Erschienen in:
01.06.2006
Tumor Bed Boost Omission After Negative Re-Excision in Breast-Conservation Treatment
verfasst von:
Douglas W. Arthur, MD, Laurie W. Cuttino, MD, Andrew C. Neuschatz, MD, Derrick T. Koo, MD, Monica M. Morris, MD, Harry D. Bear, MD, PhD, Brian J. Kaplan, MD, Kathy Dawson, PhD, David E. Wazer, MD
Erschienen in:
Annals of Surgical Oncology
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Ausgabe 6/2006
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Abstract
Background
We evaluated the necessity of a tumor bed boost after whole-breast radiotherapy for early-stage breast cancer after breast-conserving surgery and negative re-excision.
Methods
Of patients treated at the Virginia Commonwealth and Tufts Universities with breast-conservation therapy for early-stage breast cancer between 1983 and 1999, 205 required re-excision of the tumor cavity to obtain clear margins and were found to be without residual disease. Adjuvant conventionally fractionated whole-breast radiotherapy was given to a total dose of 50 Gy in 25 fractions. The tumor bed boost was omitted.
Results
The median follow-up was 98 months (range, 6–229 months). The tumor histological diagnosis was primarily infiltrating ductal carcinoma (183 cases; 89%). Nodal involvement was documented in 49 cases (24%). There were four documented recurrences at the tumor bed site. Five in-breast recurrences were documented to be in a location removed from the tumor bed. The overall Kaplan-Meier 15-year in-breast control rate was 92.4%, and the freedom from true recurrence rate was 97.6%.
Conclusions
The findings support the concept that postlumpectomy radiotherapy can be tailored according to the degree of surgical resection. There is an easily identifiable subgroup of patients who can avoid a tumor bed boost, thus resulting in a reduced treatment time and improved cosmesis, while maintaining local control rates that approach 100%. The data suggest that in patients who undergo a negative re-excision, treatment with whole-breast radiotherapy to 50 Gy is a sufficient dose to maximally reduce the risk of local recurrence.