Background
Methods
Subjects
Procedures
Anthropometry
Body composition
Metabolic syndrome definition (MS)
Analytical methods
Statistical analysis
Results
Variables | Firts Assessesment | After 6 months | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
All | No MS | MS | No MS | MS | ||||||
n
| 52 | 45 | 7 | 42 | 10 | |||||
Sex (M) n (%) | 39 | 75 | 33 | 73 | 6 | 86 | 31 | 74 | 8 | 80 |
Current age (Y)a
| 12.1 | (7.1, 17.0) | 12.2 | (7.1, 17.0) | 11.1 | (7.1, 17.1) | 12.1 | (7.1, 17.0) | 11.6 | (7.1, 17.1) |
Age at cancer diagnosis (Y)a
| 5.3 | (1.0, 13) | 6 | (0.8, 13.0) | 4 | (2, 11.1) | 6.1 | (2.1, 13.0) | 4.1 | (0.08, 12.1) |
Time since completion of therapy (Y)a
| 4 | (2, 5) | 4 | (2, 5) | 4 | (2, 5) | 4 | (2, 5) | 4 | (2, 5) |
Diagnosis (n %) | ||||||||||
ALL | 26 | 50 | 22 | 48.9 | 4 | 57.1 | 20 | 47.6 | 6 | 60.0 |
Lymphoma | 26 | 50 | 23 | 51.1 | 3 | 42.9 | 22 | 52.4 | 4 | 40.0 |
Pubertal stage (n %) | ||||||||||
1 | 33 | 63.5 | 28 | 62.2 | 5 | 71.4 | 18 | 42.9 | 7 | 70.0 |
≥ 2 | 19 | 36.5 | 17 | 37.8 | 2 | 28.6 | 24 | 57.1 | 3 | 30.0 |
Treatment recived (n %) | 0.0 | |||||||||
Ch | 35 | 67.3 | 31 | 68.9 | 4 | 57.1 | 28 | 66.7 | 7 | 70.0 |
Ch + R | 17 | 32.7 | 14 | 31.1 | 3 | 42.9 | 14 | 33.3 | 3 | 30.0 |
Nutritional Status (n %) | ||||||||||
Normal | 29 | 55.8 | 28 | 62.2 | 1 | 14.3 | 27 | 64.3 | 0 | 0 |
Overweight/Obesity | 20 | 38.4 | 14 | 31.1 | 6 | 85.7 | 13 | 31.0 | 10 | 100 |
Low weight | 3 | 5.8 | 3 | 6.7 | 0 | 0 | 2 | 4.8 | 0 | 0 |
MS Components median (min, max) | ||||||||||
WC (cm) | 70.5 (51.1, 105.7) | 69.9 (51.1, 94.8) | 78.1 (60.4, 105.7)* | 50 (10, 100) | 90 (90, 100)* | |||||
SBP (pc) | 47 (2, 99) | 42.5 (2, 93) | 58 (14, 99) | 16 (1, 70) | 65 (19, 95)* | |||||
DBP (pc) | 76 (15, 99) | 75 (15, 97) | 94 (19, 99)* | 54 (11, 92) | 94 (66, 99)* | |||||
Triglicerydes (mg/dL) | 96.6 (34, 231) | 85 (34, 205) | 182 (117, 231)* | 80 (28, 259) | 169 (104, 264)* | |||||
HDL-C (mg/dL) | 40 (18, 84) | 40 (18, 84) | 40 (18,46) | 45 (20, 80) | 37 (22, 68) | |||||
Glucose (mg/dL) | 89 (74, 116) | 89 (74, 116) | 93 (76, 112) | 93 (77, 105) | 90 (83, 115) | |||||
