Skip to main content
Erschienen in: Current Osteoporosis Reports 6/2018

19.09.2018 | Imaging (T Lang and F Wehrli, Section Editors)

Micro-Finite Element Analysis of the Proximal Femur on the Basis of High-Resolution Magnetic Resonance Images

verfasst von: Chamith S. Rajapakse, Gregory Chang

Erschienen in: Current Osteoporosis Reports | Ausgabe 6/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Hip fractures have catastrophic consequences. The purpose of this article is to review recent developments in high-resolution magnetic resonance imaging (MRI)-guided finite element analysis (FEA) of the hip as a means to determine subject-specific bone strength.

Recent Findings

Despite the ability of DXA to predict hip fracture, the majority of fractures occur in patients who do not have BMD T scores less than − 2.5. Therefore, without other detection methods, these individuals go undetected and untreated. Of methods available to image the hip, MRI is currently the only one capable of depicting bone microstructure in vivo. Availability of microstructural MRI allows generation of patient-specific micro-finite element models that can be used to simulate real-life loading conditions and determine bone strength.

Summary

MRI-based FEA enables radiation-free approach to assess hip fracture strength. With further validation, this technique could become a potential clinical tool in managing hip fracture risk.
Literatur
1.
Zurück zum Zitat Nih Consensus Development Panel on Osteoporosis Prevention D, Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001;285(6):785–95.CrossRef Nih Consensus Development Panel on Osteoporosis Prevention D, Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001;285(6):785–95.CrossRef
2.
Zurück zum Zitat Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res. 2007;22(3):465–75.CrossRef Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res. 2007;22(3):465–75.CrossRef
3.
Zurück zum Zitat Cooper Z, Mitchell SL, Lipsitz S, Harris MB, Ayanian JZ, Bernacki RE, et al. Mortality and readmission after cervical fracture from a fall in older adults: comparison with hip fracture using national Medicare data. J Am Geriatr Soc. 2015;63(10):2036–42.CrossRef Cooper Z, Mitchell SL, Lipsitz S, Harris MB, Ayanian JZ, Bernacki RE, et al. Mortality and readmission after cervical fracture from a fall in older adults: comparison with hip fracture using national Medicare data. J Am Geriatr Soc. 2015;63(10):2036–42.CrossRef
4.
Zurück zum Zitat Leibson CL, Tosteson AN, Gabriel SE, Ransom JE, Melton LJ. Mortality, disability, and nursing home use for persons with and without hip fracture: a population-based study. J Am Geriatr Soc. 2002;50(10):1644–50.CrossRef Leibson CL, Tosteson AN, Gabriel SE, Ransom JE, Melton LJ. Mortality, disability, and nursing home use for persons with and without hip fracture: a population-based study. J Am Geriatr Soc. 2002;50(10):1644–50.CrossRef
5.
Zurück zum Zitat Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002;359(9321):1929–36.CrossRef Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002;359(9321):1929–36.CrossRef
6.
Zurück zum Zitat Kanis JA, Borgstrom F, De Laet C, Johansson H, Johnell O, Jonsson B, et al. Assessment of fracture risk. Osteoporos Int. 2005;16(6):581–9.CrossRef Kanis JA, Borgstrom F, De Laet C, Johansson H, Johnell O, Jonsson B, et al. Assessment of fracture risk. Osteoporos Int. 2005;16(6):581–9.CrossRef
7.
Zurück zum Zitat Wainwright SA, Marshall LM, Ensrud KE, Cauley JA, Black DM, Hillier TA, et al. Hip fracture in women without osteoporosis. J Clin Endocrinol Metab. 2005;90(5):2787–93.CrossRef Wainwright SA, Marshall LM, Ensrud KE, Cauley JA, Black DM, Hillier TA, et al. Hip fracture in women without osteoporosis. J Clin Endocrinol Metab. 2005;90(5):2787–93.CrossRef
8.
