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Current Cardiovascular Risk Reports
Erschienen in: Current Cardiovascular Risk Reports 3/2015

01.03.2015 | Lipids (L Parnell and J Ordovas, Section Editors)

Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends

verfasst von: Mireia Urpi-Sarda, Enrique Almanza-Aguilera, Sara Tulipani, Francisco J. Tinahones, Jordi Salas-Salvadó, Cristina Andres-Lacueva

Erschienen in: Current Cardiovascular Risk Reports | Ausgabe 3/2015

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Abstract

Metabolic characterization of type 2 diabetes mellitus (T2DM) is crucial for the identification of individuals at risk for developing diabetes and T2DM-related vascular complications as well as for monitoring disease progression. The application of metabolomics to diabetes research may lead to the identification and discovery of diagnostic and prognostic T2DM biomarkers, in addition to elucidating disease pathways. In the present review, we summarize the distinct classes of metabolites that have been proposed as potential biomarkers for progressing stages of T2DM by metabolomic approaches. Several studies have demonstrated that the metabolism of carbohydrates, lipids, and amino acids is considerably altered in prediabetes and continue to vary over the course of T2DM progression. The identification of intermediate metabolites involved in glycolysis, gluconeogenesis, the tricarboxylic acid cycle, lipolysis, and proteolysis have provided evidence of these metabolic dysfunctions. Finally, given the increasing worldwide incidence of T2DM and its related complications, research should focus on the impact of lifestyle factors, particularly diet, at the metabolomic level for better understanding and improved healthcare strategies.
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Metadaten
Titel
Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends
verfasst von
Mireia Urpi-Sarda
Enrique Almanza-Aguilera
Sara Tulipani
Francisco J. Tinahones
Jordi Salas-Salvadó
Cristina Andres-Lacueva
Publikationsdatum
01.03.2015
Verlag
Springer US
Erschienen in
Current Cardiovascular Risk Reports / Ausgabe 3/2015
Print ISSN: 1932-9520
Elektronische ISSN: 1932-9563
DOI
https://doi.org/10.1007/s12170-015-0440-y

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