Open Access
01.07.2009 | Healthcare Policy and Outcomes
Centralization of Esophageal Cancer Surgery: Does It Improve Clinical Outcome?
verfasst von:
M. W. J. M. Wouters, MD, H. E. Karim-Kos, PhD, S. le Cessie, PhD, B. P. L. Wijnhoven, MD, PhD, L. P. S. Stassen, MD, PhD, W. H. Steup, MD, PhD, H. W. Tilanus, MD, PhD, R. A. E. M. Tollenaar, MD, PhD
The volume–outcome relationship for complex surgical procedures has been extensively studied. Most studies are based on administrative data and use in-hospital mortality as the sole outcome measure. It is still unknown if concentration of these procedures leads to improvement of clinical outcome. The aim of our study was to audit the process and effect of centralizing oesophageal resections for cancer by using detailed clinical data.
Methods
From January 1990 until December 2004, 555 esophagectomies for cancer were performed in 11 hospitals in the region of the Comprehensive Cancer Center West (CCCW); 342 patients were operated on before and 213 patients after the introduction of a centralization project. In this project patients were referred to the hospitals which showed superior outcomes in a regional audit. In this audit patient, tumor, and operative details as well as clinical outcome were compared between hospitals. The outcome of both cohorts, patients operated on before and after the start of the project, were evaluated.
Results
Despite the more severe comorbidity of the patient group, outcome improved after centralizing esophageal resections. Along with a reduction in postoperative morbidity and length of stay, mortality fell from 12% to 4% and survival improved significantly (P = 0.001). The hospitals with the highest procedural volume showed the biggest improvement in outcome.
Conclusion
Volume is an important determinant of quality of care in esophageal cancer surgery. Referral of patients with esophageal cancer to surgical units with adequate experience and superior outcomes (outcome-based referral) improves quality of care.
The number of publications that report on the relationship between the volume of high-risk surgical procedures and patient outcome continues to grow.1 Most studies show better outcome with increasing number of operations performed by a specialized center or surgeon. However, there is still a debate about the level of evidence of these studies and the appropriateness of minimum volume thresholds for high-risk surgical procedures.2‐4 For example, there are no randomized controlled trials that have compared outcome for complex surgical procedures between high- and low-volume hospitals. Despite this apparent lack of evidence, authors claim that many surgical deaths could be saved by centralizing these high-risk procedures.5 However, studies that have analyzed the actual effect of centralization (or regionalization) on hospital volumes and outcomes are rare.6
It has been widely acknowledged that esophagectomy for cancer is a complex surgical procedure and that concentration in high-volume centers could lead to improved outcome.7,8 However, translation of the conclusions of observational series to clinical practice is difficult. Cutoff values between high- and low-volume esophageal surgery vary greatly between studies. In The Netherlands, van Lanschot et al. investigated the volume–mortality relationship for esophageal resections, analyzing data from the Dutch National Medical Registry.9 The results of their study where in favour of patients treated in the high volume hospitals in our country, suggesting that referring patients to hospitals with higher case-volumes could reduce postoperative mortality. The purpose of our study was to analyze whether centralization of esophageal cancer surgery truly improves clinical outcome. Besides mortality, we were also interested in a more extensive set of outcome measures, including overall survival. As case mix has also been shown to be an important predictor for treatment outcomes, we included detailed clinical data of individual patient and tumor characteristics.10
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Patients and Methods
Comprehensive Cancer Center Leiden
Eleven hospitals in the mid-western part of The Netherlands are affiliated to the Comprehensive Cancer Center West (CCCW). In this urbanized area travelling distances between hospitals are not more than 45 km (30 miles). In 1997, a Professional Network of Surgical Oncologists (PNSO) involving all affiliated hospitals was established, with the objective of improving the effectiveness and efficiency of surgical care for patients with cancer. In the light of the increasing number of reports on a volume–outcome relationship for esophagectomies, the network decided to evaluate surgical care for patients with esophageal cancer treated in the CCCW region since the year 1990.