Zurück zum Zitat Siris ES, Chen YT, Abbott TA, Barrett-Connor E, Miller PD, Wehren LE, et al. Bone mineral density thresholds for pharmacological intervention to prevent fractures. Arch Intern Med. 2004;164(10):1108–12.CrossRef Siris ES, Chen YT, Abbott TA, Barrett-Connor E, Miller PD, Wehren LE, et al. Bone mineral density thresholds for pharmacological intervention to prevent fractures. Arch Intern Med. 2004;164(10):1108–12.CrossRef
9.
Zurück zum Zitat Schuit SC, van der Klift M, Weel AE, de Laet CE, Burger H, Seeman E, et al. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone. 2004;34(1):195–202.CrossRef Schuit SC, van der Klift M, Weel AE, de Laet CE, Burger H, Seeman E, et al. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone. 2004;34(1):195–202.CrossRef
10.
Zurück zum Zitat Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E. FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008;19(4):385–97.CrossRef Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E. FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008;19(4):385–97.CrossRef
11.
Zurück zum Zitat Kanis JA, Hans D, Cooper C, Baim S, Bilezikian JP, Binkley N, et al. Interpretation and use of FRAX in clinical practice. Osteoporos Int. 2011;22(9):2395–411.CrossRef Kanis JA, Hans D, Cooper C, Baim S, Bilezikian JP, Binkley N, et al. Interpretation and use of FRAX in clinical practice. Osteoporos Int. 2011;22(9):2395–411.CrossRef
12.
Zurück zum Zitat Bonnick SL. HSA: beyond BMD with DXA. Bone. 2007;41(1 Suppl 1):S9–12.PubMed Bonnick SL. HSA: beyond BMD with DXA. Bone. 2007;41(1 Suppl 1):S9–12.PubMed
13.
Zurück zum Zitat Beck TJ, Broy SB. Measurement of hip geometry-technical background. J Clin Densitom. 2015;18(3):331–7.CrossRef Beck TJ, Broy SB. Measurement of hip geometry-technical background. J Clin Densitom. 2015;18(3):331–7.CrossRef
14.
Zurück zum Zitat Silva BC, Leslie WD, Resch H, Lamy O, Lesnyak O, Binkley N, et al. Trabecular bone score: a noninvasive analytical method based upon the DXA image. J Bone Miner Res. 2014;29(3):518–30.CrossRef Silva BC, Leslie WD, Resch H, Lamy O, Lesnyak O, Binkley N, et al. Trabecular bone score: a noninvasive analytical method based upon the DXA image. J Bone Miner Res. 2014;29(3):518–30.CrossRef
15.
Zurück zum Zitat Link TM, Lang TF. Axial QCT: clinical applications and new developments. J Clin Densitom. 2014;17(4):438–48.CrossRef Link TM, Lang TF. Axial QCT: clinical applications and new developments. J Clin Densitom. 2014;17(4):438–48.CrossRef
16.
Zurück zum Zitat Lang TF, Saeed IH, Streeper T, Carballido-Gamio J, Harnish RJ, Frassetto LA, et al. Spatial heterogeneity in the response of the proximal femur to two lower-body resistance exercise regimens. J Bone Miner Res. 2014;29(6):1337–45.CrossRef Lang TF, Saeed IH, Streeper T, Carballido-Gamio J, Harnish RJ, Frassetto LA, et al. Spatial heterogeneity in the response of the proximal femur to two lower-body resistance exercise regimens. J Bone Miner Res. 2014;29(6):1337–45.CrossRef
17.
Zurück zum Zitat Treece GM, Gee AH, Tonkin C, Ewing SK, Cawthon PM, Black DM, et al. Predicting hip fracture type with cortical bone mapping (CBM) in the Osteoporotic Fractures in Men (MrOS) study. J Bone Miner Res. 2015;30(11):2067–77.CrossRef Treece GM, Gee AH, Tonkin C, Ewing SK, Cawthon PM, Black DM, et al. Predicting hip fracture type with cortical bone mapping (CBM) in the Osteoporotic Fractures in Men (MrOS) study. J Bone Miner Res. 2015;30(11):2067–77.CrossRef
18.
Zurück zum Zitat Johannesdottir F, Turmezei T, Poole KE. Cortical bone assessed with clinical computed tomography at the proximal femur. J Bone Miner Res. 2014;29(4):771–83.CrossRef Johannesdottir F, Turmezei T, Poole KE. Cortical bone assessed with clinical computed tomography at the proximal femur. J Bone Miner Res. 2014;29(4):771–83.CrossRef
19.
