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Critical Care
Erschienen in: Critical Care 5/2005

01.10.2005 | Review

Bench-to-bedside review: Oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shock

verfasst von: Dieter Rixen, John H Siegel

Erschienen in: Critical Care | Ausgabe 5/2005

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Abstract

Evidence is increasing that oxygen debt and its metabolic correlates are important quantifiers of the severity of hemorrhagic and post-traumatic shock and and may serve as useful guides in the treatment of these conditions. The aim of this review is to demonstrate the similarity between experimental oxygen debt in animals and human hemorrhage/post-traumatic conditions, and to examine metabolic oxygen debt correlates, namely base deficit and lactate, as indices of shock severity and adequacy of volume resuscitation. Relevant studies in the medical literature were identified using Medline and Cochrane Library searches. Findings in both experimental animals (dog/pig) and humans suggest that oxygen debt or its metabolic correlates may be more useful quantifiers of hemorrhagic shock than estimates of blood loss, volume replacement, blood pressure, or heart rate. This is evidenced by the oxygen debt/probability of death curves for the animals, and by the consistency of lethal dose (LD)25,50 points for base deficit across all three species. Quantifying human post-traumatic shock based on base deficit and adjusting for Glasgow Coma Scale score, prothrombin time, Injury Severity Score and age is demonstrated to be superior to anatomic injury severity alone or in combination with Trauma and Injury Severity Score. The data examined in this review indicate that estimates of oxygen debt and its metabolic correlates should be included in studies of experimental shock and in the management of patients suffering from hemorrhagic shock.
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Literatur
1.
Siegel JH, Linberg SE, Wiles CE: Therapy of low-flow shock states. In Trauma: Emergency Surgery and Critical Care. Edited by: Siegel JH. Churchill Livingston: New York; 1987:201-284.
2.
Siegel JH: Through a glass darkly: the lung as a window to monitor oxygen consumption, energy metabolism, and severity of critical illness. Clin Chem 1990, 36: 1585-1593.PubMed
3.
American College of Surgeons: Shock. In Advanced Trauma Life Support Manual. American College of Surgeons; 1997:87-108.
4.
Crowell JW, Smith EE: Oxygen deficit and irreversible hemorrhagic shock. Am J Physiol 1964, 206: 313-316.PubMed
5.
Rush BF, Rosenberg JC, Spencer FC: Changes in oxygen consumption in shock. J Surg Res 1965, 5: 252-255.PubMed
6.
Rothe CF: Oxygen deficit in hemorrhagic shock in dogs. Am J Physiol 1968, 214: 436-442.PubMed
7.
Jones CE, Crowell JW, Smith EE: A cause-effect relationship between oxygen deficit and irreversible hemorrhagic shock. Surg Gynecol Obstet 1968, 127: 93-96.PubMed
8.
Neuhof H, Wolf H, Rohtermundt R, Glaser E, Lasch HG: Oxygen consumption of the organism in hemorrhagic shock. Experimental studies [in German]. Z Kardiol 1973, 62: 663-683.PubMed
9.
Dunham CM, Siegel JH, Weireter L, Fabian M, Goodarzi S, Guadalupi P, Gettings L, Linberg SE, Vary TC: Oxygen debt and metabolic acidemia as quantitative predictors of mortality and the severity of the ischemic insult in hemorrhagic shock. Crit Care Med 1991, 19: 231-243.PubMed
10.
Cannon WB: Traumatic Shock. New York: D Appleton Co; 1923.
11.
Blalock A: Acute circulatory failure as exemplified by shock and hemorrhage. Surg Gynec Obstet 1934, 58: 551-566.