Others metabolic variables median (min, max) | ||||||||||
Insulin (μU/mL) | 18.9 (4.3, 55) | 18.7 (4.3, 55) | 28.2 (17.5, 50)* | 22.8 (3.4, 56.6) | 31.5 (24.5, 64)* | |||||
HOMA-IR | 4.3 (0.79, 13.9) | 4.2 (0.79, 12.7) | 7.4 (3.3, 13.9)* | 5.2 (0.68, 13.8) | 7.3 (5.2, 15.4)* | |||||
Adiponectin (μg/mL) | 20.3 (1.3, 70) | 23.4 (1.3, 70) | 17.5 (11.7, 25.4) | 20.2 (0.64, 57.3) | 20.3 (8.3, 37.2) | |||||
Adiponectin per Kg fat (μg/mL/kg) | 1.4 (0.07, 8.0) | 1.6 (0.07, 8.0) | 1.0 (0.38, 3.9)* | 1.7 (0.06, 14.3) | 0.90 (0.27, 3.8) | |||||
Leptin (ng/mL) | 10.1 (1.2, 30.9) | 8.0 (1.2, 30.9) | 17.5 (8.5, 28.6)* | 6.5, (1.1, 30.9) | 22 (9.4, 28.2)* | |||||
Leptin (μg/mL/kg) | 0.69 (0.11, 3.9) | 0.69 (0.11, 3.9) | 1.0 (0.35, 3.7) | 0.65 (0.11, 4.8) | 1.0 (0.30, 4.2) | |||||
Leptin to Adiponectin ratio | 0.44 (0.06, 11) | 0.35 (0.06, 11) | 0.98 (0.69, 1.5)* | 0.34 (0.05, 10.4) | 1.1 (0.31, 1.7)* | |||||
Body Fat (%) | 29.9 (8.3, 46.7) | 27.6 (8.3, 44.4) | 38.3 (31.2, 46.7)* | 25.5 (7.2, 45.5) | 39.8 (29.6, 49.3)* | |||||
VCAM (ng/mL) | 925 (425, 1730) | 930 (425, 1730) | 769 (490, 1697) | 753 (377, 2045) | 683.9 (514, 1081) | |||||
ICAM (ng/mL) | 459 (254, 1079) | 468 (254, 1079) | 412 (325, 685) | 456.5 (184, 137) | 404 (199, 631) |
MS | First assessment | After 6 months |
---|---|---|
n
| 52 | 52 |
WCa ≥90 pcb
| 15 (28.8) | 15 (28.8) |
Triglycerides ≥150 mg/dL | 9 (17.3) | 12 (23.1) |
HDL-Cc <40 mg/dL | 22 (42.3) | 22 (42.3) |
High BPd
| 14 (26.9) | 8 (15.4) |
Glucose >100 mg/dL | 4 (7.7) | 9 (17.3) |
No. of MS criteria | ||
0 | 14 (26.9) | 17 (32.7) |
1 criteria | 19 (36.5) | 17 (32.7) |
2 criteria | 12 (23.1) | 8 (15.4) |
3 criteria | 6 (11.5) | 6 (11.5) |
4 criteria | 1 (1.9) | 4 (7.7) |
MS | 7 (13.5) | 10 (19.2) |
Treatment | ||||
---|---|---|---|---|
Chemotherapy n = 32a
| Chemotherapy plus radiotherapy n = 17b
| |||
Variables | Normal | Overweigth/Obese | Normal | Overweigth/Obese |
n: number (%) | 17 | 15 (47) |
12
| 5 (29) |
Sex (M) | 12 | 12 | 9 | 4 |