Zurück zum Zitat Keaveny TM. Biomechanical computed tomography-noninvasive bone strength analysis using clinical computed tomography scans. Ann N Y Acad Sci. 2010;1192:57–65.CrossRef Keaveny TM. Biomechanical computed tomography-noninvasive bone strength analysis using clinical computed tomography scans. Ann N Y Acad Sci. 2010;1192:57–65.CrossRef
20.
Zurück zum Zitat Keyak JH, Rossi SA, Jones KA, Les CM, Skinner HB. Prediction of fracture location in the proximal femur using finite element models. Med Eng Phys. 2001;23(9):657–64.CrossRef Keyak JH, Rossi SA, Jones KA, Les CM, Skinner HB. Prediction of fracture location in the proximal femur using finite element models. Med Eng Phys. 2001;23(9):657–64.CrossRef
21.
Zurück zum Zitat Nishiyama KK, Shane E. Clinical imaging of bone microarchitecture with HR-pQCT. Curr Osteoporos Rep. 2013;11(2):147–55.CrossRef Nishiyama KK, Shane E. Clinical imaging of bone microarchitecture with HR-pQCT. Curr Osteoporos Rep. 2013;11(2):147–55.CrossRef
22.
Zurück zum Zitat Cheung AM, Adachi JD, Hanley DA, Kendler DL, Davison KS, Josse R, et al. High-resolution peripheral quantitative computed tomography for the assessment of bone strength and structure: a review by the Canadian Bone Strength Working Group. Curr Osteoporos Rep. 2013;11(2):136–46.CrossRef Cheung AM, Adachi JD, Hanley DA, Kendler DL, Davison KS, Josse R, et al. High-resolution peripheral quantitative computed tomography for the assessment of bone strength and structure: a review by the Canadian Bone Strength Working Group. Curr Osteoporos Rep. 2013;11(2):136–46.CrossRef
23.
Zurück zum Zitat Wehrli FW. Structural and functional assessment of trabecular and cortical bone by micro magnetic resonance imaging. J Magn Reson Imaging. 2007;25(2):390–409.CrossRef Wehrli FW. Structural and functional assessment of trabecular and cortical bone by micro magnetic resonance imaging. J Magn Reson Imaging. 2007;25(2):390–409.CrossRef
24.
Zurück zum Zitat Chang G, Boone S, Martel D, Rajapakse CS, Hallyburton RS, Valko M, et al. MRI assessment of bone structure and microarchitecture. J Magn Reson Imaging. 2017;46(2):323–37.CrossRef Chang G, Boone S, Martel D, Rajapakse CS, Hallyburton RS, Valko M, et al. MRI assessment of bone structure and microarchitecture. J Magn Reson Imaging. 2017;46(2):323–37.CrossRef
25.
Zurück zum Zitat Link TM, Majumdar S, Augat P, Lin JC, Newitt D, Lu Y, et al. In vivo high resolution MRI of the calcaneus: differences in trabecular structure in osteoporosis patients. J Bone Miner Res. 1998;13(7):1175–82.CrossRef Link TM, Majumdar S, Augat P, Lin JC, Newitt D, Lu Y, et al. In vivo high resolution MRI of the calcaneus: differences in trabecular structure in osteoporosis patients. J Bone Miner Res. 1998;13(7):1175–82.CrossRef
26.
Zurück zum Zitat Majumdar S, Genant HK, Grampp S, Newitt DC, Truong VH, Lin JC, et al. Correlation of trabecular bone structure with age, bone mineral density, and osteoporotic status: in vivo studies in the distal radius using high resolution magnetic resonance imaging. J Bone Miner Res. 1997;12(1):111–8.CrossRef Majumdar S, Genant HK, Grampp S, Newitt DC, Truong VH, Lin JC, et al. Correlation of trabecular bone structure with age, bone mineral density, and osteoporotic status: in vivo studies in the distal radius using high resolution magnetic resonance imaging. J Bone Miner Res. 1997;12(1):111–8.CrossRef
27.
Zurück zum Zitat Wehrli FW, Hwang SN, Ma J, Song HK, Ford JC, Haddad JG. Cancellous bone volume and structure in the forearm: noninvasive assessment with MR microimaging and image processing. Radiology. 1998;206(2):347–57.CrossRef Wehrli FW, Hwang SN, Ma J, Song HK, Ford JC, Haddad JG. Cancellous bone volume and structure in the forearm: noninvasive assessment with MR microimaging and image processing. Radiology. 1998;206(2):347–57.CrossRef
28.