12.
Wiggers CJ: The present status of the shock problem. Physiol Rev 1942, 22: 74-123.
13.
Guyton AC: Cardiac output in circulatory shock. In Circulatory Physiology: Cardiac Output and its Regulation. Edited by: Guyton AC. Philadelphia, PA: WB Saunders; 1963:333-351.
14.
Fleischer GR, Templeton J, Delgado-Paredes C: An animal model for the study of hemorrhagic shock from abdominal trauma in children. Pediatr Emerg Care 1987, 3: 18-21.
15.
Bickell WH, Bruttig SP, Wade CE: Hemodynamic response to abdominal aortotomy in the anesthetized swine. Circ Shock 1989, 28: 321-332.PubMed
16.
Vivaldi E, Macinelli S, Günther B: Experimental hemorrhagic shock in dogs: standardization. Res Exp Med (Berl) 1983, 182: 127-137.
17.
Traverso LW, Moore CC, Tillman FJ: A clinically applicable exsanguination shock model in swine. Circ Shock 1984, 12: 1-7.PubMed
18.
Carroll RG, Iams SG, Pryor WH, Allison EJ: Single hemorrhage: a clinically relevant canine model of hemorrhagic shock. Resuscitation 1988, 16: 119-126. 10.1016/0300-9572(88)90076-7PubMed
19.
Hannon JP, Wade CE, Bossone CA, Hunt MM, Loveday JA: Oxygen delivery and demand in conscious pigs subjected to fixed-volume hemorrhage and resuscitated with 7.5% NaCl in 6% Dextran. Circ Shock 1989, 29: 205-217.PubMed
20.
Mittmann U, Schmidt JD, Schmier J, Wirth RH: Hemorrhagic shock with fixed hypotension and with spontaneous recovery of blood pressure: a comparison of two shock models. Basic Res Cardiol 1976, 71: 47-59.PubMed
21.
Schoenberg MH, Smedegard G, Gerdin B, Messmer K, Arfors KE: Hemorrhagic shock in the dog: I. Correlation between survival and severity of shock. Res Exp Med 1985, 185: 21-33.
22.
Schlichting E, Lyberg T: Monitoring of tissue oxygenation in shock: an experimental study in pigs. Crit Care Med 1995, 23: 1703-1710. 10.1097/00003246-199510000-00015PubMed
23.
Beecher HK: Surgery in World War II. The Physiologic Effects of Wounds. Washington, DC: Office of the Surgeon General, Department of the Army; 1952.
24.
Artz CP, Howard JM, Sako A, Bronwell AW, Prentice T: Clinical experiences in the early management of the most severely injuried battle casualties in the Korean war. Ann Surg 1955, 141: 285-301.PubMedCentralPubMed
25.
Shoemaker WC, Czer LSC: Evaluation of the biologic importance of various hemodynamics and oxygen transport variables: which variables should be monitored in postoperative shock? Crit Care Med 1979, 7: 424-431.PubMed
26.
Shoemaker WC, Appel PL, Kram HB, Waxman K, Lee TS: Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest 1988, 94: 1176-1186.PubMed
27.
Bishop MH, Shoemaker WC, Appel PL, Meade P, Ordog GJ, Wasserberger J, Wo CJ, Rimle DA, Kram HB, Umali R, et al.: Prospective, randomized trial of survival values of cardiac index, oxygen delivery, and oxygen consumption as resuscitation end points in severe trauma. J Trauma 1995, 38: 780-787.PubMed
28.
Siegel JH, Cerra FB, Coleman B, Giovannini I, Shetye M, Border JR, McMenamy RH: Physiological and metabolic correlations in human sepsis. Surgery 1979, 86: 163-193.PubMed
29.
Siegel JH, Rivkind AI, Dala S, Goodarzi S: Early physiologic predictors of injury severity and death in blunt multiple trauma. Arch Surg 1990, 125: 498-508.PubMed
30.
Shires GT, Canizaro PC: Fluid resuscitation in the severely injured. Surg Clin North Am 1964, 55: 1341-1389.
31.
Canizaro PC, Prager MD, Shires GT: The infusion of Ringer's lactate solution during shock. Am J Surg 1971, 122: 494-502. 10.1016/0002-9610(71)90474-0PubMed
32.
Roberts I, Alderson P, Bunn F, Chinnock P, Ker K, Schierhout G: Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev 2004, 4: CD000567.PubMed
