Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Critical Care
Erschienen in: Critical Care 2/2004

01.04.2004 | Review

Preoperative recombinant human erythropoietin in anemic surgical patients

verfasst von: Terri G Monk

Erschienen in: Critical Care | Sonderheft 2/2004

Einloggen, um Zugang zu erhalten

Abstract

Preoperative anemia in a surgical patient predisposes to poor outcomes and allogeneic blood transfusions. As an alternative to transfusions, pharmacologic management of preoperative anemia with recombinant human erythropoietin (rHuEPO) has been well studied in many different types of surgery. rHuEPO, when used alone or in combination with preoperative autologous blood donation before elective surgery, stimulates erythropoiesis and helps to avoid or reduce the need for allogeneic blood transfusions. The clinical evidence on preoperative use of rHuEPO in orthopedic, cardiac, and cancer surgery, as well as in bloodless surgery, is reviewed.
Literatur
1.
Keating EM, Ritter MA: Transfusion options in total joint arthroplasty. J Arthoplasty 2002, 17: 125-128. 10.1054/arth.2002.32459CrossRef
2.
Dunne JR, Malone D, Tracy JK, Gannon C, Napolitano LM: Perioperative anemia: an independent risk factor for infection, mortality, and resource utilization in surgery. J Surg Res 2002, 102: 237-244. 10.1006/jsre.2001.6330CrossRefPubMed
3.
Carson JL, Duff RM, Berlin JA, Spence RK, Trout R, Noveck H, Strom BL: Effect of anaemia and cardiovascular disease on surgical mortality and morbidity. Lancet 1996, 348: 1055-1060. 10.1016/S0140-6736(96)04330-9CrossRefPubMed
4.
Baraldi-Junkins CA, Beck AC, Rothstein G: Hematopoiesis and cytokines. Relevance to cancer and aging. Hematol Oncol Clin North Am 2000, 14: 45-61.CrossRefPubMed
5.
Adunsky A, Lichtenstein A, Mizrahi E, Arad M, Heim M: Blood transfusion requirements in elderly hip fracture patients. Arch Gerontol Geriatr 2003, 36: 75-81. 10.1016/S0167-4943(02)00059-6CrossRefPubMed
6.
Denison U, Baumann J, Peters-Engl C, Samonigg H, Krippl P, Lang A, Obermair A, Wagner H, Sevelda P: Incidence of anaemia in breast cancer patients receiving adjuvant chemotherapy. Breast Cancer Res Treat 2003, 79: 347-353. 10.1023/A:1024016508925CrossRefPubMed
7.
Keating EM, Meding JB: Perioperative blood management practices in elective orthopaedic surgery. J Am Acad Orthop Surg 2002, 10: 393-400.PubMed
8.
Lee SJ, Liljas B, Churchill WH, Popovsky MA, Stowell CP, Cannon ME, Johannesson M: Perceptions and preferences of autologous blood donors. Transfusion 1998, 38: 757-763. 10.1046/j.1537-2995.1998.38898375515.xCrossRefPubMed
9.
Nappi J: Anemia in patients with coronary artery disease. Am J Health Syst Pharm 2003, Suppl 3: S4-S8.
10.
Benoist S, Panis Y, Pannegeon V, Alves A, Valleur P: Predictive factors for perioperative blood transfusions in rectal resection for cancer: a multivariate analysis of a group of 212 patients. Surgery 2001, 129: 433-439. 10.1067/msy.2001.112068CrossRefPubMed
11.
Chang H, Hall GA, Geerts WH, Greenwood C, McLeod RS, Sher GD: Allogeneic red blood cell transfusion is an independent risk factor for the development of postoperative bacterial infection. Vox Sang 2000, 78: 13-18. 10.1159/000031143CrossRefPubMed
12.
Amato AC, Pescatori M: Effect of perioperative blood transfusions on recurrence of colorectal cancer: meta-analysis stratified on risk factors. Dis Colon Rectum 1998, 41: 570-585.CrossRefPubMed
13.
Brand A: Immunological aspects of blood transfusions. Blood Rev 2000, 14: 130-144. 10.1054/blre.2000.0131CrossRefPubMed
14.
Vamvakas EC, Carven JH: Allogeneic blood transfusion, hospital charges, and length of hospitalization: a study of 487 consecutive patients undergoing colorectal cancer resection. Arch Pathol Lab Med 1998, 122: 145-151.PubMed
15.
McCullough J: Progress toward a pathogen-free blood supply. Clin Infect Dis 2003, 37: 88-95. 10.1086/375232CrossRefPubMed
16.
Hutchinson AB, Fergusson D, Graham ID, Laupacis A, Herrin J, Hillyer CD: Utilization of technologies to reduce allogeneic blood transfusion in the United States. Transfus Med 2001, 11: 79-85. 10.1046/j.1365-3148.2001.00290.xCrossRefPubMed
17.
Hogue CW Jr, Goodnough LT, Monk TG: Perioperative myocardial ischemic episodes are related to hematocrit level in patients undergoing radical prostatectomy. Transfusion 1998, 38: 924-931. 10.1046/j.1537-2995.1998.381098440856.xCrossRefPubMed
18.
