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Erschienen in:

01.09.2007

Low Level of IGF-1 in Obesity May Be Related to Obstructive Sleep Apnea Syndrome

verfasst von: Ahmet Ursavas, Mehmet Karadag, Yesim Ozarda Ilcol, Ilker Ercan, Basak Burgazlioglu, Funda Coskun, R. Oktay Gozu

Erschienen in: Lung | Ausgabe 5/2007

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Abstract

The aim of this study was to compare serum insulin-like growth factor (IGF-1) levels in patients with obstructive sleep apnea syndrome (OSAS) with those of nonapneic controls and to determine the risk factors of low IGF-1 levels in patients with OSAS. The study included 39 newly diagnosed moderate-to-severe OSAS patients and 36 nonapneic controls. Overnight polysomnography (PSG) was performed in all patients. The circulating levels of IGF-1 in the OSAS group were significantly lower than those of the control group (p < 0.05). There was a significant negative correlation between IGF-1 and logarithmic transformation (Ln) of the apnea-hypopnea index (AHI), duration of apnea-hypopnea, arousal index, average desaturation, and oxygen desaturation index (ODI). The result of stepwise regression analyses showed that OSAS (p = 0.001) was a risk factor for a low IGF-1 level, independent of age, gender, and body mass index (BMI). Our findings demonstrated that there was a significant negative correlation between IGF-1 and Ln AHI and that OSAS reduced the circulating levels of IGF-1.

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Titel: Low Level of IGF-1 in Obesity May Be Related to Obstructive Sleep Apnea Syndrome
verfasst von: Ahmet Ursavas
Mehmet Karadag
Yesim Ozarda Ilcol
Ilker Ercan
Basak Burgazlioglu
Funda Coskun
R. Oktay Gozu
Publikationsdatum: 01.09.2007
Verlag: Springer-Verlag
Erschienen in: Lung / Ausgabe 5/2007
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-007-9026-x

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