33.
Bunn F, Roberts I, Tasker R, Akpa E: Hypertonic versus near isotonic crystalloid fluid resuscitation in critically ill patients. Cochrane Database Syst Rev 2004, 3: CD002045.PubMed
34.
Bickell WH, Wall MJ, Pepe PE, Martin RR, Ginger VF, Allen MK, Mattox KL: Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med 1994, 331: 1105-1109. 10.1056/NEJM199410273311701PubMed
35.
Silbergleit R, Satz W, McNamara RM, Lee DC, Schoffstall JM: Effect of permissive hypotension in continuous uncontrolled intra-abdominal hemorrhage. Acad Emerg Med 1996, 3: 922-926.PubMed
36.
Siegel JH: Immediate versus delayed fluid resuscitation in patients with trauma [letter]. N Engl J Med 1995, 332: 681. 10.1056/NEJM199503093321013PubMed
37.
Siegel JH, Fabian M, Smith JA, Kingston EP, Steele KA, Wells MR, Kaplan LJ: Oxygen debt criteria quantify the effectiveness of early partial resuscitation after hypovolemic hemorrhagic shock. J Trauma 2003, 54: 862-880.PubMed
38.
Deitch EA: Animal models of sepsis and shock: a review and lessons learned. Shock 1998, 9: 1-11.PubMed
39.
Porter JM, Ivatury RR: In search of the optimal end points of resuscitation in trauma patients: a review. J Trauma 1998, 44: 908-914.PubMed
40.
Siegel JH, Farrell EJ, Miller M, Goldwyn RM, Friedman HP: Cardiorespiratory interactions as determinants of survival and the need for respiratory support in human shock states. J Trauma 1973, 13: 602-619.PubMed
41.
Davis JW, Shackford SR, Mackersie RC, Hoyt DB: Base deficit as a guide to volume resuscitation. J Trauma 1988, 28: 1464-1467.PubMed
42.
Davis JW, Shackford SR, Holbrook TL: Base deficit as a sensitive indicator of compensated shock and tissue oxygen utilization. Surg Gynecol Obstet 1991, 173: 473-476.PubMed
43.
Siegel JH, Fabian M, Smith JA, Costanino D: Use of recombinant hemoglobin solution in reversing lethal hemorrhagic hypovolemic oxygen debt shock. J Trauma 1997, 42: 199-212.PubMed
44.
Rixen D, Raum M, Holzgraefe B, Sauerland S, Nagelschmidt M, Neugebauer EA, Shock and Trauma Study Group: A pig hemorrhagic shock model: oxygen debt and metabolic acidemia as indicators of severity. Shock 2001, 16: 239-244.PubMed
45.
Cowley RA, Mergner WJ, Fischer RS, Jones RT, Trump BF: The subcellular pathology of shock in trauma patients: studies using the immediate autopsy. Am Surg 1979, 45: 255-269.PubMed
46.
Guan J, Jin DD, Jin LJ, Lu Q: Apoptosis in organs of rats in early stage after polytrauma combined with shock. J Trauma 2002, 52: 104-111.PubMed
47.
Rutherford EJ, Morris JA, Reed GW, Hall KS: Base deficit stratifies mortality and determines therapy. J Trauma 1992, 33: 417-423.PubMed
48.
Botha AJ, Moore FA, Moore EE, Peterson VM, Goode AW: Base deficit after major trauma directly relates to neutrophil CD11b expression: a proposed mechanism of shock-induced organ injury. Intensive Care Med 1997, 23: 504-509. 10.1007/s001340050365PubMed
49.
Rixen D, Raum M, Bouillon B, Lefering R, Neugebauer E, Arbeitsgemeinschaft 'Polytrauma' of the Deutschen Gesellschaft für Unfallchirurgie: Base deficit development and its prognostic significance in posttrauma critical illness: an analysis by the trauma registry of the Deutsche Gesellschaft für Unfallchirurgie. Shock 2001, 15: 83-89.PubMed
50.
Davis JW, Parks SN, Kaups KL, Gladen HE, O'Donnell-Nicol S: Admission base deficit predicts transfusion requirements and risk of complications. J Trauma 1996, 41: 769-774.PubMed
51.
Raum M, Rixen D, Gregor S, Linker R, Holzgräfe B, Neugebauer E: Crystalloids vs. hypertonic saline vs. carbonate/gelatine: volume therapy after hemorrhagic shock – a controlled, randomised experimental study on pigs. Shock 2002, (Suppl):21.
