Minji Lee, Yeonhwa Song, Su-Yeon Lee, Inhee Choi, I-Seul Park, Jiho Kim, Jin-sun Kim, Kang mo Kim, Haeng Ran Seo
Correction to: ACTN1 supports tumor growth by inhibiting Hippo signaling in hepatocellular carcinoma
Qian Chen, Xiao-Wei Zhou, Ai-Jun Zhang, Kang He
Resolvin D1 reduces cancer growth stimulating a protective neutrophil-dependent recruitment of anti-tumor monocytes
Domenico Mattoscio, Elisa Isopi, Alessia Lamolinara, Sara Patruno, Alessandro Medda, Federica De Cecco, Susanna Chiocca, Manuela Iezzi, Mario Romano, Antonio Recchiuti
Correction to: Short hairpin RNA- mediated gene knockdown of FOXM1 inhibits the proliferation and metastasis of human colon cancer cells through reversal of epithelial-to-mesenchymal transformation
KanKan Yang, LinHua Jiang, You Hu, Jing Yu, HenFeng Chen, YiZhou Yao, XinGuo Zhu
SEMAPHORINS and their receptors: focus on the crosstalk between melanoma and hypoxia
Elisabetta Valentini, Marta Di Martile, Donatella Del Bufalo, Simona D’Aguanno
Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway
Xiaofeng Liu, Kunqi Su, Xiaoyan Sun, Yang Jiang, Lijun Wang, Chenyu Hu, Chunfeng Zhang, Min Lu, Xiaojuan Du, Baocai Xing
N-acetyl cysteine induces quiescent-like pancreatic stellate cells from an active state and attenuates cancer-stroma interactions
Haimin Feng, Taiki Moriyama, Kenoki Ohuchida, Nan Sheng, Chika Iwamoto, Koji Shindo, Kengo Shirahane, Naoki Ikenaga, Shuntaro Nagai, Kohei Nakata, Kazuhiro Mizumoto, Masafumi Nakamura
The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway
Junshuang Zhao, Yang Jiang, Haiying Zhang, Jinpeng Zhou, Lian Chen, Hao Li, Jinkun Xu, Guoqing Zhang, Zhitao Jing
Correction to: KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity
Kai Teng, Shi Wei, Chi Zhang, Jiewei Chen, Jinbin Chen, Kanghua Xiao, Jun Liu, Miaomiao Dai, Xinyuan Guan, Jingping Yun, Dan Xie
IκBα targeting promotes oxidative stress-dependent cell death
Giovanna Carrà, Giuseppe Ermondi, Chiara Riganti, Luisella Righi, Giulia Caron, Alessio Menga, Enrica Capelletto, Beatrice Maffeo, Marcello Francesco Lingua, Federica Fusella, Marco Volante, Riccardo Taulli, Angelo Guerrasio, Silvia Novello, Mara Brancaccio, Rocco Piazza, Alessandro Morotti
Correction to: Circ-ASH2L promotes tumor progression by sponging miR-34a to regulate Notch1 in pancreatic ductal adenocarcinoma
Yan Chen, Zhonghu Li, Mengyun Zhang, Bo Wang, Jiaxin Ye, Yang Zhang, Di Tang, Dandan Ma, Weidong Jin, Xiaowu Li, Shuguang Wang
Chemotherapy-induced CDA expression renders resistant non-small cell lung cancer cells sensitive to 5′-deoxy-5-fluorocytidine (5′-DFCR)
Yanyun Gao, Philipp Zens, Min Su, Camila Anna Gemperli, Haitang Yang, Haibin Deng, Zhang Yang, Duo Xu, Sean R. R. Hall, Sabina Berezowska, Patrick Dorn, Ren-Wang Peng, Ralph Alexander Schmid, Wenxiang Wang, Thomas Michael Marti
Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing
Emilie Marhuenda, Christine Fabre, Cunjie Zhang, Martà Martin-Fernandez, Thomas Iskratsch, Ali Saleh, Luc Bauchet, Julien Cambedouzou, Jean-Philippe Hugnot, Hugues Duffau, James W. Dennis, David Cornu, Norbert Bakalara
Current status of ctDNA in precision oncology for hepatocellular carcinoma
Yan Li, Yuanyuan Zheng, Liwei Wu, Jingjing Li, Jie Ji, Qiang Yu, Weiqi Dai, Jiao Feng, Jianye Wu, Chuanyong Guo
Inhibition of retinoic acid receptor α phosphorylation represses the progression of triple-negative breast cancer via transactivating miR-3074-5p to target DHRS3
Siyue Lou, Hang Gao, Huanwu Hong, Zhihui Zhu, Huajun Zhao
Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis
Xueqi Yan, Yinghong Xie, Fan Yang, Yijia Hua, Tianyu Zeng, Chunxiao Sun, Mengzhu Yang, Xiang Huang, Hao Wu, Ziyi Fu, Wei Li, Shiping Jiao, Yongmei Yin
Correction to: MicroRNA-224 sustains Wnt/β-catenin signaling and promotes aggressive phenotype of colorectal cancer
Tingting Li, Qiuhua Lai, Shuyang Wang, Juanjuan Cai, Zhiyuan Xiao, Danling Deng, Liuqing He, Hongli Jiao, Yaping Ye, Li Liang, Yanqing Ding, Wenting Liao
Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities
Esteban Zamudio-Martinez, Ana Belén Herrera-Campos, Alberto Muñoz, José Manuel Rodríguez-Vargas, F. Javier Oliver
Correction to: TRIM29 facilitates the epithelial-tomesenchymal transition and the progression of colorectal cancer via the activation of the Wnt/β-catenin signaling pathway
Juntao Sun, Tianyu Zhang, Mengmeng Cheng, Liwen Hong, Chen Zhang, Mengfan Xie, Peijun Sun, Rong Fan, Zhengting Wang, Lei Wang, Jie Zhong
N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies
Fenghua Tan, Mengyao Zhao, Fang Xiong, Yumin Wang, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Yi He, Lei Shi, Fuyan Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong, Can Guo
The emerging role of β-secretases in cancer
Francesco Farris, Vittoria Matafora, Angela Bachi
KLF5-induced BBOX1-AS1 contributes to cell malignant phenotypes in non-small cell lung cancer via sponging miR-27a-5p to up-regulate MELK and activate FAK signaling pathway
Jiang Shi, Chao Yang, Jinlu An, Dexun Hao, Cong Liu, Jumin Liu, Jing Sun, Junguang Jiang
ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer
Xiaoqing Sun, Zhenyu He, Ling Guo, Caiqin Wang, Chuyong Lin, Liping Ye, Xiaoqing Wang, Yue Li, Meisongzhu Yang, Sailan Liu, Xin Hua, Wen Wen, Chao Lin, Zhiqing Long, Wenwen Zhang, Han Li, Yunting Jian, Ziyuan Zhu, Xianqiu Wu, Huanxin Lin
ZBTB28 induces autophagy by regulation of FIP200 and Bcl-XL facilitating cervical cancer cell apoptosis
Li Li, Yijia Gong, Ke Xu, Weihong Chen, Jiuyi Xia, Zhaobo Cheng, Lili Li, Renjie Yu, Junhao Mu, Xin Le, Qin Xiang, Weiyan Peng, Junying Tang, Tingxiu Xiang
The lnc-CTSLP8 upregulates CTSL1 as a competitive endogenous RNA and promotes ovarian cancer metastasis
Xinjing Wang, Xiaoduan Li, Feikai Lin, Huizhen Sun, Yingying Lin, Ziliang Wang, Xipeng Wang
ROS and TGFβ: from pancreatic tumour growth to metastasis
Chao-Hui Chang, Siim Pauklin
Pyroptosis: a new paradigm of cell death for fighting against cancer
Yixin Tan, Quanzhu Chen, Xiaoling Li, Zhaoyang Zeng, Wei Xiong, Guiyuan Li, Xiayu Li, Jianbo Yang, Bo Xiang, Mei Yi
The immune cell landscape of metastatic uveal melanoma correlates with overall survival
Anna Tosi, Rocco Cappellesso, Angelo Paolo Dei Tos, Valentina Rossi, Camillo Aliberti, Jacopo Pigozzo, Alessio Fabozzi, Marta Sbaraglia, Stella Blandamura, Paola Del Bianco, Vanna Chiarion-Sileni, Antonio Rosato
Correction to: Genistein inhibits stemness of SKOV3 cells induced by macrophages co-cultured with ovarian cancer stem-like cells through IL-8/STAT3 axis
Yingxia Ning, Weifeng Feng, Xiaocheng Cao, Kaiqun Ren, Meifang Quan, A. Chen, Chang Xu, Yebei Qiu, Jianguo Cao, Xiang Li, Xin Luo
José Baselga M.D., Ph.D. (1959–2021) leading cancer researcher and oncologist
Moshe Elkabets, Giovanni Blandino
circPVT1 regulates medullary thyroid cancer growth and metastasis by targeting miR-455-5p to activate CXCL12/CXCR4 signaling
Xun Zheng, Shu Rui, Xiao-Fei Wang, Xiu-He Zou, Yan-Ping Gong, Zhi-Hui Li
ROC1 promotes the malignant progression of bladder cancer by regulating p-IκBα/NF-κB signaling
Qi Wu, Xiaoqing Zhou, Peng Li, Mao Ding, Shengjie You, Zhaoyu Xu, Junjie Ye, Xuedong Chen, Mingyue Tan, Jun Wang, Wei Wang, Jianxin Qiu
Hypoxia-dependent drivers of melanoma progression
Simona D’Aguanno, Fabiana Mallone, Marco Marenco, Donatella Del Bufalo, Antonietta Moramarco
EMP3 mediates glioblastoma‐associated macrophage infiltration to drive T cell exclusion
Qun Chen, Jing Jin, Xin Huang, Fan Wu, Hongguang Huang, Renya Zhan
Interferon- and STING-independent induction of type I interferon stimulated genes during fractionated irradiation
Ruben S. A. Goedegebuure, Esther A. Kleibeuker, Francesca M. Buffa, Kitty C. M. Castricum, Syed Haider, Iris A. Schulkens, Luuk ten Kroode, Jaap van den Berg, Maarten A. J. M. Jacobs, Anne-Marie van Berkel, Nicole C. T. van Grieken, Sarah Derks, Ben J. Slotman, Henk M. W. Verheul, Adrian L. Harris, Victor L. Thijssen
Activation of the clock gene TIMELESS by H3k27 acetylation promotes colorectal cancer tumorigenesis by binding to Myosin-9
Meng Cao, Yi Wang, Yijing Xiao, Dandan Zheng, Chunchun Zhi, Xin Xia, Xiaoqin Yuan
What are the applications of single-cell RNA sequencing in cancer research: a systematic review