Current age (Y) | 12.1 (8.1, 17.0) | 12 (7.1, 17.0) | 12.6 (7.1, 16.1) | 12.1 (8.0, 17.1) |
Age at cancer diagnosis (Y) | 6.0 (2.0, 13.0) | 4.0 (2.0, 12.1) | 6.5 (0.08, 12.1) | 7 (1.0, 11.1) |
Time since completion of therapy (Y) | 4.0 (2.0, 5.1) | 4.0 (2.1, 5.1) | 3.1 (3.0, 5.0) | 4.0 (2.0, 5.0) |
Weight (kg) | 46.9 (18.1, 91.2) | 48.9 (26.2, 102.9) | ||
Height (cm) | 148.4 (116.2, 178) | 157.9 (123, 176.1) | ||
Diagnosis : ALL/Lymphoma | 11/6 | 9/6 | 4/8 | 1/4 |
Pubertal stage | ||||
1 | 9 | 13* | 5 | 3 |
≥ 2 | 8 | 2 | 7 | 2 |
MS Components | ||||
WC (pc) | 25 (10, 75) | 90 (50, 100)* | 50 (10, 90) | 90 (75, 100) |
SBP (pc) | 47 (3, 92) | 53 (18, 93) | 17 (2, 65) | 47 (20, 99) |
DBP (pc) | 76 (15, 94) | 82 (57, 99) | 75 (19, 96) | 89 (39, 99) |
Triglicerydes (mg/dL) | 76 (34, 149) | 114 (50, 231) | 72 (35, 164) | 188 (148, 210) |
HDL-C (mg/dL) | 42 (25, 84) | 39.5 (26, 78) | 42 (18, 64) | 43 (18, 48) |
Glucose (mg/dL) | 90 (75.5, 115.7) | 91 (76, 105.7) | 86 (74, 112.5) | 93 (82, 99) |
Others metabolic variables | ||||
Insulin (μU/mL) | 16.3 (9.1, 38.7) | 24.9 (14.2, 35.3)* | 20.5 (4.3, 50) | 36.3 (19, 55) |
HOMA-IR | 3.6 (1.7, 9.5) | 5.5 (2.8, 8.2)* | 4.3 (0.79, 13.9) | 8.3 (4.7, 12.7) |
Adiponectin (μg/mL) | 23 (1.3, 44.3) | 22 (6.8, 70) | 19.1 (11.7, 41.2) | 16 (1.3, 27.6) |
Adiponectin per Kg fat (μg/mL/kg) | 1.5 (0.39, 6.7) | 1.2 (0.28, 4.9) | 1.8 (0.51, 5.1) | 0.75 (0.7, 1.8) |
Leptin ((μg/mL) | 4.4 (2, 13.4) | 18.2 (9.8, 30.9)* | 7.4 (1.2, 19.0) | 17.5 (13.5, 18.5) |
Leptin per Kg fat (μg/mL/kg) | 0.49 (0.11, 3.0) | 1.0 (0.34, 3.7)* | 0.46 (0.16, 3.9) | 0.72 (0.53, 1.31) |
Leptin to Adiponectin ratio | 0.27 (0.08, 2.7) | 0.98 (0.20, 3.0)* | 0.33 (0.06, 0.76) | 0.85 (0.67, 11.0) |
Body Fat (%) | 23.4, (9.9, 36.2) | 38.3 (32.0, 46.7)* | 27.4 (8.3, 38.1) | 37.1 (28.5, 40.2) |
VCAM (ng/mL) | 1058 (561, 1727) | 818 (425, 1730) | 856 (586, 1207) | 989 (490, 1697) |
ICAM (ng/mL) | 459 (254, 661) | 418 (294, 1079) | 500 (265, 952) | 398 (324, 598) |
MS | ||||
Yes/No | 0/17 | 4/11 | 1/11 | 2/3 |
Treatment | ||||
---|---|---|---|---|
Chemotherapya
