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Critical Care
Erschienen in: Critical Care 1/2004

01.02.2003 | Review

Bench-to-bedside review: β2-Agonists and the acute respiratory distress syndrome

verfasst von: Gavin D Perkins, Daniel F McAuley, Alex Richter, David R Thickett, Fang Gao

Erschienen in: Critical Care | Ausgabe 1/2004

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Abstract

The acute respiratory distress syndrome (ARDS) is a devastating constellation of clinical, radiological and pathological signs characterized by failure of gas exchange and refractory hypoxia. Despite nearly 30 years of research, no specific pharmacological therapy has yet proven to be efficacious in manipulating the pathophysiological processes that underlie this condition. Several in vitro and in vivo animal or human studies suggest a potential role for β2-agonists in the treatment of ARDS. These agents have been shown to reduce pulmonary neutrophil sequestration and activation, accelerate alveolar fluid clearance, enhance surfactant secretion, and modulate the inflammatory and coagulation cascades. They are also used widely in clinical practice and are well tolerated in critically ill patients. The present review examines the evidence supporting a role for β2-agonists as a specific pharmacological intervention in patients with ARDS.
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Metadaten
Titel
Bench-to-bedside review: β2-Agonists and the acute respiratory distress syndrome
verfasst von
Gavin D Perkins
Daniel F McAuley
Alex Richter
David R Thickett
Fang Gao
Publikationsdatum
01.02.2003
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 1/2004
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc2417

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