Dunne JR, Gannon CJ, Osborn TM, Taylor MD, Malone DL, Napolitano LM: Preoperative anemia in colon cancer: assessment of risk factors. Am Surg 2002, 68: 582-587.PubMed
19.
Arnoux R, Corman J, Peloquin A, Smeesters C, St Louis G: Adverse effect of blood transfusions on patient survival after resection of rectal cancer. Can J Surg 1988, 31: 121-126.PubMed
20.
Procrit ® epoetin alfa [prescribing information] Bridgewater, NJ: Ortho Biotech Products, LP 2002.
21.
Goodnough LT, Monk TG, Andriole GL: Erythropoietin therapy. N Engl J Med 1997, 336: 933-938. 10.1056/NEJM199703273361307CrossRefPubMed
22.
Monk TG, Goodnough LT, Brecher ME, Colberg JW, Andriole GL, Catalona WJ: A prospective randomized comparison of three blood conservation strategies for radical prostatectomy. Anesthesiology 1999, 91: 24-33. 10.1097/00000542-199907000-00008CrossRefPubMed
23.
Brecher ME, Goodnough LT, Monk T: Where does preoperative erythropoietin therapy count? A mathematical perspective. Transfusion 1999, 39: 392-395. 10.1046/j.1537-2995.1999.39499235672.xCrossRefPubMed
24.
Avall A, Hyllner M, Bengtson JP, Carlsson L, Bengtsson A: Recombinant human erythropoietin in preoperative autologous blood donation did not influence the haemoglobin recovery after surgery. Acta Anaesthesiol Scand 2003, 47: 687-692.CrossRefPubMed
25.
Goldberg MA: Perioperative epoetin alfa increases red blood cell mass and reduces exposure to transfusions: results of randomized clinical trials. Semin Hematol 1997, 34: 41-47.PubMed
26.
Faris PM, Ritter MA, Abels RI: The effects of recombinant human erythropoietin on perioperative transfusion requirements in patients having a major orthopaedic operation. The American Erythropoietin Study Group. J Bone Joint Surg Am 1996, 78: 62-72.PubMed
27.
Goldberg MA, McCutchen JW, Jove M, Di Cesare P, Friedman RJ, Poss R, Guilfoyle M, Frei D, Young D: A safety and efficacy comparison study of two dosing regimens of epoetin alfa in patients undergoing major orthopedic surgery. Am J Orthop 1996, 25: 544-552.PubMed
28.
Lofthouse RA, Boitano MA, Davis JR, Jinnah RH: Preoperative administration of epoetin alfa to reduce transfusion requirements in elderly patients having primary total hip or knee reconstruction. J South Orthop Assoc 2000, 9: 175-181.PubMed
29.
Rauh MA, Bayers-Thering M, LaButti RS, Krackow KA: Preoperative administration of epoetin alfa to total joint arthroplasty patients. Orthopedics 2002, 25: 317-320.PubMed
30.
de Andrade JR, Jove M, Landon G, Frei D, Guilfoyle M, Young DC: Baseline hemoglobin as a predictor of risk of transfusion and response to epoetin alfa in orthopedic surgery patients. Am J Orthop 1996, 25: 533-542.PubMed
31.
Fearon JA, Weinthal J: The use of recombinant erythropoietin in the reduction of blood transfusion rates in craniosynostosis repair in infants and children. Plast Reconstr Surg 2002, 109: 2190-2196. 10.1097/00006534-200206000-00002CrossRefPubMed
32.
Laupacis A, Fergusson D: Erythropoietin to minimize perioperative blood transfusion: a systematic review of randomized trials. The International Study of Perioperative Transfusion (ISPOT) Investigators. Transfus Med 1998, 8: 309-317. 10.1046/j.1365-3148.1998.00171.xCrossRefPubMed
33.
Yazicioglu L, Eryilmaz S, Sirlak M, Inan MB, Aral A, Tasoz R, Eren NT, Kaya B, Akalin H: Recombinant human erythropoietin administration in cardiac surgery. J Thoac Cardiovasc Surg 2001, 122: 741-745. 10.1067/mtc.2001.115426CrossRef
34.
Qvist N, Boesby S, Wolff B, Hansen CP: Recombinant human erythropoietin and hemoglobin concentration at operation and during the postoperative period: reduced need for blood transfusions in patients undergoing colorectal surgery: prospective double-blind placebo-controlled study. World J Surg 1999, 23: 30-35. 10.1007/s002689900561CrossRefPubMed
35.
Kosmadakis N, Messaris E, Maris A, Katsaragakis S, Leandros E, Konstadoulakis MM, Androulakis G: Perioperative erythropoietin administration in patients with gastrointestinal tract cancer: prospective randomized double-blind study. Ann Surg 2003, 237: 417-421. 10.1097/00000658-200303000-00017PubMedCentralPubMed
36.
Levine EA, Laborde C, Hambrick E, McKnight CA, Vijayakumar S: Influence of erythropoietin on transfusion requirements in patients receiving preoperative chemoradiotherapy for rectal cancer. Dis Colon Rectum 1999, 42: 1065-1069.CrossRefPubMed
37.