52.
Schultz SC, Powell CC, Bernard E, Malcolm DS: Diaspirin crosslinked hemoglobin (DCLHb) attenuates bacterial translocation. Artif Cells Blood Substit Immobil Biotechnol 1995, 23: 647-664.PubMed
53.
Powell CC, Schultz SC, Malcolm DS: Diaspirin crosslinked hemoglobin (DCLHb): more effective than lactated Ringers solution in restoring central venous oxygen saturation after hemorrhagic shock in rats. Artif Cells Blood Substit Immobil Biotechnol 1996, 24: 197-200.PubMed
54.
DeAngeles DA, Scott AM, McGrath AM, Korent VA, Rodenkirch LA, Conhaim RL, Harms BA: Resuscitation from hemorrhagic shock with diaspirin cross-linked hemoglobin, blood, or starch. J Trauma 1997, 42: 406-412.PubMed
55.
Huckabee WE: Abnormal resting blood lactate. I. The significance of hyperlactatemia in hospitalized patients. Am J Med 1961, 30: 833-839. 10.1016/0002-9343(61)90171-1
56.
Weil MH, Afifi AA: Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure (shock). Circulation 1970, 16: 989-1001.
57.
Harken AH: Lactic acidosis. Surg Gynecol Obstet 1976, 142: 593-606.PubMed
58.
Bakker J, Coffernils M, Leon M, Gris P, Vincent JL: Blood lactate levels are superior to oxygen-derived variables in predicting outcome in septic shock. Chest 1991, 99: 956-962.PubMed
59.
Vary TC, Siegel JH, Rivkind A: Clinical and therapeutic significance of metabolic patterns of lactic acidosis. Perspect Crit Care 1988, 1: 85-132.
60.
Raum M, Rixen D, Linker R, Gregor S, Holzgraefe B, Neugebauer E: Influence of lactate infusion solutions on the plasma lactate concentration. Anasthesiol Intensivmed Notfallmed Schmerzther 2002, 37: 356-358. 10.1055/s-2002-32241PubMed
61.
Abramson D, Scalea TM, Hitchcock R, Trooskin SZ, Henry SM, Greenspan J: Lactate clearance and survival following injury. J Trauma 1993, 35: 584-589.PubMed
62.
Lavery RF, Livingston DH, Tortella BJ, Sambol JT, Slomovitz BM, Siegel JH: The utility of venous lactate to triage injured patients in the trauma center. J Am Coll Surg 2000, 190: 656-994. 10.1016/S1072-7515(00)00271-4PubMed
63.
Abou-Khalil B, Scalea TM, Trooskin SZ, Henry SM, Hitchcock R: Hemodynamic responses to shock in young trauma patients: need for invasive monitoring. Crit Care Med 1994, 22: 633-639.PubMed
64.
Mikulaschek A, Henry SM, Donovan R, Scalea TM: Serum lactate is not predicted by anion gap or base excess after trauma resuscitation. J Trauma 1996, 40: 218-222.PubMed
65.
Kollmorgen DR, Murray KA, Sullivan JJ, Mone MC, Barton RG: Predictors of mortality in pulmonary contusion. Am J Surg 1994, 168: 659-664.PubMed
66.
James JH, Luchette FA, McCarter FD, Fischer JE: Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis. Lancet 1999, 354: 505-508. 10.1016/S0140-6736(98)91132-1PubMed
67.
Mackersie RC, Tiwary AD, Shackford SR, Hoyt DB: Intraabdominal injury following blunt trauma. Identifying the high-risk patient using objective risk factors. Arch Surg 1989, 124: 809-813.PubMed
68.
Davis JW, Mackersie RC, Holbrook TL, Hoyt DB: Base deficit as an indicator of significant abdominal injury. Ann Emerg Med 1991, 20: 842-844.PubMed
69.
Kincaid EH, Chang MC, Letton RW, Chen JG, Meredith JW: Admission base deficit in pediatric trauma: a study using the National Trauma Data Bank. J Trauma 2001, 51: 332-335.PubMed
70.
Randolph LC, Takacs M, Davis KA: Resuscitation in the pediatric trauma population: admission base deficit remains an important prognostic indicator. J Trauma 2002, 53: 838-842.PubMed
71.
