Erschienen in:
01.04.2013 | Letter
Impact of sepsis-associated cytokine storm on plasma NGAL during acute kidney injury in a model of polymicrobial sepsis
verfasst von:
Gordon P Otto, Martin Busch, Maik Sossdorf, Ralf A Claus
Erschienen in:
Critical Care
|
Ausgabe 2/2013
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Excerpt
Acute kidney injury (AKI) is a common, early and severe organ dysfunction during sepsis [
1]. One promising biomarker for its early detection is neutrophil gelatinase-associated lipocalin (NGAL) [
2,
3]. During sepsis, cytokines, including TNFα, IL6 and IL10, initiate a broad variety of signalling that affect AKI development. Using a lipo polysaccharide-induced AKI animal model, correlation of NGAL expression to TNFα but not IL6 expression was previously described [
4]. During polymicrobial sepsis, it remains unclear whether there is a correlation between protein levels and the role of plasma NGAL as an inflammatory protein rather than a marker of AKI. …