Lvyuan Li, Fang Xiong, Yumin Wang, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Yi He, Lei Shi, Fuyan Wang, Qianjin Liao, Bo Xiang, Ming Zhou, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong, Can Guo
Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma
Chenyu Ding, Xuehan Yi, Xiangrong Chen, Zanyi Wu, Honghai You, Xiaoyong Chen, Gaoqi Zhang, Yong Sun, Xingyao Bu, Xiyue Wu, Zhangya Lin, Jianjun Gu, Yuanxiang Lin, Dezhi Kang
The potential role of the extracellular matrix in the activity of trabectedin in UPS and L-sarcoma: evidences from a patient‐derived primary culture case series in tridimensional and zebrafish models
Alessandro De Vita, Federica Recine, Giacomo Miserocchi, Federica Pieri, Chiara Spadazzi, Claudia Cocchi, Silvia Vanni, Chiara Liverani, Anna Farnedi, Francesco Fabbri, Valentina Fausti, Roberto Casadei, Francesca Brandolini, Giorgio Ercolani, Davide Cavaliere, Alberto Bongiovanni, Nada Riva, Lorena Gurrieri, Giandomenico Di Menna, Sebastiano Calpona, Silvia Angela Debonis, Laura Mercatali, Toni Ibrahim
MYLK4 promotes tumor progression through the activation of epidermal growth factor receptor signaling in osteosarcoma
Mengkai Yang, Tao Zhang, Yangfeng Zhang, Xiaojun Ma, Jing Han, Ke Zeng, Yafei Jiang, Zongyi Wang, Zhuoying Wang, Jing Xu, Yingqi Hua, Zhengdong Cai, Wei Sun
Correction to: Downregulation of lncRNA ZNF582-AS1 due to DNA hypermethylation promotes clear cell renal cell carcinoma growth and metastasis by regulating the N(6)-methyladenosine modification of MT-RNR1
Wuping Yang, Kenan Zhang, Lei Li, Yawei Xu, Kaifang Ma, Haibiao Xie, Jingcheng Zhou, Lin Cai, Yanqing Gong, Kan Gong
SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell survival via ameliorating oxidative stress
Qiao Li, Manran Liu, Yan Sun, Ting Jin, Pengpeng Zhu, Xueying Wan, Yixuan Hou, Gang Tu
Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma
Xiao Yang, Jia-shun Wu, Mao Li, Wei-long Zhang, Xiao-lei Gao, Hao-fan Wang, Xiang-hua Yu, Xin Pang, Mei Zhang, Xin-hua Liang, Ya-ling Tang
HSP90-dependent PUS7 overexpression facilitates the metastasis of colorectal cancer cells by regulating LASP1 abundance
Dan Song, Ming Guo, Shuai Xu, Xiaotian Song, Bin Bai, Zhengyan Li, Jie Chen, Yanxin An, Yongzhan Nie, Kaichun Wu, Shiqi Wang, Qingchuan Zhao
Splicing factor SRSF1 promotes breast cancer progression via oncogenic splice switching of PTPMT1
Jun-Xian Du, Yi-Hong Luo, Si-Jia Zhang, Biao Wang, Cong Chen, Gui-Qi Zhu, Ping Zhu, Cheng-Zhe Cai, Jing-Lei Wan, Jia-Liang Cai, Shi-Ping Chen, Zhi Dai, Wei Zhu
Advances in drug development for hepatocellular carcinoma: clinical trials and potential therapeutic targets
Xiang-Yuan Luo, Kong-Ming Wu, Xing-Xing He
Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment
Di Ye, Huanji Xu, Hongwei Xia, Chenliang Zhang, Qiulin Tang, Feng Bi
Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance
Guo-Hua Li, Qiang Qu, Ting-Ting Qi, Xin-Qi Teng, Hai-Hong Zhu, Jiao-Jiao Wang, Qiong Lu, Jian Qu
Deciphering the temporal heterogeneity of cancer-associated fibroblast subpopulations in breast cancer
Freja Albjerg Venning, Kamilla Westarp Zornhagen, Lena Wullkopf, Jonas Sjölund, Carmen Rodriguez-Cupello, Pontus Kjellman, Mikkel Morsing, Morteza Chalabi Hajkarim, Kyoung Jae Won, Janine Terra Erler, Chris Denis Madsen
Correction to: Linc-SCRG1 accelerates progression of hepatocellular carcinoma as a ceRNA of miR26a to derepress SKP2
Jun-Jie Hu, Cui Zhou, Xin Luo, Sheng-Zheng Luo, Zheng-Hong Li, Zi-Xin Xu, Ming-Yi Xu
RETRACTED ARTICLE: Exosomal DLX6-AS1 from hepatocellular carcinoma cells induces M2 macrophage polarization to promote migration and invasion in hepatocellular carcinoma through microRNA-15a-5p/CXCL17 axis
Lin-pei Wang, Jing Lin, Xiao-qiu Ma, Dong-yao Xu, Chun-feng Shi, Wei Wang, Xiao-jie Jiang
Patient-derived tumor models: a more suitable tool for pre-clinical studies in colorectal cancer
Giulia Rizzo, Andrea Bertotti, Simonetta Maria Leto, Stefania Vetrano
Hypoxic tumor-derived exosomal miR-31-5p promotes lung adenocarcinoma metastasis by negatively regulating SATB2-reversed EMT and activating MEK/ERK signaling
Fengqiang Yu, Mingqiang Liang, Yu Huang, Weidong Wu, Bin Zheng, Chun Chen
Cell surface Nucleolin represents a novel cellular target for neuroblastoma therapy
Chiara Brignole, Veronica Bensa, Nuno A. Fonseca, Genny Del Zotto, Silvia Bruno, Ana F. Cruz, Fabiana Malaguti, Barbara Carlini, Fabio Morandi, Enzo Calarco, Patrizia Perri, Vera Moura, Laura Emionite, Michele Cilli, Francesco De Leonardis, Annalisa Tondo, Loredana Amoroso, Massimo Conte, Alberto Garaventa, Angela R. Sementa, Maria V. Corrias, Mirco Ponzoni, Joao N. Moreira, Fabio Pastorino
Correction to: Akt/FoxM1 signaling pathway-mediated upregulation of MYBL2 promotes progression of human glioma
Xue Zhang, Qiao-Li LV, Yuan-Tao Huang, Li-Hua Zhang, Hong-Hao Zhou
Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization
Upasana Ray, Debarshi Roy, Ling Jin, Prabhu Thirusangu, Julie Staub, Yinan Xiao, Eleftheria Kalogera, Andrea E. Wahner Hendrickson, Grace D. Cullen, Krista Goergen, Ann L. Oberg, Viji Shridhar
LINC00511 drives invasive behavior in hepatocellular carcinoma by regulating exosome secretion and invadopodia formation
Xueqiang Peng, Xinyu Li, Shuo Yang, Mingyao Huang, Shibo Wei, Yingbo Ma, Yan Li, Bo Wu, Hongyuan Jin, Bowen Li, Shilei Tang, Qing Fan, Jingang Liu, Liang Yang, Hangyu Li
Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
Hao Zhang, Ziyu Dai, Wantao Wu, Zeyu Wang, Nan Zhang, Liyang Zhang, Wen-Jing Zeng, Zhixiong Liu, Quan Cheng
Preclinical models as patients’ avatars for precision medicine in colorectal cancer: past and future challenges
Erika Durinikova, Kristi Buzo, Sabrina Arena
Determinants of resistance to VEGF-TKI and immune checkpoint inhibitors in metastatic renal cell carcinoma
Revati Sharma, Elif Kadife, Mark Myers, George Kannourakis, Prashanth Prithviraj, Nuzhat Ahmed
A novel lncRNA ARST represses glioma progression by inhibiting ALDOA-mediated actin cytoskeleton integrity
Jun Sun, Dong He, Yibing Fu, Rui Zhang, Hua Guo, Zhaojuan Wang, Yanan Wang, Taihong Gao, Yanbang Wei, Yuji Guo, Qi Pang, Qian Liu
A HIF1α-GPD1 feedforward loop inhibits the progression of renal clear cell carcinoma via mitochondrial function and lipid metabolism
Ren Liu, Yuanfa Feng, Yulin Deng, Zhihao Zou, Jianheng Ye, Zhiduan Cai, Xuejin Zhu, Yingke Liang, Jianming Lu, Hui Zhang, Yong Luo, Zhaodong Han, Yangjia Zhuo, Qingling Xie, Chi Tin Hon, Yuxiang Liang, Chin-Lee Wu, Weide Zhong
A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma
Vid Mlakar, Edouard Morel, Simona Jurkovic Mlakar, Marc Ansari, Fabienne Gumy-Pause
Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
Jing Cai, Mei Yi, Yixin Tan, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong, Bo Xiang
Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer
Andreia Peixoto, Dylan Ferreira, Rita Azevedo, Rui Freitas, Elisabete Fernandes, Marta Relvas-Santos, Cristiana Gaiteiro, Janine Soares, Sofia Cotton, Beatriz Teixeira, Paula Paulo, Luís Lima, Carlos Palmeira, Gabriela Martins, Maria José Oliveira, André M. N. Silva, Lúcio Lara Santos, José Alexandre Ferreira
CD151 drives cancer progression depending on integrin α3β1 through EGFR signaling in non-small cell lung cancer
Jianjie Zhu, Tingting Cai, Jieqi Zhou, Wenwen Du, Yuanyuan Zeng, Ting Liu, Yulong Fu, Yue Li, Qian Qian, Xiuwei H. Yang, Qinglin Li, Jian-an Huang, Zeyi Liu
CircPVT1 promotes proliferation of lung squamous cell carcinoma by binding to miR-30d/e
Jie Shi, Xin Lv, Lizhong Zeng, Wei Li, Yujie Zhong, Jingyan Yuan, Shanshan Deng, Boxuan Liu, Bo Yuan, Yang Chen, Zongjuan Ming, Xia Yang, Ping Fang, Shuanying Yang, Guoan Chen
Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation
Zhihui Dou, Dapeng Zhao, Xiaohua Chen, Caipeng Xu, Xiaodong Jin, Xuetian Zhang, Yupei Wang, Xiaodong Xie, Qiang Li, Cuixia Di, Hong Zhang
TRIM37 orchestrates renal cell carcinoma progression via histone H2A ubiquitination-dependent manner
Chenkui Miao, Chao Liang, Pu Li, Bianjiang Liu, Chao Qin, Han Yuan, Yiyang Liu, Jundong Zhu, Yankang Cui, Aiming Xu, Shangqian Wang, Shifeng Su, Jie Li, Pengfei Shao, Zengjun Wang
Circulating tumor DNA tracking through driver mutations as a liquid biopsy-based biomarker for uveal melanoma