Retrospective Registration
All surgically treated esophageal carcinomas from 1990 to 1999 were identified through the cancer registry of the CCCW, in which all cancer patients diagnosed and treated in the mid-western part of The Netherlands (1.7 million inhabitants) are registered. All 11 hospitals formally gave their consent to participate in this audit and were subsequently visited by two investigators who retrieved the original patient files. Patient demographics, pathological notes, data on surgical and (neo)adjuvant treatments, comorbidity as well as postoperative morbidity, mortality, length of stay, and survival were extracted from the patients’ files. Pathological notes were reviewed in detail by two independent researchers and all cancers were staged according to the tumor–node–metastasis (TNM) staging system of the International Union against Cancer (UICC) 1997. The obtained pTNM stages were then cross-checked with the tumor stages in the cancer registry. Discrepancies in tumor stage were discussed between the researchers and a trained data manager from the CCCW/cancer registry database. If consensus could not be reached, the tumor stage was classified as “unknown.”
Intervention
In January 2000 the results of this retrospective analysis were presented at the PNSO meeting.10 Differences in volume and outcome between hospitals were discussed and all surgeons agreed to participate in a prospective registration. Also, all surgeons agreed upon the scenario of having to refer esophageal cancer patients to centers with a better outcome if their own results proved to be unfavorable (outcome-based referral). These referrals were on a voluntary basis, however, for both the patient and surgeon.
Prospective Registration
From January 2000 until December 2004 the same data were prospectively collected from the original patient files, and again all affiliated hospitals took part in this exercise. Completeness of the data was cross-checked with the independently collected information from the cancer registry. Each year, interim results were presented and discussed within the group of surgeons at the meeting of the PNSO.
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Control Group
To put the data of the CCCW in national perspective, we compared the outcome of the CCCW region with the results of the nearest referral center for esophagectomy outside the CCCW region. In this high-volume university hospital, information of patients operated on for an esophageal carcinoma is prospectively collected from original patient files by a data manager.
Statistics
Differences in patient, tumor, and treatment characteristics, as well as in outcome measurements were assessed using the Kruskal–Wallis test for continuous variables and the chi-square test for categorical variables. Patients with an “unknown” status for a given variable were excluded for the analyses. Duration of survival was calculated as the difference between date of surgery and either date of death or date of last patient contact. To prevent the problem of differential follow-up, for all groups follow-up was cut-off at 2 years after surgery. Observed survival rates were estimated by using the Kaplan–Meier method. The log-rank test was used to assess differences in survival between patients who were operated in different time periods and in low- versus high-volume hospitals. The Cox proportional hazard model was used to calculate hazard ratios, adjusting for possible confounding variables. All analyses were conducted using SPSS software (version 12.0; SPSS Inc., Chicago, IL).
Results
Hospital Volume
Between 1990 and 2004, evaluation and treatment of patients with esophageal cancer was performed in 11 hospitals in the region of the CCCW (one university hospital, five teaching hospitals, and five general hospitals). In 555 consecutive patients, an esophageal tumor was resected with curative intent. Figure 1a illustrates the distribution of surgical procedures within the studied time period for the 11 hospitals, and Fig. 1b shows the resection rates for esophageal carcinomas diagnosed in the CCCW region in three different time periods.
Fig. 1
a Number of esophageal resections in hospitals in region of CCCW per 5-year period (1990–1994, 1995–1999, 2000–2004). *Hospitals that abandoned esophageal resections during 2000–2004 period. Hospital 4 abandoned esophageal resections after 1st January 2005. b Resection rates of newly diagnosed patients with esophagus carcinoma in hospitals in CCCW region per 5-year period (1990–1994, 1995–1999, 2000–2004)
×
From 1990 to 1999, none of the hospitals performed more than seven esophageal resections per year (low-volume hospitals; LVH). From the year 2000 onwards, a gradual concentration of esophageal resections occurred, and in two hospitals (I and II) procedural volumes increased to more than ten resections per year (high-volume hospitals; HVH). In the same period of time, a mean annual number of 56 esophageal resections was performed in the nearest high-volume center.
