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Current Osteoporosis Reports

Erschienen in:

29.10.2018 | Bone and Joint Pain (T King and S Amin, Section Editors)

Mechanisms Underlying Bone and Joint Pain

verfasst von: Joshua Havelin, Tamara King

Erschienen in: Current Osteoporosis Reports | Ausgabe 6/2018

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Abstract

Purpose of Review

The goal of this review is to provide a broad overview of the current understanding of mechanisms underlying bone and joint pain.

Recent Findings

Bone or joint pathology is generally accompanied by local release of pro-inflammatory cytokines, growth factors, and neurotransmitters that activate and sensitize sensory nerves resulting in an amplified pain signal. Modulation of the pain signal within the spinal cord and brain that result in net increased facilitation is proposed to contribute to the development of chronic pain.

Summary

Great strides have been made in our understanding of mechanisms underlying bone and joint pain that will guide development of improved therapeutic options for these patients. Continued research is required for improved understanding of mechanistic differences driving different components of bone and/or joint pain such as movement related pain compared to persistent background pain. Advances will guide development of more individualized and comprehensive therapeutic options.

Hawker GA, Stewart L, French MR, Cibere J, Jordan JM, March L, et al. Understanding the pain experience in hip and knee osteoarthritis--an OARSI/OMERACT initiative. Osteoarthr Cartil. 2008;16(4):415–22. https://doi.org/10.1016/j.joca.2007.12.017.CrossRef

Hawker GA, Stanaitis I. Osteoarthritis year in review 2014: clinical. Osteoarthr Cartil. 2014;22(12):1953–7. https://doi.org/10.1016/j.joca.2014.06.018.CrossRef

Paice JA, Ferrell B. The management of cancer pain. CA Cancer J Clin. 2011;61(3):157–82. https://doi.org/10.3322/caac.20112.CrossRefPubMed

Mercadante S. Breakthrough pain in cancer patients: prevalence, mechanisms and treatment options. Curr Opin Anaesthesiol. 2015;28(5):559–64. https://doi.org/10.1097/ACO.0000000000000224.CrossRefPubMed

Eitner A, Hofmann GO, Schaible HG. Mechanisms of osteoarthritic pain. Studies in Humans and Experimental Models. Front Mol Neurosci. 2017;10:349. https://doi.org/10.3389/fnmol.2017.00349.CrossRefPubMedPubMedCentral

•• Ivanusic JJ. Molecular mechanisms that contribute to bone marrow pain. Front Neurol. 2017;8:458. https://doi.org/10.3389/fneur.2017.00458. This recent review gives a nice update on what is known regarding peripheral mechanisms driving bone pain. CrossRefPubMedPubMedCentral

Jimenez-Andrade JM, Mantyh WG, Bloom AP, Ferng AS, Geffre CP, Mantyh PW. Bone cancer pain. Ann N Y Acad Sci. 2010;1198:173–81. https://doi.org/10.1111/j.1749-6632.2009.05429.x.CrossRefPubMedPubMedCentral

Alliston T, Hernandez CJ, Findlay DM, Felson DT, Kennedy OD. Bone marrow lesions in osteoarthritis: what lies beneath. J Orthop Res. 2017;36:1818–25. https://doi.org/10.1002/jor.23844.CrossRef

Schaible HG, Schmidt RF. Activation of groups III and IV sensory units in medial articular nerve by local mechanical stimulation of knee joint. J Neurophysiol. 1983;49(1):35–44. https://doi.org/10.1152/jn.1983.49.1.35.CrossRefPubMed

10.

Schaible HG, Schmidt RF. Responses of fine medial articular nerve afferents to passive movements of knee joints. J Neurophysiol. 1983;49(5):1118–26. https://doi.org/10.1152/jn.1983.49.5.1118.CrossRefPubMed

11.