Prisca Bustamante, Thupten Tsering, Jacqueline Coblentz, Christina Mastromonaco, Mohamed Abdouh, Cristina Fonseca, Rita P. Proença, Nadya Blanchard, Claude Laure Dugé, Rafaella Atherino Schmidt Andujar, Emma Youhnovska, Miguel N. Burnier, Sonia A. Callejo, Julia V. Burnier
Interfering with Tumor Hypoxia for Radiotherapy Optimization
Irma Telarovic, Roland H. Wenger, Martin Pruschy
Integrated multi-omics analyses on patient-derived CRC organoids highlight altered molecular pathways in colorectal cancer progression involving PTEN
Marta Codrich, Emiliano Dalla, Catia Mio, Giulia Antoniali, Matilde Clarissa Malfatti, Stefania Marzinotto, Mariaelena Pierobon, Elisa Baldelli, Carla Di Loreto, Giuseppe Damante, Giovanni Terrosu, Carlo Ennio Michele Pucillo, Gianluca Tell
Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway
Xinxin Cheng, Jie Wang, Chunling Liu, Tianduo Jiang, Ningzhi Yang, Dan Liu, Huanhuan Zhao, Zhelong Xu
RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA
Meng Zhang, Senlin Zhao, Cong Tan, Yanzi Gu, Xuefeng He, Xiang Du, Dawei Li, Ping Wei
USP1-dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells
Yuning Liao, Zhenlong Shao, Yuan Liu, Xiaohong Xia, Yuanfei Deng, Cuifu Yu, Wenshuang Sun, Weiyao Kong, Xiaoyue He, Fang Liu, Zhiqiang Guo, Guoxing Chen, Daolin Tang, Huoye Gan, Jinbao Liu, Hongbiao Huang
Current approach and novel perspectives in nasopharyngeal carcinoma: the role of targeting proteasome dysregulation as a molecular landmark in nasopharyngeal cancer
Ramon Yarza, Mateo Bover, Maria Teresa Agulló-Ortuño, Lara Carmen Iglesias-Docampo
Targeting WD repeat domain 5 enhances chemosensitivity and inhibits proliferation and programmed death-ligand 1 expression in bladder cancer
Jingtong Zhang, Qianghua Zhou, Keji Xie, Liang Cheng, Shengmeng Peng, Ruihui Xie, Lixuan Liu, Yangjie Zhang, Wen Dong, Jinli Han, Ming Huang, Yuelong Chen, Tianxin Lin, Jian Huang, Xu Chen
Correction to: RETRACTED ARTICLE: Long non-coding RNA LINC00968 attenuates drug resistance of breast cancer cells through inhibiting the Wnt2/β-catenin signaling pathway by regulating WNT2
Dian-Hui Xiu, Gui-Feng Liu, Shao-Nan Yu, Long-Yun Li, Guo-Qing Zhao, Lin Liu, Xue-Feng Li
LncRNA CARMN overexpression promotes prognosis and chemosensitivity of triple negative breast cancer via acting as miR143-3p host gene and inhibiting DNA replication
Xiaonan Sheng, Huijuan Dai, Yueyao Du, Jing Peng, Rui Sha, Fan Yang, Liheng Zhou, Yanping Lin, Shuguang Xu, Yifan Wu, Wenjin Yin, Jinsong Lu
Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer
Jingjing Yang, Yulu Zhou, Shuduo Xie, Ji Wang, Zhaoqing Li, Lini Chen, Misha Mao, Cong Chen, Aihua Huang, Yongxia Chen, Xun Zhang, Noor Ul Hassan Khan, Linbo Wang, Jichun Zhou
Patient-derived cell lines and orthotopic mouse model of peritoneal carcinomatosis recapitulate molecular and phenotypic features of human gastric adenocarcinoma
Shumei Song, Yan Xu, Longfei Huo, Shuangtao Zhao, Ruiping Wang, Yuan Li, Ailing W. Scott, Melissa Pool Pizzi, Ying Wang, Yibo Fan, Kazuto Harada, Jiankang Jin, Lang Ma, Xiaodan Yao, Namita D. Shanbhag, Qiong Gan, Sinchita Roy-Chowdhuri, Brian D. Badgwell, Zhenning Wang, Linghua Wang, Jaffer A. Ajani
Correction to: Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression
Dong-liang Chen, Huai-qiang Ju, Yun-xin Lu, Le-zong Chen, Zhao-lei Zeng, Dong-sheng Zhang, Hui-yan Luo, Feng Wang, Miao-zhen Qiu, De-shen Wang, Da-zhi Xu, Zhi-wei Zhou, Helene Pelicano, Peng Huang, Dan Xie, Feng-hua Wang, Yu-hong Li, Rui-hua Xu
TRAIL promotes epithelial-to-mesenchymal transition by inducing PD-L1 expression in esophageal squamous cell carcinomas
Huanyu Zhang, Guohui Qin, Chaoqi Zhang, Huiyun Yang, Jinyan Liu, Hongwei Hu, Peng Wu, Shasha Liu, Li Yang, Xinfeng Chen, Xueke Zhao, Lidong Wang, Yi Zhang
HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML
Zheng Li, Fangce Wang, Xiaoxue Tian, Jun Long, Bin Ling, Wenjun Zhang, Jun Xu, Aibin Liang
PARP inhibitors in gastric cancer: beacon of hope
Yali Wang, Kun Zheng, Yongbiao Huang, Hua Xiong, Jinfang Su, Rui Chen, Yanmei Zou
C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer
Kosuke Sasaki, Shigetsugu Takano, Satoshi Tomizawa, Yoji Miyahara, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Mamoru Takada, Masayuki Ohtsuka
A systematic review on poly(I:C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy
Jorrit De Waele, Tias Verhezen, Sanne van der Heijden, Zwi N. Berneman, Marc Peeters, Filip Lardon, An Wouters, Evelien L. J. M. Smits
Integrin alpha-V is an important driver in pancreatic adenocarcinoma progression
Marius Kemper, Alina Schiecke, Hanna Maar, Sergey Nikulin, Andrey Poloznikov, Vladimir Galatenko, Michael Tachezy, Florian Gebauer, Tobias Lange, Kristoffer Riecken, Alexander Tonevitsky, Achim Aigner, Jakob Izbicki, Udo Schumacher, Daniel Wicklein
Identification and monitoring of mutations in circulating cell-free tumor DNA in hepatocellular carcinoma treated with lenvatinib
Yasutoshi Fujii, Atsushi Ono, C. Nelson Hayes, Hiroshi Aikata, Masami Yamauchi, Shinsuke Uchikawa, Kenichiro Kodama, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Daiki Miki, Wataru Okamoto, Tomokazu Kawaoka, Masataka Tsuge, Michio Imamura, Kazuaki Chayama
Long non-coding RNA DLEU2 drives EMT and glycolysis in endometrial cancer through HK2 by competitively binding with miR-455 and by modulating the EZH2/miR-181a pathway
Peixin Dong, Ying Xiong, Yosuke Konno, Kei Ihira, Noriko Kobayashi, Junming Yue, Hidemichi Watari
Cancer: a mirrored room between tumor bulk and tumor microenvironment
Pablo Hernández-Camarero, Elena López-Ruiz, Juan Antonio Marchal, Macarena Perán
A positive feedback loop between Periostin and TGFβ1 induces and maintains the stemness of hepatocellular carcinoma cells via AP-2α activation
Gang Chen, Yi Wang, Xin Zhao, Xiao-zai Xie, Jun-gang Zhao, Tuo Deng, Zi-yan Chen, Han-bin Chen, Yi-fan Tong, Zhen Yang, Xi-wei Ding, Peng-yi Guo, Hai-tao Yu, Li-jun Wu, Si-na Zhang, Qian-dong Zhu, Jun-jian Li, Yun-feng Shan, Fu-xiang Yu, Zheng-ping Yu, Jing-lin Xia
Correction to: Pyroptosis: a new paradigm of cell death for fighting against cancer
Yixin Tan, Quanzhu Chen, Xiaoling Li, Zhaoyang Zeng, Wei Xiong, Guiyuan Li, Xiayu Li, Jianbo Yang, Bo Xiang, Mei Yi
Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT
Qing Li, Zhi-Wei Zhou, Wei Duan, Cheng-Yuan Qian, Shu-Nan Wang, Meng-Sheng Deng, Dan Zi, Jian-Min Wang, Cheng-Yi Mao, Guanbin Song, Dong Wang, Kenneth D. Westover, Cheng-Xiong Xu
Gut microbiota-mediated immunomodulation in tumor
Xinyi Liu, Yanjie Chen, Si Zhang, Ling Dong
A 5′-tRNA halve, tiRNA-Gly promotes cell proliferation and migration via binding to RBM17 and inducing alternative splicing in papillary thyroid cancer
Litao Han, Hejing Lai, Yichen Yang, Jiaqian Hu, Zhe Li, Ben Ma, Weibo Xu, Wanlin Liu, Wenjun Wei, Duanshu Li, Yu Wang, Qiwei Zhai, Qinghai Ji, Tian Liao
Correction to: A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma
Bo Zhou, Hongxu Chen, Dong Wei, Yi Kuang, Xiaobiao Zhao, Guangyao Li, Jun Xie, Ping Chen
Nuclear Transglutaminase 2 interacts with topoisomerase II⍺ to promote DNA damage repair in lung cancer cells
Xiao Lei, Kun Cao, Yuanyuan Chen, Hui Shen, Zhe Liu, Hongran Qin, Jianming Cai, Fu Gao, Yanyong Yang
Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
Snehangshu Kundu, Muhammad Akhtar Ali, Niklas Handin, Louis P. Conway, Veronica Rendo, Per Artursson, Liqun He, Daniel Globisch, Tobias Sjöblom
Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype
Dmitry Chernyakov, Alexander Groß, Annika Fischer, Nicola Bornkessel, Christoph Schultheiss, Dennis Gerloff, Bayram Edemir
EIF4A3-induced circ_0084615 contributes to the progression of colorectal cancer via miR-599/ONECUT2 pathway
Zhipeng Jiang, Qinwen Tai, Xiaojun Xie, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang, Shuang Chen
Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth
Mariachiara Buccarelli, Quintino Giorgio D’Alessandris, Paola Matarrese, Cristiana Mollinari, Michele Signore, Andrea Cappannini, Maurizio Martini, Pierluigi D’Aliberti, Gabriele De Luca, Francesca Pedini, Alessandra Boe, Mauro Biffoni, Roberto Pallini, Lucia Ricci-Vitiani
Correction to: Current status of ctDNA in precision oncology for hepatocellular carcinoma
