Introduction
Methods
Subjects and study design
Study protocols
Digital thermal monitoring of vascular reactivity
DTM indices
Adjustment of DTM indices
Coronary artery calcium scanning
Computed tomography angiography
Statistical analysis
Results
Normal
N = 28 | Non-obstructive CAD
N = 74 | Obstructive CAD
N = 27 |
P value | |
---|---|---|---|---|
Age (years) | 61 ± 9 | 64 ± 9 | 65 ± 10 | 0.15 |
Male gender | 68% (19) | 65% (48) | 67% (18) | 0.8 |
Current smoker | 18% (5) | 16% (12) | 18% (5) | 0.8 |
SBP (mm Hg) | 134 ± 21 | 134 ± 20 | 135 ± 21 | 0.9 |
DBP (mm Hg) | 75 ± 11 | 75 ± 12 | 76 ± 11 | 0.6 |
Hypertensiona
| 82% (23) | 84% (62) | 89% (24) | 0.23 |
Anti-hypertensive medication | 87% (20) | 87% (54) | 91% (22) | 0.57 |
Total cholesterol (mg/dl) | 170 ± 28 | 172 ± 26 | 180 ± 26 | 0.19 |
HDL-C (mg/dl) | 60 ± 16 | 58.4 ± 15.3 | 55.1 ± 15.4 | 0.66 |
LDL-C (mg/dl) | 93.1 ± 28.5 | 98.9 ± 36.8 | 91.6 ± 31.4 | 0.37 |
Triglycerides (mg/dl) | 91 ± 43 | 85 ± 39 | 118 ± 37 | 0.09 |
Hypercholesterolemiab
| 43% (12) | 45% (33) | 59% (16) | 0.06 |
Cholesterol-lowering medication | 83% (10) | 85% (28) | 81% (13) | 0.61 |
Diabetes mellitusc
| 18% (5) | 24% (18) | 30% (8) | 0.13 |
Family history of CHDd
| 32% (9) | 34% (25) | 37% (10) | 0.8 |
Body mass index (kg/m2) | 29.7 ± 4.1 | 30.3 ± 4.6 | 30.4 ± 3.9 | 0.96 |
Framingham risk score (%) | 11.2 ± 5.9 | 13.7 ± 6.8 | 15.1 ± 7.2 | 0.01 |
LVEF | 63.9 ± 4.9 | 64.2 ± 3.6 | 63.5 ± 4.6 | 0.77 |
CAC score | 0 | 241 ± 42 | 720 ± 124 | 0.0001 |
Baseline fingertip temperature (°C) | 29.2 ± 1.8 | 29.1 ± 1.9 | 28.1 ± 2.3 | 0.39 |
TR | 1.05 ± 1.26 | 0.52 ± 0.85 | 0.16 ± 0.73 | 0.01 |
aTR | 1.77 ± 1.18 | 1.24 ± 1.14 | 0.94 ± 0.92 | 0.009 |
TMP-AUC | 272.6 ± 139.2 | 225.5 ± 152.6 | 144.9 ± 119.9 | 0.009 |
aTMP-AUC | 355.6 ± 242.4 | 277.4 ± 182.4 | 184.4 ± 171.2 | 0.001 |
NVR | 161.5 ± 147.4 | 77.6 ± 88.2 | 48.8 ± 63.8 | 0.015 |
Vascular function and coronary artery disease
Models |
R
|
R
2
| β | 95% CI |
P value | |
---|---|---|---|---|---|---|
a: Single variables
| ||||||
II | CAC | 0.48 | 0.24 | 0.49 | 0.01 to 0.55 | 0.0001 |
III | TR | 0.29 | 0.11 | −0.34 | −0.05 to −0.42 | 0.001 |
IV | aTR | 0.32 | 0.12 | −0.39 | −0.02 to −0.51 | 0.001 |