n = 32 | Chemotherapy plus radiotherapy n =17 | |||
Variables | Normal | Overweigth/Obese | Normal | Overweigth/Obese |
n: number (%) |
18
| 14 (40) | 9 | 8 (47) |
Sex: M | 13 | 11 | 6 | 7 |
Current age (Y) | 12.5 (8.0, 17.1) | 11.6 (8.0, 17.1) | 14.0 (8.4, 17.0) | 13.0 (8.1, 18.0) |
Age at cancer diagnosis (Y) | 6.0 (2, 13) | 4.0 (2, 12) | 6.0 (0.08, 12) | 70 (1.0, 11.1) |
Time since completion of therapy (Y) | 4.0 (2.1, 5.0) | 4.0 (2.1, 5.0) | 3.1 (3.0, 5.0) | 4.0 (2.0, 5.0) |
Δ Body weight (kg) (6 mo - first assessement) | 1.6 (−2.5, 5.3) | 2.0 (−1.2, 5.1) | ||
Δ Height (cm) (6 mo - first assessment) | 2.6 (1.7, 6.0) | 1.0 (0.2, 3.5)* | ||
Diagnosis : ALL/Lymphoma | 11/7 | 9/5 | 3/6 | 2/6 |
Pubertal stage | ||||
1 | 8 | 9 | 3 | 2 |
≥ 2 | 10 | 5 | 6 | 6 |
MS Components | ||||
WC (pc) | 25 (10, 50) | 90 (35, 100)* | 30 (10, 50) | 83 (50, 90)** |
SBP (pc) | 15.5 (0, 55) | 64 (2, 95)* | 13 (1, 38) | 21 (3, 65) |
DBP (pc) | 54 (22, 92) | 87 (13, 99)* | 53 (38, 79) | 71 (39, 85) |
Triglicerydes (mg/dL) | 80 (28, 191) | 124 (66, 264)* | 91 (28, 259) | 105 (56, 218) |
HDL-C (mg/dL) | 47.3 (24.6, 79.5) | 38.5 (21.7, 67.6)* | 46 (32, 56) | 37 (20, 60) |
Glucose (mg/dL) | 93 (76.6, 102) | 97.5 (83.5, 115) | 88.5 (76.6, 100.6) | 92.6 (82.7, 101.2) |
Others metabolic variables | ||||
Insulin (μU/mL) | 25 (8.3, 35.4) | 33.4 (22.8, 64)* | 14.9 (3.4, 43.9) | 28.9 (16.9, 52.3) |
HOMA-IR | 4.8 (1.7, 7.0) | 7.8 (5.2, 15.4)* | 3.4 (0.68, 10.9) | 6.6 (4.0, 11.4) |
Adiponectin (μg/mL) | 21.9 (7.7, 42.1) | 20.2 (6.6, 57.3) | 20.9 (11.6, 28.9) | 15.3 (0.64, 33.0) |
Adiponectin per Kg fat (μg/mL/kg) | 1.7 (0.45, 14.3) | 1.0 (0.27, 4.2) | 1.9 (0.62, 4.2) | 0.78 (0.06, 6.6) |
Leptin ((μg/mL) | 5.2 (1.8, 30.9) | 21 (9.4, 40.7)* | 6.2 (1.6, 25.1) | 9.5 (3.6, 27.6) |
Leptin per Kg fat (μg/mL/kg) | 0.63 (0.13, 2.6) | 1.1 (0.30, 4.4)* | 0.39 (0.11, 4.8) | 0.67 (0.13, 4.2) |
Leptin to Adiponectin ratio | 0.26 (0.05, 1.1) | 1.2 (0.81, 3.5)* | 0.34 (0.11, 1.2) | 0.93 (0.11, 10.4) |
Body Fat (%) | 22 (11.2, 35.7) | 39.8 (33.4, 49.3)* | 23 (10.9, 43.4) | 30.7 (18.7, 37.7) |