Patient, Tumor, and Treatment Characteristics
Table 1 shows the patient, tumor, and procedural characteristics of esophageal resections performed in three consecutive time periods. There was no significant difference in age, gender, histological type or location of the tumors. However, the number of patients with comorbidities increased during the study period. Stage I tumors were more frequently seen in the later time periods, and an increasing number of transhiatal resections were performed. The number of nodes evaluated by the pathologist changed in time, with a mean number of 6.3, 7.5, and 13.5 nodes reported for the different time periods. In the 2000–2004 time period more neoadjuvant chemotherapy was used, especially in patients with a tumor in the lower esophagus, included in a trial on perioperative epirubicin, cisplatin, and fluorouracil (ECF).11
Table 1
Characteristics of patients who underwent esophageal resection by period of surgery
Characteristics
1990–1994
1995–1999
2000–2004
P value
No. of patients
%
No. of patients
%
No. of patients
%
Age (years)
0.19
Median
66
65
64
Range
37–87
33–85
33–86
Gender
0.70
Male
109
70.8
139
74.3
159
74.3
Female
45
29.2
48
25.7
55
25.7
Comorbidity
0.25a,b
No
68
44.2
74
39.6
83
38.8
1 organ system
51
33.1
61
32.6
85
39.7
2 organ systems
19
12.3
30
16.0
41
19.2
≥3 organ systems
4
2.6
7
3.7
4
1.9
Unknown
12
7.8
15
8.0
1
0.5
Histology
0.93a,c
Adenocarc.
107
69.5
130
69.5
144
67.3
Squamous carc.
45
29.2
51
27.3
52
24.5
Barrett’s dysplasia
1
0.6
3
1.6
6
2.8
Others
–
–
2
1.1
5
2.3
Unknown
1
0.6
1
0.5
7
3.3
Tumor localization
0.97a,d
Cervical esoph.
4
2.6
3
1.6
4
1.9
Mid esoph.
23
14.9
30
16.0
32
15.0
Distal esoph./GE junction
127
82.5
152
81.3
177
82.7
Unknown
–
–
2
1.1
1
0.5
Stage (pTNM)
0.65a
0
2
1.3
5
2.7
6
2.8
I
10
6.5
26
13.9
31
14.5
II
80
51.9
80
42.8
82
38.3
III
52
33.8
60
32.1
74
34.6
IV
9
5.8
12
6.4
15
7.0
Unknown
1
0.6
4
2.1
6
2.8
Neoadjuvant treatment
<0.001a,e
No
150
97.4
165
88.2
160
74.8
Chemo ± radiotherapy
2
1.3
19
10.1
54
25.2
Unknown
2
1.3
3
1.6
–
–
Surgical approach
<0.001a,f
Abdomino-cervical
53
34.4
97
51.9
156
72.9
Thoraco-abdominal
62
40.3
34
18.2
11
5.9
Abd-thor-cervical
16
10.4
27
14.4
27
12.6
Abdominal
23
14.9
29
15.5
15
7.0
Unknown
–
–
–
–
5
2.3
Anastomoses
<0.001g
Cervical
69
44.8
126
67.4
187
87.4
Thoracic
60
39.0
30
16.0
12
5.6
Abdominal
25
16.2
31
16.6
15
7.0
Total no. of patients
154
187
214
GE gastro-esophageal
a“Unknown” category was excluded
bLinear trend analysis
cSquamous versus adenocarcinoma plus Barrett’s dysplasia
dDistal esophagus/GE-junction versus others
eNo neoadjuvant therapy versus others
fAbdomino-cervical versus others
gCervical versus thoracic plus abdominal
Outcome
The outcome of esophagectomies in the CCCW region improved with time (Table 2). The percentage of patients with a microscopic radical resection (R0) improved from 69% to 73%. The number of patients who left the hospital without adverse events was highest in the 2000–2004 period. Hospital stay was shortened significantly and in-hospital mortality was reduced almost threefold. As shown in Fig. 2, significantly better 2-year survival is seen for the last time period (P = 0.001). After exclusion of in-hospital mortality, this difference is still significant (P = 0.045).