IV | TMP-AUC | 0.38 | 0.14 | −0.38 | −0.02 to −0.46 | 0.0001 |
V | aTMP-AUC | 0.43 | 0.18 | −0.43 | −0.01 to −0.66 | 0.0001 |
VI | NVR | 0.28 | 0.08 | −0.28 | −0.001 to −0.46 | 0.009 |
b: Combination variables
| ||||||
VII | NVR | 0.40 | 0.17 | −0.17 | −0.001 to −0.45 | 0.01 |
+ | ||||||
aTR | −0.41 | −0.003 to −0.62 | 0.009 | |||
VIII | NVR | 0.53 | 0.28 | −0.19 | −0.001 to −0.43 | 0.006 |
+ | ||||||
TMP-AUC | −0.45 | −0.02 to −0.64 | 0.0001 | |||
IX | NVR | 0.71 | 0.51 | −0.11 | −0.001 to −0.19 | 0.03 |
+ | ||||||
aTMP-AUC | −0.46 | −0.02 to −0.59 | 0.0001 | |||
+ | 0.0002 | |||||
CAC | 0.36 | 0.02 to 0.48 | ||||
X | NVR | 0.72 | 0.52 | −0.14 | 0.001 to 0.41 | 0.03 |
+ | ||||||
aTMP-AUC | −0.47 | −0.02 to −0.51 | 0.0001 | |||
+ | ||||||
CAC | 0.35 | −0.003 to −0.22 | 0.003 | |||
+ | ||||||
FRS | 0.12 | −0.001 to 0.21 | 0.2 |
Model | Normal | Non-obstructive CAD | Obstructive CAD |
---|---|---|---|
Unadjusted | |||
Odds of TR | 1 (ref) | 4.10 (1.8–12.7), P = 0.005 | 8.90 (1.9–14.6), P = 0.002 |
Odds of aTR | 1 (ref) | 4.23 (1.8–9.5), P = 0.001 | 10.78 (2.9–24.7), P = 0.001 |
Odds of TMP-AUC | 1 (ref) | 5.35 (2.1–9.4), P = 0.0001 | 10.31 (3.5–17.65), P = 0.0001 |
Odds of aTMP-AUC | 1 (ref) | 6.19 (2.4–15.9), P = 0.0001 | 12.14 (5.5–25.4), P = 0.0001 |
Odds of NVR | 1 (ref) | 1.59 (1.05–3.2), P = 0.04 | 4.69 (1.63–13.5), P = 0.004 |
Odds of CAC | 1 (ref) | 6.04 (1.3–18.6), P = 0.0001 | 11.87 (2.4–20.2), P = 0.0001 |
Odds of FRS | 1 (ref) | 1.09 (0.7–1.7), P = 0.74 | 1.72 (1.0–3.1), P = 0.08 |
Adjusted for age, gender, diabetes mellitus, hypertension, hypercholesterolemia, family history of CHD, smoking status | |||
Odds of TR | 1 (ref) | 3.82 (1.1–14.2), P = 0.007 | 8.51 (1.8–19.6), P = 0.005 |
Odds of aTR | 1 (ref) | 3.90 (1.7–7.6), P = 0.001 | 8.69 (2.6–9.2), P = 0.001 |
Odds of TMP-AUC | 1 (ref) | 4.37 (1.7–16.1), P = 0.003 | 9.61 (3.1–18.1), P = 0.002 |
Odds of aTMP-AUC | 1 (ref) | 5.76 (2.1–19.6), P = 0.002 | 11.63 (5.1–28.5), P = 0.001 |
Odds of NVR | 1 (ref) | 1.49 (1.01–3.4), P = 0.05 | 3.61 (1.1–11.6), P = 0.009 |
Odds of CAC | 1 (ref) | 5.62 (1.4–12.8), P = 0.006 | 10.53 (2.3–25.1), P = 0.002 |
Odds of FRS | 1 (ref) | 1.04 (0.6–1.5), P = 0.85 | 1.69 (0.9–2.9), P = 0.21 |