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Immunologic Research
Erschienen in: Immunologic Research 3/2017

12.12.2016 | Original Article

LPS-treated bone marrow-derived dendritic cells induce immune tolerance through modulating differentiation of CD4+ regulatory T cell subpopulations mediated by 3G11 and CD127

verfasst von: Fang Zhou, Guang-Xian Zhang, Abdolmohamad Rostami

Erschienen in: Immunologic Research | Ausgabe 3/2017

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Abstract

Intravenous transfer of LPS-treated bone marrow-derived dendritic cells blocks development of autoimmunity induced by CD4+ T cells in vivo. However, cellular mechanisms of dendritic cell-mediated immune tolerance have not yet been fully elucidated. Here, we report that there are two new subpopulations of CD4+CD25+FoxP3+GITR+ regulatory T cells (CD127+3G11+ and CD127+3G11− cells). LPS-treated dendritic cells facilitate development of CD4+CD127+3G11− regulatory T cells but inhibit that of CD4+CD127+3G11+ regulatory T cells. LPS-induced tolerogenic dendritic cells may cause immune tolerance through modulating balance of different subsets of CD4+ regulatory T cells mediated by CD127 and 3G11. Our results imply a new potential cellular mechanism of dendritic cell-mediated immune tolerance.
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Metadaten
Titel
LPS-treated bone marrow-derived dendritic cells induce immune tolerance through modulating differentiation of CD4+ regulatory T cell subpopulations mediated by 3G11 and CD127
verfasst von
Fang Zhou
Guang-Xian Zhang
Abdolmohamad Rostami
Publikationsdatum
12.12.2016
Verlag
Springer US
Erschienen in
Immunologic Research / Ausgabe 3/2017
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-016-8881-z

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