Mortality and quality of life in the five years after severe sepsis

Severe sepsis is an increasingly common condition that is associated with high levels of morbidity and mortality as well as placing a large burden upon healthcare resources throughout the world [1‐4]. The morbidity and mortality from sepsis remain high [2‐4]. For those who survive severe sepsis, many will develop complications associated with significant long-term sequelae [5‐11]. Perhaps unsurprisingly, health related quality of life (QOL) and activities of daily living (ADL) are frequently significantly diminished [5‐12].

QOL is a very important outcome for patients after critical care and has been shown to be poor in all subgroups of critical illness compared to the general population at various time points [13‐16]. Poor QOL leads to poor patient satisfaction and high health care resource utilization [17, 18]. There has been little work following up patients with severe sepsis for mortality beyond three years and no work looking at changes in QOL over a five-year period. Only one study looking at ADL has followed up such patients for functional outcomes to this time point [9].

The aim of this study was to determine the mortality and QOL in patients in the five years after severe sepsis. As secondary outcomes of interest, we also wanted to study the patients' willingness to be treated in an ICU again if they become critically ill, the nature of their memories of the ICU, their satisfaction with their current QOL and the impact of the index illness on their place of residence and employment status.

This was a prospective cohort study of patients with severe sepsis with ethics approval granted by the Scottish multi-center research ethics committee and informed consent obtained from all patients' quality of life follow-up after three years. The ethics committee approval required the research team to make contact with patients indirectly through their parent hospital team, and first and only if the patients agreed, could the research team contact the patient. Mortality follow-up used national registry databases which are known to have an accuracy of 99%.

The flow of patients through the study is presented in Figure 1. Mortality follow-up was complete. The baseline, ICU and hospital characteristics for all groups are presented in Table 1. In summary of these data, the cohort had a median age of 58 (45 to 67), a high severity of illness (APACHE II = 23 (17 to 28); Simplified Acute Physiology Score (SAPS II) = 41 (30 to 54)) and a low level of chronic comorbidities (median 0 (0 to 0). The subjects were 53% male and had a range of organ system dysfunctions with respiratory failure being most common (65%). Infection was microbiologically confirmed in 35% of cases, with bronchopulmonary infection the most common source (48%), followed by other infections (21%) and blood infections (14%). Gram positive infection made up 16% and Gram negative infection (10%) of proven infections. Further data related to the severity, site and nature of sepsis are presented in Table 2.

The survival data show that 267 patients (63%) survived to leave the ICU, 249 (57%) survived to leave the hospital, 185 (42%) survived to 3.5 years and 172 (39%) survived to 5 years (Figure 2). Loss to follow-up occurred in 79/494 (16%) patients. Of the 185 survivors at 3.5 years, 28 withdrew and 72 were lost to follow-up, leaving 85 responders. Of the 172 survivors at five years, 26 withdrew and 78 were lost to follow-up, leaving 67 responders.

Table 3 shows the QOL outcomes including EQ-5D and SF-36 domains and component scores. EQ-5D scores are 0.64 (SD 0.36) at 3.5 years and 0.68 (SD 0.32) at 5 years. SF-36 PCS is lower than population controls at 41.8 (SD 11.8) at 3.5 years and 44.8 (SD 12.7) at 5 years. SF-36 MCS is 47.7 (SD 14.6) at 3.5 years and 48.8 (SD 12.6) at 5 years.

At five years, the SF-36 PCS of 44.8 is significantly lower than the mean population norm of 50 (P = 0.001). The equivalent comparison for the mental component at five years shows no significant difference (P = 0.453).

At five years all patients stated they would be willing to be treated in an ICU again if they become critically ill, 19% had unpleasant memories of ICU events, 80% were either very happy or mostly happy with their current QOL, with 75% either working less or not working at all compared to before their critical illness (see Table 4).

This cohort study was designed to study mortality and QOL in the five years after ICU admission for severe sepsis and demonstrates a high mortality in this cohort of patients at this time point. The majority of this mortality occurs in hospital and within the first year but there is an ongoing attrition over the entire five-year period. This attrition has been demonstrated in other general ICU cohorts, but in sepsis cohorts follow-up has not previously been over such a long time period [14, 15, 23]. This study also demonstrates poor physical QOL scores in sepsis patients compared to age- and sex-matched population controls at 3.5 and 5 years. The QOL scores in this cohort are broadly similar to QOL scores up to five years in other cohorts of critically ill cohorts [14, 15, 17, 24]. As has been previously demonstrated in other critically ill cohorts, mental QOL is only slightly below the age- and sex-matched population control level [12, 14, 15, 17, 24]. All our patients stated they would be willing to be treated in an ICU again if they become critically ill.

In a landmark study, Quartin et al. followed up survivors of severe sepsis for eight years and showed an excess mortality compared to population controls [11]. Other studies have looked at survival in severe sepsis subgroups, such as community-acquired pneumonia, but find the same pattern in excess long-term mortality [25‐27]. A post-hoc follow-up of patients from the PROWESS (Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis) study showed that the reduction in mortality seen at 28 days was lost after hospital discharge through to 3.6 years although most patients in this study were followed up for shorter durations [28]. When we compare five-year mortality data for this group, we can look at results from general ICU [14, 15, 24, 29] or acute respiratory distress syndrome (ARDS) patients [17]. All these studies demonstrate an ongoing attrition in these cohorts with time compared to age- and sex-matched population cohorts. These results seem broadly similar to severe sepsis mortality outcomes although the younger age on ICU admission in our cohort may explain the slightly lower than expected mortality rates between 3.5 and 5 years [9, 11, 25‐27].