Kettelhack C, Hones C, Messinger D, Schlag PM: Randomized multicentre trial of the influence of recombinant human erythropoietin on intraoperative and postoperative transfusion need in anaemic patients undergoing right hemicolectomy for carcinoma. Br J Surg 1998, 85: 63-67. 10.1046/j.1365-2168.1998.00564.xCrossRefPubMed
38.
Rosenblum N, Levine MA, Handler T, Lepor H: The role of preoperative epoetin alfa in men undergoing radical retropubic prostatectomy. J Urol 2000, 163: 829-833. 10.1097/00005392-200003000-00029CrossRefPubMed
39.
Scott SN, Boeve TJ, McCulloch TM, Fitzpatrick KA, Karnell LH: The effects of epoetin alfa on transfusion requirements in head and neck cancer patients: a prospective, randomized, placebo-controlled study. Laryngoscope 2002, 112: 1221-1229. 10.1097/00005537-200207000-00015CrossRefPubMed
40.
Sesti F, Ticconi C, Bonifacio S, Piccione E: Preoperative administration of recombinant human erythropoietin in patients undergoing gynecologic surgery. Gynecol Obstet Invest 2002, 54: 1-5. 10.1159/000064688CrossRefPubMed
41.
Mercuriali F, Zanella A, Barosi G, Inghilleri G, Biffi E, Vinci A, Colotti MT: Use of erythropoietin to increase the volume of autologous blood donated by orthopedic patients. Transfusion 1993, 33: 55-60. 10.1046/j.1537-2995.1993.33193142311.xCrossRefPubMed
42.
Mercuriali F, Inghilleri G, Biffi E, Colotti MT, Vinci A, Oriani G: Epoetin alfa in low hematocrit patients to facilitate autologous blood donation in total hip replacement: a randomized, double-blind, placebo-controlled, dose-ranging study. Acta Haematol 1998, 100: 69-76. 10.1159/000040868CrossRefPubMed
43.
Goodnough LT, Price TH, Rudnick S, Soegiarso RW: Preoperative red cell production in patients undergoing aggressive autologous blood phlebotomy with and without erythropoietin therapy. Transfusion 1992, 32: 441-445. 10.1046/j.1537-2995.1992.32592327718.xCrossRefPubMed
44.
Goodnough LT, Price TH, Friedman KD, Johnston M, Ciavarella D, Khan N, Sacher R, Vogler WR, Wissel M, Abels RI: A phase III trial of recombinant human erythropoietin therapy in nonanemic orthopedic patients subjected to aggressive removal of blood for autologous use: dose, response, toxicity, and efficacy. Transfusion 1994, 34: 66-71. 10.1046/j.1537-2995.1994.34194098608.xCrossRefPubMed
45.
Braga M, Gianotti L, Vignali A, Gentilini O, Servida P, Bordignon C, Di Carlo V: Evaluation of recombinant human erythropoietin to facilitate autologous blood donation before surgery in anaemic patients with cancer of the gastrointestinal tract. Br J Surg 1995, 82: 1637-1640.CrossRefPubMed
46.
Hyllner M, Avall A, Swolin B, Bengtson J-P, Bengtsson A: Autologous blood transfusion in radical hysterectomy with and without erythropoietin therapy. Obstet Gynecol 2002, 99: 757-762. 10.1016/S0029-7844(02)01661-7CrossRefPubMed
47.
Lee J-H, Lee SH, Oh JH: Minimal effective dosage of recombinant human erythropoietin in spinal surgery. Clin Orthop 2003, 413: 71-76.CrossRef
48.
Cogliano J, Kisner D: Bloodless medicine and surgery in the OR and beyond. AORN J 2002, 76: 830. 832–837, 839, 841CrossRefPubMed
49.
Beholz S, Liu J, Thoelke R, Spiess C, Konertz W: Use of desmopressin and erythropoietin in an anaemic Jehovah's Witness patient with severely impaired coagulation capacity undergoing stentless aortic valve replacement. Perfusion 2001, 16: 485-489.CrossRefPubMed
50.
Sarac TP, Clifford C, Waters J, Clair DG, Ouriel K: Preoperative erythropoietin and blood conservation management for thoracoabdominal aneurysm repair in a Jehovah's Witness. J Vasc Surg 2003, 37: 453-455. 10.1067/mva.2003.73CrossRefPubMed
51.
Murphy DP, O'Donnell T, McDonnell J, McElwain JP: Treatment of anaemia in the polytrauma Jehovah's Witness. Ir Med J 2003, 96: 8-10.PubMed
52.
Podesta A, Parodi E, Dottori V, Crivellari R, Passerone GC: Epoetin alpha in elective coronary and valve surgery in Jehovah's Witnesses patients. Experience in 45 patients. Minerva Cardioangiol 2002, 50: 125-131.PubMed
53.
Cothren C, Moore EE, Offner PJ, Haenel JB, Johnson JL: Blood substitute and erythropoietin therapy in a severely injured Jehovah's witness. N Engl J Med 2002, 346: 1097-1098. 10.1056/NEJM200204043461420CrossRefPubMed
Metadaten
Titel
Preoperative recombinant human erythropoietin in anemic surgical patients
verfasst von
Terri G Monk
Publikationsdatum
01.04.2004
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe Sonderheft 2/2004
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc2824