Yan Li, Yuanyuan Zheng, Liwei Wu, Jingjing Li, Jie Ji, Qiang Yu, Weiqi Dai, Jiao Feng, Jianye Wu, Chuanyong Guo
Immuno-genomic classification of colorectal cancer organoids reveals cancer cells with intrinsic immunogenic properties associated with patient survival
Eun Jeong Cho, Minsuh Kim, Daum Jo, Jihye Kim, Ji-Hye Oh, Hee Chul Chung, Sun-hye Lee, Deokhoon Kim, Sung-Min Chun, Jihun Kim, Hyeonjin Lee, Tae Won Kim, Chang Sik Yu, Chang Ohk Sung, Se Jin Jang
Neutrophil extracellular traps in cancer: not only catching microbes
Livia Ronchetti, Nouha Setti Boubaker, Maddalena Barba, Patrizia Vici, Aymone Gurtner, Giulia Piaggio
CK2-mediated phosphorylation of Che-1/AATF is required for its pro-proliferative activity
Valeria Catena, Tiziana Bruno, Simona Iezzi, Silvia Matteoni, Annalisa Salis, Cristina Sorino, Gianluca Damonte, Maurizio Fanciulli
Neutrophil Extracellular Traps: A New Player in Cancer Metastasis and Therapeutic Target
Dakai Yang, Jing Liu
Correction to: Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1
Yujun Tang, Yishi Lu, Yuan Chen, Lei Luo, Lei Cai, Bangjian Peng, Wenbin Huang, Hangyu Liao, Liang Zhao, Mingxin Pan
Circular RNA circ_001422 promotes the progression and metastasis of osteosarcoma via the miR-195-5p/FGF2/PI3K/Akt axis
Bingsheng Yang, Lutao Li, Ge Tong, Zhirui Zeng, Jianye Tan, Zexin Su, Zhengwei Liu, Jiezhao Lin, Wenwen Gao, Jianping Chen, Sisi Zeng, Guofeng Wu, Lin Li, Shuang Zhu, Qiuzhen Liu, Lijun Lin
Correction to: Gallbladder cancer-associated fibroblasts promote vasculogenic mimicry formation and tumor growth in gallbladder cancer via upregulating the expression of NOX4, a poor prognosis factor, through IL-6-JAK-STAT3 signal pathway
Mu-Su Pan, Hui Wang, Kamar Hasan Ansari, Xin-Ping Li, Wei Sun, Yue-Zu Fan
Circulating extracellular vesicles from individuals at high-risk of lung cancer induce pro-tumorigenic conversion of stromal cells through transfer of miR-126 and miR-320
Francesca Pontis, Luca Roz, Mavis Mensah, Miriam Segale, Massimo Moro, Giulia Bertolini, Ilaria Petraroia, Giovanni Centonze, Anna Maria Ferretti, Paola Suatoni, Ugo Pastorino, Orazio Fortunato, Gabriella Sozzi
A review of Dynamin 2 involvement in cancers highlights a promising therapeutic target
Delphine Trochet, Marc Bitoun
Optimizing cisplatin delivery to triple-negative breast cancer through novel EGFR aptamer-conjugated polymeric nanovectors
Lisa Agnello, Silvia Tortorella, Annachiara d’Argenio, Clarissa Carbone, Simona Camorani, Erica Locatelli, Luigi Auletta, Domenico Sorrentino, Monica Fedele, Antonella Zannetti, Mauro Comes Franchini, Laura Cerchia
A vision of immuno-oncology: the Siena think tank of the Italian network for tumor biotherapy (NIBIT) foundation
Michele Maio, Michael Lahn, Anna Maria Di Giacomo, Alessia Covre, Luana Calabrò, Ramy Ibrahim, Bernard Fox, Sergio Abrignani, Allavena Paola, Andrea Anichini, Andrea Ardizzoni, Aversa Gregorio, Mohammad Azab, Marc Ballas, Massimo Barberis, Nicholas L. Bayless, Bryan Bell, Andrea Bifarini, Christian Blank, Petter Brodin, Roberto Camerini, Carbone Ennio, Michele Ceccarelli, Colizzi Francesca, John Connolly, Coral Sandra, Robin Cornelissen, Alexander Eggermont, Joseph Eid, David Fajgenbaum, Elisabetta Ferretti, Soldano Ferrone, Francesca Finotello, Keith Flaherty, Fonsatti Ester, Fratta Elisabetta, Catherine Sautès Fridman, Wolf H. Fridman, Patrick Garcia, Pier Federico Gherardini, Asthika Goonewardene, Graham Hacking, Kevin Heller, Tyler W. Hulett, Imperiale Michael, Daniel Jacobson, Martin Janek, Stefanie Joho, Harold Keer, Samir Kleif, Nikesh Kotecha, Mark Kotter, Nevan Krogan, Antonio Lanzavecchia, Franco Locatelli, Pier-Luigi Lollini, Alberto Mantovani, Alessia Melacarne, Giovanni Melillo, Michael Menden, Daniela Minerva, Lorenzo Moretta, Fouad Namouni, Pier Giorgio Natali, Andrea Necchi, Paola Nisticò, Paga Cosimo, Palmieri Giuseppe, Drew Pardoll, Luis Paz-Ares, Kimberly Plessala, Solange Peters, Robert M. Prins, Olivier Provendier, Rino Rappuoli, Maria Rescigno, Dominik Ruettinger, Barbara Seliger, Alessandro Sette, Sigalotti Luca, Marko Spasic, Giampaolo Tortora, Zlatko Trajanoski, Patrizia Tunici, Chiara Vitale, Jon Wigginton, Mahesh Yadav, Haochen Yu
Statins: a repurposed drug to fight cancer
Wen Jiang, Jin-Wei Hu, Xu-Ran He, Wei-Lin Jin, Xin-Yang He
An immunotherapeutic approach to decipher the role of long non-coding RNAs in cancer progression, resistance and epigenetic regulation of immune cells
Krishnapriya M. Varier, Hemavathi Dhandapani, Wuling Liu, Jialei Song, Chunlin Wang, Anling Hu, Yaacov Ben-David, Xiangchun Shen, Yanmei Li, Babu Gajendran
Cellular senescence or stemness: hypoxia flips the coin
Daniel Otero-Albiol, Amancio Carnero
Molecular features and vulnerabilities of recurrent chordomas
Carolin Seeling, André Lechel, Michael Svinarenko, Peter Möller, Thomas F. E. Barth, Kevin Mellert
Ribosomal L1 domain-containing protein 1 coordinates with HDM2 to negatively regulate p53 in human colorectal Cancer cells
Li Ding, Zhiping Zhang, Chenhong Zhao, Lei Chen, Zhiqiang Chen, Jie Zhang, Yaxian Liu, Yesen Nie, Yanzhi He, Kai Liao, Xinyue Zhang
Establishment and characterization of patient-derived head and neck cancer models from surgical specimens and endoscopic biopsies
Daniel Strüder, Theresa Momper, Nina Irmscher, Mareike Krause, Jan Liese, Sebastian Schraven, Annette Zimpfer, Sarah Zonnur, Ann-Sophie Burmeister, Björn Schneider, Bernhard Frerich, Robert Mlynski, Christina Große-Thie, Christian Junghanss, Claudia Maletzki
Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis
Manuel Pedro Jimenez-García, Antonio Lucena-Cacace, Daniel Otero-Albiol, Amancio Carnero
Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting
Beatrice Parma, Vignesh Ramesh, Paradesi Naidu Gollavilli, Aarif Siddiqui, Luisa Pinna, Annemarie Schwab, Sabine Marschall, Shuman Zhang, Christian Pilarsky, Francesca Napoli, Marco Volante, Sophia Urbanczyk, Dirk Mielenz, Henrik Daa Schrøder, Marc Stemmler, Heiko Wurdak, Paolo Ceppi
Correction to: Knockdown of FOXO3a induces epithelial-mesenchymal transition and promotes metastasis of pancreatic ductal adenocarcinoma by activation of the β-catenin/TCF4 pathway through SPRY2
Jun Li, Rumeng Yang, Yuting Dong, Manyao Chen, Yu Wang, Guoping Wang
Cellular based immunotherapy for primary liver cancer
Yuanyuan Zheng, Yan Li, Jiao Feng, Jingjing Li, Jie Ji, Liwei Wu, Qiang Yu, Weiqi Dai, Jianye Wu, Yingqun Zhou, Chuanyong Guo
Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target
Silpa Gampala, Fenil Shah, Xiaoyu Lu, Hye-ran Moon, Olivia Babb, Nikkitha Umesh Ganesh, George Sandusky, Emily Hulsey, Lee Armstrong, Amber L. Mosely, Bumsoo Han, Mircea Ivan, Jing-Ruey Joanna Yeh, Mark R. Kelley, Chi Zhang, Melissa L. Fishel
Retraction Note: Dual loading miR-218 mimics and Temozolomide using AuCOOH@FA-CS drug delivery system: promising targeted antitumor drug delivery system with sequential release functions
Li Fan, Qian Yang, Jiali Tan, Youbei Qiao, Qiaofeng Wang, Jingya He, Hong Wu, Yongsheng Zhang
Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target
Xuan Xu, Yiming Lei, Lingjun Chen, Haoxiong Zhou, Huiling Liu, Jie Jiang, Yidong Yang, Bin Wu
Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma
Fengzhi Li, Ieman A. M. Aljahdali, Renyuan Zhang, Kent L. Nastiuk, John J. Krolewski, Xiang Ling
XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor verdinexor
Lijia Pan, Cheng Cheng, Peiwen Duan, Kai Chen, Yeming Wu, Zhixiang Wu
Altered proTGFα/cleaved TGFα ratios offer new therapeutic strategies in renal carcinoma
Sara García-Alonso, Inés Romero-Pérez, Lucía Gandullo-Sánchez, Luis Chinchilla, Alberto Ocaña, Juan Carlos Montero, Atanasio Pandiella
Identification of novel COX-2 / CYP19A1 axis involved in the mesothelioma pathogenesis opens new therapeutic opportunities
Barbara Nuvoli, Barbara Antoniani, Roberta Libener, Antonio Maconi, Andrea Sacconi, Mariantonia Carosi, Rossella Galati
Complement inhibitor CSMD1 modulates epidermal growth factor receptor oncogenic signaling and sensitizes breast cancer cells to chemotherapy
Chrysostomi Gialeli, Emre Can Tuysuz, Johan Staaf, Safia Guleed, Veronika Paciorek, Matthias Mörgelin, Konstantinos S. Papadakos, Anna M. Blom
SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression
