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Magnetic Resonance Materials in Physics, Biology and Medicine

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06.07.2016 | Research Article

Magnetization transfer imaging of cortical bone in vivo using a zero echo time sequence in mice at 4.7 T: a feasibility study

verfasst von: Magda Marcon, Markus Weiger, Daniel Keller, Moritz C. Wurnig, Christian Eberhardt, Daniel Eberli, Andreas Boss

Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine | Ausgabe 6/2016

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Abstract

Objective

To investigate the feasibility of magnetization transfer (MT) imaging in mice in vivo for the assessment of cortical bone.

Materials and methods

MT-zero echo time data were acquired at 4.7 T in six mice using MT preparation pulses with two different flip angles (FAs) and a series of ten different off-resonance frequencies (500–15000 Hz). Regions of interest were drawn at multiple levels of the femoral cortical bone. The MT ratio (MTR) was computed for each combination of FAs and off-resonance frequencies. T1 measurements were used to estimate the direct saturation (DS) using a Bloch equation simulation. Estimation of the absorption line width of cortical bone from T2* measurements was also performed.

Results

MTR values were higher using 3000° FA than 1000° FA. MTR values decreased toward higher off-resonance frequencies. Maximum mean MTR ± standard deviation (SD) of 58.57 ± 5.22 (range 50.44–70.61) was measured with a preparation pulse of 3000° and off-resonance frequency of 500 Hz. Maximum “true” MT effect was estimated at around 2–3 and 5 kHz, respectively, for 1000° and 3000° FA. Mean full width at half maximum ± SD of 577 ± 91 Hz was calculated for the absorption spectral line of the cortical bone.

Conclusion

MT imaging can be used for the assessment of cortical bone in mice in vivo. DS effects are negligible using preparation pulses with off-resonance frequencies greater than 3 kHz.

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Titel: Magnetization transfer imaging of cortical bone in vivo using a zero echo time sequence in mice at 4.7 T: a feasibility study
verfasst von: Magda Marcon
Markus Weiger
Daniel Keller
Moritz C. Wurnig
Christian Eberhardt
Daniel Eberli
Andreas Boss
Publikationsdatum: 06.07.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine / Ausgabe 6/2016
Print ISSN: 0968-5243
Elektronische ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-016-0577-9

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Magnetization transfer imaging of cortical bone in vivo using a zero echo time sequence in mice at 4.7 T: a feasibility study

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Materials and methods

Results

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