Weitere Artikel der Sonderheft 2/2004

Critical Care 2/2004 Zur Ausgabe

Review

Infectious and immunologic consequences of blood transfusion

Review

Transfusion trigger: when to transfuse?

Review

Intraoperative blood salvage in vascular surgery – worth the effort?

Review

Iron supplementation in the intensive care unit: when, how much, and by what route?

Review

How low is too low? Cardiac risks with anemia

Review

Autologous blood donation

Neu im Fachgebiet AINS

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Hinter dieser Appendizitis steckte ein Erreger

23.04.2024 Appendizitis Nachrichten

Schmerzen im Unterbauch, aber sonst nicht viel, was auf eine Appendizitis hindeutete: Ein junger Mann hatte Glück, dass trotzdem eine Laparoskopie mit Appendektomie durchgeführt und der Wurmfortsatz histologisch untersucht wurde.

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 Leitsymptom Rückenschmerzen Nachrichten

Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Mehr Schaden als Nutzen durch präoperatives Aussetzen von GLP-1-Agonisten?

23.04.2024 Operationsvorbereitung Nachrichten

Derzeit wird empfohlen, eine Therapie mit GLP-1-Rezeptoragonisten präoperativ zu unterbrechen. Eine neue Studie nährt jedoch Zweifel an der Notwendigkeit der Maßnahme.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

hier abonnieren
Bildnachweise