Zurück zum Zitat Krug R, Banerjee S, Han ET, Newitt DC, Link TM, Majumdar S. Feasibility of in vivo structural analysis of high-resolution magnetic resonance images of the proximal femur. Osteoporos Int. 2005;16(11):1307–14.CrossRef Krug R, Banerjee S, Han ET, Newitt DC, Link TM, Majumdar S. Feasibility of in vivo structural analysis of high-resolution magnetic resonance images of the proximal femur. Osteoporos Int. 2005;16(11):1307–14.CrossRef
29.
Zurück zum Zitat • Chang G, Deniz CM, Honig S, Rajapakse CS, Egol K, Regatte RR, et al. Feasibility of three-dimensional MRI of proximal femur microarchitecture at 3 tesla using 26 receive elements without and with parallel imaging. J Magn Reson Imaging. 2014;40(1):229–38 This study demonstrates the feasibility of generating microstructural MR images in human subjects. CrossRef • Chang G, Deniz CM, Honig S, Rajapakse CS, Egol K, Regatte RR, et al. Feasibility of three-dimensional MRI of proximal femur microarchitecture at 3 tesla using 26 receive elements without and with parallel imaging. J Magn Reson Imaging. 2014;40(1):229–38 This study demonstrates the feasibility of generating microstructural MR images in human subjects. CrossRef
30.
Zurück zum Zitat • Han M, Chiba K, Banerjee S, Carballido-Gamio J, Krug R. Variable flip angle three-dimensional fast spin-echo sequence combined with outer volume suppression for imaging trabecular bone structure of the proximal femur. J Magn Reson Imaging. 2015;41(5):1300–10 This study demonstrates the feasibility of generating microstructural MR images in human subjects. CrossRef • Han M, Chiba K, Banerjee S, Carballido-Gamio J, Krug R. Variable flip angle three-dimensional fast spin-echo sequence combined with outer volume suppression for imaging trabecular bone structure of the proximal femur. J Magn Reson Imaging. 2015;41(5):1300–10 This study demonstrates the feasibility of generating microstructural MR images in human subjects. CrossRef
31.
Zurück zum Zitat Rajapakse CS, Kobe EA, Batzdorf AS, Hast MW, Wehrli FW. Accuracy of MRI-based finite element assessment of distal tibia compared to mechanical testing. Bone. 2017;108:71–8.CrossRef Rajapakse CS, Kobe EA, Batzdorf AS, Hast MW, Wehrli FW. Accuracy of MRI-based finite element assessment of distal tibia compared to mechanical testing. Bone. 2017;108:71–8.CrossRef
32.
Zurück zum Zitat van Rietbergen B, Majumdar S, Newitt D, MacDonald B. High-resolution MRI and micro-FE for the evaluation of changes in bone mechanical properties during longitudinal clinical trials: application to calcaneal bone in postmenopausal women after one year of idoxifene treatment. Clin Biomech (Bristol, Avon). 2002;17(2):81–8.CrossRef van Rietbergen B, Majumdar S, Newitt D, MacDonald B. High-resolution MRI and micro-FE for the evaluation of changes in bone mechanical properties during longitudinal clinical trials: application to calcaneal bone in postmenopausal women after one year of idoxifene treatment. Clin Biomech (Bristol, Avon). 2002;17(2):81–8.CrossRef
33.
Zurück zum Zitat Al Mukaddam M, Rajapakse CS, Bhagat YA, Wehrli FW, Guo W, Peachey H, et al. Effects of testosterone and growth hormone on the structural and mechanical properties of bone by micro-MRI in the distal tibia of men with hypopituitarism. J Clin Endocrinol Metab. 2014;99(4):1236–44.CrossRef Al Mukaddam M, Rajapakse CS, Bhagat YA, Wehrli FW, Guo W, Peachey H, et al. Effects of testosterone and growth hormone on the structural and mechanical properties of bone by micro-MRI in the distal tibia of men with hypopituitarism. J Clin Endocrinol Metab. 2014;99(4):1236–44.CrossRef
34.