Cavanaugh DJ, Lee H, Lo L, Shields SD, Zylka MJ, Basbaum AI, et al. Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci U S A. 2009;106(22):9075–80. https://doi.org/10.1073/pnas.0901507106.CrossRefPubMedPubMedCentral

12.

Woller SA, Eddinger KA, Corr M, Yaksh TL. An overview of pathways encoding nociception. Clin Exp Rheumatol. 2018;36(1):172.PubMed

13.

Usoskin D, Furlan A, Islam S, Abdo H, Lonnerberg P, Lou D, et al. Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nat Neurosci. 2015;18(1):145–53. https://doi.org/10.1038/nn.3881.CrossRefPubMed

14.

Zylka MJ, Rice FL, Anderson DJ. Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron. 2005;45(1):17–25. https://doi.org/10.1016/j.neuron.2004.12.015.CrossRefPubMed

15.

Scherrer G, Imamachi N, Cao YQ, Contet C, Mennicken F, O’Donnell D, et al. Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell. 2009;137(6):1148–59. https://doi.org/10.1016/j.cell.2009.04.019.CrossRefPubMedPubMedCentral

16.

Okun A, DeFelice M, Eyde N, Ren J, Mercado R, King T, et al. Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents. Mol Pain. 2011;7:4. https://doi.org/10.1186/1744-8069-7-4.CrossRefPubMedPubMedCentral

17.

King T, Qu C, Okun A, Mercado R, Ren J, Brion T, et al. Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity. Pain. 2011;152(9):1997–2005. https://doi.org/10.1016/j.pain.2011.04.020.CrossRefPubMedPubMedCentral

18.

Barabas ME, Kossyreva EA, Stucky CL. TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons. PLoS One. 2012;7(10):e47988. https://doi.org/10.1371/journal.pone.0047988.CrossRefPubMedPubMedCentral

19.

Havelin J, Imbert I, Sukhtankar D, Remeniuk B, Pelletier I, Gentry J, et al. Mediation of movement-induced breakthrough cancer pain by IB4-binding nociceptors in rats. J Neurosci. 2017;37(20):5111–22. https://doi.org/10.1523/JNEUROSCI.1212-16.2017.CrossRefPubMedPubMedCentral

20.

Abraira VE, Ginty DD. The sensory neurons of touch. Neuron. 2013;79(4). https://doi.org/10.1016/j.neuron.2013.07.051.CrossRefPubMed

21.

Bourane S, Duan B, Koch SC, Dalet A, Britz O, Garcia-Campmany L, et al. Gate control of mechanical itch by a subpopulation of spinal cord interneurons. Science. 2015;350(6260):550–4. https://doi.org/10.1126/science.aac8653.CrossRefPubMedPubMedCentral

22.

•• Duan B, Cheng L, Ma Q. Spinal circuits transmitting mechanical pain and itch. Neurosci Bull. 2017. https://doi.org/10.1007/s12264-017-0136-z. This recent review outlines the gains in our understanding of processing and modulation of pain and itch within the spinal cord. CrossRefPubMedPubMedCentral

23.

Li L, Rutlin M, Abraira Victoria E, Cassidy C, Kus L, Gong S, et al. The functional organization of cutaneous low-threshold mechanosensory neurons. Cell. 2011;147(7):1615–27. https://doi.org/10.1016/j.cell.2011.11.027.CrossRefPubMedPubMedCentral

24.

Ma Q. Labeled lines meet and talk: population coding of somatic sensations. J Clin Invest. 2010;120(11):3773–8. https://doi.org/10.1172/JCI43426.CrossRefPubMedPubMedCentral

25.

Todd AJ. Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn. Mol Pain. 2017;13:1744806917693003. https://doi.org/10.1177/1744806917693003.CrossRefPubMedPubMedCentral

26.

Bonin RP, Wang F, Desrochers-Couture M, Ga Secka A, Boulanger ME, Cote DC, et al. Epidural optogenetics for controlled analgesia. Mol Pain. 2016;12:174480691662905. https://doi.org/10.1177/1744806916629051.CrossRef

27.

