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Immunologic Research
Erschienen in: Immunologic Research 1-3/2010

01.07.2010

Mechanisms involved in antibody- and complement-mediated allograft rejection

verfasst von: Barbara A. Wasowska

Erschienen in: Immunologic Research | Ausgabe 1-3/2010

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Abstract

Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to study pathogenesis of antibody- and complement-mediated endothelial cell injury leading to graft rejection. In this review, we discuss mechanisms of antibody-mediated graft rejection resulting from activation of complement by C1q- and MBL (mannose-binding lectin)-dependent pathways and interactions with a variety of effector cells, including macrophages and monocytes through Fcγ receptors and complement receptors.
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Metadaten
Titel
Mechanisms involved in antibody- and complement-mediated allograft rejection
verfasst von
Barbara A. Wasowska
Publikationsdatum
01.07.2010
Verlag
Humana Press Inc
Erschienen in
Immunologic Research / Ausgabe 1-3/2010
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-009-8136-3

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