Zurück zum Zitat Rajapakse CS, Leonard MB, Kobe EA, Slinger MA, Borges KA, Billig E, et al. The efficacy of low-intensity vibration to improve bone health in patients with end-stage renal disease is highly dependent on compliance and muscle response. Acad Radiol. 2017;24(11):1332–42.CrossRef Rajapakse CS, Leonard MB, Kobe EA, Slinger MA, Borges KA, Billig E, et al. The efficacy of low-intensity vibration to improve bone health in patients with end-stage renal disease is highly dependent on compliance and muscle response. Acad Radiol. 2017;24(11):1332–42.CrossRef
35.
Zurück zum Zitat Wehrli FW, Rajapakse CS, Magland JF, Snyder PJ. Mechanical implications of estrogen supplementation in early postmenopausal women. J Bone Miner Res. 2010;25(6):1406–14.CrossRef Wehrli FW, Rajapakse CS, Magland JF, Snyder PJ. Mechanical implications of estrogen supplementation in early postmenopausal women. J Bone Miner Res. 2010;25(6):1406–14.CrossRef
36.
Zurück zum Zitat Zhang XH, Liu XS, Vasilic B, Wehrli FW, Benito M, Rajapakse CS, et al. In vivo microMRI-based finite element and morphological analyses of tibial trabecular bone in eugonadal and hypogonadal men before and after testosterone treatment. J Bone Miner Res. 2008;23(9):1426–34.CrossRef Zhang XH, Liu XS, Vasilic B, Wehrli FW, Benito M, Rajapakse CS, et al. In vivo microMRI-based finite element and morphological analyses of tibial trabecular bone in eugonadal and hypogonadal men before and after testosterone treatment. J Bone Miner Res. 2008;23(9):1426–34.CrossRef
37.
Zurück zum Zitat Lam SC, Wald MJ, Rajapakse CS, Liu Y, Saha PK, Wehrli FW. Performance of the MRI-based virtual bone biopsy in the distal radius: serial reproducibility and reliability of structural and mechanical parameters in women representative of osteoporosis study populations. Bone. 2011;49(4):895–903.CrossRef Lam SC, Wald MJ, Rajapakse CS, Liu Y, Saha PK, Wehrli FW. Performance of the MRI-based virtual bone biopsy in the distal radius: serial reproducibility and reliability of structural and mechanical parameters in women representative of osteoporosis study populations. Bone. 2011;49(4):895–903.CrossRef
38.
Zurück zum Zitat Rajapakse CS, Leonard MB, Bhagat YA, Sun W, Magland JF, Wehrli FW. Micro-MR imaging-based computational biomechanics demonstrates reduction in cortical and trabecular bone strength after renal transplantation. Radiology. 2012;262(3):912–20.CrossRef Rajapakse CS, Leonard MB, Bhagat YA, Sun W, Magland JF, Wehrli FW. Micro-MR imaging-based computational biomechanics demonstrates reduction in cortical and trabecular bone strength after renal transplantation. Radiology. 2012;262(3):912–20.CrossRef
39.
Zurück zum Zitat Rajapakse CS, Phillips EA, Sun W, Wald MJ, Magland JF, Snyder PJ, et al. Vertebral deformities and fractures are associated with MRI and pQCT measures obtained at the distal tibia and radius of postmenopausal women. Osteoporos Int. 2014;25(3):973–82.CrossRef Rajapakse CS, Phillips EA, Sun W, Wald MJ, Magland JF, Snyder PJ, et al. Vertebral deformities and fractures are associated with MRI and pQCT measures obtained at the distal tibia and radius of postmenopausal women. Osteoporos Int. 2014;25(3):973–82.CrossRef
40.
Zurück zum Zitat Wald MJ, Magland JF, Rajapakse CS, Bhagat YA, Wehrli FW. Predicting trabecular bone elastic properties from measures of bone volume fraction and fabric on the basis of micromagnetic resonance images. Magn Reson Med. 2012;68(2):463–73.CrossRef Wald MJ, Magland JF, Rajapakse CS, Bhagat YA, Wehrli FW. Predicting trabecular bone elastic properties from measures of bone volume fraction and fabric on the basis of micromagnetic resonance images. Magn Reson Med. 2012;68(2):463–73.CrossRef
41.
Zurück zum Zitat Wald MJ, Magland JF, Rajapakse CS, Wehrli FW. Structural and mechanical parameters of trabecular bone estimated from in vivo high-resolution magnetic resonance images at 3 tesla field strength. J Magn Reson Imaging. 2010;31(5):1157–68.CrossRef Wald MJ, Magland JF, Rajapakse CS, Wehrli FW. Structural and mechanical parameters of trabecular bone estimated from in vivo high-resolution magnetic resonance images at 3 tesla field strength. J Magn Reson Imaging. 2010;31(5):1157–68.CrossRef
