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Erschienen in:

01.04.2009 | Commentary

Leukocyte phenotyping to stratify septic shock patients

verfasst von: Jonathan E McDunn, Richard S Hotchkiss

Erschienen in: Critical Care | Ausgabe 2/2009

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Abstract

In a recent study conducted in a cohort of 52 septic patients, Monserrat and coworkers found that profound failure of peripheral T cells to convert from a naïve phenotype to an activated phenotype has positive predictive value in identifying patients who do not recover. These data support the hypothesis that failure of the innate immune system to engage the T-cell compartment contributes to sepsis mortality and provides motivation for the development and clinical evaluation of immunostimulatory therapies for patients with sepsis.

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Lin RY, Astiz ME, Saxon JC, Rackow EC: Altered leukocyte immunophenotypes in septic shock. Studies of HLA-DR, CD11b, CD14, and IL-2R expression. Chest 1993, 104: 847-853. 10.1378/chest.104.3.847CrossRefPubMed

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Titel: Leukocyte phenotyping to stratify septic shock patients
verfasst von: Jonathan E McDunn
Richard S Hotchkiss
Publikationsdatum: 01.04.2009
Verlag: BioMed Central
Erschienen in: Critical Care / Ausgabe 2/2009
Elektronische ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc7748

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Leukocyte phenotyping to stratify septic shock patients

Abstract

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