Table 2
Outcome after esophageal resections in region of CCCW (1990–1994, 1995–1999, 2000–2004)
Outcome
1990–1994
1995–1999
2000–2004
P value
No. of patients
%
No. of patients
%
No. of patients
%
Margins
0.57a,c
R0
107
69.5
140
74.9
156
72.9
R1
34
22.1
21
11.2
39
18.2
R2
10
6.5
25
13.4
12
5.6
Unknown
3
1.9
1
0.5
7
3.3
Complications
0.20a
No
43
27.9
46
24.6
70
32.7
Yes
106
68.8
140
74.9
143
66.8
Unknown
5
3.2
1
0.5
1
0.5
Reintervention
0.27a,d
None
115
74.4
155
82.9
163
76.2
1
27
17.5
21
11.2
32
15.0
2
5
3.2
7
3.7
12
5.6
≥3
2
1.3
3
1.6
3
1.4
Unknown
5
3.2
1
0.5
4
1.9
Hospital stay (days)b
0.002
Median
20
21
17
Range
(9–92)
(9–125)
(8–273)
In-hospital mortality
0.003a
No
131
85.1
160
85.6
204
95.3
Yes
22
14.3
23
12.3
10
4.7
Unknown
1
0.6
4
2.1
–
–
Total no. of patients
154
187
214
a“Unknown” category excluded
bPatients who died during hospital stay were not included
cR0 versus R1 plus R2
dNo reintervention versus others
Fig. 2
Two-year survival after resection for all stages of esophageal carcinoma in three time periods (p1: 1990–1994, p2: 1995–1999, p3: 2000–2004), including hospital mortality
×
Table 3 shows the results of a multivariate analysis for the risk of dying after surgery in the three time periods with adjustments for the impact of the covariates: stage, comorbidity, surgical approach, and neoadjuvant treatments. Somewhat higher stages of the disease and more patients with multiple comorbidities were operated in the last time period. Although there are significant differences in surgical approach and the use of neoadjuvant chemotherapy between time periods, the survival benefit in the 2000–2004 period remains significant in multivariate analysis [hazard ratio (HR) 0.61]. An analysis of the data after exclusion of patients who received (neo)adjuvant treatment showed similar improvements in mortality rates and survival after 2000. Also, a multivariate analysis was performed after exclusion of the patients who died during hospital stay (Table 4). Improvements in survival stayed (borderline) significant after adjustments for differences in stage, age, gender, and comorbidities (P = 0.05), but after introducing surgical approach in the model, significance was lost (P = 0.25).
Table 3
Cox multivariate model adjusted for the impact of covariates on the risk of dying (HR) for patients who underwent esophageal resection for cancer by period of surgery
HR
95% CI
Univariate
1990–1994
1.00
1995–1999
0.89
0.69–1.14
2000–2004
0.66
0.50–0.86
Adjusted for stagea and comorbiditya
1990–1994
1.00
1995–1999
0.82
0.61–1.11
2000–2004
0.57
0.42–0.77
Adjusted for stagea, comorbiditya, and surgical approacha
1990–1994
1.00
1995–1999
0.85
0.62–1.15
2000–2004
0.60
0.43–0.84
Adjusted for stagea, comorbiditya, surgical approacha, and neoadjuvant treatmenta
1990–1994
1.00
1995–1999
0.85
0.63–1.16
2000–2004
0.61
0.44–0.86
HR hazard ratio, CI confidence interval
a“Unknown” categories excluded
Table 4
Cox multivariate model adjusted for the impact of covariates on the risk of dying (HR) for patients who underwent esophageal resection by period of surgery (patients who died in-hospital excluded)
HR
95% CI
Univariate
1990–1994
1.00
1995–1999
0.87
0.64–1.20
2000–2004
0.66
0.48–0.91
Adjusted for stagea
1990–1994
1.00
1995–1999
0.90
0.65–1.24
2000–2004
0.67
0.48–0.93
Adjusted for stagea, age, and gender
1990–1994
1.00
1995–1999
0.88
0.64–1.22
2000–2004
0.67
0.48–0.93
Adjusted for stagea, age, gender, and comorbiditya
1990–1994
1.00
1995–1999
0.88
0.64–1.22
2000–2004
0.67
0.48–0.93
Adjusted for stagea, age, gender, comorbiditya, and surgical approach
1990–1994
1.00
1995–1999
0.92
0.66–1.29
2000–2004
0.75
0.52–1.07
HR hazard ratio, CI confidence interval
a“Unknown” categories were excluded
In Table 5 patient, tumor, and treatment characteristics of patients operated on in hospitals with fewer than ten resections a year (low-volume hospitals LVH) and with more than nine resections a year (high-volume hospitals HVH) are shown. Only patients operated in a year in which the procedural volume of the hospital concerned exceeded nine resections were included in the HVH group. In this group more patients with more comorbidity were operated, and the transhiatal approach was used more often than the transthoracic approach. Significantly more adverse events occurred in the LVH group, with a mortality rate of 6.3% in the LVH group and 2.9% in the HVH group (Table 6). After exclusion of the patients who died in hospital, median hospital stay was 8 days shorter in the HVH group. Survival analysis did not show a difference in 2-year survival between the LVH and HVH group (P = 0.63).