Fangce Wang, Zheng Li, Jie Zhou, Guangming Wang, Wenjun Zhang, Jun Xu, Aibin Liang
RETRACTED ARTICLE: Ethaselen synergizes with oxaliplatin in tumor growth inhibition by inducing ROS production and inhibiting TrxR1 activity in gastric cancer
Haiyong Zhang, Jing Wu, Jinqiu Yuan, Huafu Li, Yawei Zhang, Wang Wu, Wei Chen, Chunming Wang, Sijun Meng, Songyao Chen, Mingyu Huo, Yulong He, Changhua Zhang
FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma
Taoyue Yang, Peng Shen, Qun Chen, Pengfei Wu, Hao Yuan, Wanli Ge, Lingdong Meng, Xumin Huang, Yuzhe Fu, Yihan Zhang, Weikang Hu, Yi Miao, Zipeng Lu, Kuirong Jiang
Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish
Juanjuan Luo, Chunjiao Lu, Meilan Feng, Lu Dai, Maya Wang, Yang Qiu, Huilu Zheng, Yao Liu, Li Li, Bo Tang, Chuan Xu, Yajun Wang, Xiaojun Yang
Synthetic lethality and synergetic effect: the effective strategies for therapy of IDH-mutated cancers
Kun Yao, Hua Liu, Jiajun Yin, Jianmin Yuan, Hong Tao
Pyroptosis at the forefront of anticancer immunity
Reid Loveless, Ryan Bloomquist, Yong Teng
SCD1, autophagy and cancer: implications for therapy
Francesca Ascenzi, Claudia De Vitis, Marcello Maugeri-Saccà, Christian Napoli, Gennaro Ciliberto, Rita Mancini
Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer
Chunfeng Xie, Xu Zhou, Chunhua Liang, Xiaoting Li, Miaomiao Ge, Yue Chen, Juan Yin, Jianyun Zhu, Caiyun Zhong
Poliovirus receptor (PVR)-like protein cosignaling network: new opportunities for cancer immunotherapy
Baokang Wu, Chongli Zhong, Qi Lang, Zhiyun Liang, Yizhou Zhang, Xin Zhao, Yang Yu, Heming Zhang, Feng Xu, Yu Tian
The component of the m6A writer complex VIRMA is implicated in aggressive tumor phenotype, DNA damage response and cisplatin resistance in germ cell tumors
Vera Miranda-Gonçalves, João Lobo, Catarina Guimarães-Teixeira, Daniela Barros-Silva, Rita Guimarães, Mariana Cantante, Isaac Braga, Joaquina Maurício, Christoph Oing, Friedemann Honecker, Daniel Nettersheim, Leendert H. J. Looijenga, Rui Henrique, Carmen Jerónimo
CRISPR/Cas9 revitalizes adoptive T-cell therapy for cancer immunotherapy
Sasan Ghaffari, Nastaran Khalili, Nima Rezaei
MEN1 silencing aggravates tumorigenic potential of AR-independent prostate cancer cells through nuclear translocation and activation of JunD and β-catenin
Yakun Luo, Virginie Vlaeminck-Guillem, Silvère Baron, Sarah Dallel, Chang Xian Zhang, Muriel Le Romancer
The Anterior GRadient (AGR) family proteins in epithelial ovarian cancer
Delphine Fessart, Jacques Robert, Cecile Hartog, Eric Chevet, Frederic Delom, Guillaume Babin
Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK
Chaofan Peng, Yuqian Tan, Peng Yang, Kangpeng Jin, Chuan Zhang, Wen Peng, Lu Wang, Jiahui Zhou, Ranran Chen, Tuo Wang, Chi Jin, Jiangzhou Ji, Yifei Feng, Junwei Tang, Yueming Sun
Cyclin G2 reverses immunosuppressive tumor microenvironment and potentiates PD-1 blockade in glioma
Sen Li, Chenyang Zhao, Jinlan Gao, Xinbin Zhuang, Shuang Liu, Xuesha Xing, Qi Liu, Chen Chen, Shusen Wang, Yang Luo
SHOX2 cooperates with STAT3 to promote breast cancer metastasis through the transcriptional activation of WASF3
Yong Teng, Reid Loveless, Elayne M Benson, Li Sun, Austin Y Shull, Chloe Shay
CIRP promotes the progression of non-small cell lung cancer through activation of Wnt/β-catenin signaling via CTNNB1
Yi Liao, Jianguo Feng, Weichao Sun, Chao Wu, Jingyao Li, Tao Jing, Yuteng Liang, Yonghui Qian, Wenlan Liu, Haidong Wang
Chemoresistance is mediated by ovarian cancer leader cells in vitro
Nazanin Karimnia, Amy L. Wilson, Emma Green, Amelia Matthews, Thomas W. Jobling, Magdalena Plebanski, Maree Bilandzic, Andrew N. Stephens
Retraction Note: TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways
Run-Wei Yang, Ying-Yue Zeng, Wen-Ting Wei, Yan-Mei Cui, Hui-Ying Sun, Yue-Long Cai, Xin-Xin Nian, Yun-Teng Hu, Yu-Ping Quan, Sheng-Lu Jiang, Meng Wang, Ya-Li Zhao, Jun-Feng Qiu, Ming-Xuan Li, Jia-Huan Zhang, Mei-Rong He, Li Liang, Yan-Qing Ding, Wen-Ting Liao
The HIF1α-PDGFD-PDGFRα axis controls glioblastoma growth at normoxia/mild-hypoxia and confers sensitivity to targeted therapy by echinomycin
Gong Peng, Yin Wang, Pengfei Ge, Christopher Bailey, Peng Zhang, Di Zhang, Zhaoli Meng, Chong Qi, Qian Chen, Jingtao Chen, Junqi Niu, Pan Zheng, Yang Liu, Yan Liu
Combinational blockade of MET and PD-L1 improves pancreatic cancer immunotherapeutic efficacy
Enliang Li, Xing Huang, Gang Zhang, Tingbo Liang
Sulfarotene, a synthetic retinoid, overcomes stemness and sorafenib resistance of hepatocellular carcinoma via suppressing SOS2-RAS pathway
Feng Qi, Wenxing Qin, Yao Zhang, Yongde Luo, Bing Niu, Quanlin An, Biwei Yang, Keqing Shi, Zhijie Yu, Junwei Chen, Xin Cao, Jinglin Xia
The role of dosimetry and biological effects in metastatic castration–resistant prostate cancer (mCRPC) patients treated with 223Ra: first in human study
Rosa Sciuto, Sandra Rea, Sara Ungania, Antonella Testa, Valentina Dini, Maria Antonella Tabocchini, Clarice Patrono, Antonella Soriani, Valentina Palma, Raffaella Marconi, Lidia Strigari
Downregulated CLIP3 induces radioresistance by enhancing stemness and glycolytic flux in glioblastoma
Hyunkoo Kang, Sungmin Lee, Kyeongmin Kim, Jaewan Jeon, Seok-Gu Kang, HyeSook Youn, Hae Yu Kim, BuHyun Youn
Neuromedin U induces an invasive phenotype in CRC cells expressing the NMUR2 receptor
Patrycja Przygodzka, Ewelina Sochacka, Kamila Soboska, Marcin Pacholczyk, Izabela Papiewska-Pająk, Tomasz Przygodzki, Przemysław Płociński, Steven Ballet, An De Prins, Joanna Boncela
ALKBH5-HOXA10 loop-mediated JAK2 m6A demethylation and cisplatin resistance in epithelial ovarian cancer
Sipei Nie, Lin Zhang, Jinhui Liu, Yicong Wan, Yi Jiang, Jing Yang, Rui Sun, Xiaolling Ma, Guodong Sun, Huangyang Meng, Mengting Xu, Wenjun Cheng
The CD112R/CD112 axis: a breakthrough in cancer immunotherapy
Taofei Zeng, Yuqing Cao, Tianqiang Jin, Yu Tian, Chaoliu Dai, Feng Xu
PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models
Lavinia Morosi, Marina Meroni, Paolo Ubezio, Ilaria Fuso Nerini, Lucia Minoli, Luca Porcu, Nicolò Panini, Marika Colombo, Barbara Blouw, David W. Kang, Enrico Davoli, Massimo Zucchetti, Maurizio D’Incalci, Roberta Frapolli
RETRACTED ARTICLE: Long non-coding RNA SLC2A1-AS1 induced by GLI3 promotes aerobic glycolysis and progression in esophageal squamous cell carcinoma by sponging miR-378a-3p to enhance Glut1 expression
Hongtao Liu, Qing Zhang, Yinsen Song, Yibin Hao, Yunxia Cui, Xin Zhang, Xueying Zhang, Yue Qin, Guangzhao Zhu, Feng Wang, Jinghan Dang, Shanshan Ma, Yanting Zhang, Wenna Guo, Shenglei Li, Fangxia Guan, Tianli Fan
Regorafenib enhances anti-PD1 immunotherapy efficacy in murine colorectal cancers and their combination prevents tumor regrowth
Dennis Doleschel, Sabine Hoff, Susanne Koletnik, Anne Rix, Dieter Zopf, Fabian Kiessling, Wiltrud Lederle
The non-canonical mechanism of ER stress-mediated progression of prostate cancer
Artem N. Pachikov, Ryan R. Gough, Caroline E. Christy, Mary E. Morris, Carol A. Casey, Chad A. LaGrange, Ganapati Bhat, Anatoly V. Kubyshkin, Iryna I. Fomochkina, Evgeniya Y. Zyablitskaya, Tatiana P. Makalish, Elena P. Golubinskaya, Kateryna A. Davydenko, Sergey N. Eremenko, Jean-Jack M. Riethoven, Amith S. Maroli, Thomas S. Payne, Robert Powers, Alexander Y. Lushnikov, Amanda J. Macke, Armen Petrosyan
circHMGCS1–016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma
Ya-Ping Xu, Ze-Ning Dong, Si-Wei Wang, Yi-Min Zheng, Chi Zhang, Ying-Qun Zhou, Yu-Jie Zhao, Yan Zhao, Feng Wang, Rui Peng, Mao-Chun Tang, Dou-sheng Bai, Xiao-Yong Huang, Chuan-Yong Guo
ZNF507 affects TGF-β signaling via TGFBR1 and MAP3K8 activation in the progression of prostate cancer to an aggressive state
Wookbong Kwon, Seong-Kyoon Choi, Daehwan Kim, Hyeon-Gyeom Kim, Jin-Kyu Park, Jee Eun Han, Gil-Jae Cho, Sungho Yun, Wookyung Yu, Se-Hyeon Han, Yun-Sok Ha, Jun Nyung Lee, Tae Gyun Kwon, Dong-Hyung Cho, Jun-Koo Yi, Myoung Ok Kim, Zae Young Ryoo, Song Park
TAGLN mediated stiffness-regulated ovarian cancer progression via RhoA/ROCK pathway
Xiao Wei, Hua Lou, Dongchen Zhou, Yijuan Jia, Huayi Li, Quanfu Huang, Jingjing Ma, Zongyuan Yang, Chaoyang Sun, Yunchong Meng, Sen Xu, Xin Yang, Xiaoting Li, Teng Ji, Zhongzhen Guo, Qinglei Gao