42.
Zurück zum Zitat Bhagat YA, Rajapakse CS, Magland JF, Love JH, Wright AC, Wald MJ, et al. Performance of muMRI-based virtual bone biopsy for structural and mechanical analysis at the distal tibia at 7T field strength. J Magn Reson Imaging. 2011;33(2):372–81.CrossRef Bhagat YA, Rajapakse CS, Magland JF, Love JH, Wright AC, Wald MJ, et al. Performance of muMRI-based virtual bone biopsy for structural and mechanical analysis at the distal tibia at 7T field strength. J Magn Reson Imaging. 2011;33(2):372–81.CrossRef
43.
Zurück zum Zitat Chang G, Rajapakse CS, Babb JS, Honig SP, Recht MP, Regatte RR. In vivo estimation of bone stiffness at the distal femur and proximal tibia using ultra-high-field 7-Tesla magnetic resonance imaging and micro-finite element analysis. J Bone Miner Metab. 2012;30(2):243–51.CrossRef Chang G, Rajapakse CS, Babb JS, Honig SP, Recht MP, Regatte RR. In vivo estimation of bone stiffness at the distal femur and proximal tibia using ultra-high-field 7-Tesla magnetic resonance imaging and micro-finite element analysis. J Bone Miner Metab. 2012;30(2):243–51.CrossRef
44.
Zurück zum Zitat Chang G, Rajapakse CS, Diamond M, Honig S, Recht MP, Weiss DS, et al. Micro-finite element analysis applied to high-resolution MRI reveals improved bone mechanical competence in the distal femur of female pre-professional dancers. Osteoporos Int. 2013;24(4):1407–17.CrossRef Chang G, Rajapakse CS, Diamond M, Honig S, Recht MP, Weiss DS, et al. Micro-finite element analysis applied to high-resolution MRI reveals improved bone mechanical competence in the distal femur of female pre-professional dancers. Osteoporos Int. 2013;24(4):1407–17.CrossRef
45.
Zurück zum Zitat Rajapakse CS, Magland J, Zhang XH, Liu XS, Wehrli SL, Guo XE, et al. Implications of noise and resolution on mechanical properties of trabecular bone estimated by image-based finite-element analysis. J Orthop Res. 2009;27(10):1263–71.CrossRef Rajapakse CS, Magland J, Zhang XH, Liu XS, Wehrli SL, Guo XE, et al. Implications of noise and resolution on mechanical properties of trabecular bone estimated by image-based finite-element analysis. J Orthop Res. 2009;27(10):1263–71.CrossRef
46.
Zurück zum Zitat Zhang N, Magland JF, Rajapakse CS, Bhagat YA, Wehrli FW. Potential of in vivo MRI-based nonlinear finite-element analysis for the assessment of trabecular bone post-yield properties. Med Phys. 2013;40(5). 052303.CrossRef Zhang N, Magland JF, Rajapakse CS, Bhagat YA, Wehrli FW. Potential of in vivo MRI-based nonlinear finite-element analysis for the assessment of trabecular bone post-yield properties. Med Phys. 2013;40(5). 052303.CrossRef
47.
Zurück zum Zitat Zhang N, Magland JF, Rajapakse CS, Lam SB, Wehrli FW. Assessment of trabecular bone yield and post-yield behavior from high-resolution MRI-based nonlinear finite element analysis at the distal radius of premenopausal and postmenopausal women susceptible to osteoporosis. Acad Radiol. 2013;20(12):1584–91.CrossRef Zhang N, Magland JF, Rajapakse CS, Lam SB, Wehrli FW. Assessment of trabecular bone yield and post-yield behavior from high-resolution MRI-based nonlinear finite element analysis at the distal radius of premenopausal and postmenopausal women susceptible to osteoporosis. Acad Radiol. 2013;20(12):1584–91.CrossRef
48.
Zurück zum Zitat Carballido-Gamio J, Harnish R, Saeed I, Streeper T, Sigurdsson S, Amin S, et al. Proximal femoral density distribution and structure in relation to age and hip fracture risk in women. J Bone Miner Res. 2013;28(3):537–46.CrossRef Carballido-Gamio J, Harnish R, Saeed I, Streeper T, Sigurdsson S, Amin S, et al. Proximal femoral density distribution and structure in relation to age and hip fracture risk in women. J Bone Miner Res. 2013;28(3):537–46.CrossRef
