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Current Rheumatology Reports

Erschienen in:

01.03.2021 | Osteoarthritis (M Goldring and T Griffin, Section Editors)

Metabolic Regulation of Tendon Inflammation and Healing Following Injury

verfasst von: Jessica E. Ackerman, Katherine T. Best, Samantha N. Muscat, Alayna E. Loiselle

Erschienen in: Current Rheumatology Reports | Ausgabe 3/2021

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Abstract

Purpose of Review

This review seeks to provide an overview of the role of inflammation and metabolism in tendon cell function, tendinopathy, and tendon healing. We have summarized the state of knowledge in both tendon and enthesis.

Recent Findings

Recent advances in the field include a substantial improvement in our understanding of tendon cell biology, including the heterogeneity of the tenocyte environment during homeostasis, the diversity of the cellular milieu during in vivo tendon healing, and the effects of inflammation and altered metabolism on tendon cell function in vitro. In addition, the mechanisms by which altered systemic metabolism, such as diabetes, disrupts tendon homeostasis continue to be better understood.

Summary

A central conclusion of this review is the critical need to better define fundamental cellular and signaling mechanisms of inflammation and metabolism during tendon homeostasis, tendinopathy, and tendon healing in order to identify therapies to enhance or maintain tendon function.

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Titel: Metabolic Regulation of Tendon Inflammation and Healing Following Injury
verfasst von: Jessica E. Ackerman
Katherine T. Best
Samantha N. Muscat
Alayna E. Loiselle
Publikationsdatum: 01.03.2021
Verlag: Springer US
Erschienen in: Current Rheumatology Reports / Ausgabe 3/2021
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI: https://doi.org/10.1007/s11926-021-00981-4

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Clinical Approach to Diagnosis and Therapy of Polyarteritis Nodosa

Update on Post-Streptococcal Reactive Arthritis: Narrative Review of a Forgotten Disease

A Review of Complement Activation in SLE

Systemic Lupus Erythematosus in Children and Young People

Into Clinical Practice: Diagnosis and Therapy of Retroperitoneal Fibrosis