Duan B, Cheng L, Bourane S, Britz O, Padilla C, Garcia-Campmany L, et al. Identification of spinal circuits transmitting and gating mechanical pain. Cell. 2014;159(6):1417–32. https://doi.org/10.1016/j.cell.2014.11.003.CrossRefPubMedPubMedCentral

28.

•• Koch SC, Acton D, Goulding M. Spinal circuits for touch, pain, and itch. Annu Rev Physiol. 2018;80:189–217. https://doi.org/10.1146/annurev-physiol-022516-034303. An in depth review of spinal circuits mediating touch pain and itch. CrossRefPubMed

29.

•• Tracey I. Neuroimaging mechanisms in pain: from discovery to translation. Pain. 2017;158(Suppl 1):S115–S22. https://doi.org/10.1097/j.pain.0000000000000863. A recent review covering advances in our understanding of pain perception within the brain that have been made using neuroimaging. CrossRefPubMed

30.

Navratilova E, Morimura K, Xie JY, Atcherley CW, Ossipov MH, Porreca F. Positive emotions and brain reward circuits in chronic pain. J Comp Neurol. 2016;524(8):1646–52. https://doi.org/10.1002/cne.23968.CrossRefPubMedPubMedCentral

31.

Navratilova E, Atcherley CW, Porreca F. Brain circuits encoding reward from pain relief. Trends Neurosci. 2015;38(11):741–50. https://doi.org/10.1016/j.tins.2015.09.003.CrossRefPubMedPubMedCentral

32.

•• Porreca F, Navratilova E. Reward, motivation and emotion of pain and its relief. Pain. 2017;158(Suppl 1):S43–S9. https://doi.org/10.1097/j.pain.0000000000000798. A review on recent advances in our understanding of the motivational aspects of pain and pain relief. CrossRefPubMedPubMedCentral

33.

Davis KD, Seminowicz DA. Insights for clinicians from brain imaging studies of pain. Clin J Pain. 2017;33(4):291–4. https://doi.org/10.1097/ajp.0000000000000439.CrossRefPubMedPubMedCentral

34.

Kuner R, Flor H. Structural plasticity and reorganisation in chronic pain. Nat Rev Neurosci. 2016;18:20–30. https://doi.org/10.1038/nrn.2016.162.CrossRefPubMed

35.

Smith A, López-Solà M, McMahon K, Pedler A, Sterling M. Multivariate pattern analysis utilizing structural or functional MRI-in individuals with musculoskeletal pain and healthy controls: a systematic review. Semin Arthritis Rheum. 2017;47(3):418–31. https://doi.org/10.1016/j.semarthrit.2017.06.005.CrossRefPubMed

36.

Mansour AR, Farmer MA, Baliki MN, Apkarian AV. Chronic pain: the role of learning and brain plasticity. Restor Neurol Neurosci. 2014;32(1):129–39. https://doi.org/10.3233/RNN-139003.CrossRefPubMedPubMedCentral

37.

Apkarian AV, Sosa Y, Krauss BR, Thomas PS, Fredrickson BE, Levy RE, et al. Chronic pain patients are impaired on an emotional decision-making task. Pain. 2004;108(1–2):129–36. https://doi.org/10.1016/j.pain.2003.12.015.CrossRefPubMed

38.

Apkarian AV, Sosa Y, Sonty S, Levy RM, Harden RN, Parrish TB, et al. Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J Neurosci. 2004;24(46):10410–5. https://doi.org/10.1523/JNEUROSCI.2541-04.2004.CrossRefPubMedPubMedCentral

39.

Langford LA, Schmidt RF. Afferent and efferent axons in the medial and posterior articular nerves of the cat. Anat Rec. 1983;206(1):71–8. https://doi.org/10.1002/ar.1092060109.CrossRefPubMed

40.

