Introduction
Materials and methods
Patients
Study design
Biochemistry
Statistical analysis
Results
Episodic migraine | Chronic migrainea | Controls (female) | Cluster headache | Controls (male) | |
---|---|---|---|---|---|
n. | 19 | 51 | 31 | 18 | 16 |
Age (years) | 41,6±16,2 | 51,6±10,9 | 52,1±17,8 | 46,2±15,8 | 58,7±13,8 |
Menopause | 36% (7/19) | 62% (32/51) | 54% (17/31) | N.A. | N.A. |
Sampling during migraine/headache attack | 0% | 53% | N.A. | 39% | N.A. |
BDI (n.)
no/mild/mod./severe
| 18
12/4/2
| 49
26/11/7/5
| N.A. | 18
14/3/0/1
| N.A. |
SAS (n.)
low/moderate/severe
| 17
14/3/0
| 48
27/18/3
| N.A. | 18
16/2/0
| N.A. |
HIT-6 (n.)
mild/mod./relevant/severe
| 18
5/0/0/13
| 49
1/2/2/44
| N.A. | 18
2/5/3/8
| N.A. |
MIDAS (n.)
I→IV (low→severe disability)
| 18
2/4/5/7
| 49
4/5/3/37
| N.A. | N.A. | N.A. |
Episodic migraine
Episodic migraine | Controls |
P
| |
---|---|---|---|
AP (ng/mL) | 1.3 ± 0.5 | 0.6 ± 0.3 | < 0.01 |
EAP (ng/mL) | 0.7 ± 0.2 | 0.4 ± 0.1 | < 0.01 |
DHEA (ng/mL) | 2.9 ± 1.5 | 5.1 ± 3.8 | < 0.05 |
DHEAS (μg/mL) | 2.4 ± 1.1 | 2.7 ± 2.0 | n.s. |
Chronic migraine (including medication-overuse)
Chronic migraine (overall population) | Controls |
P
| |
---|---|---|---|
AP (ng/mL) | 1.1 ± 0.3 | 0.61 ± 0.3 | < 0.01 |
EAP (ng/mL) | 0.4 ± 0.2 | 0.41 ± 01 | n.s. |
DHEA (ng/mL) | 1.6 ± 1.1 | 5.1 ± 3.8 | < 0.01 |
DHEAS (μg/mL) | 1.2 ± 0.9 | 2.76 ± 2.0 | < 0.01 |
Episodic migraine (n = 19) | Chronic migraine (n = 51) |
P
| |
---|---|---|---|
DHEA (ng/mL) | 2.9 ± 1.5 | 1.6 ± 1.1 | < 0.01 |
DHEAS (μg/mL) | 2.4 ± 1.1 | 1.2 ± 0.9 | < 0.01 |
AP (ng/mL) | 1.3 ± 0.5 | 1.1 ± 0.3 | n.s. |
Chronic migraine during attack (n = 27) | Chronic migraine no attack (n = 24) | Controls | |
---|---|---|---|
AP (ng/mL) | 1.1 ± 0.4* | 1.1 ± 0.2* | 0.6 ± 0.3 |
EAP (ng/mL) | 0.5 ± 0.1 | 0.4 ± 0.2 | 0.4 ± 0.1 |
DHEA (ng/mL) | 1.4 ± 0.9* | 1.8 ± 1.2* | 5.1 ± 3.8 |
DHEAS (μg/mL) | 1.5 ± 1.1* | 1.0 ± 0.6* | 2.7 ± 2.0 |
Cluster headache
Cluster headache | Controls |
P
| |
---|---|---|---|
AP (ng/mL) | 0.3 ± 0.1 | 0.7 ± 0.2 | < 0.01 |
EAP (ng/mL) | 0.4 ± 0.1 | 0.3 ± 0.2 | n.s. |
DHEA (ng/mL) | 2.9 ± 2.2 | 4.3 ± 5.0 | n.s. |
DHEAS (μg/mL) | 2.6 ± 1.7 | 2.2 ± 1.7 | n.s. |