Background
Methods
Study population
4D Flow CMR protocol
3D vortex core identification using the Lambda2-method
Vortex core analysis workflow
3D quantitative characterization of diastolic vortex ring core
Intra and interobserver reproducibility
Vortex-Mitral flow association
Statistical analysis
Results
Subject characteristics
21 subjects | Subject A | Subject B | Subject C | Total | |
---|---|---|---|---|---|
age (years) | 21±10 | 10 | 9 | 13 | 20±10 |
male/female | 8/13 | female | male | female | 9/15 |
heart rate (bpm) | 69±11 | 90 | 107 | 91 | 73±14 |
diastasis duration (ms) | 108±73 | 22 | 0 | 0 | 95±77 |
E/A ratio | 2.6±0.8 | 2.3 | 1.83 | 1.95 | 2.5±0.7 |
Characterization of 3D LV vortex ring cores
3D Quantification of LV vortex ring core parameters
C (clockwise) in degrees | L | R | Vortex Orientation in degrees | Vortex CI | |
---|---|---|---|---|---|
E-vortex ring
| 89°±23° | 0.19±0.04 | 0.27±0.07 | 71° ± 9° | 0.79±0.09 |
A-vortex ring*
| 100°±23° | 0.15±0.05 | 0.20±0.09 | 74° ± 4° | 0.57±0.06 |
Statistical Significant
| No | p=0.001 | p=0.048 | No | p<0.001 |
Inter and intra-observer variation
C | L | R | Vortex Orientation | |
---|---|---|---|---|
Intraclass correlation (absolute agreement)
| 0.940 (p<0.001) | 0.976 (p<0.001) | 0.964 (p<0.001) | 0.985 (p<0.001) |
Mean difference
| 0.8 | 0.002 | 0.003 | 0.286 |
Confidence interval difference
| −2.4;4.0 | −0.003;0.006 | −0.006;0.013 | −0.239;0.811 |
p value difference
| 0.62 | 0.42 | 0.49 | 0.28 |
Mean relative unsigned difference
| 7% | 4% | 6% | 1.5% |
Coefficient of variance
| 11% | 9% | 13% | 3% |
C | L | R | Vortex Orientation | |
---|---|---|---|---|
Intraclass correlation (absolute agreement)
| 0.980 (p < 0.000) | 0.985 (p < 0.000) | 0.988 (p < 0.000) | 0.971 (p < 0.000) |
Mean difference
| 1.7 | 0.000 | 0.001 | 0.46444 |
Confidence interval difference
| −0.1;3.6 | −0.003;0.003 | −0.004;0.007 | −0.279;1.208 |
p value difference
| 0.07 | 0.90 | 0.58 | 0.21 |
Mean relative unsigned difference
| 3% | 2% | 3% | 1% |
Coefficient of variance
| 7% | 7% | 7% | 3% |