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Seminars in Immunopathology

Erschienen in:

01.09.2009 | Review

Liver architecture, cell function, and disease

verfasst von: Hiromi Ishibashi, Minoru Nakamura, Atsumasa Komori, Kiyoshi Migita, Shinji Shimoda

Erschienen in: Seminars in Immunopathology | Ausgabe 3/2009

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Abstract

The liver is an organ consisting of the largest reticulo-endothelial cell network in the body and playing an important role in host defense against invading microorganisms. The organ is comprised of parenchymal cells and many different types of non-parenchymal cells, all of which play a significant role. Even biliary epithelial cells are not only the target in autoimmune liver diseases but also have central role in orchestrating several immune cells involved in both innate and acquired immunity. Tissue damage caused by various agents results in inflammation, necrosis, fibrosis, and, eventually, distortion of normal hepatic architecture, cirrhosis, and functional deterioration.

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Titel: Liver architecture, cell function, and disease
verfasst von: Hiromi Ishibashi
Minoru Nakamura
Atsumasa Komori
Kiyoshi Migita
Shinji Shimoda
Publikationsdatum: 01.09.2009
Verlag: Springer-Verlag
Erschienen in: Seminars in Immunopathology / Ausgabe 3/2009
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-009-0155-6

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