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01.08.2009 | Hepatobiliary-Pancreas

Liver fibrosis staging with contrast-enhanced ultrasonography: prospective multicenter study compared with METAVIR scoring

verfasst von: F. Staub, C. Tournoux-Facon, J. Roumy, C. Chaigneau, M. Morichaut-Beauchant, P. Levillain, C. Prevost, C. Aubé, J. Lebigot, F. Oberti, J. B. Galtier, H. Laumonier, H. Trillaud, P. H. Bernard, J. F. Blanc, S. Sironneau, F. Machet, J. Drouillard, V. de Ledinghen, P. Couzigou, P. Foucher, L. Castéra, F. Tranquard, Y. Bacq, L. d’Altéroche, P. Ingrand, J. P. Tasu

Erschienen in: European Radiology | Ausgabe 8/2009

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Abstract

We prospectively assessed contrast-enhanced sonography for evaluating the degree of liver fibrosis as diagnosed via biopsy in 99 patients. The transit time of microbubbles between the portal and hepatic veins was calculated from the difference between the arrival time of the microbubbles in each vein. Liver biopsy was obtained for each patient within 6 months of the contrast-enhanced sonography. Histological fibrosis was categorized into two classes: (1) no or moderate fibrosis (F0, F1, and F2 according to the METAVIR staging) or (2) severe fibrosis (F3 and F4). At a cutoff of 13 s for the transit time, the diagnosis of severe fibrosis was made with a specificity of 78.57%, a sensitivity of 78.95%, a positive predictive value of 78.33%, a negative predictive value of 83.33%, and a performance accuracy of 78.79%. Therefore, contrast-enhanced ultrasound can help with differentiation between moderate and severe fibrosis.

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Titel: Liver fibrosis staging with contrast-enhanced ultrasonography: prospective multicenter study compared with METAVIR scoring
verfasst von: F. Staub
C. Tournoux-Facon
J. Roumy
C. Chaigneau
M. Morichaut-Beauchant
P. Levillain
C. Prevost
C. Aubé
J. Lebigot
F. Oberti
J. B. Galtier
H. Laumonier
H. Trillaud
P. H. Bernard
J. F. Blanc
S. Sironneau
F. Machet
J. Drouillard
V. de Ledinghen
P. Couzigou
P. Foucher
L. Castéra
F. Tranquard
Y. Bacq
L. d’Altéroche
P. Ingrand
J. P. Tasu
Publikationsdatum: 01.08.2009
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 8/2009
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-009-1313-x

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Liver fibrosis staging with contrast-enhanced ultrasonography: prospective multicenter study compared with METAVIR scoring

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