Background
Methods
Study subjects
Case | Age range (y) | Weight (kg) | Dosage (MBq) | Dosage/Weight (MBq/kg) | Tumor location | Pathologya | TNM classification | Stage |
---|---|---|---|---|---|---|---|---|
1 | 80–89 | 43.3 | 142 | 3.3 | L S3 | Ade | pT1aN0M0 | IA |
2 | 70–79 | 56.5 | 166 | 2.9 | R S6 | SCC | cT3N2M0 | IIIA |
3 | 80–89 | 50.0 | 239 | 4.8 | L S1 + 2 | Ade | cT2aN0M0 | IB |
4 | 60–69 | 46.3 | 162 | 3.5 | L S8 | SCC | pT2aN0M0 | IB |
5 | 80–89 | 52.6 | 283 | 5.4 | R S7 | Ade | pT2aN2M0 | IB |
6 | 60–69 | 63.0 | 164 | 2.6 | R S6 | SCC | pT1aN0M0 | IA |
7 | 70–79 | 48.6 | 146 | 3.0 | R S3 | Ade | pT1bN0M0 | IA |
8 | 70–79 | 46.5 | 144 | 3.1 | R S2 | Ade | pT2aN1M0 | IIA |
9 | 70–79 | 72.4 | 292 | 4.0 | R S5 | SCC | pT1aN0M0 | IA |
10 | 70–79 | 47.4 | 242 | 5.1 | R S1 | Ade | cT4N2M0 | IIIB |
11 | 30–39 | 40.7 | 147 | 3.6 | R S8 | MEDC | pT1bN0M0 | IA |
12 | 70–79 | 45.9 | 294 | 6.4 | L S9 | Ade | pT1bN0M0 | IA |
13 | 50–59 | 50.0 | 239 | 4.8 | R S1 | Ade | pT1aN0M0 | IA |
14 | 60–69 | 65.7 | 276 | 4.2 | L S1 + 2 | SCC | cT4N3M1b | IV |
15 | 50–59 | 60.7 | 294 | 4.8 | L S5 | Ade | pT2aN1M1b | IV |
16 | 60–69 | 52.1 | 243 | 4.7 | R S2 | SCC | cT4N3M0 | IIIB |
17 | 80–89 | 56.2 | 236 | 4.2 | R S2 | Ade | pT1aN0M0 | IA |
18 | 70–79 | 57.4 | 145 | 2.5 | R S7 | LCNEC | pT2aN2M0 | IB |
19 | 70–79 | 78.4 | 242 | 3.1 | L S1 + 2 | SCC | pT1bN0M0 | IA |
20 | 50–59 | 60.6 | 242 | 4.0 | R S1 | Ade | pT1bN2M0 | IIIA |
21 | 60–69 | 67.2 | 243 | 3.6 | L S3 | Ade | pT3N1M0 | IIIA |
22 | 80–89 | 48.5 | 240 | 5.0 | R S10 | Ade | pT2bN0M0 | IIA |
23 | 60–69 | 64.7 | 243 | 3.8 | L S10 | SCC | pT3N0M0 | IIB |
24 | 70–79 | 51.4 | 242 | 4.7 | L S9 | Ade | pT2bN0M0 | IIA |
25 | 60–69 | 54.8 | 292 | 5.3 | R S3 | Ade | pT2aN0M0 | IIA |
26 | 60–69 | 45.9 | 224 | 4.9 | L S1 + 2 | Ade | pT4N0M0 | IIIA |
27 | 80–89 | 62.7 | 242 | 3.9 | L S1 + 2 | SCC | cT3N0M0 | IIB |
28 | 70–79 | 55.4 | 146 | 2.6 | R S4 | Ade | cT2bN1M1b | IV |
29 | 60–69 | 59.4 | 239 | 4.0 | R S2 | Ade | pT2bN0M0 | IIA |
30 | 70–79 | 53.0 | 145 | 2.7 | L S10 | PC | pT2aN1M0 | IIB |
31 | 70–79 | 55.3 | 237 | 4.3 | R S1 | PC | pT1aN0M0 | IA |
32 | 70–79 | 50.7 | 146 | 2.9 | L S4 | Ade | pT1aN3M0 | IIIB |
33 | 60–69 | 68.8 | 274 | 4.0 | R S5 | Ade | cT2aN2M1 | IV |