Table 5
Characteristics of patients who underwent esophageal resection by hospital volume in the 2000–2004 time period
aPatients who died during hospital stay were not included
b“Unknown” category excluded
cR0 versus R1 plus R2
dNo reintervention versus others
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Discussion
In the last decade, many studies have been published that have addressed the volume–outcome relationship for complex surgical procedures.1,12 The results of these studies focus on the rather high difference in mortality rates between high- and low-volume providers for esophageal resections for cancer.7 As a consequence, these authors speculate that concentration of these high-risk surgical procedures in centers with adequate experience could avoid thousands of preventable deaths.5,13 However, the present study is the first that shows an actual improvement in outcome after the process of centralization of esophageal resections for cancer.
Chowdhury et al. reviewed 163 studies that looked at the volume–outcome relationship for complex surgical procedures.1 Seventy-three percent of these studies showed significant better outcomes in high-volume hospitals and for high-volume surgeons. However, most studies are registry-based and omit important case-mix adjustments from clinical data. Moreover, hospital mortality is often presented as the sole outcome measure, without presenting other dimensions of quality of care. Therefore, there is solid criticism on the methodological issues, which hampers centralization initiatives for complex surgical procedures, especially in The Netherlands. Despite the expected benefits of centralizing complex surgical procedures at high-volume providers, there are few studies that show an actual improvement in clinical outcome after centralization of a specific procedure.14 As a part of a broader initiative, the Leapfrog Group, a large coalition of private and public purchasers of health insurance in the USA, has been referring their patients to high-volume providers of esophagectomies since 2000. Although expectations about the beneficial effects of this intervention were high, no results have been published yet.5,13
Our study adds clinical proof to the effectiveness of concentrating complex surgical procedures: not only was hospital mortality reduced to a third of the original value, but also other outcome indicators, such as the number and severity of adverse events, showed improvement after centralization of esophagectomies in the CCCW region in The Netherlands. This was also reflected in a lower number of reinterventions and shorter length of stay. Remarkable is the significant improvement in survival that is already demonstrated after a limited concentration of esophageal resections (Fig. 2). In our opinion, overall survival, adjusted for differences in tumor stages, should be the most important performance indicator in surgical oncology, being even more valuable than operative mortality.
In an earlier article from our group we showed that case mix is an important determinant of outcome and should be part of every study comparing outcome between providers.10 Therefore, we tried to study the effect of differences in case mix between the hospitals. The identification of more patients with multiple comorbid diseases and more patients with stage IV disease in the last time period (Table 1) supports our conclusion that outcome improved with centralization of esophageal resections.
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However, our study has several limitations. First, the accuracy of the registry database should be confirmed. This was done by comparing the results with the data of the independently retrieved information in the cancer registry of the CCCW. Only 3% of the patients operated on for esophageal cancer in our region were missing from our prospective database. The treatment and outcome characteristics of this small group of patients did not differ significantly from those of the original group. An earlier report on a detailed medical audit confirms the accuracy of clinical outcomes databases on major fields such as operative mortality, major complications, and significant factors in risk stratification.15
Secondly, our dataset is still limited, though more (co)variables were included than in most volume–outcome studies. In contrast to the available data on case-mix variations, no information on structural changes in perioperative care was available. To our knowledge no important improvements in the treatment of esophageal cancer are known from the literature, nor within the region of the CCCW. Nevertheless, progress in anesthesiological techniques and postoperative care within the study period could have interfered with our findings. In addition, limited data were available on the survival of patients in the later time period (2-year survival). This could be insufficient to evaluate differences in disease control obtained by transthoracic and transhiatal procedures. Recently, the 5-year survival data of the Dutch randomized controlled trial comparing these surgical approaches were published.16 No survival benefit was shown for either approach. Nevertheless, after introducing surgical approach in our multivariate analyses (Table 4), the statistical difference in survival between the time periods was lost, suggesting an important role for the choice of operative approach. In our opinion, the choice for a transhiatal or transthoracic procedure is made in a decision-making process in which careful interpretation of diagnostic images and surgical experience are combined. The increase in hospital volumes, as a result of the concentration of esophagectomies in our study, might have led to better surgical decision-making, especially in the choice of operative approaches.