Coggeshall RE, Hong KA, Langford LA, Schaible HG, Schmidt RF. Discharge characteristics of fine medial articular afferents at rest and during passive movements of inflamed knee joints. Brain Res. 1983;272(1):185–8.CrossRefPubMed

41.

Grigg P, Schaible HG, Schmidt RF. Mechanical sensitivity of group III and IV afferents from posterior articular nerve in normal and inflamed cat knee. J Neurophysiol. 1986;55(4):635–43. https://doi.org/10.1152/jn.1986.55.4.635.CrossRefPubMed

42.

Schaible HG, Schmidt RF, Willis WD. Enhancement of the responses of ascending tract cells in the cat spinal cord by acute inflammation of the knee joint. Exp Brain Res. 1987;66(3):489–99.CrossRefPubMed

43.

Schaible HG, Schmidt RF. Effects of an experimental arthritis on the sensory properties of fine articular afferent units. J Neurophysiol. 1985;54(5):1109–22. https://doi.org/10.1152/jn.1985.54.5.1109.CrossRefPubMed

44.

Jimenez-Andrade JM, Mantyh WG, Bloom AP, Xu H, Ferng AS, Dussor G, et al. A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain. Bone. 2010;46(2):306–13. https://doi.org/10.1016/j.bone.2009.09.013.CrossRefPubMed

45.

Guedon JM, Longo G, Majuta LA, Thomspon ML, Fealk MN, Mantyh PW. Dissociation between the relief of skeletal pain behaviors and skin hypersensitivity in a model of bone cancer pain. Pain. 2016;157(6):1239–47. https://doi.org/10.1097/j.pain.0000000000000514.CrossRefPubMedPubMedCentral

46.

Mach DB, Rogers SD, Sabino MC, Luger NM, Schwei MJ, Pomonis JD, et al. Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur. Neuroscience. 2002;113(1):155–66.CrossRefPubMed

47.

Mantyh PW. The neurobiology of skeletal pain. Eur J Neurosci. 2014;39(3):508–19. https://doi.org/10.1111/ejn.12462.CrossRefPubMedPubMedCentral

48.

Ivanusic JJ. The evidence for the spinal segmental innervation of bone. Clin Anat. 2007;20(8):956–60. https://doi.org/10.1002/ca.20555.CrossRefPubMed

49.

Kaan TK, Yip PK, Patel S, Davies M, Marchand F, Cockayne DA, et al. Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats. Brain. 2010;133(9):2549–64. https://doi.org/10.1093/brain/awq194.CrossRefPubMed

50.

Price TJ, Flores CM. Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B4 binding in primary afferent neurons of the rat and mouse. J Pain. 2007;8(3):263–72. https://doi.org/10.1016/j.jpain.2006.09.005.CrossRefPubMed

51.

Molliver DC, Snider WD. Nerve growth factor receptor TrkA is down-regulated during postnatal development by a subset of dorsal root ganglion neurons. J Comp Neurol. 1997;381(4):428–38.CrossRefPubMed

52.

Molliver DC, Wright DE, Leitner ML, Parsadanian AS, Doster K, Wen D, et al. IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron. 1997;19(4):849–61.CrossRefPubMed

53.

Laedermann CJ, Pertin M, Suter MR, Decosterd I. Voltage-gated sodium channel expression in mouse DRG after SNI leads to re-evaluation of projections of injured fibers. Mol Pain. 2014;10:19. https://doi.org/10.1186/1744-8069-10-19.CrossRefPubMedPubMedCentral

54.

Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, et al. The cellular and synaptic architecture of the mechanosensory dorsal horn. Cell. 2017;168(1–2):295–310 e19. https://doi.org/10.1016/j.cell.2016.12.010.CrossRefPubMedPubMedCentral

55.