VCAM (ng/mL) | 801 (503, 2045) | 818 (514, 1522) | 617 (377, 1166) | 727 (394, 1178) |
ICAM (ng/mL) | 404 (234, 753) | 440 (200. 1124) | 571 (184, 966) | 411 (307, 1037) |
MS | ||||
Yes/No | 0/18 | 7/14 | 0/9 | 3/5 |
Outcome variables | Fat percentage tertile (values)a
| HOMA-IR tertile a
| Adiponectin tertilea
| Leptin tertilea
| Leptin adiponectin ratio tertilea
| |||||
---|---|---|---|---|---|---|---|---|---|---|
2 (24.2–35.0) | 3 (35.1–46.7) | 2 (3.6–5.5) | 3 (5.6–13.9) | 2 (15.3–25.4) | 3 (25.5–44.3) | 2 (4.1–13.4) | 3 (13.5–30.8) | 2 (0.3–0.7) | 3 (0.8–2.9) | |
MS | ||||||||||
Waist circumference (cm) | ||||||||||
Coeficient | 9.5 | 17.7 | 6.2 | 13.8 | −1.9 | −6.2 | 7.6 | 15.7 | 10.0 | 14.6 |
95% CI | 3.4; 16.6 | 11.6; 23.7 | −0.6; 13.1 | 6.9; 20.7 | −10.1; 6.3 | −14.4; 1.9 | 0.6; 14.6 | 8.7; 22.6 | 2.8; 17.1 | 7.4; 21.7 |
P
|
0.033
|
0.000
| 0.075 |
<0.001
| 0.641 | 0.133 |
0.033
|
<0.001
|
0.007
|
<0.001
|
Blood Pressure (mmHg) | ||||||||||
Systolic BP | ||||||||||
Coeficient | 0.2 | 6.2 | 2.3 | 6.2 | −1.4 | −0.3 | 0.4375 | 5.4 | 3.1 | 7.6 |
95% CI | −6.4; 6.9 | −0.5; 12.8 | −4.4; 9.1 | −0.4; 12.8 | −8.3; 5.6 | −7.4; 6.8 | −6.4; 7.3 | −1.4; 12.3 | −3.6; 9.8 | 0.9; 14.3 |
P
| 0.944 | 0.068 | 0.488 | 0.066 | 0.693 | 0.940 | 0.898 | 0.117 | 0.353 |
0.027
|
Diastolic BP | ||||||||||
Coeficient | 1.3 | 6.1 | 1.0 | 3.6 | 2.3 | 1.9 | 1.8 | 5.9 | 2.3 | 5.4 |
95% CI | −4.0; 7.1 | 0.3; 11.8 | −5.0; 6.9 | −2.3; 9.4 | −4.0; 8.5 | −4.4; 8.3 | −4.4; 7.9 | −0.3; 12.0 | −3.9; 8.5 | −0.8; 11.6 |
P
| 0.654 |
0.040
| 0.745 | 0.227 | 0.473 | 0.542 | 0.570 | 0.061 | 0.470 | 0.088 |
Glucose (mg/dL) | ||||||||||
Coeficient | 4.9 | 0.1 | 4.9 | 10.6 | −5.1 | −0.6 | 4.2 | 2.3 | 1.3 | 2.9 |
95% CI | −0.8; 10.6 | −5.6; 4.7 | −0.1; 10.0 | 5.6; 15.7 | −10.9; 0.8 | −6.4; 5.2 | −1.8; 10.1 | −3.6; 8.3 | −4.7; 7.3 | −3.1; 8.9 |
P
| 0.089 | 0.983 | 0.055 |
<0.001
| 0.087 | 0.838 | 0.165 | 0.433 | 0.657 | 0.341 |
Triglycerides (mg/dL) | ||||||||||
Coeficient | 28.4 | 52.3 | 36.6 | 38.8 | 3.7 | −23.1 | 14.2 | 56.7 | 31.7 | 56.4 |
