Recent researches stigmatize that the steady increase in life expectancy in Europe, USA, Canada, Japan and England will allow many of the children born in 2000 to reach 100 years of life [
1]. In this perspective, the main objective of the geriatrician is to analyze risk factors for diseases and conditions that can lead to functional limitations for the elderly, in order to avoid people to reach a disability state. In summary, the increase in life expectancy must coincide with an expectation of health, good health and self-sufficiency for the last part of life [
2]. Old age is a situation in which a number of factors (molecular, cellular, physiological, immunological and psycho-social events) help to set up a scenario of “exhaustion of reserves”; this consist of a inability to functional adaptations and an accumulation of deficits of many organs [
3]. This situation undergoes a dynamic process that oscillates between a “successful” and pathological aging, which establishes a situation of vulnerability that is identified with the fragility state. Undoubtedly, to the fragility state contribute the same factors that have contributed to the increased life expectancy, which is attested at the moment at 80 years of age [
4]. Many factors have allowed this “stretching”, i.e. the decrease of infant mortality, antibiotic therapy and prevention of cardiovascular and metabolic diseases, but also, especially in industrialized countries, the improvement of hygienic and nutrition conditions [
5]. However, if aging is not accompanied by a healthy condition, the costs related to disabilities or frailty age-related could lead to the overgrowth of the public health expense with a negative impact on social welfare.