Peterson DL, Schinco MA, Kerwin AJ, Griffen MM, Pieper P, Tepas JJ: Evaluation of initial base deficit as a prognosticator of outcome in the pediatric trauma population. Am Surg 2004, 70: 326-328.PubMed
72.
Davis JW, Kaups KL: Base deficit in the elderly: a marker of severe injury and death. J Trauma 1998, 45: 873-877.PubMed
73.
Rixen D, Raum M, Bouillon B, Schlosser LE, Neugebauer E, Arbeitsgemeinschaft Polytrauma der Deutschen Gesellschaft für Unfallchirurgie: Predicting the outcome in severe injuries: an analysis of 2069 patients from the trauma register of the German Society of Traumatology (DGU) [in German]. Unfallchirurg 2001, 104: 230-239. 10.1007/s001130050719PubMed
74.
Boyd CR, Tolson MA, Copes WS: Evaluating trauma care: The TRISS method. J Trauma 1987, 27: 370-378.PubMed
75.
Lemeshow S, Hosmer DW: A review of goodness of fit statistics for use in the development of logistic regression models. Am J Epid 1982, 115: 92-106.
76.
Siegel JH, Rixen D: Clinical and physiologic scoring systems for sepsis and organ dysfunction. In Sepsis and Multiple Organ Dysfunction: A Multidiscipliary Approach. Edited by: Deitch EA, Vincent J-L, Windsor A. New York: WB Saunders; 2002:165-178.
77.
Rixen D, Siegel JH: Metabolic correlates of oxygen debt predict posttrauma early acute respiratory distress syndrome and the related cytokine response. J Trauma 2000, 49: 392-403.PubMed
78.
Rixen D, Raum M, Holzgraefe B, Schäfer U, Hess S, Tenhunen J, Tuomisto L, Neugebauer EA, Shock and Trauma Study Group: Local lactate and histamine changes in small bowel circulation measured by microdialysis in pig hemorrhagic shock. Shock 2002, 18: 355-359. 10.1097/00024382-200210000-00011PubMed
79.
Hartmann M, Montgomery A, Jonsson K, Haglund U: Tissue oxygenation in hemorrhagic shock measured as transcutaneous oxygen tension, subcutaneous oxygen tension, and gastrointestinal intramucosal pH in pigs. Crit Care Med 1991, 19: 205-210.PubMed
80.
Powell CC, Schultz SC, Burris DG, Drucker WR, Malcolm DS: Subcutaneous oxygen tension: a useful adjunct in assessment of perfusion status. Crit Care Med 1995, 23: 867-873. 10.1097/00003246-199505000-00015PubMed
81.
Beerthuizen GIJM, Goris RJA, Kreuzer FJA: Early detection of shock in critically ill patients by skeletal muscle PO 2 assessment. Arch Surg 1989, 124: 853-855.PubMed
82.
Hopf HW, Glass-Heidenreich L, Silva J, Pearce F, Ochsner MG, Rozycki G, Frankel H, Upton R, Champion H, Drucker W, et al.: Subcutaneous tissue oxygen tension in 'well resuscitated' trauma patients. Crit Care Med 1994, 22: A60.
83.
McKinley BA, Parmley CL, Butler BD: Skeletal muscle PO 2 , PCO 2 , and pH in hemorrhage, shock, and resuscitation in dogs. J Trauma 1997, 44: 119-127.
84.
Knudson MM, Lee S, Erickson V, Morabito D, Derugin N, Manley GT: Tissue oxygen monitoring during hemorrhagic shock and resuscitation: a comparison of lactated Ringer's solution, hypertonic saline dextran, and HBOC-201. J Trauma 2003, 54: 242-252.PubMed
85.
Cairns CB, Moore FA, Haenel JB, Gallea BL, Ortner JP, Rose SJ, Moore EE: Evidence for early supply independent mitochondrial dysfunction in patients developing multiple organ failure after trauma. J Trauma 1997, 42: 532-536.PubMed
86.
Slomovitz BM, Lavery RF, Tortella BJ, Siegel JH, Bachl BL, Ciccone A: Validation of a hand-held device in determination of blood lactate in critically injured patients. Crit Care Med 1998, 26: 1523-1528. 10.1097/00003246-199809000-00019PubMed
87.
Gutierrez G, Brown SD: Response of the macrocirculation. In Pathophysiology of Shock, Sepsis and Organ Failure. Edited by: Schlag G, Redl H. New York: Springer-Verlag; 1993:215-229.
88.
