Introduction
Materials and methods
Subjects
Characteristic | Mean (± SD) |
---|---|
Age (years) | 38 ± 18 |
Sex (M/F) | 10/11 |
Height (cm) | 161 ± 12 |
Weight (kg) | 56 ± 19 |
FVC (% predicted) | 44 ± 12 |
28 ± 26 | |
FEV1 (% predicted) | |
TLC (% predicted) | 99 ± 26 |
RV (% predicted) | 208 ± 67 |
Hemodynamic study
Study protocol
Statistical analysis
Results
Inhaled nitric oxide challenge
Baseline | INO | Dobutamine | INO+Dobutamine | |
---|---|---|---|---|
Cardiac index (l/min/m2) | 3.2 ± 1.2 | 3.2 ± 1.2 | 4.7 ± 1.2** | 4.4 ± 1.2** |
Heart rate (beats/min) | 87 ± 18 | 86 ± 17 | 113 ± 18** | 109 ± 19** |
SVI (ml/m2) | 36 ± 10 | 37 ± 9 | 44 ± 16** | 41 ± 11** |
CVP (mmHg) | 2.5 ± 2.8 | 3.1 ± 3.1 | 2.4 ± 2.5 | 2.7 ± 2.9 |
MPAP (mmHg) | 26 ± 10 | 24 ± 9** | 31 ± 15* | 27 ± 12 |
PAOP (mmHg) | 7 ± 3 | 7.4 ± 4 | 8 ± 4 | 7 ± 3 |
MPAP-PAOP (mmHg) | 19 ± 10 | 17 ± 9** | 23 ± 14 | 20 ± 11 |
PVRI (dyne/s/cm5/m2) | 535 ± 285 | 477 ± 293* | 441 ± 331 | 416 ± 265** |
MAP (mmHg) | 86 ± 11 | 87 ± 10 | 86 ± 10 | 85 ± 10 |
SVRI (dyne/s/cm5/m2) | 2363 ± 764 | 2348 ± 786 | 1346 ± 243** | 1614 ± 439** |
Qs/Qt (%) | 23 ± 5 | 20 ± 5* | 26 ± 5** | 25 ± 7 |
PaO2/FiO2 (mmHg) | 327 ± 90 | 418 ± 104** | 296 ± 90* | 390 ± 111** |
PaCO2 (mmHg) | 51 ± 12 | 52 ± 12 | 51 ± 13 | 50 ± 13 |
Baseline 1 | INO | Dobutamine | INO+Dobutamine | |
---|---|---|---|---|
Cardiac index (l/min/m2) | 3.9 ± 1.9 | 3.8 ± 1.5 | 5.6 ± 1.4 | 4.5 ± 0.3 |
Heart rate (beats/min) | 87 ± 17 | 85 ± 12 | 115 ± 25 | 114 ± 23* |
SVI (ml/m2) | 43 ± 15 | 43 ± 13 | 53 ± 27 | 42 ± 12 |
CVP (mmHg) | 3.2 ± 2.8 | 4 ± 3 | 3.2 ± 2.7 | 3.2 ± 3.9 |
MPAP (mmHg) | 33 ± 16 | 28 ± 14 | 37 ± 17 | 36 ± 17 |
PAOP (mmHg) | 9.4 ± 2 | 7.8 ± 1 | 12.5 ± 5 | 9.2 ± 3.3 |
MPAP-PAOP (mmHg) | 24 ± 15 | 20 ± 14 | 24 ± 17 | 27 ± 18 |
PVRI (dyne/s/cm5/m2) | 781 ± 424 | 662 ± 355 | 569 ± 321 | 641 ± 335* |
MAP (mmHg) | 86 ± 10 | 88 ± 9 | 90 ± 14 | 79 ± 11 |
SVRI (dyne/s/cm5/m2) | 1919 ± 684 | 1974 ± 712 | 1272 ± 256 | 1391 ± 237* |