49.
Zurück zum Zitat Engelke K, Nagase S, Fuerst T, Small M, Kuwayama T, Deacon S, et al. The effect of the cathepsin K inhibitor ONO-5334 on trabecular and cortical bone in postmenopausal osteoporosis: the OCEAN study. J Bone Miner Res. 2014;29(3):629–38.CrossRef Engelke K, Nagase S, Fuerst T, Small M, Kuwayama T, Deacon S, et al. The effect of the cathepsin K inhibitor ONO-5334 on trabecular and cortical bone in postmenopausal osteoporosis: the OCEAN study. J Bone Miner Res. 2014;29(3):629–38.CrossRef
50.
Zurück zum Zitat Yang L, Sycheva AV, Black DM, Eastell R. Site-specific differential effects of once-yearly zoledronic acid on the hip assessed with quantitative computed tomography: results from the HORIZON Pivotal Fracture Trial. Osteoporos Int. 2013;24(1):329–38.CrossRef Yang L, Sycheva AV, Black DM, Eastell R. Site-specific differential effects of once-yearly zoledronic acid on the hip assessed with quantitative computed tomography: results from the HORIZON Pivotal Fracture Trial. Osteoporos Int. 2013;24(1):329–38.CrossRef
51.
Zurück zum Zitat Keaveny TM, McClung MR, Genant HK, Zanchetta JR, Kendler D, Brown JP, et al. Femoral and vertebral strength improvements in postmenopausal women with osteoporosis treated with denosumab. J Bone Miner Res. 2014;29(1):158–65.CrossRef Keaveny TM, McClung MR, Genant HK, Zanchetta JR, Kendler D, Brown JP, et al. Femoral and vertebral strength improvements in postmenopausal women with osteoporosis treated with denosumab. J Bone Miner Res. 2014;29(1):158–65.CrossRef
52.
Zurück zum Zitat Keyak JH, Sigurdsson S, Karlsdottir GS, Oskarsdottir D, Sigmarsdottir A, Kornak J, et al. Effect of finite element model loading condition on fracture risk assessment in men and women: the AGES-Reykjavik study. Bone. 2013;57(1):18–29.CrossRef Keyak JH, Sigurdsson S, Karlsdottir GS, Oskarsdottir D, Sigmarsdottir A, Kornak J, et al. Effect of finite element model loading condition on fracture risk assessment in men and women: the AGES-Reykjavik study. Bone. 2013;57(1):18–29.CrossRef
53.
Zurück zum Zitat Nishiyama KK, Ito M, Harada A, Boyd SK. Classification of women with and without hip fracture based on quantitative computed tomography and finite element analysis. Osteoporos Int. 2014;25(2):619–26.CrossRef Nishiyama KK, Ito M, Harada A, Boyd SK. Classification of women with and without hip fracture based on quantitative computed tomography and finite element analysis. Osteoporos Int. 2014;25(2):619–26.CrossRef
54.
Zurück zum Zitat Rajapakse CS, Magland JF, Wald MJ, Liu XS, Zhang XH, Guo XE, et al. Computational biomechanics of the distal tibia from high-resolution MR and micro-CT images. Bone. 2010;47(3):556–63.CrossRef Rajapakse CS, Magland JF, Wald MJ, Liu XS, Zhang XH, Guo XE, et al. Computational biomechanics of the distal tibia from high-resolution MR and micro-CT images. Bone. 2010;47(3):556–63.CrossRef
55.
Zurück zum Zitat • Chang G, Honig S, Brown R, Deniz CM, Egol KA, Babb JS, et al. Finite element analysis applied to 3-T MR imaging of proximal femur microarchitecture: lower bone strength in patients with fragility fractures compared with control subjects. Radiology. 2014;272(2):464–74 This study demontrate the usefulness of MRI-based FEA for assessment of proximal femur bone quality beyond the capabilities of DXA.CrossRef • Chang G, Honig S, Brown R, Deniz CM, Egol KA, Babb JS, et al. Finite element analysis applied to 3-T MR imaging of proximal femur microarchitecture: lower bone strength in patients with fragility fractures compared with control subjects. Radiology. 2014;272(2):464–74 This study demontrate the usefulness of MRI-based FEA for assessment of proximal femur bone quality beyond the capabilities of DXA.CrossRef
56.