Gomersall CD, Joynt GM, Freebaim RC: Resuscitation of critically ill patients based on gastric tonometry: a prospective, randomized controlled trial. Crit Care Med 2000, 28: 607-613. 10.1097/00003246-200003000-00001PubMed
89.
Zander R: Relevance of base excess and lactate concentration on diagnosis and treatment [in German]. Anasthesiol Intensivmed Notfallmed Schmerzther 2002, 37: 343-346. 10.1055/s-2002-32237PubMed
90.
Goodyer AVN: Left ventricular function and tissue hypoxia in irreversible hemorrhagic and endotoxic shock. Am J Physiol 1967, 212: 444-450.PubMed
91.
Reinhart K, Rudolph T, Bredle DL, Cain SM: O 2 uptake in bled dogs after resuscitation with hypertonic saline or hydroxyethylstarch. Am J Physiol 1989, 257: H238-H243.PubMed
92.
Sheffer N, Hirshberg A, Barnea O: Myocardial balance O 2 during fluid resuscitation in uncontrolled hemorrhage: computer model. J Trauma 1997, 42: 647-651.PubMed
93.
Oestern HJ, Trentz O, Kolbow H, Hempelmann G, Trentz OA, Donay F: Predictive value of metabolic profiles in multiple trauma. Chir Forum Exp Klein Forsch 1978, 1: 69-72.
94.
Oestern HJ, Trentz O, Hempelmann G, Trentz OA, Sturm J: Cardiorespiratory and metabolic patterns in multiple trauma patients. Resuscitation 1979, 7: 169-184. 10.1016/0300-9572(79)90024-8PubMed
95.
Brandl M, Pscheidl E, Amann W, Barjasic A, Pasch T: Biochemical and hormonal parameters with multiple trauma. Prog Clin Biol Res 1989, 308: 743-749.PubMed
96.
Woltmann A, Kress HG: The prognostic value of the delayed cutaneous immune reaction following multiple trauma in comparison with other clinical parameters. Anaesthesist 1991, 40: 276-281.PubMed
97.
Nast-Kolb D, Waydhas C, Jochum M, Duswald KH, Machleidt W, Spannagl M, Schramm W, Fritz H, Schweiberer L: Biochemical factors as objective parameters for assessing the prognosis in polytrauma [in German]. Unfallchirurg 1992, 95: 59-66.PubMed
98.
Waydhas C, Nast-Kolb D, Jochum M, Trupka A, Lenk S, Fritz H, Duswald KH, Schweiberer L: Inflammatory mediators, infection, sepsis, and multiple organ failure after severe trauma. Arch Surg 1992, 127: 460-467.PubMed
99.
Roumen RM, Redl H, Schlag G, Sandtner W, Koller W, Goris RJ: Scoring systems and blood lactate concentrations in relation to the development of adult respiratory distress syndrome and multiple organ failure in severely traumatized patients. J Trauma 1993, 35: 349-355.PubMed
100.
Sauaia A, Moore FA, Moore EE, Haenel JB, Read RA, Lezotte DC: Early predictors of postinjury multiple organ failure. Arch Surg 1994, 129: 39-45.PubMed
101.
Dunham CM, Frankenfield D, Belzberg H, Wiles CE, Cushing B, Grant Z: Inflammatory markers: superior predictors of adverse outcome in blunt trauma patients? Crit Care Med 1994, 22: 667-672.PubMed
102.
Scalea TM, Maltz S, Yelon J, Trooskin SZ, Duncan AO, Sclafani SJ: Resuscitation of multiple trauma and head injury: role of crystalloid fluids and inotropes. Crit Care Med 1994, 20: 1610-1615.
103.
Manikis P, Jankowski S, Zhang H, Kahn RJ, Vincent JL: Correlation of serial blood lactate levels to organ failure and mortality after trauma. Am J Emerg Med 1995, 13: 619-622. 10.1016/0735-6757(95)90043-8PubMed
104.
Ivatury RR, Simon RJ, Havriliak D, Garcia C, Greenbarg J, Stahl WM: Gastric mucosal pH and oxygen delivery and oxygen consumption indices in the assessment of adequacy of resuscitation after trauma: a prospective, randomized study. J Trauma 1995, 39: 128-134.PubMed
105.
Regel G, Grotz M, Weltner T, Sturm JA, Tscherne H: Pattern of organ failure following severe trauma. World J Surg 1996, 20: 422-429. 10.1007/s002689900067PubMed
106.