Rutlin M, Ho CY, Abraira VE, Cassidy C, Bai L, Woodbury CJ, et al. The cellular and molecular basis of direction selectivity of Adelta-LTMRs. Cell. 2014;159(7):1640–51. https://doi.org/10.1016/j.cell.2014.11.038.CrossRefPubMedPubMedCentral

56.

Zimmerman A, Bai L, Ginty DD. The gentle touch receptors of mammalian skin. Science. 2014;346(6212):950–4. https://doi.org/10.1126/science.1254229.CrossRefPubMedPubMedCentral

57.

Jeon OH, David N, Campisi J, Elisseeff JH. Senescent cells and osteoarthritis: a painful connection. J Clin Invest. 2018;128(4):1229–37. https://doi.org/10.1172/JCI95147.CrossRefPubMedPubMedCentral

58.

Syx D, Tran PB, Miller RE, Malfait AM. Peripheral mechanisms contributing to osteoarthritis pain. Curr Rheumatol Rep. 2018;20(2):9. https://doi.org/10.1007/s11926-018-0716-6.CrossRefPubMedPubMedCentral

59.

Krustev E, Rioux D, McDougall JJ. Mechanisms and mediators that drive arthritis pain. Curr Osteoporos Rep. 2015;13(4):216–24. https://doi.org/10.1007/s11914-015-0275-y.CrossRefPubMed

60.

Braun T, Schett G. Pathways for bone loss in inflammatory disease. Curr Osteoporos Rep. 2012;10(2):101–8. https://doi.org/10.1007/s11914-012-0104-5.CrossRefPubMed

61.

Cook AD, Christensen AD, Tewari D, McMahon SB, Hamilton JA. Immune cytokines and their receptors in inflammatory pain. Trends Immunol. 2018;39(3):240–55. https://doi.org/10.1016/j.it.2017.12.003.CrossRefPubMed

62.

Felson DT. The sources of pain in knee osteoarthritis. Curr Opin Rheumatol. 2005;17(5):624–8.CrossRefPubMed

63.

Denk F, Bennett DL, McMahon SB. Nerve growth factor and pain mechanisms. Annu Rev Neurosci. 2017;40(1):307–25. https://doi.org/10.1146/annurev-neuro-072116-031121.CrossRefPubMed

64.

Jimenez-Andrade JM, Mantyh WG, Bloom AP, Freeman KT, Ghilardi JR, Kuskowski MA, et al. The effect of aging on the density of the sensory nerve fiber innervation of bone and acute skeletal pain. Neurobiol Aging. 2012;33(5):921–32. https://doi.org/10.1016/j.neurobiolaging.2010.08.008.CrossRefPubMed

65.

Chartier SR, Thompson ML, Longo G, Fealk MN, Majuta LA, Mantyh PW. Exuberant sprouting of sensory and sympathetic nerve fibers in nonhealed bone fractures and the generation and maintenance of chronic skeletal pain. Pain. 2014;155(11):2323–36. https://doi.org/10.1016/j.pain.2014.08.026.CrossRefPubMedPubMedCentral

66.

Jimenez-Andrade JM, Martin CD, Koewler NJ, Freeman KT, Sullivan LJ, Halvorson KG, et al. Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture. Pain. 2007;133(1–3):183–96. https://doi.org/10.1016/j.pain.2007.06.016.CrossRefPubMed

67.

Falk S, Bannister K, Dickenson AH. Cancer pain physiology. Br J Pain. 2014;8(4):154–62. https://doi.org/10.1177/2049463714545136.CrossRefPubMedPubMedCentral

68.

Falk S, Dickenson AH. Pain and nociception: mechanisms of cancer-induced bone pain. J Clin Oncol. 2014;32(16):1647–54. https://doi.org/10.1200/JCO.2013.51.7219.CrossRefPubMed

69.