The beneficial effects of the centralization process conducted in the last time period are further supported by the comparison of outcome between LVHs and the hospitals that acquired the status of HVH (≥10 resections/year) in the last time period (Table 6). Although differences in operative mortality are not significant, they strongly suggest that the most important improvement in outcome is made in the HVHs, which now parallel the outcome in the nearest high-volume referral center (data not shown). Differences in case mix, especially comorbidities, are also in favor of the HVHs (Table 5). Continuation of the centralization process and the outcome registration in our region will elucidate the mechanisms behind these improvements in patient outcome. From 1st January 2005 esophagus resections in the region of the CCCW are concentrated in three hospitals with mean annual volume of more than 15 esophagus resections.
Finally, the feedback we gave to individual surgeons and hospital organizations on their performance (mirror information) could in itself have influenced practice patterns and dedication of the professionals. When outcomes data are used for internal peer review within institutions, changes in the process of care can be initiated by surgeons or hospitals themselves. A good example is the Veterans Affairs National Surgical Quality Improvement Program (NSQIP) in which feedback to providers and managers led to a decrease in the relative risk for postoperative mortality of 27% and a 45% decrease in postoperative morbidity.17 However, this program was more detailed, consisting of outcome-based annual reports, periodic assessment of performance, self-assessment tools, structured site visits, and dissemination of best practices. Nevertheless, the observed improvements in outcome in our study could be not only a result of the concentration of services but also of the introduced feedback on surgical performance. This could explain the improved outcome that was also demonstrated in the LVHs, being of a lesser magnitude than the improvements in HVHs (Table 6).
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Some authors believe that procedural volume, as a proxy for quality, is preferable above direct outcomes measurement.18,19 The availability and easy access of these data and the avoidance of the statistical problem of small sample size are mentioned as important advantages.20 However, in a study from our own country, van Heek et al. showed that, despite a 10-year-long “evidence-based” plea for centralization of pancreatic surgery, no reduction of mortality or change in referral pattern was seen in The Netherlands.21 The problem is that provider volume as a quality measure only holds true on average, and is a poor predictor of quality in individual hospitals or surgeons.22,23
In our opinion, continuous monitoring of clinical outcomes not only has the ability to assess quality of care but can actually improve surgical performance. A number of methods for surgical monitoring, which take into account different levels of prior risk, have been described in the literature.24,25 A routinely conducted medical audit, providing hospitals and surgeons with individualized and pooled outcome information, can be a stimulus for the introduction of a range of improvements in hospital and surgical care.26‐28 In addition, a national or regional approach, such as the example for esophageal cancer surgery in our study, clarifies important differences in quality of care. In a peer-review environment or when reliable, hospital-specific outcome information is made available to the public, actual changes in referral patterns can be made (outcome-based referral).
Acknowledgement
The authors thank the participating surgeons for their cooperative and selfless attitude in improving the quality of care for esophageal cancer patients in the region of the Comprehensive Cancer Center West.
Open Access
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Open AccessThis is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
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Centralization of Esophageal Cancer Surgery: Does It Improve Clinical Outcome?
verfasst von
M. W. J. M. Wouters, MD H. E. Karim-Kos, PhD S. le Cessie, PhD B. P. L. Wijnhoven, MD, PhD L. P. S. Stassen, MD, PhD W. H. Steup, MD, PhD H. W. Tilanus, MD, PhD R. A. E. M. Tollenaar, MD, PhD
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Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.
Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?
Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.