34 | 60–69 | 57.2 | 245 | 4.3 | R S1 | SCC | cT3N2M0 | IIIA |
35 | 70–79 | 45.6 | 242 | 5.3 | R S1 | Ade | pT1aN0M0 | IA |
36 | 80–89 | 54.6 | 274 | 5.0 | L S1 + 2 | Ade | pT3N1M0 | IIIA |
37 | 70–79 | 46.6 | 146 | 3.1 | R S3 | Ade | pT1aN2M0 | IIIA |
38 | 80–89 | 51.4 | 292 | 5.7 | R S10 | LCNEC | pT2aN0M0 | IIA |
39 | 80–89 | 74.8 | 273 | 3.6 | R S4 | Ade | pT2aN0M0 | IIA |
40 | 60–69 | 51.9 | 166 | 3.2 | R S3 | Ade | cT2aN0M1b | IV |
41 | 70–79 | 40.8 | 164 | 4.0 | R S3 | Ade | pT2aN0M0 | IB |
42 | 50–59 | 45.2 | 166 | 3.7 | L S3 | SCC | cT4N2M0 | IIIB |
43 | 50–59 | 61.4 | 266 | 4.3 | R S7 | PC | pT2aN2M1 | IV |
44 | 50–59 | 72.2 | 290 | 4.0 | L S10 | SCC | cT2bN3M0 | IIIB |
45 | 60–69 | 62.4 | 166 | 2.7 | R S1 | LCNEC | pT2aN0M0 | IIA |
46 | 60–69 | 54.3 | 274 | 5.1 | R S8 | Ade | pT1aN0M0 | IA |
47 | 70–79 | 59.4 | 164 | 2.8 | R S3 | SCC | pT2aN0M0 | IB |
48 | 60–69 | 65.6 | 239 | 3.6 | L S3 | Ade | pT2aN1M0 | IIA |
49 | 70–79 | 61.9 | 292 | 4.7 | R S3 | SCC | pT1bN2M0 | IIIA |
50 | 60–69 | 60.9 | 290 | 4.8 | R S6 | ASCC | pT1aN1M0 | IIA |
Image acquisition and reconstruction
Image processing
Statistical analysis
Results
Reproducibility
Op1Ob1 | Op1Ob2 | Op2Ob1 | Op2Ob2 | ICC intra-operator reproducibility | ICC inter-operator reproducibility | |||||
---|---|---|---|---|---|---|---|---|---|---|
n = 50 | Op1Ob1 vs. Op1Ob2 | Op2Op1 vs. Op2Op2 | Op1Ob1 vs. Op2Ob1 | Op1Ob1 vs. Op2Ob2 | Op1Ob2 vs. Op2Ob1 | Op1Ob2 vs. Op2Ob2 | ||||
SUVmax | 9.1 ± 4.9 | 9.1 ± 4.9 | 9.1 ± 4.9 | 9.1 ± 4.9 | 1 | 1 | 1 | 1 | 1 | 1 |
MTV2.0 | 55.0 ± 100.6 | 54.9 ± 102.5 | 52.8 ± 96.6 | 52.8 ± 96.4 | >0.999 | >0.999 | 0.997 | 0.997 | 0.997 | 0.997 |
MTV2.5 | 39.4 ± 72.1 | 39.3 ± 72.5 | 39.1 ± 70.7 | 38.9 ± 70.4 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 | 0.999 |
MTV3.0 | 29.7 ± 51.7 | 29.7 ± 51.6 | 29.8 ± 51.3 | 29.7 ± 51.1 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 |
MTV3.5 | 23.4 ± 38.2 | 23.4 ± 38.1 | 23.5 ± 38.0 | 23.4 ± 37.8 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 |
MTV35% | 25.0 ± 31.9 | 24.3 ± 31.7 | 23.7 ± 31.5 | 23.7 ± 31.5 | 0.998 | >0.999 | 0.997 | 0.992 | 0.997 | 0.997 |
MTV40% | 19.2 ± 22.9 | 18.9 ± 22.8 | 18.6 ± 22.7 | 18.6 ± 22.7 | 0.998 | >0.999 | 0.998 | 0.996 | 0.998 | 0.998 |