Thakur M, Rahman W, Hobbs C, Dickenson AH, Bennett DL. Characterisation of a peripheral neuropathic component of the rat monoiodoacetate model of osteoarthritis. PLoS One. 2012;7(3):e33730. https://doi.org/10.1371/journal.pone.0033730.CrossRefPubMedPubMedCentral

70.

Thakur M, Dickenson AH, Baron R. Osteoarthritis pain: nociceptive or neuropathic? Nat Rev Rheumatol. 2014;10(6):374–80. https://doi.org/10.1038/nrrheum.2014.47.CrossRefPubMed

71.

King T, Vardanyan A, Majuta L, Melemedjian O, Nagle R, Cress AE, et al. Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer. Pain. 2007;132(1–2):154–68. https://doi.org/10.1016/j.pain.2007.06.026.CrossRefPubMedPubMedCentral

72.

Peters CM, Ghilardi JR, Keyser CP, Kubota K, Lindsay TH, Luger NM, et al. Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain. Exp Neurol. 2005;193(1):85–100. https://doi.org/10.1016/j.expneurol.2004.11.028.CrossRefPubMed

73.

Sabino MA, Mantyh PW. Pathophysiology of bone cancer pain. J Support Oncol. 2005;3(1):15–24.PubMed

74.

Jimenez-Andrade JM, Bloom AP, Stake JI, Mantyh WG, Taylor RN, Freeman KT, et al. Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain. J Neurosci. 2010;30(44):14649–56. https://doi.org/10.1523/JNEUROSCI.3300-10.2010.CrossRefPubMedPubMedCentral

75.

Okun A, Liu P, Davis P, Ren J, Remeniuk B, Brion T, et al. Afferent drive elicits ongoing pain in a model of advanced osteoarthritis. Pain. 2012;153(4):924–33. https://doi.org/10.1016/j.pain.2012.01.022.CrossRefPubMedPubMedCentral

76.

Remeniuk B, Sukhtankar D, Okun A, Navratilova E, Xie JY, King T, et al. Behavioral and neurochemical analysis of ongoing bone cancer pain in rats. Pain. 2015;156(10):1864–73. https://doi.org/10.1097/j.pain.0000000000000218.CrossRefPubMedPubMedCentral

77.

Havelin J, Imbert I, Cormier J, Allen J, Porreca F, King T. Central sensitization and neuropathic features of ongoing pain in a rat model of advanced osteoarthritis. J Pain. 2016;17(3):374–82. https://doi.org/10.1016/j.jpain.2015.12.001.CrossRefPubMed

78.

Arendt-Nielsen L, Egsgaard LL, Petersen KK, Eskehave TN, Graven-Nielsen T, Hoeck HC, et al. A mechanism-based pain sensitivity index to characterize knee osteoarthritis patients with different disease stages and pain levels. Eur J Pain. 2015;19(10):1406–17. https://doi.org/10.1002/ejp.651.CrossRefPubMed

79.

Pujol J, Martinez-Vilavella G, Llorente-Onaindia J, Harrison BJ, Lopez-Sola M, Lopez-Ruiz M, et al. Brain imaging of pain sensitization in patients with knee osteoarthritis. Pain. 2017;158(9):1831–8. https://doi.org/10.1097/j.pain.0000000000000985.CrossRefPubMed

80.

•• Schaible HG. Osteoarthritis pain. Recent advances and controversies. Curr Opin Support Palliat Care. 2018. https://doi.org/10.1097/SPC.0000000000000334. A recent review on osteoarthritis pain.

81.

Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;152(3 Suppl):S2–15. https://doi.org/10.1016/j.pain.2010.09.030.CrossRefPubMed

82.

Lee A, Ellman MB, Yan D, Kroin JS, Cole BJ, van Wijnen AJ, et al. A current review of molecular mechanisms regarding osteoarthritis and pain. Gene. 2013;527(2):440–7. https://doi.org/10.1016/j.gene.2013.05.069.CrossRefPubMedPubMedCentral

83.