95% CI | −2.9; 59.8 | 20.9; 83.7 | 4.1; 69.0 | 6.3; 71.3 | −30.8; 38.1 | −57.5; 11.4 | −16.7; 45.0 | 25.8; 87.6 | 0.5; 62.9 | 25.2; 87.7 |
P
| 0.075 |
0.002
|
0.028
|
0.020
| 0.832 | 0.184 | 0.360 |
0.001
|
0.046
|
0.001
|
HDL-C (mg/dL) | ||||||||||
Coeficient | −6.0 | −3.0 | −2.3 | −8.2 | −5.1 | 1.9 | −1.1875 | −4.9 | −5.3 | −9.4 |
95% CI | −14.5; 2.6 | −11.6; 5.5 | −10.6; 6.1 | −16.6; 0.1 | −13.2; 3.0 | −6.2; 10.0 | −9.4; 7.0 | −13.1; 3.3 | −13.2; 2.6 | −17.3; −1.5 |
P
| 0.167 | 0.477 | 0.586 | 0.053 | 0.213 | 0.644 | 0.773 | 0.237 | 0.182 |
0.021
|
Adipokines | ||||||||||
Adiponectin (μg/mL) | ||||||||||
Coeficient | −4.6 | 4.3 | 0.3 | −1.1 | 2.0 | 1.9 | - | - | ||
95% CI | −12.9; 3.8 | −4.2; 12.8 | −8.7; 9.3 | −9.9; 7.8 | - | - | −6.9; 10.8 | −6.9; 10.7 | ||
P
| 0.274 | 0.317 | 0.950 | 0.809 | 0.656 | 0.667 | ||||
Adiponectin (μg/mL/Kg) | ||||||||||
Coeficient | −0.7 | −0.5 | −0.5 | −1.7 | −0.5 | −1.0 | - | - | ||
95% CI | −2.1; 0.6 | −1.8; 0.9 | −1.8; 0.7 | −2.9; −0.5 | - | - | −1.9; 0.9 | −2.3; 0.4 | ||
P
| 0.288 | 0.497 | 0.408 |
0.009
| 0.445 | 0.165 | ||||
Leptin (μg/mL) | ||||||||||
Coeficient | 7.3 | 16.0 | 4.3 | 10.0 | 4.9 | 2.0 | - | - | - | |
95% CI | 4.6; 10.0 | 13.2; 18.8 | −0.3; 9.0 | 5.4; 14.6 | -0.3; 10.2 | −3.2; 7.3 | ||||
P
|
<0.001
|
<0.001
| 0.069 |
<0.001
| 0.067 | 0.441 | ||||
Leptin (μg/mL/Kg) | ||||||||||
Coeficient | 0.6 | 1.0 | 0.7 | 0.3 | 0.7 | 0.1 | - | - | - | - |
95% CI | 0.1; 1.2 | 0.4; 1.5 | 0.1; 1.3 | −0.3; 0.9 | 0.1; 1.2 | -0.4; 0.7 | ||||
P
|
0.048
|
0.001
|
0.037
| 0.341 |
0.032
| 0.699 | ||||
Insulin resistance | ||||||||||
Fasting insulin (mμ/mL) | ||||||||||
Coeficient | 13.3 | 10.6 | - | - | −2.2 | −2.3 | 10.6 | 15.0 | 11.2 | 13.1 |
95% CI | 7.0; 19.6 | 4.3; 16.9 | −10.1; 5.6 | −10.1; 5.5 | 4.2; 17.0 | 8.6; 21.4 | 4.6; 17.9 | 6.4; 19.8 | ||
P
|
<0.001
|
0.001
| 0.569 | 0.559 |
0.002
|
<0.001
|
0.001
|
<0.001
| ||
HOMA-IR | ||||||||||
Coeficient | 3.2 | 2.3 | - | - | −0.8 | −0.6 | 2.6 | 3.4 | 2.6 | 3.1 |
95% CI | 1.6; 4.9 | 0.7; 3.9 | −2.8; 1.1 | −2.5; 1.3 | 0.9; 4.3 | 1.7; 5.1 | 0.9; 4.3 | 1.3; 4.8 | ||
P