MTV45% | 15.0 ± 17.1 | 14.9 ± 17.1 | 14.8 ± 16.9 | 14.8 ± 16.9 | >0.999 | 1 | >0.999 | 0.999 | >0.999 | >0.999 |
MTVARG | 43.0 ± 62.1 | 43.0 ± 62.1 | 43.0 ± 62.1 | 43.0 ± 62.1 | 1 | 1 | 1 | 1 | 1 | 1 |
TLG2.0 | 225.2 ± 365.2 | 224.9 ± 369.0 | 220.4 ± 354.5 | 220.0 ± 353.5 | >0.999 | >0.999 | 0.999 | 0.999 | 0.999 | 0.999 |
TLG2.5 | 190.4 ± 304.6 | 190.1 ± 305.5 | 189.8 ± 300.1 | 189.2 ± 298.9 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 |
TLG3.0 | 164.0 ± 253.7 | 163.7 ± 253.4 | 164.4 ± 251.8 | 163.8 ± 250.7 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 |
TLG3.5 | 143.6 ± 215.0. | 143.4 ± 214.7 | 144.1 ± 213.7 | 143.6 ± 212.9 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 |
TLG35% | 132.7 ± 179.5 | 131.8 ± 179.7 | 131.4 ± 179.2 | 131.3 ± 179.1 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 |
TLG40% | 112.8 ± 148.3 | 112.3 ± 148.3 | 112.2 ± 147.7 | 112.1 ± 147.7 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 |
TLG45% | 96.2 ± 124.7 | 96.0 ± 124.7 | 96.0 ± 123.9 | 96.0 ± 123.9 | >0.999 | 1 | >0.999 | >0.999 | >0.999 | >0.999 |
TLGARG | 196.4 ± 290.0 | 196.4 ± 290.0 | 196.4 ± 290.0 | 196.4 ± 290.0 | 1 | 1 | 1 | 1 | 1 | 1 |
Op1Ob1 | Op1Ob2 | Op2Ob1 | Op2Ob2 | ICC intra-operator reproducibility | ICC inter-operator reproducibility | |||||
---|---|---|---|---|---|---|---|---|---|---|
n = 50 | Op1Ob1 vs. Op1Ob2 | Op2Op1 vs. Op2Op2 | Op1Ob1 vs. Op2Ob1 | Op1Ob1 vs. Op2Ob2 | Op1Ob2 vs. Op2Ob1 | Op1Ob2 vs. Op2Ob2 | ||||
SUVmax | 11.1 ± 6.0 | 11.1 ± 6.0 | 11.1 ± 6.0 | 11.1 ± 6.0 | 1 | 1 | 1 | 1 | 1 | 1 |
MTV2.0 | 56.2 ± 107.2 | 56.2 ± 107.9 | 54.1 ± 101.0 | 54.7 ± 101.8 | >0.999 | >0.999 | 0.996 | 0.995 | 0.993 | 0.994 |
MTV2.5 | 41.9 ± 79.6 | 41.8 ± 79.3 | 41.6 ± 77.6 | 41.9 ± 78.0 | >0.999 | >0.999 | 0.999 | 0.998 | 0.997 | 0.997 |
MTV3.0 | 33.1 ± 60.9 | 33.0 ± 60.3 | 33.5 ± 60.6 | 33.3 ± 60.3 | >0.999 | >0.999 | >0.999 | 0.998 | 0.998 | 0.998 |
MTV3.5 | 27.3 ± 48.2 | 27.2 ± 47.7 | 27.5 ± 47.8 | 27.7 ± 48.1 | >0.999 | >0.999 | >0.999 | 0.998 | 0.998 | 0.998 |
MTV35% | 21.0 ± 29.0 | 20.9 ± 28.7 | 20.5 ± 28.7 | 20.6 ± 28.8 | >0.999 | >0.999 | 0.998 | 0.997 | 0.996 | 0.997 |
MTV40% | 16.6 ± 21.2 | 16.5 ± 21.0 | 16.4 ± 21.0 | 16.5 ± 21.1 | >0.999 | >0.999 | 0.999 | 0.999 | 0.998 | 0.999 |