Devor M. Sodium channels and mechanisms of neuropathic pain. J Pain. 2006;7(1 Suppl 1):S3–S12. https://doi.org/10.1016/j.jpain.2005.09.006.CrossRefPubMed

84.

Bao L. Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons. Mol Pain. 2015;11:61. https://doi.org/10.1186/s12990-015-0065-7.CrossRefPubMedPubMedCentral

85.

Devor M. Ectopic discharge in Abeta afferents as a source of neuropathic pain. Exp Brain Res. 2009;196(1):115–28. https://doi.org/10.1007/s00221-009-1724-6.CrossRefPubMed

86.

Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009;10(9):895–926. https://doi.org/10.1016/j.jpain.2009.06.012.CrossRefPubMedPubMedCentral

87.

Schwei MJ, Honore P, Rogers SD, Salak-Johnson JL, Finke MP, Ramnaraine ML, et al. Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain. J Neurosci. 1999;19(24):10886–97.CrossRefPubMedPubMedCentral

88.

Clark AK, Old EA, Malcangio M. Neuropathic pain and cytokines: current perspectives. J Pain Res. 2013;6:803–14. https://doi.org/10.2147/JPR.S53660.CrossRefPubMedPubMedCentral

89.

Gao YJ, Ji RR. Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. Pharmacol Ther. 2010;126(1):56–68. https://doi.org/10.1016/j.pharmthera.2010.01.002.CrossRefPubMedPubMedCentral

90.

De Koninck Y. Altered chloride homeostasis in neurological disorders: a new target. Curr Opin Pharmacol. 2007;7(1):93–9. https://doi.org/10.1016/j.coph.2006.11.005.CrossRefPubMed

91.

Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, et al. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature. 2005;438(7070):1017–21. https://doi.org/10.1038/nature04223.CrossRefPubMed

92.

Mapplebeck JC, Beggs S, Salter MW. Sex differences in pain: a tale of two immune cells. Pain. 2016;157(Suppl 1):S2–6. https://doi.org/10.1097/j.pain.0000000000000389.CrossRefPubMed

93.

Lai J, Luo MC, Chen Q, Porreca F. Pronociceptive actions of dynorphin via bradykinin receptors. Neurosci Lett. 2008;437(3):175–9. https://doi.org/10.1016/j.neulet.2008.03.088.CrossRefPubMedPubMedCentral

94.

Ji RR, Berta T, Nedergaard M. Glia and pain: is chronic pain a gliopathy? Pain. 2013;154(Suppl 1):S10–28. https://doi.org/10.1016/j.pain.2013.06.022.CrossRefPubMedPubMedCentral

95.

Beggs S, Salter MW. The known knowns of microglia-neuronal signalling in neuropathic pain. Neurosci Lett. 2013;557(Pt A):37–42. https://doi.org/10.1016/j.neulet.2013.08.037.CrossRefPubMed

96.

Trang T, Beggs S, Salter MW. Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain. Neuron Glia Biol. 2011;7(1):99–108. https://doi.org/10.1017/S1740925X12000087.CrossRefPubMed

97.

Zhou YQ, Liu Z, Liu HQ, Liu DQ, Chen SP, Ye DW, et al. Targeting glia for bone cancer pain. Expert Opin Ther Targets. 2016;20(11):1365–74. https://doi.org/10.1080/14728222.2016.1214716.CrossRefPubMed

98.

Tran PB, Miller RE, Ishihara S, Miller RJ, Malfait AM. Spinal microglial activation in a murine surgical model of knee osteoarthritis. Osteoarthritis Cart. 2017;25(5):718–26. https://doi.org/10.1016/j.joca.2016.09.007.CrossRef

99.

Prescott SA, Ma Q, De Koninck Y. Normal and abnormal coding of somatosensory stimuli causing pain. Nat Neurosci. 2014;17(2):183–91. https://doi.org/10.1038/nn.3629.CrossRefPubMedPubMedCentral

100.

