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01.12.2014 | Clinical Article - Neurosurgical Techniques | Ausgabe 12/2014

Acta Neurochirurgica 12/2014

Localizing hand motor area using resting-state fMRI: validated with direct cortical stimulation

Zeitschrift:
Acta Neurochirurgica > Ausgabe 12/2014
Autoren:
Tian-ming Qiu, Chao-gan Yan, Wei-jun Tang, Jin-song Wu, Dong-xiao Zhuang, Cheng-jun Yao, Jun-feng Lu, Feng-ping Zhu, Ying Mao, Liang-fu Zhou
Wichtige Hinweise
Tian-ming Qiu and Chao-gan Yan contributed equally to this paper.

Abstract

Background

Resting-state functional magnetic resonance imaging (R-fMRI) is a promising tool in clinical application, especially in presurgical mapping for neurosurgery. This study aimed to investigate the sensitivity and specificity of R-fMRI in the localization of hand motor area in patients with brain tumors validated by direct cortical stimulation (DCS). We also compared this technique to task-based blood oxygenation level-dependent (BOLD) fMRI (T-fMRI).

Methods

R-fMRI and T-fMRI were acquired from 17 patients with brain tumors. The cortex sites of the hand motor area were recorded by DCS. Site-by-site comparisons between R-fMRI/T-fMRI and DCS were performed to calculate R-fMRI and T-fMRI sensitivity and specificity using DCS as a “gold standard”. R-fMRI and T-fMRI performances were compared statistically

Results

A total of 609 cortex sites were tested with DCS and compared with R-fMRI findings in 17 patients. For hand motor area localization, R-fMRI sensitivity and specificity were 90.91 and 89.41 %, respectively. Given that two subjects could not comply with T-fMRI, 520 DCS sites were compared with T-fMRI findings in 15 patients. The sensitivity and specificity of T-fMRI were 78.57 and 84.76 %, respectively. In the 15 patients who successfully underwent both R-fMRI and T-fMRI, there was no statistical difference in sensitivity or specificity between the two methods (p = 0.3198 and p = 0.1431, respectively)

Conclusions

R-fMRI sensitivity and specificity are high for localizing hand motor area and even equivalent or slightly higher compared with T-fMRI. Given its convenience for patients, R-fMRI is a promising substitute for T-fMRI for presurgical mapping

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