A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene
Gregory R. Moe, Lindsay M. Steirer, Joshua A. Lee, Adarsha Shivakumar, Alejandro D. Bolanos
RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma
Yuanbo Cui, Chunyan Zhang, Shanshan Ma, Zhe Li, Wenjie Wang, Ya Li, Yingchao Ma, Jiarui Fang, Yaping Wang, Wei Cao, Fangxia Guan
Activin-A impedes the establishment of CD4+ T cell exhaustion and enhances anti-tumor immunity in the lung
Ioannis Morianos, Aikaterini Tsitsopoulou, Konstantinos Potaris, Dimitrios Valakos, Ourania Fari, Giannis Vatsellas, Clementine Bostantzoglou, Andreas Photiades, Mina Gaga, Georgina Xanthou, Maria Semitekolou
Correction to: Pyroptosis: a new paradigm of cell death for fighting against cancer
Yixin Tan, Quanzhu Chen, Xiaoling Li, Zhaoyang Zeng, Wei Xiong, Guiyuan Li, Xiayu Li, Jianbo Yang, Bo Xiang, Mei Yi
Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer
Chaoqun Liu, Zhihua Pan, Qian Chen, Zetao Chen, Weiwei Liu, Ling Wu, Muhong Jiang, Wandie Lin, Yujie Zhang, Weihao Lin, Rui Zhou, Liang Zhao
Correction to: Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
Jing Cai, Mei Yi, Yixin Tan, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong, Bo Xiang
RETRACTED ARTICLE: LNCAROD enhances hepatocellular carcinoma malignancy by activating glycolysis through induction of pyruvate kinase isoform PKM2
Guizhi Jia, Yan Wang, Chengjie Lin, Shihui Lai, Hongliang Dai, Zhiqian Wang, Luo Dai, Huizhao Su, Yanjie Song, Naiwen Zhang, Yukuan Feng, Bo Tang
Embedding similarities between embryos and circulating tumor cells: fundamentals of abortifacients used for cancer metastasis chemoprevention
Jie Wang, Xiaobo Yu, Huayi Peng, Yusheng Lu, Shuhui Li, Qing Shi, Jian Liu, Haiyan Dong, Vladimir Katanaev, Lee Jia
MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-κB signaling
Yang Wang, Jing Zhang, Yang-Jia Li, Nan-Nan Yu, Wan-Ting Liu, Jun-Ze Liang, Wen Wen Xu, Zheng-Hua Sun, Bin Li, Qing-Yu He
Chemotherapy-triggered changes in stromal compartment drive tumor invasiveness and progression of breast cancer
Jana Plava, Monika Burikova, Marina Cihova, Lenka Trnkova, Bozena Smolkova, Pavel Babal, Lucia Krivosikova, Pavol Janega, Lucia Rojikova, Slavka Drahosova, Martin Bohac, Lubos Danisovic, Lucia Kucerova, Svetlana Miklikova
Dendrimer-modified gold nanorods as a platform for combinational gene therapy and photothermal therapy of tumors
Lili Ye, Yaoming Chen, Jizong Mao, Xiaotian Lei, Qian Yang, Chunhui Cui
Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC
Chengmei Huang, Ruizhang Ou, Xiaoning Chen, Yaxin Zhang, Jiexi Li, Yihao Liang, Xiaohui Zhu, Lei Liu, Mingzhou Li, Dagui Lin, Junfeng Qiu, Guanglong Liu, Lingjie Zhang, Yuanyuan Wu, Huiyi Tang, Yanmin Liu, Li Liang, Yanqing Ding, Wenting Liao
Current status of research on exosomes in general, and for the diagnosis and treatment of kidney cancer in particular
Weipu Mao, Keyi Wang, Zonglin Wu, Bin Xu, Ming Chen
Radiation induces NORAD expression to promote ESCC radiotherapy resistance via EEPD1/ATR/Chk1 signalling and by inhibiting pri-miR-199a1 processing and the exosomal transfer of miR-199a-5p
Yuchen Sun, Jizhao Wang, Yuan Ma, Jing Li, Xuanzi Sun, Xu Zhao, Xiaobo Shi, Yunfeng Hu, Fengyi Qu, Xiaozhi Zhang
Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer
Shangwei Zhong, Ji-Hak Jeong, Changhao Huang, Xueyan Chen, Shohreh Iravani Dickinson, Jasreman Dhillon, Li Yang, Jun-Li Luo
PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance
Chenchen Feng, Yuqing Li, Kunping Li, Yinfeng Lyu, Wenhui Zhu, Haowen Jiang, Hui Wen
Retraction Note: MicroRNA-506 inhibits tumor growth and metastasis in nasopharyngeal carcinoma through the inactivation of the Wnt/β-catenin signaling pathway by downregulating LHX2
Tian-Song Liang, Ying-Juan Zheng, Juan Wang, Jing-Yi Zhao, Dao-Ke Yang, Zhang-Suo Liu
Retraction Note: Interplay between cancer cells and M2 macrophages is necessary for miR-550a-3-5p down-regulation-mediated HPV-positive OSCC progression
Ming-xin Cao, Wei-long Zhang, Xiang-hua Yu, Jia-shun Wu, Xin-wei Qiao, Mei-chang Huang, Ke Wang, Jing-biao Wu, Ya-Jie Tang, Jian Jiang, Xin-hua Liang, Ya-ling Tang
Pharmacology-based ranking of anti-cancer drugs to guide clinical development of cancer immunotherapy combinations
Vincent Lemaire, Colby S. Shemesh, Anand Rotte
Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3
Yipei Jing, Xueke Jiang, Li Lei, Meixi Peng, Jun Ren, Qiaoling Xiao, Yao Tao, Yonghong Tao, Junpeng Huang, Lu Wang, Yuting Tang, Zailin Yang, Zesong Yang, Ling Zhang
Modelling hypersensitivity to trastuzumab defines biomarkers of response in HER2 positive breast cancer
Laura Díaz-Gil, Fara Brasó-Maristany, Claudriana Locatelli, Ariana Centa, Balász Győrffy, Alberto Ocaña, Aleix Prat, Atanasio Pandiella
Alloantigen-activated (AAA) CD4+ T cells reinvigorate host endogenous T cell immunity to eliminate pre-established tumors in mice
Kazuhiro Mochizuki, Shogo Kobayashi, Nobuhisa Takahashi, Kotaro Sugimoto, Hideki Sano, Yoshihiro Ohara, Shin Mineishi, Yi Zhang, Atsushi Kikuta
Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells
Chengguo Li, Qian Shen, Peng Zhang, Tao Wang, Weizhen Liu, Ruidong Li, Xianxiong Ma, Xiangyu Zeng, Yuping Yin, Kaixiong Tao
Positive feedback between lncRNA FLVCR1-AS1 and KLF10 may inhibit pancreatic cancer progression via the PTEN/AKT pathway
Jiewei Lin, Shuyu Zhai, Siyi Zou, Zhiwei Xu, Jun Zhang, Lingxi Jiang, Xiaxing Deng, Hao Chen, Chenghong Peng, Jiaqiang Zhang, Baiyong Shen
Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells
Tamara Rothenburger, Dominique Thomas, Yannick Schreiber, Paul R. Wratil, Tamara Pflantz, Kirsten Knecht, Katie Digianantonio, Joshua Temple, Constanze Schneider, Hanna-Mari Baldauf, Katie-May McLaughlin, Florian Rothweiler, Berna Bilen, Samira Farmand, Denisa Bojkova, Rui Costa, Nerea Ferreirós, Gerd Geisslinger, Thomas Oellerich, Yong Xiong, Oliver T. Keppler, Mark N. Wass, Martin Michaelis, Jindrich Cinatl Jr
An SETD1A/Wnt/β-catenin feedback loop promotes NSCLC development
Rui Wang, Jian Liu, Kai Li, Ganghua Yang, Sisi Chen, Jie Wu, Xinming Xie, Hong Ren, Yamei Pang
L1CAM promotes ovarian cancer stemness and tumor initiation via FGFR1/SRC/STAT3 signaling
Marco Giordano, Alessandra Decio, Chiara Battistini, Micol Baronio, Fabrizio Bianchi, Alessandra Villa, Giovanni Bertalot, Stefano Freddi, Michela Lupia, Maria Giovanna Jodice, Paolo Ubezio, Nicoletta Colombo, Raffaella Giavazzi, Ugo Cavallaro
VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody
Laura Micheli, Carmen Parisio, Elena Lucarini, Alessia Vona, Alessandra Toti, Alessandra Pacini, Tommaso Mello, Serena Boccella, Flavia Ricciardi, Sabatino Maione, Grazia Graziani, Pedro Miguel Lacal, Paola Failli, Carla Ghelardini, Lorenzo Di Cesare Mannelli
Restoration of the immune function as a complementary strategy to treat Chronic Lymphocytic Leukemia effectively
Carol Moreno, Cecilia Muñoz, María José Terol, José-Ángel Hernández-Rivas, Miguel Villanueva
Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis
Oxana Schmidt, Nadja Nehls, Carolin Prexler, Kristina von Heyking, Tanja Groll, Katharina Pardon, Heathcliff D. Garcia, Tim Hensel, Dennis Gürgen, Anton G. Henssen, Angelika Eggert, Katja Steiger, Stefan Burdach, Günther H. S. Richter
Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models
Camilla Coulson-Gilmer, Robert D. Morgan, Louisa Nelson, Bethany M. Barnes, Anthony Tighe, René Wardenaar, Diana C. J. Spierings, Helene Schlecht, George J. Burghel, Floris Foijer, Sudha Desai, Joanne C. McGrail, Stephen S. Taylor
The novel circSLC6A6/miR-1265/C2CD4A axis promotes colorectal cancer growth by suppressing p53 signaling pathway
Zeyin Rong, Zai Luo, Zhongmao Fu, Pengshan Zhang, Tengfei Li, Jianming Zhang, Zhonglin Zhu, Zhilong Yu, Qi Li, Zhengjun Qiu, Chen Huang
M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way
Kai Li, Zi-Yang Peng, Shan Gao, Qing-Shi Wang, Rui Wang, Xiang Li, Guo-Dong Xiao, Jing Zhang, Hong Ren, Shou-Ching Tang, Xin Sun
Serological assessment of collagen fragments and tumor fibrosis may guide immune checkpoint inhibitor therapy
Christina Jensen, Neel I. Nissen, Claus S. Von Arenstorff, Morten A. Karsdal, Nicholas Willumsen
The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?
