Erschienen in:
01.11.2012 | ASSISTED REPRODUCTION TECHNOLOGIES
Metaphase II (MII) oocytes obtained at different time points in the same in vitro fertilization cycle
verfasst von:
Hakan Cakmak, Victor Y. Fujimoto, A. Musa Zamah, Mitchell P. Rosen, Nam D. Tran, Marcelle I. Cedars, Paolo F. Rinaudo
Erschienen in:
Journal of Assisted Reproduction and Genetics
|
Ausgabe 11/2012
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Excerpt
Oocyte maturation is required to complete meiosis and to produce a competent oocyte able to sustain embryo development, implantation and pregnancy. In humans, meiosis begins in the developing ovaries at 11–12 weeks of gestation [
4]. The oocytes progress to diplotene stage of prophase I and then arrest until ovulation, an event that can occur decades later. Oocytes resume meiotic maturation in response to the midcycle luteinizing hormone (LH) surge. This final oocyte maturation can be induced medically with either human chorionic gonadotropin (hCG) or a gonadotropin-releasing hormone agonist (GnRHa). The former binds the LH receptor, while GnRHa promotes the release of endogenous gonadotropin stores from the hypophysis. …