There have been a few papers looking at differences in QOL outcomes in severe sepsis patients. A study by Heyland et al. suggested that SF-36 QOL scores were lower than the general population and that SF-36 had a good reliability and validity in this group [10]. A study by Hofhuis et al. showed poor QOL scores at six months after an ICU stay compared to age- and sex-matched controls [5]. A study by Granja et al. also found poor QOL in survivors of sepsis that was comparable to other non-septic critical illness survivors [30]. A study by Longo et al. studied patients receiving activated protein C compared to unmatched controls and looked at mortality and QOL outcome up to seven months after ICU discharge [31]. They found an 11.8% absolute risk reduction for mortality in the activated protein C patients at seven months and improvements in a variety of QOL scores. This study was limited by small sample size and the lack of matching. Further studies have looked at ADL in severe sepsis survivors [9]. This study demonstrated that many severe sepsis patients have poor levels of activity (measured by ADL) in the period before severe sepsis and go on to have further functional disability in the five years after sepsis but not all of these patients are admitted to an ICU during their illness. The exact relationship between ADL and physical QOL in severe sepsis survivors is not fully understood but the information we elucidate from these metrics are likely to overlap to some degree.

The current study focuses on QOL outcomes up to five years after severe sepsis. There are no studies we have identified that studied QOL in severe sepsis patients for this long a time period. The most comparable studies are ones of general ICU cohorts [14, 15, 24] and of ARDS patients [17]. Broadly, these QOL scores are similar to those of other critically ill cohorts over this long follow-up [30]. It is interesting to note that the mental QOL scores are only slightly below the age- and sex-matched population control levels, which seems at odds with papers suggesting high levels of psychological morbidity and cognitive dysfunction after critical illness [9, 12, 15, 17, 24, 32‐35]. This may suggest a problem with the sensitivity or calibration of the SF-36 MCS in patients after critical illness since reports of depression, anxiety and post-traumatic stress disorders after severe sepsis and other critical illness seem so consistent [15, 34‐38]. Clearly, cognitive dysfunction is not measured in the SF-36 MCS per se but it may confound the measurement of both mental and physical QOL scores.

It was very interesting to find that all our patients would be willing to undergo treatment in an ICU again if they become critically ill despite generally poor physical QOL scores and 19 to 29% having either unpleasant recall or memories of their ICU stay [37, 39, 40]. Despite the relatively poor QOL scores, the vast majority (80%) of patients reported they were mostly or very happy with their current QOL [41]. Of course, there could be a cognitive bias in these responses as it must be difficult to state you would not want life saving treatments or that you have a poor QOL. These data also seem to somewhat contradict the results of previous work in acutely ill patients [40]. With regard to employment status, 34% were in full time employment at five years with 75% stating they now work less or are now not working, since their illness [17, 18, 32]. Although it must be identified that some of this reduction in employment is due to retirements. This change in employment status speaks to the broad long-term financial impact of severe sepsis on patients and their families [15, 18, 42].

This study has a number of strengths and limitations that need to be considered. Strengths include the multi-center nature of the data and the fact that all adult general ICUs in one country were included. Further strengths include the prolonged follow-up period that has not been attained in previous studies. Compared to previous studies in this field, this is a reasonable sized study, but from an epidemiological perspective the limited patient number reduces the ability to make strong conclusions about this cohort. Limitations include the loss to follow-up in this study. The cohorts were not approached for consent for long term follow-up until well after their index ICU admission, thus denying us shorter term QOL data. The ethics committee approval required the research team to make contact with patients indirectly through their parent hospital team first and only if the patients agreed could the research team contact the patient. We believe that this additional step led to a significantly lower recruitment and retention to the study than a direct approach would have achieved. This has the potential to introduce a recruitment bias into the study data collection, although we are unable to identify the magnitude of direction of such a bias. Since it is likely that poor QOL is more common in those patients who die during follow-up, there is likely excess QOL loss to follow-up in the highest risk patients and, therefore, these QOL results may, on average, be better than those actually experienced by the patients. This issue is standard to all studies using prospective cohort designs. With regard to the generalizability of the results, we recruited patients from all adult ICU patients in one country which enhances the generalizability but we only recruited patients with an APACHE II score ≥25 making this a sicker cohort than in some studies of severe sepsis. It is noted that despite the inclusion criteria for this cohort being APACHE II ≥25, some patients with lower APACHE II scores were recruited to the study. In this study we demonstrated that 35% of infections were microbiologically confirmed compared to those in European Prevalence of Infection in Intensive Care (EPIC) and 60% in Sepsis Occurrence in Acutely Ill Patients (SOAP) studies [43, 44]. A further limitation is the lack of pre-morbid data on physical or psychological morbidity and function [9, 34, 45]. Recent studies have identified the high level of pre-morbid physical, psychological and cognitive dysfunction in this group and that levels of these morbidities may not always be significantly higher than in the post-morbid recovery phase of critical illness [9, 34, 45]. We are, therefore, unable to confidently determine the acuity of these symptoms or their relationship to the current levels of dysfunction to the index illness in our patient group. Finally, it has been suggested by one author that QOL data should be adjusted for pre-morbid conditions, we did not do this as we believe that this is not an accepted methodological standard for QOL measurement [46].

Patients with severe sepsis have a high ongoing mortality after severe sepsis with only 61% surviving five years. They also have a significantly lower physical QOL compared to the population norm but mental QOL scores were only slightly below population norms up to five years after severe sepsis. Mortality and QOL outcomes were broadly similar to other critically ill cohorts throughout the five years of follow-up. These data need to be considered when evaluating longer-term outcomes and when considering the cost-effectiveness of care in this patient group.