Suzuki R, Rahman W, Hunt SP, Dickenson AH. Descending facilitatory control of mechanically evoked responses is enhanced in deep dorsal horn neurones following peripheral nerve injury. Brain Res. 2004;1019(1–2):68–76. https://doi.org/10.1016/j.brainres.2004.05.108.CrossRefPubMed

101.

Ossipov MH, Dussor GO, Porreca F. Central modulation of pain. J Clin Invest. 2010;120(11):3779–87. https://doi.org/10.1172/JCI43766.CrossRefPubMedPubMedCentral

102.

Burgess SE, Gardell LR, Ossipov MH, Malan TP Jr, Vanderah TW, Lai J, et al. Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci. 2002;22(12):5129–36.CrossRefPubMedPubMedCentral

103.

Bannister K, Qu C, Navratilova E, Oyarzo J, Xie JY, King T, et al. Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain. Pain. 2017;158(12):2386–95. https://doi.org/10.1097/j.pain.0000000000001040.CrossRefPubMedPubMedCentral

104.

King T, Qu C, Okun A, Melemedjian OK, Mandell EK, Maskaykina IY, et al. Contribution of PKMzeta-dependent and independent amplification to components of experimental neuropathic pain. Pain. 2012;153(6):1263–73. https://doi.org/10.1016/j.pain.2012.03.006.CrossRefPubMedPubMedCentral

105.

Qu C, King T, Okun A, Lai J, Fields HL, Porreca F. Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy. Pain. 2011;152(7):1641–8. https://doi.org/10.1016/j.pain.2011.03.002.CrossRefPubMedPubMedCentral

106.

Bajic D, Craig MM, Mongerson CRL, Borsook D, Becerra L. Identifying rodent resting-state brain networks with independent component analysis. Front Neurosci. 2017;11:685. https://doi.org/10.3389/fnins.2017.00685.CrossRefPubMedPubMedCentral

107.

Borsook D, Hargreaves R, Becerra L. Can functional magnetic resonance imaging improve success rates in CNS drug discovery? Expert Opin Drug Discov. 2011;6(6):597–617. https://doi.org/10.1517/17460441.2011.584529.CrossRefPubMedPubMedCentral

108.

Colon E, Bittner EA, Kussman B, McCann ME, Soriano S, Borsook D. Anesthesia, brain changes, and behavior: insights from neural systems biology. Prog Neurobiol. 2017;153:121–60. https://doi.org/10.1016/j.pneurobio.2017.01.005.CrossRefPubMed

109.

Peng K, Steele SC, Becerra L, Borsook D. Brodmann area 10: collating, integrating and high level processing of nociception and pain. Prog Neurobiol. 2018;161:1–22. https://doi.org/10.1016/j.pneurobio.2017.11.004.CrossRefPubMed

110.

Parks EL, Geha PY, Baliki MN, Katz J, Schnitzer TJ, Apkarian AV. Brain activity for chronic knee osteoarthritis: dissociating evoked pain from spontaneous pain. Eur J Pain. 2011;15(8):843 e1–14. https://doi.org/10.1016/j.ejpain.2010.12.007.CrossRef

111.

Tetreault P, Mansour A, Vachon-Presseau E, Schnitzer TJ, Apkarian AV, Baliki MN. Brain connectivity predicts placebo response across chronic pain clinical trials. PLoS Biol. 2016;14(10):e1002570. https://doi.org/10.1371/journal.pbio.1002570.CrossRefPubMedPubMedCentral

Titel: Mechanisms Underlying Bone and Joint Pain
verfasst von: Joshua Havelin
Tamara King
Publikationsdatum: 29.10.2018
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 6/2018
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-018-0493-1

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Springer Medizin

Mechanisms Underlying Bone and Joint Pain

Abstract

Purpose of Review

Recent Findings

Summary

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Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Ärztliche Empathie hilft gegen Rückenschmerzen

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

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Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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