Zurück zum Zitat •• Rajapakse CS, Hotca A, Newman BT, Ramme A, Vira S, Kobe EA, et al. Patient-specific hip fracture strength assessment with microstructural mr imaging-based finite element modeling. Radiology. 2017;283(3):854–61 This study provides the technical details on how to implement nonlinear FEA on the basis of high-resolution MRI to determine the fracture strength of the proximal femur under real-life loading conditions. CrossRef •• Rajapakse CS, Hotca A, Newman BT, Ramme A, Vira S, Kobe EA, et al. Patient-specific hip fracture strength assessment with microstructural mr imaging-based finite element modeling. Radiology. 2017;283(3):854–61 This study provides the technical details on how to implement nonlinear FEA on the basis of high-resolution MRI to determine the fracture strength of the proximal femur under real-life loading conditions. CrossRef
57.
Zurück zum Zitat Chang G, Hotca-Cho A, Rusinek H, Honig S, Mikheev A, Egol K, et al. Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength. MAGMA. 2015;28(4):407–12.CrossRef Chang G, Hotca-Cho A, Rusinek H, Honig S, Mikheev A, Egol K, et al. Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength. MAGMA. 2015;28(4):407–12.CrossRef
58.
Zurück zum Zitat Chang G, Rajapakse CS, Regatte RR, Babb J, Saxena A, Belmont HM, et al. 3 Tesla MRI detects deterioration in proximal femur microarchitecture and strength in long-term glucocorticoid users compared with controls. J Magn Reson Imaging. 2015;42(6):1489–96.CrossRef Chang G, Rajapakse CS, Regatte RR, Babb J, Saxena A, Belmont HM, et al. 3 Tesla MRI detects deterioration in proximal femur microarchitecture and strength in long-term glucocorticoid users compared with controls. J Magn Reson Imaging. 2015;42(6):1489–96.CrossRef
59.
Zurück zum Zitat Greenspan SL, Myers ER, Maitland LA, Resnick NM, Hayes WC. Fall severity and bone mineral density as risk factors for hip fracture in ambulatory elderly. JAMA. 1994;271(2):128–33.CrossRef Greenspan SL, Myers ER, Maitland LA, Resnick NM, Hayes WC. Fall severity and bone mineral density as risk factors for hip fracture in ambulatory elderly. JAMA. 1994;271(2):128–33.CrossRef
60.
Zurück zum Zitat Keyak JH. Improved prediction of proximal femoral fracture load using nonlinear finite element models. Med Eng Phys. 2001;23(3):165–73.CrossRef Keyak JH. Improved prediction of proximal femoral fracture load using nonlinear finite element models. Med Eng Phys. 2001;23(3):165–73.CrossRef
61.
Zurück zum Zitat Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. 1993;94(6):646–50. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. 1993;94(6):646–50.
Metadaten
Titel
Micro-Finite Element Analysis of the Proximal Femur on the Basis of High-Resolution Magnetic Resonance Images
verfasst von
Chamith S. Rajapakse
Gregory Chang
Publikationsdatum
19.09.2018
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 6/2018
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-018-0481-5

Weitere Artikel der Ausgabe 6/2018

Current Osteoporosis Reports 6/2018 Zur Ausgabe

Kidney and Bone (I Salusky and T Nickolas, Section Editors)

Non-renal-Related Mechanisms of FGF23 Pathophysiology

Cancer-induced Musculoskeletal Diseases (J Sterling and E Keller, section editors)

Contributions of the Bone Microenvironment to Monoclonal Gammopathy of Undetermined Significance Pathogenesis

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Medizinstudium Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Aquatherapie bei Fibromyalgie wirksamer als Trockenübungen

03.05.2024 Fibromyalgiesyndrom Nachrichten

Bewegungs-, Dehnungs- und Entspannungsübungen im Wasser lindern die Beschwerden von Patientinnen mit Fibromyalgie besser als das Üben auf trockenem Land. Das geht aus einer spanisch-brasilianischen Vergleichsstudie hervor.

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärztinnen und Psychotherapeuten.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.