Charpentier C, Audibert G, Dousset B, Weber M, Garric J, Wel-fringer P, Laxenaire MC: Is endotoxin and cytokine release related to a decrease in gastric intramucosal pH after hemorrhagic shock. Intensive Care Med 1997, 23: 1040-1048. 10.1007/s001340050454PubMed
107.
Nast-Kolb D, Waydhas C, Gippner-Steppert C, Schneider I, Trupka A, Ruchholtz S, Zettl R, Schweiberer L, Jochum M: Indicators of the posttraumatic inflammatory response correlate with organ failure in patients with multiple injuries. J Trauma 1997, 42: 446-454.PubMed
108.
Sauaia A, Moore FA, Moore EE, Norris JM, Lezotte DC, Hamman RF: Multiple organ failure can be predicted as early as 12 hours after injury. J Trauma 1998, 45: 291-301.PubMed
109.
Blow O, Magliore L, Claridge JA, Butler K, Young JS: The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma. J Trauma 1999, 47: 964-969.PubMed
110.
Claridge JA, Crabtree TD, Pelletier SJ, Butler K, Sawyer RG, Young JS: Persistent occult hypoperfusion is associated with a significant increase in infection rate and mortality in major trauma patients. J Trauma 2000, 48: 8-14.PubMed
111.
Crowl AC, Young JS, Kahler DM, Claridge JA, Chrzanowski DS, Pomphrey M: Occult hypoperfusion is associated with increased morbidity in patients undergoing early femur fracture fixation. J Trauma 2000, 48: 260-267.PubMed
112.
Ertel W, Keel M, Eid K, Platz A, Trentz O: Control of severe hemorrhage using C-clamp and pelvic packing in multiply injured patients with pelvic ring disruption. J Orthop Trauma 2001, 15: 468-474. 10.1097/00005131-200109000-00002PubMed
113.
Cerovic O, Golubovic V, Spec-Marn A, Kremzar B, Vidmar G: Relationship between injury severity and lactate levels in severely injured patients. Intensive Care Med 2003, 29: 1300-1305. 10.1007/s00134-003-1753-8PubMed
114.
Egger G, Aigner R, Glasner A, Hofer HP, Mitterhammer H, Zelzer S: Blood polymorphonuclear leukocyte migration as a predictive marker for infections in severe trauma: comparison with various inflammation parameters. Intensive Care Med 2004, 30: 331-334. 10.1007/s00134-003-2111-6PubMed
115.
Davis JW, Kaups KL, Parks SN: Base deficit is superior to pH in evaluating clearance of acidosis after traumatic shock. J Trauma 1998, 44: 114-118.PubMed
116.
Krishna G, Sleigh JW, Rahman H: Physiological predictors of death in exsanguinating trauma patients undergoing conventional trauma surgery. Aust N Z J Surg 1998, 68: 826-829. 10.1046/j.1440-1622.1998.01468.xPubMed
117.
Fosse E, Pillgram-Larsen J, Svennevig JL, Nordby C, Skulberg A, Mollnes TE, Abdelnoor M: Complement activation in injured patients occurs immediately and is dependent on the severity of the trauma. Injury 1998, 29: 509-514. 10.1016/S0020-1383(98)00113-2PubMed
118.
Brown GE, Silver GM, Reiff J, Allen RC, Fink MP: Polymorphonuclear neutrophil chemiluminescence in whole blood from blunt trauma patients with multiple injuries. J Trauma 1999, 46: 297-305.PubMed
119.
Eberhard LW, Morabito DJ, Matthay MA, Mackersie RC, Campbell AR, Marks JD, Alonso JA, Pittet JF: Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients. Crit Care Med 2000, 28: 125-131. 10.1097/00003246-200001000-00021PubMed
120.
Harbrecht BG, Doyle HR, Clancy KD, Townsend RN, Billiar TR, Peitzman AB: The impact of liver dysfunction on outcome in patients with multiple injuries. Am Surg 2001, 67: 122-126.PubMed
Metadaten
Titel
Bench-to-bedside review: Oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shock
verfasst von
Dieter Rixen
John H Siegel
Publikationsdatum
01.10.2005
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 5/2005
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc3526