Jiayao Ma, Lingjuan Huang, Die Hu, Shan Zeng, Ying Han, Hong Shen
Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies
Jing Zhou, Qing Ji, Qi Li
Correction to: Long non-coding RNA SLC2A1-AS1 induced by GLI3 promotes aerobic glycolysis and progression in esophageal squamous cell carcinoma by sponging miR-378a-3p to enhance Glut1 expression
Hongtao Liu, Qing Zhang, Yinsen Song, Yibin Hao, Yunxia Cui, Xin Zhang, Xueying Zhang, Yue Qin, Guangzhao Zhu, Feng Wang, Jinghan Dang, Shanshan Ma, Yanting Zhang, Wenna Guo, Shenglei Li, Fangxia Guan, Tianli Fan
CircGSK3B promotes RORA expression and suppresses gastric cancer progression through the prevention of EZH2 trans-inhibition
Xianxiong Ma, Hengyu Chen, Lei Li, Feng Yang, Chuanqing Wu, Kaixiong Tao
Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development
Yang Yang, Bing Zhao, Xuejiao Gao, Jinbing Sun, Juan Ye, Jun Li, Peng Cao
Correction to: Embedding similarities between embryos and circulating tumor cells: fundamentals of abortifacients used for cancer metastasis chemoprevention
Jie Wang, Xiaobo Yu, Huayi Peng, Yusheng Lu, Shuhui Li, Qing Shi, Jian Liu, Haiyan Dong, Vladimir Katanaev, Lee Jia
Ex vivo expanded allogeneic natural killer cells have potent cytolytic activity against cancer cells through different receptor-ligand interactions
Daun Jung, Young Seok Baek, In Jee Lee, Ki Yeon Kim, Heejoo Jang, Sohyun Hwang, Jieun Jung, Yong-wha Moon, Kyung-Soon Park, Yong-Soo Choi, Hee Jung An
Correction to: Gut microbiota influence tumor development and Alter interactions with the human immune system
Yanshan Ge, Xinhui Wang, Yali Guo, Junting Yan, Aliya Abuduwaili, Kasimujiang Aximujiang, Jie Yan, Minghua Wu
Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma
Raghupathy Vengoji, Pranita Atri, Muzafar A. Macha, Parthasarathy Seshacharyulu, Naveenkumar Perumal, Kavita Mallya, Yutong Liu, Lynette M. Smith, Satyanarayana Rachagani, Sidharth Mahapatra, Moorthy P. Ponnusamy, Maneesh Jain, Surinder K. Batra, Nicole Shonka
Hsa_circ_0004296 inhibits metastasis of prostate cancer by interacting with EIF4A3 to prevent nuclear export of ETS1 mRNA
Shiyu Mao, Wentao Zhang, Fuhan Yang, Yadong Guo, Hong Wang, Yuan Wu, Ruiliang Wang, Niraj Maskey, Zongtai Zheng, Cheng Li, Wenchao Ma, Junfeng Zhang, Yang Yan, Xudong Yao
Super-enhancer-associated TMEM44-AS1 aggravated glioma progression by forming a positive feedback loop with Myc
Erbao Bian, Xueran Chen, Li Cheng, Meng Cheng, Zhigang Chen, Xiaoyu Yue, Zhengwei Zhang, Jie Chen, Libo Sun, Kebing Huang, Cheng Huang, Zhiyou Fang, Bing Zhao, Jun Li
Retraction Note: Long non-coding RNA LINC00968 attenuates drug resistance of breast cancer cells through inhibiting the Wnt2/β-catenin signaling pathway by regulating WNT2
Dian-Hui Xiu, Gui-Feng Liu, Shao-Nan Yu, Long-Yun Li, Guo-Qing Zhao, Lin Liu, Xue-Feng Li
ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway
Hongyu Li, Xin Shen, Mengjun Ma, Wenzhou Liu, Wen Yang, Peng Wang, Zhaopeng Cai, Rujia Mi, Yixuan Lu, Jiahao Zhuang, Yuhang Jiang, Yihui Song, Yanfeng Wu, Huiyong Shen
MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
Xu Chen, Wei Wang, Yufang Li, Yi Huo, Han Zhang, Fan Feng, Wenjin Xi, Tianze Zhang, Jinjian Gao, Fan Yang, Siyi Chen, Angang Yang, Tao Wang
Long noncoding RNA SGO1-AS1 inactivates TGFβ signaling by facilitating TGFB1/2 mRNA decay and inhibits gastric carcinoma metastasis
Donglan Huang, Ke Zhang, Wenying Zheng, Ruixin Zhang, Jiale Chen, Nan Du, Yuanyuan Xia, Yan Long, Yixue Gu, Jianhua Xu, Min Deng
High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer
Franziska Böttger, Andrea Vallés-Martí, Loraine Cahn, Connie R. Jimenez
Arachidonic acid drives adaptive responses to chemotherapy-induced stress in malignant mesothelioma
Mario Cioce, Claudia Canino, Harvey Pass, Giovanni Blandino, Sabrina Strano, Vito Michele Fazio
Fibroblast growth factor receptor fusions in cancer: opportunities and challenges
Lingfeng Chen, Yanmei Zhang, Lina Yin, Binhao Cai, Ping Huang, Xiaokun Li, Guang Liang
The emerging role of ISWI chromatin remodeling complexes in cancer
Yanan Li, Han Gong, Pan Wang, Yu Zhu, Hongling Peng, Yajuan Cui, Heng Li, Jing Liu, Zi Wang
Chlorpromazine induces cytotoxic autophagy in glioblastoma cells via endoplasmic reticulum stress and unfolded protein response
Silvia Matteoni, Paola Matarrese, Barbara Ascione, Lucia Ricci-Vitiani, Roberto Pallini, Veronica Villani, Andrea Pace, Marco G. Paggi, Claudia Abbruzzese
Lnc-RP11-536 K7.3/SOX2/HIF-1α signaling axis regulates oxaliplatin resistance in patient-derived colorectal cancer organoids
Qingguo Li, Huizhen Sun, Dakui Luo, Lu Gan, Shaobo Mo, Weixing Dai, Lei Liang, Yufei Yang, Midie Xu, Jing Li, Peiyong Zheng, Xinxiang Li, Yan Li, Ziliang Wang
Correction to: Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer
Chunfeng Xie, Xu Zhou, Chunhua Liang, Xiaoting Li, Miaomiao Ge, Yue Chen, Juan Yin, Jianyun Zhu, Caiyun Zhong
PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells
Ji Hyeon You, Jaewang Lee, Jong-Lyel Roh
C-Myc-activated long non-coding RNA LINC01050 promotes gastric cancer growth and metastasis by sponging miR-7161-3p to regulate SPZ1 expression
Ziwei Ji, Tianbin Tang, Mengxia Chen, Buyuan Dong, Wenjing Sun, Nan Wu, Hao Chen, Qian Feng, Xingyi Yang, Rong Jin, Lei Jiang
DNMT1-induced miR-378a-3p silencing promotes angiogenesis via the NF-κB signaling pathway by targeting TRAF1 in hepatocellular carcinoma
Bin Zhu, Jun-Jie Chen, Ying Feng, Jun-Ling Yang, Hua Huang, Wen Yuan Chung, Yi-Lin Hu, Wan-Jiang Xue
Therapeutic inhibition of GAS6-AS1/YBX1/MYC axis suppresses cell propagation and disease progression of acute myeloid leukemia
Hao Zhou, Wei Liu, Yongming Zhou, Zhenya Hong, Jian Ni, Xiaoping Zhang, Ziping Li, Mengyuan Li, Wenjuan He, Donghua Zhang, Xuexing Chen, Jianhua Zhu
Correction to: Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity
Tao Qin, Bai Li, Xiaoyue Feng, Shujun Fan, Lei Liu, Dandan Liu, Jun Mao, Ying Lu, Jinfeng Yang, Xiaotang Yu, Qingqing Zhang, Jun Zhang, Bo Song, Man Li, Lianhong Li
BH3-mimetics: recent developments in cancer therapy
Paul A. Townsend, Maria V. Kozhevnikova, Olivier N. F. Cexus, Andrey A. Zamyatnin Jr, Surinder M. Soond
Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells
Ravi Chauhan, Ajaz A. Bhat, Tariq Masoodi, Puneet Bagga, Ravinder Reddy, Ashna Gupta, Zahoor Ahmad Sheikh, Muzafar A. Macha, Mohammad Haris, Mayank Singh
ASB2 is a direct target of FLI1 that sustains NF-κB pathway activation in germinal center-derived diffuse large B-cell lymphoma
Giulio Sartori, Sara Napoli, Luciano Cascione, Elaine Yee Lin Chung, Valdemar Priebe, Alberto Jesus Arribas, Afua Adjeiwaa Mensah, Michela Dall’Angelo, Chiara Falzarano, Laura Barnabei, Mattia Forcato, Andrea Rinaldi, Silvio Bicciato, Margot Thome, Francesco Bertoni
Retraction Note: A positive feedback loop consisting of C12orf59/NF-κB/CDH11 promotes gastric cancer invasion and metastasis
Zhang Jia-Xing, He Wei-Ling, Feng Zi-Hao, Chen Dong-Liang, Gao Ying, He Ying, Qin Kai, Zheng Zhou-San, Chen Cui, Weng Hui-Wen, Yun Miao, Ye Sheng, Xu Rui-Hua, Xie Dan
STOML2 interacts with PHB through activating MAPK signaling pathway to promote colorectal Cancer proliferation
Wenhui Ma, Yuehong Chen, Wenjun Xiong, Wenyi Li, Zhuoluo Xu, Ying Wang, Zhigang Wei, Tingyu Mou, Zhaokun Wu, Mingzhen Cheng, Yini Zou, Yu Zhu, Weijie Zhou, Feng Liu, Yan Geng
SNHG17 promotes colorectal tumorigenesis and metastasis via regulating Trim23-PES1 axis and miR-339-5p-FOSL2-SNHG17 positive feedback loop
Zehua Bian, Mingyue Zhou, Kaisa Cui, Fan Yang, Yulin Cao, Shengbai Sun, Bingxin Liu, Liang Gong, Jiuming Li, Xue Wang, Chaoqun Li, Surui Yao, Yuan Yin, Shenglin Huang, Bojian Fei, Zhaohui Huang
CircRNA-DOPEY2 enhances the chemosensitivity of esophageal cancer cells by inhibiting CPEB4-mediated Mcl-1 translation
Zhenchuan Liu, Shaorui Gu, Kaiqin Wu, Lei Li, Chenglai Dong, Wenli Wang, Yongxin Zhou
Alternative splicing of NF-YA promotes prostate cancer aggressiveness and represents a new molecular marker for clinical stratification of patients
Silvia Belluti, Valentina Semeghini, Giovanna Rigillo, Mirko Ronzio, Daniela Benati, Federica Torricelli, Luca Reggiani Bonetti, Gianluca Carnevale, Giulia Grisendi, Alessia Ciarrocchi, Massimo Dominici, Alessandra Recchia, Diletta Dolfini, Carol Imbriano
Correction to: Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway
Xuehui Wang, Changle Ji, Jiashu Hu, Xiaochong Deng, Wenfang Zheng, Yunhe Yu, Kaiyao Hua, Xiqian Zhou, Lin Fang
Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects
Ilaria Romito, Manuela Porru, Maria Rita Braghini, Luca Pompili, Nadia Panera, Annalisa Crudele, Daniela Gnani, Cristiano De Stefanis, Marco Scarsella, Silvia Pomella, Stefano Levi Mortera, Emmanuel de Billy, Adrian Libenzio Conti, Valeria Marzano, Lorenza Putignani, Manlio Vinciguerra, Clara Balsano, Anna Pastore, Rossella Rota, Marco Tartaglia, Carlo Leonetti, Anna Alisi
Correction to: LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification
