The mortality rate of ovarian malignant tumors ranks first in gynecological malignant tumors [
1,
2]. Epithelial ovarian cancer is a popular ovarian cancer, about 85 to 90% of ovarian cancer belong to this cancer type [
3]. People have been studying ovarian cancer for more than 150 years. Unfortunately, the mortality rate of ovarian cancer has not decreased. The anatomical location of the ovary is hidden, and the early symptoms are not obvious [
4,
5]. In recent years, although the surgical treatment and chemotherapy of epithelial ovarian cancer (OC) have been improving constantly [
6,
7]. Therefore, how to find and control the related factors of proliferation, invasion and metastasis, and then improve the survival rate of patients with epithelial ovarian cancer has become a research hotspot.
Many scholars have done a lot of research on epithelial ovarian cancer, and current research focuses on gene regulation levels, including DNA methylation, group egg protein modification, and non-coding RNA, among which non-coding RNA has received unprecedented attention [
8,
9]. Studies have showed that miRNAs have a key place in almost all important life activities [
10,
11]. At present, it has been found that it is related to many diseases, among which the identification of miRNAs in tumors and the exploration of their functions have become the hotspot and frontier of life science research [
12]. MicroRNAs (miRNAs) are a class of small (19 to 25 nt), non-coding, highly stable RNAs that regulate mRNA and protein expression [
13]. Moreover, they should specify that several studies have indicated that miRNAs have been involved in regulating various biological processes, such as cellular differentiation, proliferation, angiogenesis, metabolism and cancer development [
14,
15]. Many kinds of miRNAs have been proved to be abnormally appeared in carcinoma of ovary. MiRNAs are involved in biological processes related to the development of ovarian cancer [
16]. The study has also found that miRNAs are associated with staging, grading, and histological subtypes of ovarian cancer, suggesting that miRNAs can be screened for ovarian cancer as a class of biomarkers [
17,
18]. Some studies have showed that miRNA-802 has obvious differences in the expression levels of various tumor cells and surrounding healthy tissues [
19,
20]. However, current research on miRNA-802 in ovarian cancer is rarely reported.
In recent years, research have found that miRNAs make a difference in biological through downstream target genes [
21]. YWHAZ belongs to the 14–3-3 gene family. Studies have found that YWHAZ have a vital function in tumor migration, inhibited apoptosis and regulated signal transduction [
22,
23]. It is abnormally expressed in many malignant tumor cells [
24]. The YWHAZ mechanism of action on the development of ovarian carcinoma is not clear. Based on the above studies, it was hypothesized that miRNA-802 may regulate the development of ovarian cancer through YWHAZ expression. This study main purpose was to attest the mechanism of miRNA-802 regulation of ovarian cancer, to verify the role and relationship of YWHAZ in miRNA-802-regulated ovarian carcinoma, and to demonstrate a theoretical basis for finding new drug targets.