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Crapo JD, Glassroth J, Karlinsky JB and King TE (Eds): Baum’s Textbook of Pulmonary Diseases, 7th edition

Research

Hospital-acquired sinusitis is a common cause of fever of unknown origin in orotracheally intubated critically ill patients

Research

Efficiency of 7.2% hypertonic saline hydroxyethyl starch 200/0.5 versus mannitol 15% in the treatment of increased intracranial pressure in neurosurgical patients – a randomized clinical trial [ISRCTN62699180]

Book report

Fundamentals of Anaesthesia and QBase Anesthesia 6

Commentary

The role of leadership in overcoming staff turnover in critical care

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Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Hinter dieser Appendizitis steckte ein Erreger

23.04.2024 Appendizitis Nachrichten

Schmerzen im Unterbauch, aber sonst nicht viel, was auf eine Appendizitis hindeutete: Ein junger Mann hatte Glück, dass trotzdem eine Laparoskopie mit Appendektomie durchgeführt und der Wurmfortsatz histologisch untersucht wurde.

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 Leitsymptom Rückenschmerzen Nachrichten

Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Mehr Schaden als Nutzen durch präoperatives Aussetzen von GLP-1-Agonisten?

23.04.2024 Operationsvorbereitung Nachrichten

Derzeit wird empfohlen, eine Therapie mit GLP-1-Rezeptoragonisten präoperativ zu unterbrechen. Eine neue Studie nährt jedoch Zweifel an der Notwendigkeit der Maßnahme.

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