Pingfu Hou, Sen Meng, Minle Li, Tian Lin, Sufang Chu, Zhongwei Li, Junnian Zheng, Yuming Gu, Jin Bai
Correction to: Lentinan inhibits tumor angiogenesis via interferon γ and in a T cell independent manner
Shengming Deng, Guoxi Zhang, Jiajie Kuai, Peng Fan, Xuexiang Wang, Pei Zhou, Dan Yang, Xichen Zheng, Xiaomei Liu, Qunli Wu, Yuhui Huang
Mechanisms of cytokine release syndrome and neurotoxicity of CAR T-cell therapy and associated prevention and management strategies
Xinyi Xiao, Shengkang Huang, Sifei Chen, Yazhuo Wang, Qihang Sun, Xinjie Xu, Yuhua Li
Retraction Note: Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors
Jie Yuan, Fan Zhang, Dennis Hallahan, Zhen Zhang, Liming He, Ling-Gang Wu, Meng You, Qin Yang
Correction to: MiR-10a-5p targets TFAP2C to promote gemcitabine resistance in pancreatic ductal adenocarcinoma
Guangbing Xiong, Hua Huang, Mengyu Feng, Gang Yang, Suli Zheng, Lei You, Lianfang Zheng, Ya Hu, Taiping Zhang, Yupei Zhao
Heterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer
Cenzhu Wang, Kun Xu, Runtian Wang, Xin Han, Jinhai Tang, Xiaoxiang Guan
Zebrafish xenograft model for studying mechanism and treatment of non-small cell lung cancer brain metastasis
Ruo-Yue Fan, Jia-Qi Wu, Yu-Yang Liu, Xiang-Yu Liu, Si-Tong Qian, Chong-Yong Li, Ping Wei, Zhe Song, Ming-Fang He
TMPRSS4 promotes cancer stem–like properties in prostate cancer cells through upregulation of SOX2 by SLUG and TWIST1
Yunhee Lee, Junghwa Yoon, Dongjoon Ko, Minyeong Yu, Soojin Lee, Semi Kim
Epigenetic activation of the elongator complex sensitizes gallbladder cancer to gemcitabine therapy
Sunwang Xu, Cen Jiang, Ruirong Lin, Xiaopeng Wang, Xiaoqiang Hu, Wei Chen, Xiangjin Chen, Tao Chen
Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy
Xin Peng, Shaolu Zhang, Wenhui Jiao, Zhenxing Zhong, Yuqi Yang, Francois X. Claret, Moshe Elkabets, Feng Wang, Ran Wang, Yuxu Zhong, Zhe-Sheng Chen, Dexin Kong
Correction to: Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas
Faiqa Mudassar, Han Shen, Geraldine O’Neill, Eric Hau
Deciphering the nonsense-mediated mRNA decay pathway to identify cancer cell vulnerabilities for effective cancer therapy
Roberta Bongiorno, Mario Paolo Colombo, Daniele Lecis
Correction to: LncRNA SNHG1 contributes to sorafenib resistance by activating the Akt pathway and is positively regulated by miR-21 in hepatocellular carcinoma cells
Weidong Li, Xuesong Dong, Changjun He, Gang Tan, Ziyi Li, Bo Zhai, Jing Feng, Xian Jiang, Chang Liu, Hongchi Jiang, Xueying Sun
BUB1 drives the occurrence and development of bladder cancer by mediating the STAT3 signaling pathway
Ning Jiang, Yihao Liao, Miaomiao Wang, Youzhi Wang, Keke Wang, Jianing Guo, Peikang Wu, Boqiang Zhong, Tao Guo, Changli Wu
Correction to: PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance
Chenchen Feng, Yuqing Li, Kunping Li, Yinfeng Lyu, Wenhui Zhu, Haowen Jiang, Hui Wen
Insights into high-risk multiple myeloma from an analysis of the role of PHF19 in cancer
Hussein Ghamlouch, Eileen M. Boyle, Patrick Blaney, Yubao Wang, Jinyoung Choi, Louis Williams, Michael Bauer, Daniel Auclair, Benedetto Bruno, Brian A. Walker, Faith E. Davies, Gareth J. Morgan
Upregulation of ERK-EGR1-heparanase axis by HDAC inhibitors provides targets for rational therapeutic intervention in synovial sarcoma
Cinzia Lanzi, Enrica Favini, Laura Dal Bo, Monica Tortoreto, Noemi Arrighetti, Nadia Zaffaroni, Giuliana Cassinelli
Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug
Emilia Alors-Perez, Ricardo Blázquez-Encinas, Sonia Alcalá, Cristina Viyuela-García, Sergio Pedraza-Arevalo, Vicente Herrero-Aguayo, Juan M. Jiménez-Vacas, Andrea Mafficini, Marina E. Sánchez-Frías, María T. Cano, Fernando Abollo-Jiménez, Juan A. Marín-Sanz, Pablo Cabezas-Sainz, Rita T. Lawlor, Claudio Luchini, Laura Sánchez, Juan M. Sánchez-Hidalgo, Sebastián Ventura, Laura Martin-Hijano, Manuel D. Gahete, Aldo Scarpa, Álvaro Arjona-Sánchez, Alejandro Ibáñez-Costa, Bruno Sainz Jr, Raúl M. Luque, Justo P. Castaño
Novel approaches in cancer treatment: preclinical and clinical development of small non-coding RNA therapeutics
Rossana Cuciniello, Stefania Filosa, Stefania Crispi
Correction to: Sur-X, a novel peptide, kills colorectal cancer cells by targeting survivin-XIAP complex
Wanxia Fang, Xiaofang Che, Guohui Li, Anhui Wang, Yizhe Wang, Xiaonan Shi, Kezuo Hou, Xiaojie Zhang, Xiujuan Qu, Yunpeng Liu
Correction to: Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression
Dongmei Zhang, Jingrong Lin, Yulin Chao, Lu Zhang, Lei Jin, Na Li, Ruiping He, Binbin Ma, Wenzhi Zhao, Chuanchun Han
Correction to: USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer
Xiaojun Man, Chiyuan Piao, Xuyong Lin, Chuize Kong, Xiaolu Cui, Yuanjun Jiang
ZIP10 is a negative determinant for anti-tumor effect of mannose in thyroid cancer by activating phosphate mannose isomerase
Sharui Ma, Na Wang, Rui Liu, Rui Zhang, Hui Dang, Yubo Wang, Simeng Wang, Zekun Zeng, Meiju Ji, Peng Hou
30 years of CIK cell therapy: recapitulating the key breakthroughs and future perspective
Amit Sharma, Ingo G. H. Schmidt-Wolf
DISE/6mer seed toxicity-a powerful anti-cancer mechanism with implications for other diseases
Ashley Haluck-Kangas, Monal Patel, Bidur Paudel, Aparajitha Vaidyanathan, Andrea E. Murmann, Marcus E. Peter
The IRF2/CENP-N/AKT signaling axis promotes proliferation, cell cycling and apoptosis resistance in nasopharyngeal carcinoma cells by increasing aerobic glycolysis
Cheng-Lin Qi, Mao-Ling Huang, You Zou, Rui Yang, Yang Jiang, Jian-Fei Sheng, Yong-Gang Kong, Ze-Zhang Tao, Hong-Yan Feng, Qing-Quan Hua, Li-Hong Bu, Shi-Ming Chen
Loss of epidermal MCPIP1 is associated with aggressive squamous cell carcinoma
Weronika Szukala, Agata Lichawska-Cieslar, Roza Pietrzycka, Maria Kulecka, Izabela Rumienczyk, Michal Mikula, Iwona Chlebicka, Piotr Konieczny, Katarzyna Dziedzic, Jacek C Szepietowski, Giulia Fontemaggi, Janusz Rys, Jolanta Jura
Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth
Rupesh Shrestha, Kumaravel Mohankumar, Greg Martin, Amanuel Hailemariam, Syng-ook Lee, Un-ho Jin, Robert Burghardt, Stephen Safe
Blockade of glutamine-dependent cell survival augments antitumor efficacy of CPI-613 in head and neck cancer
Liwei Lang, Fang Wang, Zhichun Ding, Xiangdong Zhao, Reid Loveless, Jin Xie, Chloe Shay, Peng Qiu, Yonggang Ke, Nabil F. Saba, Yong Teng
Correction to: Epigenetic mediated zinc finger protein 671 downregulation promotes cell proliferation and tumorigenicity in nasopharyngeal carcinoma by inhibiting cell cycle arrest
Jian Zhang, Xin Wen, Na Liu, Ying-Qin Li, Xin-Ran Tang, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Pan-Pan Zhang, Jun Ma, Ying Sun
WNT11/ROR2 signaling is associated with tumor invasion and poor survival in breast cancer
Kerstin Menck, Saskia Heinrichs, Darius Wlochowitz, Maren Sitte, Helen Noeding, Andreas Janshoff, Hannes Treiber, Torben Ruhwedel, Bawarjan Schatlo, Christian von der Brelie, Stefan Wiemann, Tobias Pukrop, Tim Beißbarth, Claudia Binder, Annalen Bleckmann
Correction to: Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy
Xin Peng, Shaolu Zhang, Wenhui Jiao, Zhenxing Zhong, Yuqi Yang, Francois X. Claret, Moshe Elkabets, Feng Wang, Ran Wang, Yuxu Zhong, Zhe-Sheng Chen, Dexin Kong
The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells
Chiara Naro, Monica De Musso, Francesca Delle Monache, Valentina Panzeri, Pierre de la Grange, Claudio Sette
HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer
Yiwei Huang, Zhencong Chen, Tao Lu, Guoshu Bi, Ming Li, Jiaqi Liang, Zhengyang Hu, Yuansheng Zheng, Jiacheng Yin, Junjie Xi, Zongwu Lin, Cheng Zhan, Wei Jiang, Qun Wang, Lijie Tan
Retraction Note: TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells’ invasion
Chao Zhang, Xin Zhang, Ran Xu, Bin Huang, An-Jing Chen, Chao Li, Jian Wang, Xin-Gang Li
Correction to: YPEL3 suppresses epithelial–mesenchymal transition and metastasis of nasopharyngeal carcinoma cells through the Wnt/β-catenin signaling pathway
Jian Zhang, Xin Wen, Xian-Yue Ren, Ying-Qin Li, Xin-Ran Tang, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Ying Sun, Na Liu, Jun Ma
Retraction Note: MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance
Shan Zhou, Jinping Lu, Yuejin Li, Chan Chen, Yongqiang Cai, Gongjun Tan, Zhengke Peng, Zhenlin Zhang, Zigang Dong, Tiebang Kang, Faqing Tang
Correction to: microRNA-193a stimulates pancreatic cancer cell repopulation and metastasis through modulating TGF-β2/TGF-βRIII signalings
Chi Fang, Chen-yun Dai, Zhu Mei, Ming-jie Jiang, Dian-na Gu, Qian Huang, Ling Tian
Correction to: Novel approaches in cancer treatment: preclinical and clinical development of small non-coding RNA therapeutics
Rossana Cuciniello, Stefania Filosa, Stefania Crispi
Correction to: HDAC3 deteriorates colorectal cancer progression via microRNA-296-3p/TGIF1/TGFβ axis
Jinxiao Li, Man Hu, Na Liu, Huarong Li, Zhaomin Yu, Qian Yan, Minfeng Zhou, Yayuan Wang, Yanjuan Song, Guangtao Pan, Fengxia Liang, Rui Chen