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Erschienen in: Journal of Neural Transmission 2/2014

01.02.2014 | Translational Neurosciences - Short communication

Mild hypothermia protects against oxygen glucose deprivation (OGD)-induced cell death in brain slices from adult mice

verfasst von: Mar Hernández-Guillamon, Laura Ortega, Cristina Merino-Zamorano, Mireia Campos-Martorell, Anna Rosell, Joan Montaner

Erschienen in: Journal of Neural Transmission | Ausgabe 2/2014

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Abstract

Most of neuroprotective strategies in stroke have failed to move from bench to bedside. One explanation might be the use of excessive uniform and smooth experimental models. Therefore, we have employed a more stringent in vitro model based on cultured brain slices from adult mice submitted to OGD. Using this acute model, we have confirmed that mild hypothermia protects against OGD-induced cell death when cooling the tissue during and after OGD, but not when hypothermia is induced only during reoxygenation.
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Metadaten
Titel
Mild hypothermia protects against oxygen glucose deprivation (OGD)-induced cell death in brain slices from adult mice
verfasst von
Mar Hernández-Guillamon
Laura Ortega
Cristina Merino-Zamorano
Mireia Campos-Martorell
Anna Rosell
Joan Montaner
Publikationsdatum
01.02.2014
Verlag
Springer Vienna
Erschienen in
Journal of Neural Transmission / Ausgabe 2/2014
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-013-1090-1

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