|
<0.001
|
0.007
| 0.391 | 0.537 |
0.003
|
<0.001
|
0.004
|
0.001
|
Outcome variables | Fat percentage Change tertiles (values) | HOMA-IR Change tertiles (values) | Adiponectin Change tertile (values) | Leptin Change tertile (values) | Leptin adiponectin ratio tertile (values) | |||||
---|---|---|---|---|---|---|---|---|---|---|
Decreased (−5.9 – −0.7) | Increased (1.3–5.6) | Decreased (−7.2–0.2) | Increased (1.8–7.3) | Decreased (−55.6 – −3.2) | Increased (2.1–21.9) | Decreased (−13.4 – −0.4) | Increased (2.7–17.5) | Decreased (−1.1 – −0.01) | Increased (0.1–1.5) | |
MS | ||||||||||
Waist circumference (cm) | ||||||||||
Coeficient | −3.8 | 0.6 | −0.1 | 2.5 | −0.3 | 0.6 | −0.1 | 2.7 | −1.5 | 2.5 |
95% CI | −6.2;-1.4 | −1.7;2.8 | −2.4; 2.3 | 0.1; 4.9 | −2.9; 2.4 | −2.2; 3.3 | −2.6; 2.5 | 0.1; 5.3 | −3.9; 0.9 | 0.1; 5.0 |
P
|
0.003
| 0.623 | 0.950 |
0.041
| 0.850 | 0.668 | 0.963 |
0.041
| 0.218 |
0.042
|
Blood Pressure (mmHg) | ||||||||||
Systolic BP | ||||||||||
Coeficient | 0.1 | −6.8 | 5.1 | 6.7 | −3.5 | −4.0 | −3.5 | −1.7 | −7.3 | −5.4 |
95% CI | −9.2; 9.5 | −15.5;1.9 | −2.8; 13.1 | −1.3; 14.6 | −12.3; 5.3 | −12.8; 4.8 | −12.5; 5.6 | −10.9; 7.5 | −16.1; 1.6 | −14.3; 3.6 |
P
| 0.975 | 0.123 | 0.202 | 0.098 | 0.425 | 0.361 | 0.447 | 0.709 | 0.104 | 0.235 |
Diastolic BP | ||||||||||
Coeficient | −5.6 | −7.7 | 6.1 | 3.6 | −2.9 | 2.2 | −5.1 | −0.2 | −3.4 | −3.5 |
95% CI | −13.9; 2.6 | −15.3;-0.0 | −1.1; 13.3 | −3.5; 10.8 | −10.3; 4.5 | −5.1; 9.6 | −12.6; 2.4 | −7.9; 7.4 | −11.1; 4.2 | −11.3; 4.2 |
P
| 0.175 | 0.049 | 0.093 | 0.312 | 0.433 | 0.542 | 0.180 | 0.955 | 0.375 | 0.366 |
Glucose | ||||||||||
Coeficient | 0.3 | 1.9 | −5.5 | 5.1 | −2.0 | −1.7 | −6.9 | 1.7 | −5.9 | 1.5 |
95% CI | −6.4; 6.9 | −4.4; 8.1 | −10.4; −0.7 | 0.2; 10.0 | −7.9; 4.0 | −7.8; 4.4 | −12.3; -1.5 | −3.7;7.2 | −11.5; 0.4 | −4.1; 7.2 |
P
| 0.936 | 0.549 |
0.027
|
0.043
| 0.509 | 0.568 |
0.013
| 0.529 |
0.037
| 0.590 |
Triglycerides | ||||||||||
Coeficient | −3.8 | −5.4 | −3.6 | 30.0 | 9.4 | 1.7 | −8.9 | 2.9 | −40.7 | −10.8 |