Qs/Qt (%) | 19 ± 5 | 11 ± 4* | 24 ± 7 | 15 ± 12 |
PaO2/FiO2 (mmHg) | 366 ± 113 | 448 ± 92 | 344 ± 95 | 435 ± 115 |
PaCO2 (mmHg) | 51 ± 20 | 52 ± 23 | 53 ± 24 | 56 ± 23 |
Baseline | INO | Dobutamine | INO+Dobutamine | |
---|---|---|---|---|
Cardiac index (l/min/m2) | 3.6 ± 0.6 | 3.6 ± 0.5 | 5.1± 0.6 | 4.7± 0.5** |
Heart rate (beats/min) | 90 ± 26 | 90 ± 25 | 102 ± 22 | 104 ± 18 |
SVI (ml/m2) | 43 ± 12 | 43 ± 10 | 52 ± 10 | 47 ± 7 |
CVP (mmHg) | 1.4 ± 1.9 | 1.6 ± 2.1 | 1.9 ± 2.4 | 1.4 ± 2 |
MPAP (mmHg) | 24 ± 4 | 22 ± 3 | 26 ± 5 | 24 ± 3 |
PAOP (mmHg) | 5.7 ± 2.7 | 6.5 ± 3.5 | 6.2 ± 3.3 | 5.6 ± 2.6 |
MPAP-PAOP (mmHg) | 18 ± 2 | 16 ± 2* | 20 ± 2 | 18 ± 3 |
PVRI (dyne/s/cm5/m2) | 591 ± 148 | 548 ± 140 | 448 ± 96* | 460 ± 98* |
MAP (mmHg) | 83 ± 15 | 83 ± 11 | 87 ± 13 | 89 ± 13 |
SVRI (dyne/s/cm5/m2) | 1826 ± 261 | 1825 ± 230 | 1371 ± 193 | 1495 ± 197** |
Qs/Qt (%) | 20 ± 7 | 17 ± 4 | 30 ± 6* | 22 ± 5 |
PaO2/FiO2 (mmHg) | 276 ± 56 | 350 ± 48* | 260 ± 56 | 319 ± 65 |
PaCO2 (mmHg) | 54 ± 11 | 55 ± 11 | 54 ± 12 | 53 ± 12 |
Baseline | INO | Dobutamine | INO+Dobutamine | |
---|---|---|---|---|
Cardiac index (l/min/m2) | 3.2 ± 1.9 | 3.2 ± 2.3 | 5.0 ± 2.7 | 4.7 ± 2.4** |
Heart rate (beats/min) | 83 ± 28 | 83 ± 30 | 104 ± 28 | 101 ± 29* |
SVI (ml/m2) | 38 ± 11 | 39 ± 13 | 49 ± 18 | 47 ± 19 |
CVP (mmHg) | 2.5 ± 3 | 2.5 ± 3.1 | 2.0 ± 1.8 | 2.0 ± 2.0 |
MPAP (mmHg) | 23 ± 7 | 21 ± 7 | 25 ± 8 | 24 ± 9 |
PAOP (mmHg) | 6.6 ± 4.5 | 6.0 ± 4.9 | 5.3 ± 4.7 | 5.0 ± 4.0 |
MPAP-PAOP (mmHg) | 16 ± 8 | 15 ± 6 | 19 ± 7* | 19 ± 9 |
PVRI (dyne/s/cm5/m2) | 671 ± 277 | 601 ± 247 | 471 ± 262* | 492 ± 300* |
MAP (mmHg) | 87 ± 12 | 89 ± 11 | 91 ± 9 | 93 ± 12 |
SVRI (dyne/s/cm5/m2) | 2524 ± 873 | 2625 ± 1012 | 1654 ± 541 | 1824 ± 683** |
Qs/Qt (%) | 23 ± 11 | 15 ± 6 | 28 ± 10* | 17 ± 5 |
PaO2/FiO2 (mmHg) | 322 ± 115 | 442 ± 103* | 310 ± 93 | 419 ± 90* |
PaCO2 (mmHg) | 45 ± 11 | 44 ± 11 | 43 ± 11 | 45 ± 13 |