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Pediatric Nephrology
Erschienen in: Pediatric Nephrology 12/2015

01.12.2015 | Original Article

Long-term outcome of childhood IgA nephropathy with minimal proteinuria

verfasst von: Asumi Higa, Yuko Shima, Taketsugu Hama, Masashi Sato, Hironobu Mukaiyama, Hiroko Togawa, Ryojiro Tanaka, Kandai Nozu, Mayumi Sako, Kazumoto Iijima, Koichi Nakanishi, Norishige Yoshikawa

Erschienen in: Pediatric Nephrology | Ausgabe 12/2015

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Abstract

Background

Some patients with childhood immunoglobulin A nephropathy (IgAN) progress to end-stage renal disease within 20 years, while others achieve spontaneous remission even without medication. Prognosis of IgAN with minimal proteinuria (MP-IgAN, <0.5 g/day/1.73 m2) at diagnosis seems to be generally good. However, the long-term outcome for patients with childhood MP-IgAN has not yet been determined.

Methods

We retrospectively analyzed 385 children newly diagnosed with biopsy-proven IgAN between June 1976 and July 2009 whose renal biopsy specimens could be evaluated by the Oxford classification criteria. Of these 385 children with IgAN, 106 (27.5 %) were diagnosed with MP-IgAN. We compared clinical and pathological findings between the 106 patients with MP-IgAN and the remaining 279 patients to elucidate the characteristics of MP-IgAN in children.

Results

Patients with MP-IgAN were identified through a school screening program (73.6 %) or upon presentation with gross hematuria (26.4 %). Patients with MP-IgAN had significantly milder pathological symptoms than those with IgAN. The most frequently used therapeutic regimes were angiotensin converting enzyme inhibitors (30.2 %) and no therapy (36.8 %). None of the patients with MP-IgAN reached stage III chronic kidney disease within 15 years after onset. Four patients with MP-IgAN (3.8 %) received immunosuppressive therapy during the course of the disease.

Conclusion

Our results indicate that the outcome of patients with a diagnosis of childhood MP-IgAN is good, but that careful long-term observation is required.
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Metadaten
Titel
Long-term outcome of childhood IgA nephropathy with minimal proteinuria
verfasst von
Asumi Higa
Yuko Shima
Taketsugu Hama
Masashi Sato
Hironobu Mukaiyama
Hiroko Togawa
Ryojiro Tanaka
Kandai Nozu
Mayumi Sako
Kazumoto Iijima
Koichi Nakanishi
Norishige Yoshikawa
Publikationsdatum
01.12.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Nephrology / Ausgabe 12/2015
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-015-3176-5

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