95% CI | −37.7; 30.2 | −37.6; 26.8 | −31.5; 24.3 | 1.7; 58.3 | −22.2; 41.0 | −30.5; 33.8 | −41.1; 23.2 | −29.8; 35.5 | −70.4; −11.1 | −40.9; 19.4 |
P
| 0.823 | 0.738 | 0.797 |
0.038
| 0.551 | 0.918 | 0.579 | 0.861 |
0.008
| 0.476 |
HDL-C | ||||||||||
Coeficient | 0.6 | −1.8 | 2.4 | 3.6 | −8.3 | −0.5 | 1.0 | 3.0 | 2.6 | 0.3 |
95% CI | −7.1; 8.4 | −9.0; 5.4 | −4.2; 9.0 | −3.2; 10.4 | −14.5; −2.1 | −6.9; 5.9 | −6.0; 8.0 | −4.2; 10.2 | −4.4; 9.6 | −6.9; 7.6 |
P
| 0.867 | 0.620 | 0.469 | 0.288 |
0.010
| 0.886 | 0.770 | 0.401 | 0.453 | 0.926 |
Adipokines | ||||||||||
Adiponectin | ||||||||||
Coeficient | 0.1 | −3.9 | 5.8 | 2.5 | - | - | −1.2 | −2.4 | - | - |
95% CI | −4.0; 4.8 | −9.0; 1.3 | 1.3; 10.3 | −2.3; 7.3 | −6.1; 3.8 | −7.4; 2.6 | ||||
P
| 0.980 | 0.138 |
0.013
| 0.298 | 0.639 | 0.332 | ||||
Leptin | ||||||||||
Coeficient | 0.3 | 1.4 | −1.8 | 1.1 | 2.8 | 3.5 | - | - | - | - |
95% CI | −4.3; 4.9 | −2.9; 5.6 | −5.5; 1.9 | −2.8; 5.0 | −0.8; 6.5 | −0.2; 7.1 | ||||
P
| 0.895 | 0.511 | 0.331 | 0.569 | 0.130 | 0.063 | ||||
Insulin resistance | ||||||||||
Fasting insulin (mμ/mL) | ||||||||||
Coeficient | −6.9 | 0.1 | - | - | −1.1 | −6.3 | −4.1 | 2.5 | −7.6 | 2.4 |
95% CI | −12.7; -1.1 | −5.8; 6.0 | −7.8; 5.7 | −13.2; 0.6 | −11.1; 2.9 | −4.6; 9.6 | −14.1; −1.1 | −4.3; 9.0 | ||
P
|
0.020
| 0.978 | 0.753 | 0.072 | 0.241 | 0.480 |
0.023
| 0.476 | ||
HOMA-IR | ||||||||||
Coeficient | 1.8 | 1.7 | - | - | −0.4 | −1.7 | −1.1 | 0.9 | −2.2 | 0.8 |
95% CI | 0.1; 3.4 | 0.1; 3.4 | −2.2; 1.5 | −3.6; 0.2 | −3.1; 0.8 | −1.0; 2.9 | −3.9; -0.4 | −1.0; 2.6 | ||
P
|
0.033
|
0.043
| 0.708 | 0.083 | 0.237 | 0.345 |
0.017
| 0.387 |
Variable | First assessment | After 6 months | ||||
---|---|---|---|---|---|---|
ORa
| 95% IC |
P
| ORa
| 95% IC |
p
| |
Body fat percentage | 5.1 | 1.9; 22.0 |
0.028
| 9.0 | 2.0; 41.1 |
0.004
|
HOMA-IR index | 2.3 | 0.2; 1.4 | 0.137 | 5.5 | 1.6; 19.3 |
0.007
|
Leptin | 4.8 | 1.4; 17.2 |
0.015
| 5.7 | 1.6; 20.2 |
0.007
|
Adiponectin | 0.5 | 0.2; 1.5 | 0.189 | 0.9 | 0.4; 2.0 |
0.728
|
Leptin to adiponectin ratio | 5.2 | 1.2; 22.6 |
0.027
| 9.4 | 2.0; 43.8 |
0.004
|