MTV45% | 13.2 ± 15.7 | 13.1 ± 15.5 | 13.1 ± 15.5 | 13.1 ± 15.6 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 |
MTVARG | 50.4 ± 76.2 | 50.4 ± 76.2 | 50.4 ± 76.2 | 50.4 ± 76.2 | 1 | 1 | 1 | 1 | 1 | 1 |
TLG2.0 | 259.1 ± 431.3 | 258.6 ± 430.8 | 254.4 ± 414.8 | 256.8 ± 418.8 | >0.999 | >0.999 | 0.998 | 0.997 | 0.996 | 0.997 |
TLG2.5 | 227.2 ± 372.8 | 226.4 ± 370.5 | 226.4 ± 365.4 | 228.2 ± 368.4 | >0.999 | >0.999 | >0.999 | 0.998 | 0.998 | 0.998 |
TLG3.0 | 203.4 ± 325.8 | 202.6 ± 322.9 | 205.4 ± 324.8 | 203.8 ± 322.0 | >0.999 | >0.999 | >0.999 | 0.999 | 0.998 | 0.998 |
TLG3.5 | 184.5 ± 288.8 | 183.8 ± 286.3 | 184.9 ± 285.5 | 186.5 ± 288.3 | >0.999 | >0.999 | >0.999 | 0.999 | 0.998 | 0.999 |
TLG35% | 145.2 ± 206.5 | 144.5 ± 204.8 | 144.3 ± 204.7 | 145.4 ± 206.3 | >0.999 | >0.999 | >0.999 | >0.999 | 0.999 | 0.999 |
TLG40% | 125.8 ± 173.3 | 125.2 ± 171.9 | 125.0 ± 171.2 | 126.0 ± 172.6 | >0.999 | >0.999 | >0.999 | >0.999 | 0.999 | >0.999 |
TLG45% | 108.1 ± 145.3 | 107.6 ± 144.1 | 107.3 ± 143.2 | 108.1 ± 144.3 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 | >0.999 |
TLGARG | 249.4 ± 383.5 | 249.4 ± 383.5 | 249.4 ± 383.5 | 249.4 ± 383.5 | 1 | 1 | 1 | 1 | 1 | 1 |
Parameter changes from the early phase to the delayed phase
Early Phase (E) | Delayed Phase (D) | D/E (mean) | P-value | |
---|---|---|---|---|
n = 50 | ||||
SUVmax | 9.1 ± 4.9 | 11.1 ± 6.0 | 1.22 | <0.0001 |
MTV2.0 | 55.0 ± 100.6 | 56.2 ± 107.2 | 1.02 | NS |
MTV2.5 | 39.4 ± 72.1 | 41.9 ± 79.6 | 1.06 | NS |
MTV3.0 | 29.7 ± 51.7 | 33.1 ± 60.9 | 1.11 | <0.05 |
MTV3.5 | 23.4 ± 38.2 | 27.3 ± 48.2 | 1.17 | <0.05 |
MTV35% | 25.0 ± 31.9 | 21.0 ± 29.0 | 0.84 | <0.001 |
MTV40% | 19.2 ± 22.9 | 16.6 ± 21.2 | 0.86 | <0.001 |
MTV45% | 15.0 ± 17.1 | 13.2 ± 15.7 | 0.88 | <0.001 |
MTVARG | 43.0 ± 62.1 | 50.4 ± 76.2 | 1.17 | <0.05 |
TLG2.0 | 225.2 ± 365.2 | 259.1 ± 431.3 | 1.15 | <0.01 |
TLG2.5 | 190.4 ± 304.6 | 227.2 ± 372.8 | 1.19 | <0.001 |
TLG3.0 | 164.0 ± 253.7 | 203.4 ± 325.8 | 1.24 | <0.001 |
TLG3.5 | 143.6 ± 215.0. | 184.5 ± 288.8 | 1.28 | <0.001 |
TLG35% | 132.7 ± 179.5 | 145.2 ± 206.5 | 1.09 | <0.05 |
TLG40% | 112.8 ± 148.3 | 125.8 ± 173.3 | 1.12 | <0.01 |
TLG45% | 96.2 ± 124.7 | 108.1 ± 145.3 | 1.12 | <0.01 |
TLGARG | 196.4 ± 290.0 | 249.4 ± 383.5 | 1.27 | <0.001 |